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Dr Katharine Carter

Senior Lecturer

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

I have two main areas of research interests: the study of leishmaniasis and drug delivery.  My research on leishmaniasis has been involved in understanding the underlying immunological mechansims involved in the control of the disease, the mechananism responible for drug resistance, and development of novel vaccine fomulations to control the infection.  I work on L. donovani, L. major  and L. mexicana  and we have recently started using luciferase-expressing parasites to track the infection.   My drug delivery studies have focused on using non-ionic surfactant vesicles (NIV) to improve drug delivery by the intravenous or pulmonary routes. We are currently involved in commercialising NIV for the pulmonary delivery ('Inhalosomes') through the spin-out comany 'Inhalosome-C Ltd', which is involved in developing a cisplatin product for the treatment of lung cancer.

B10 Fo luc cells imaged using the IVIS® system

Cells were treated with an anticancer drug (columns 3-10) - with the highest concentration in colum 3 and the lowest in column 10.  Column 2 shows the results for the control cells and column 11 shows the results for the negative control. This type of assay is used for screening anticancer compounds.  

Publications

Evaluation of minor groove binders (MGBs) as novel anti-mycobacterial agents, and the effect of using non-ionic surfactant vesicles as a delivery system to improve their efficacy
Hlaka Lerato, Rosslee Michael-Jon, Ozturk Mumin, Kumar Santosh, Parihar Suraj, Brombacher Frank, Khalaf Abedawn, Carter Katharine, Scott Fraser, Suckling Colin, Guler Reto
Journal of Antimicrobial Chemotherapy Vol 72, pp. 3334–3341, (2017)
http://dx.doi.org/10.1093/jac/dkx326
New avenues for drug delivery in Leishmania: using treatment of visceral leishmaniasis with amphotericin B as an exemplar.
Carter Katharine, Mullen Alexander
Drug Discovery in LeishmaniasisDrug Discovery in Leishmaniasis, (2016)
An evaluation of minor groove binders as anti-lung cancer therapeutics
Scott Fraser, Khalaf Abedawn, Suckling Colin, Carter Katharine, Grant Mary, Henderson Catherine, Westrop Gareth, Watson David
Bioorganic and Medicinal Chemistry Letters, (2016)
http://dx.doi.org/10.1016/j.bmcl.2016.06.040
Chemical and antimicrobial profiling of propolis from different regions within Libya
Siheri Weam, Zhang Tong, Ebiloma Godwin Unekwuojo, Biddau Marco, Woods Nicola, Hussain Muattaz Yassein, Clements Carol J., Fearnley James, Edrada Ebel RuAngelie, Paget Timothy, Müller Sylke, Carter Katharine C., Ferro Valerie A., De Koning Harry P., Watson David G.
PLoS One Vol 11, (2016)
http://dx.doi.org/10.1371/journal.pone.0155355
In vitro selection of miltefosine resistance in promastigotes of Leishmania donovani from Nepal : genomic and metabolomic characterization
Shaw C. D., Lonchamp J., Downing T., Imamura H., Freeman T. M., Cotton J. A., Sanders M., Blackburn G., Dujardin J. C., Rijal S., Khanal B., Illingworth C. J. R., Coombs G. H., Carter K. C.
Molecular Microbiology Vol 99, pp. 1134-1148, (2016)
http://dx.doi.org/10.1111/mmi.13291
Nanocarriers made from non-ionic surfactants or natural polymers for pulmonary drug delivery.
Carter Katharine, Puig Mireia
Current Pharmaceutical Design, (2015)

more publications

Professional activities

4th Worldleish Congress on Leishmaniasis 2009 in Lucknow, India
Keynote/plenary speaker
2009

more professional activities

Projects

Development of a vaccine against leishmaniasis (Vacation Scholarship)
Carter, Katharine (Principal Investigator)
Period 06-Jun-2016 - 17-Jul-2016
Development of starting materials for cell-based treatments (project plan for SMART grant)
Carswell, Hilary (Principal Investigator) Carter, Katharine (Co-investigator) Currie, Susan (Co-investigator) Pickard, Benjamin (Co-investigator)
Period 01-Apr-2015 - 31-Mar-2016
BBSRC RESEARCH EXPERIENCE PLACEMENTS 2010
Carter, Katharine (Principal Investigator) Currie, Susan (Co-investigator) Edrada-Ebel, Ruangelie (Co-investigator)
Period 01-Jul-2010 - 31-Aug-2010
KTA Application: Development of a commercially viable non- ionic surfactant vesicle amphotericin B formulation.
Carter, Katharine (Principal Investigator) Ferro, Valerie (Principal Investigator) Mullen, Alexander (Principal Investigator)
Improve AMB-NIV formulation
Period 08-Mar-2012 - 30-Sep-2012
Knowledge Transfer Account / RA4842
Carter, Katharine (Principal Investigator)
Period 01-Jan-2012 - 30-Sep-2012
Development of a diagnostic test for lesihmaniasis
Carter, Katharine (Principal Investigator)
Period 12-Jul-2013 - 31-Mar-2014

more projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Hamnett Wing John Arbuthnott Building

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