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Dr Edmond Chan

Lecturer

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

We are interested in dissecting the cell stress response and its regulation by signalling networks. Our strategy is to use molecular cell biology and genetics to probe sets of pathways and critical regulatory factors, both to understand normal biology and to highlight potential sensitive nodes to prioritise as new drug targets.

Our long-standing focus has been to understand the role and regulation of the autophagy cell homeostasis pathway. By directing different cytoplasmic cargo to the lysosome, autophagy plays an essential degradative role that helps maintain metabolism and cellular quality control, thus outlining two of its critical pro-survival functions. As such, better understanding of autophagy mechanisms will provides strategies on how to improve overall cell health, reduce cellular damage and, in turn, slow cellular ageing.

 

Link to Chan Lab page

 

Link to Google Scholar

 

 

Biography

I obtained my Ph.D. at the University of Alberta, Canada, studying the RAS-MAPK signalling and cellular transformation using cDNA library and mutagenesis screens. This work helped identify a novel RAS guanine nucleotide exchange factor, a novel hypothermia-driven mode of RAS activation and oncogenic regulation the kinase cRAF1. I carried out postdoctoral work in Medical Genetics, University of British Columbia, Canada, studying new therapies for Huntington disease. Our approach was to dissect molecular mechanisms by gene expression profiling in different mouse models. My work on Huntington disease led me to study the function of Huntington-associated protein 1 (HAP1) which also regulated endocytic trafficking. I gained further training in membrane cell biology at Cancer Research UK London Research Institute, leading to my interest in autophagy. In these initial studies, I discovered ULK proteins using siRNA screens for regulatory factors.  We have been further investigating the signalling mechanisms linking ULK1 to autophagy, which has expanded into the several streams underlying my current research.

Publications

Targeting BCR-ABL-Independent TKI resistance in chronic myeloid leukemia by mTOR and autophagy inhibition
Mitchell Rebecca, Hopcroft Lisa E M, Baquero Pablo, Allan Elaine K, Hewit Kay, James Daniel, Hamilton Graham, Mukhopadhyay Arunima, O'Prey Jim, Hair Alan, Melo Junia V, Chan Edmond, Ryan Kevin M, Maguer-Satta Véronique, Druker Brian J, Clark Richard E, Mitra Subir, Herzyk Pawel, Nicolini Franck E, Salomoni Paolo, Helgason G Vignir
Journal of the National Cancer Institute, (2017)
http://dx.doi.org/10.1093/jnci/djx236
Lysosomotropism depends on glucose : a chloroquine resistance mechanism
Gallagher Laura E, Radhi Ohood A, Abudullah Mahmud O, McCluskey Anthony G, Boyd Marie, Chan Edmond Y W
Cell Death and Disease Vol 8, (2017)
http://dx.doi.org/10.1038/cddis.2017.416
ATG7 regulates energy metabolism, differentiation and survival of Philadelphia chromosome-positive cells
Karvela Maria, Baquero Pablo, Kuntz Elodie M., Mukhopadhyay Arunima, Mitchell Rebecca, Allan Elaine K., Chan Edmond, Kranc Kamil R., Calabretta Bruno, Salomoni Paolo, Gottlieb Eyal, Holyoake Tessa L., Vignir Helgason G.
Autophagy, (2016)
http://dx.doi.org/10.1080/15548627.2016.1162359
Autophagy in human cancer cell lines during infection with the ICP34.5-deleted oncolytic HSV1716
Lima Ana, Braidwood Lynne, Learmonth Kirsty, Chan Edmond, Conner Joe
8th International Conference on Oncolytic Virus Therapeutics, (2014)
The roles of sphingosine kinases 1 and 2 in regulating the Warburg effect in prostate cancer cells
Watson David G, Tonelli Francesca, Al Osaimi Manal, Williamson Leon, Chan Edmond, Gorshkova Irina, Berdyshev Evgeny, Bittman Robert, Pyne Nigel J, Pyne Susan
Cellular Signalling Vol 25, pp. 1011-1017, (2013)
http://dx.doi.org/10.1016/j.cellsig.2013.01.002
Regulation of nutrient-sensitive autophagy by uncoordinated 51-like kinases 1 and 2
McAlpine Fiona, Williamson Leon E, Tooze Sharon A, Chan Edmond Y W
Autophagy Vol 9, pp. 361 - 373, (2013)
http://dx.doi.org/10.4161/auto.23066

more publications

Projects

BBSRC Doctoral Training Grant (DTG) | Williamson, Leon Edward
Chan, Edmond (Principal Investigator) Plevin, Robin (Co-investigator) Williamson, Leon Edward (Research Co-investigator)
Period 01-Oct-2011 - 28-Apr-2017
Epsrc Doctoral Training Grant | Davidson, Scott
Cebula, Izabela (Principal Investigator) Chan, Edmond (Principal Investigator) Grant, Mary (Co-investigator) Yu, Jun (Co-investigator) Davidson, Scott (Research Co-investigator)
Period 01-Nov-2012 - 17-Dec-2016
Summer student project on role of ULK signalling for autophagy of mitochondria
Chan, Edmond (Principal Investigator)
Period 03-Jun-2013 - 29-Jul-2013
Targeting autophagy as a strategy for inhibiting breast cancer metastasis
Chan, Edmond (Principal Investigator)
Period 01-Oct-2012 - 30-Sep-2016
Modulating the autophagy cellular stress response pathway in neural stem cells
Chan, Edmond (Principal Investigator) Carswell, Hilary (Co-investigator)
Period 01-Aug-2013 - 31-Jul-2014
Regulation of autophagy by the Rho-ROCK pathway in mammalian cells
Chan, Edmond (Principal Investigator)
Period 01-Aug-2009 - 01-Jan-2011

more projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Hamnett Wing John Arbuthnott Building

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