Synthetic Low Density Lipoprotein for Animal Component Free Tissue Culture

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Background

The recent explosion in molecular biology has led to increased demand for tissue culture media. Usually this media is supplemented with foetal calf serum which provides essential lipids to maintain cell viability and promote growth. Serum, however, is expensive and suffers from inherent biological variability, potential contamination from adventitious agents and increased regulatory scrutiny. This has led to the drive for animal component-free media but until now there has been no real animal-free lipid supplement available.

 

Technology

Groundbreaking research from the University of Strathclyde has produced a synthetic low density lipoprotein (sLDL) which can be prepared from animal-free ingredients and provides all the required lipids in one product. sLDL circumvents the problems associated with serum, and its constituents can be more accurately controlled. Unlike current artificial lipid supplements, sLDL also provides the cells with lipids in the correct biological format for natural assimilation via the LDL pathway.

 

Key Benefits

  • Prepared from certified animal free materials
  • Controlled lipid profile & concentration
  • Biomimetic
  • Capable of cGMP production
  • Chemically and physically stable (4°C)
  • Filterable (0.2 µm)
  • Surfactant, cyclodextrin and protein free

 

Markets and Applications

sLDL has applications in tissue culture and engineering, cellular therapy, and in vitro cell research.

 

 

Licensing and Development

The technology is protected by patent applications filed by the University of Strathclyde as WO2005/047490, WO2005/020956 and WO98/13385. Contact is welcomed from organisations interested in developing, licensing or exploiting this technology. Please contact rkes@strath.ac.uk quoting reference number 0160.

This project has received assistance from the Proof of Concept Programme managed by Scottish Enterprise.  The Proof of Concept Programme supports the pre-commercialisation of leading-edge technologies emerging from Scotland's universities, research institutes and NHS Trusts.

 

 

Contact Information

For further information please contact the Knowledge Exchange Hub:

0141  548 4759

ke-hub@strath.ac.uk

If your query relates to medical devices, please contact

 

Contact us

For further information please contact Research & Knowledge Exchange Services on 0141 548 3707 or email rkes@strath.ac.uk