Dr Katherine Duncan

Senior Lecturer

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Marine Natural Products Drug Discovery

We discover new medicines, primarily antibiotics, from the oceans.

Since the discovery of penicliin in 1928, natural products produced by microorganisms have provided society with a multitude of antibiotics, which has revolutionized modern medicine. Some bacteria are better than others at producing biologically active chemicals, in fact the Order Actinomycetales (within the Phyla Actinobacteria) are unsurpassed, as they produce over 70% of bioactive microbial natural products. Since the "golden age" of drug discovery from the 1930s-1970s, rediscovery of known chemistry has resulted in a decline in new drugs reaching clinical trials.

In the 1970s the field of marine natural products started (with the advent of SCUBA diving), scientists focused for the first time on the marine environment as a source of new biodiversity and thus chemical diversity. This research field traditionally studied marine invertebrates, such as sponges and coral, however much focus is now dedicated to the bacteria both within sediment and in association with macro marine organisms as a sustainable (through culture and fermentation) source of new chemistry.


Our multi-disciplinary research knowledge within the area of drug discovery encompasses biotechnology, metabolomics, microbiology, next generation sequencing, anticancer and antimicrobial bioactivities, whole genome sequencing, genome mining for biosynthetic gene clusters, molecular biology, natural products chemistry and bioinformatics, providing a powerful strategy for high-throughput and innovative drug discovery. We aim to accelerate the discovery of new drugs through several scientific research areas:

  • Exploring Taxonomic, Phylogenetic and Geographic Boundaries of Specialized Metabolites for Targeted Drug Discovery and Drug Lead Prioritization
  • Integrated -omics Approaches to Drug Discovery
  • Understanding Microbial Interactions for Informed Bioprospecting, Biotechnology and Biomedicine Applications

Please visit the Duncan lab website: www.medicinesfromthesea.com

Publications

Comparative metabologenomics analysis of polar actinomycetes
Soldatou Sylvia, Eldjárn Grímur Hjörleifsson, Ramsey Andrew, van der Hooft Justin J J, Hughes Alison H, Rogers Simon, Duncan Katherine R
Marine Drugs Vol 19 (2021)
https://doi.org/10.3390/md19020103
Exploring the chemical space of macro- and micro-algae using comparative metabolomics
Hughes Alison H, Magot Florent, Tawfike Ahmed F, Rad-Menéndez Cecilia, Thomas Naomi, Young Louise C, Stucchi Laura, Carettoni Daniele, Stanley Michele S, Edrada-Ebel RuAngelie, Duncan Katherine R
Microorganisms Vol 9 (2021)
https://doi.org/10.3390/microorganisms9020311
Linking genomics and metabolomics to chart specialized metabolic diversity
van der Hooft Justin J J, Mohimani Hosein, Bauermeister Anelize, Dorrestein Pieter C, Duncan Katherine R, Medema Marnix H
Chemical Society Reviews Vol 49, pp. 3297-3314 (2020)
https://doi.org/10.1039/D0CS00162G
Bioassay- and metabolomics-guided screening of bioactive soil actinomycetes from the ancient city of Ihnasia, Egypt
Sebak Mohamed, Saafan Amal E, AbdelGhani Sameh, Bakeer Walid, El-Gendy Ahmed O, Castaño Espriu Laia, Duncan Katherine, Edrada-Ebel RuAngelie
PLOS One Vol 14 (2019)
https://doi.org/10.1371/journal.pone.0226959
The Natural Products Atlas : an open access knowledge base for microbial natural products discovery
van Santen Jeffrey A, Jacob Grégoire, Singh Amrit Leen, Aniebok Victor, Balunas Marcy J, Bunsko Derek, Carnevale Neto Fausto, Castanño-Espriu Laia, Chang Chen, Clark Trevor N, Cleary Little Jessica L, Delgadillo David A, Dorrestein Pieter C, Duncan Katherine R, Egan Joseph M, Galey Melissa M, Haeckl FP Jake, Hua Alex, Hughes Alison H, Iskakova Dasha, Khadilkar Aswad, Lee Jung-Ho, Lee Sanghoon, LeGrow Nicole, Liu Dennis Y, Macho Jocelyn M, McCaughey Catherine S, Medema Marnix H, Neupane Ram P, O’Donnell Timothy J, Paula Jasmine S, Sanchez Laura M, Shaikh Anam F, Soldatou Sylvia, Terlouw Barbara R, Tran Tuan Anh, Valentine Mercia, van der Hooft Justin J J, Vo Duy A, Wang Mingxun, Wilson Darryl, Zink Katherine E, Linington Roger G
ACS Central Science Vol 5, pp. 1824-1833 (2019)
https://doi.org/10.1021/acscentsci.9b00806
Awakening ancient polar actinobacteria : diversity, evolution and specialized metabolite potential
Millán-Aguiñaga Natalie, Soldatou Sylvia, Brozio Sarah, Munnoch John T, Howe John, Hoskisson Paul A, Duncan Katherine R
Microbiology Vol 165, pp. 1169-1180 (2019)
https://doi.org/10.1099/mic.0.000845

More publications

Professional activities

STEMM Bank Scotland
Recipient
1/2021
Technical University of Dresden, Department of Chemistry, Germany - Invited Seminar (delivered remotely due to COVID-19)
Invited speaker
15/4/2020
Scripps Institution of Oceanography, Marine Biology Seminar, UCSD, CA, USA
Invited speaker
6/3/2020
Autonomous University of Baja California, Department of Marine Biology, Ensenada, Mexico
Invited speaker
2/3/2020
Gordon Research Conference on Marine Natural Products
Speaker
23/2/2020
Scottish metabolomics network
Participant
14/11/2019

More professional activities

Projects

SULSA NP Bioeconomy
Duncan, Katherine (Principal Investigator)
01-Jan-2020 - 31-Jan-2021
University of Strathclyde Interdisciplinary Centre for Doctoral Training in Antimicrobial Resistance (AMR)
Corrigan, Damion (Co-investigator) Duncan, Katherine (Co-investigator) McCormick, Christopher (Co-investigator) Murray, Paul (Co-investigator) Dunphy, Raymond David (Post Grad Student) Riordan, Lily (Post Grad Student) Lasserre, Perrine (Post Grad Student)
01-Jan-2019 - 31-Jan-2023
University of Strathclyde Interdisciplinary Centre for Doctoral Training in Antimicrobial Resistance (AMR)
Duncan, Katherine (Co-investigator) Corrigan, Damion (Co-investigator) Murray, Paul (Co-investigator) Corrigan, Damion (Co-investigator) Riordan, Lily (Post Grad Student)
01-Jan-2019 - 31-Jan-2023
Research Excellence Award - Applying machine learning to 'omics data for accelerated marine antibiotic discovery - Darren Scobie
Duncan, Katherine (Principal Investigator) Herron, Paul (Co-investigator)
01-Jan-2019 - 30-Jan-2022
Combatting antimicrobial resistance through new software for natural product discovery
Duncan, Katherine (Co-investigator) Rogers, Simon (Principal Investigator)
BBSRC TRDF
01-Jan-2018 - 01-Jan-2019
Combatting antimicrobial resistance through new software for Natural Products Discovery (Tools and Resources Development Fund)
Duncan, Katherine (Principal Investigator) Hoskisson, Paul (Co-investigator)
01-Jan-2018 - 30-Jan-2020

More projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Hamnett Wing

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