pharmaceutical capsules on a conveyor belt in a factory

Chemical & process engineering Health and wellbeing

We're active innovators in pharmaceutical processing, monitoring technology, and process development.

A number of our academics are research partners within the National Centre for Continuous Manufacturing and Crystallization (CMAC) which focuses on transitioning the pharmaceutical industry from batch to continuous operation.

We've developed crystallization and isolation process development workflows and offer training in their industrial application. Our modeling team has simulated the interactions between proteins and peptides with small molecules.

 

Meet the team

miguel jorge smiling at the camera

Dr Miguel Jorge

Predicting solubility of complex pharmaceutical molecules is essential to optimise drug manufacture and to better identify promising new compounds. Our group is using molecular simulation to predict how drug molecules dissolve in different solvents, aiming to replace current regression-based methods by more physically-based (and hence more predictive) approaches.

Paul Mulheran smiling at the camera

Dr Paul Mulheran

The design of highly immunogenic immunogens for the development of monoclonal antibodies: this current PhD project is part of the IBioIC CTP funded by the BBSRC. We're modeling how peptides adsorb to nanoparticle adjuvants to promote the production of antibodies that have potential use in anti-cancer therapies.

 

iain burns smiling at the camera

Dr Iain Burns

I'm working on the investigation of laser-induced nucleation with application to crystallisation in the continuous manufacturing of pharmaceutical compounds. In situ monitoring of crystallisation by static and dynamic light scattering. 

Chris Price smiling at the camera

Dr Chris Price

I'm looking at the manipulation of pharmaceutical crystallization to enhance purity, to increase yield and reduce processing time using ultrasound. A KTP with Alconbury Weston Ltd which facilitated the development of the first integrated continuous pharmaceutical filtration washing and drying system.

Karen Johnston smiling at the camera

Dr Karen Johnston

The polymorphic form of pharmaceutical compounds affects important manufacturing properties such as the solubility. My group uses molecular dynamics simulations to investigate how interfaces affect the nucleation of particular polymorphs.

Prof Jan Sefcik smiling at the camera

Professor Jan Sefcik

We develop experimental workflows for product and process development of particulate systems for pharmaceutical applications to obtain better control of critical quality attributes in medicines manufacturing.

Dr Paul Grassia

Dr Paul Grassia

I'm interested in dewatering of solid-liquid suspensions.  The ability to reduce water footprints by dewatering wastewater suspensions facilitates the extraction of clean water from waste, thereby permitting water recycling. Recovery and distribution of clean, recycled water can promote health and wellbeing in water-stressed and/or water-scarce regions.