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Dr John Connolly

Senior Lecturer

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Qualifications: Graduated with a B.Sc. Honours in Physiology and Biochemistry from the University of Southampton and then a Ph.D. in Neurophysiology with Professor Gerald Kerkut in the same department.


Postdoctoral work was then carried out at the Dept. of Physics, University of California, San Diego with Professor Mauricio Montal (patch clamping of reconstituted nicotinic acetylcholine receptors in planar lipid bilayers); the Molecular Neurobiology Laboratory of Professor Stephen Heinemann at the Salk Institute in La Jolla, California as a Muscular Dystrophy Association Postdoctoral Fellow (first expression, functional and pharmacological characterisation of the neuronal nicotinic acetylcholine receptor gene family) and in the Department of Pharmacology, University College London with Professor David Colquhoun (patch clamping nicotinic receptors in brain slice preparations) before taking up a lectureship at the University of Strathclyde.


Current research interests include the characterisation of antibodies which may be useful for the development of diagnostic tests for CJD, the amino acid determinants of the kinetics of antagonist interactions with nicotinic acetylcholine receptors, the interaction of alcohol with nicotinic acetylcholine receptors and the characterisation of novel pharmacological activities of plant extracts.


Member of the Physiology Society, Pharmacology Society, Biochemical Society and Society for Neuroscience (USA)


Teaching responsibilities in all years for Bioscience and MPharm programs, including course coordination of three classes. Academic Selector for the MPharm program from 2002 till early 2013.  Member of the Higher Education Academy.


The tonic and toxic effects of alcohol and its metabolites
Connolly J.G.
Pharmaceutical ChemistryPharmaceutical Chemistry, (2011)
An antibody to the aggregated synthetic prion protein peptide (PrP106-126) selectively recognizes disease-associated prion protein (PrPSc) from human brain specimens
Jones Michael, Wight Darren, McLoughlin Victoria, Norrby Katherine, Ironside James W., Connolly John G., Farquhar Christine F., MacGregor Ian R., Head Mark W.
Brain Pathology Vol 19, pp. 293-302, (2009)
Production and characterisation of a panel of monoclonal antibodies against native human cellular prion protein
Jones Michael, McLoughlin Victoria, Connolly J.G., Farquhar Christine F., MacGregor Ian R., Head Mark W.
Hybridoma Vol 28, pp. 13-20, (2009)
The role of the amino acid residue at α1:189 in the binding of neuromuscular blocking agents to mouse and human muscle nicotinic acetylcholine receptors
Gopal P., Tate R., Pow E., Hill D., Connolly J.G.
British Journal of Pharmacology Vol 150, pp. 920-931, (2007)
Purification of normal cellular prion protein from human platelets and the formation of a high molecular weight prion protein complex following platelet activation
Jones Michael, Head Mark W., Connolly John, Farquhar Christine F., Hornsey Valerie S., Pepper Duncan S., MacGregor Ian R.
Biochemical and Biophysical Research Communications Vol 335, pp. 48-56, (2005)
Properties of the cellular prion protein expressed in Xenopus oocytes
Connolly John G., Tate Roth J., McLennan Neil F., Brown Debbie, Telling Glenn C., Fraser Jan, Head Mark W.
NeuroReport Vol 13, pp. 1229-1233, (2002)

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Strathclyde Institute of Pharmacy and Biomedical Sciences
John Arbuthnott Building Robertson Wing

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