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Dr Katherine Duncan

Strathclyde Chancellor's Fellow

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Marine Natural Products Drug Discovery

We discover new medicines, primarily antibiotics, from the oceans.

Since the discovery of penicliin in 1928, natural products produced by microorganisms have provided society with a multitude of antibiotics, which has revolutionized modern medicine. Some bacteria are better than others at producing biologically active chemicals, in fact the Order Actinomycetales (within the Phyla Actinobacteria) are unsurpassed, as they produce over 70% of bioactive microbial natural products. Since the "golden age" of drug discovery from the 1930s-1970s, rediscovery of known chemistry has resulted in a decline in new drugs reaching clinical trials.

In the 1970s the field of marine natural products started (with the advent of SCUBA diving), scientists focused for the first time on the marine environment as a source of new biodiversity and thus chemical diversity. This research field traditionally studied marine invertebrates, such as sponges and coral, however much focus is now dedicated to the bacteria both within sediment and in association with macro marine organisms as a sustainable (through culture and fermentation) source of new chemistry.


Our multi-disciplinary research knowledge within the area of drug discovery encompasses biotechnology, metabolomics, microbiology, next generation sequencing, anticancer and antimicrobial bioactivities, whole genome sequencing, genome mining for biosynthetic gene clusters, molecular biology, natural products chemistry and bioinformatics, providing a powerful strategy for high-throughput and innovative drug discovery. We aim to accelerate the discovery of new drugs through several scientific research areas:

  • Exploring Taxonomic, Phylogenetic and Geographic Boundaries of Specialized Metabolites for Targeted Drug Discovery and Drug Lead Prioritization
  • Integrated -omics Approaches to Drug Discovery
  • Understanding Microbial Interactions for Informed Bioprospecting, Biotechnology and Biomedicine Applications

Please visit the Duncan lab website: www.medicinesfromthesea.com

Publications

Temperature driven changes in benthic bacterial diversity influences biogeochemical cycling in coastal sediments
Hicks Natalie, Liu Xuan, Gregory Richard, Kenny John, Lucaci Anita, Lenzi Luca, Paterson David M., Duncan Katherine R.
Frontiers in Microbiology Vol 9, (2018)
http://dx.doi.org/10.3389/fmicb.2018.01730
An integrative approach to decipher the chemical antagonism between the competing endophytes paraconiothyrium variabile and Bacillus subtilis
Vallet Marine, Vanbellingen Quentin P., Fu Tingting, Le Caer Jean-Pierre, Della-Negra Serge, Touboul David, Duncan Katherine R., Nay Bastien, Brunelle Alain, Prado Soizic
Journal of Natural Products Vol 80, pp. 2863–2873, (2017)
http://dx.doi.org/10.1021/acs.jnatprod.6b01185
Antarctic sponge associated microbial chemistry with biomedical relevance– the need for ecologically driven studies
Buchholz Holger H., Duncan Katherine R.
Current Organic Chemistry, (2016)
Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking
Wang Mingxun, Carver Jeremy J, Phelan Vanessa V, Sanchez Laura M, Garg Neha, Peng Yao, Nguyen Don Duy, Watrous Jeramie, Kapono Clifford A, Luzzatto-Knaan Tal, Porto Carla, Bouslimani Amina, Melnik Alexey V, Meehan Michael J, Liu Wei-Ting, Crüsemann Max, Boudreau Paul D, Esquenazi Eduardo, Sandoval-Calderón Mario, Kersten Roland D, Pace Laura A, Quinn Robert A, Duncan Katherine R, Hsu Cheng-Chih, Floros Dimitrios J, Gavilan Ronnie G, Kleigrewe Karin, Northen Trent, Dutton Rachel J, Parrot Delphine, Carlson Erin E, Aigle Bertrand, Michelsen Charlotte F, Jelsbak Lars, Sohlenkamp Christian, Pevzner Pavel, Edlund Anna, McLean Jeffrey, Piel Jörn, Murphy Brian T, Gerwick Lena, Liaw Chih-Chuang, Yang Yu-Liang, Humpf Hans-Ulrich, Maansson Maria, Keyzers Robert A, Sims Amy C, Johnson Andrew R, Sidebottom Ashley M, Sedio Brian E, Klitgaard Andreas, Larson Charles B, Boya P Cristopher A, Torres-Mendoza Daniel, Gonzalez David J, Silva Denise B, Marques Lucas M, Demarque Daniel P, Pociute Egle, O'Neill Ellis C, Briand Enora, Helfrich Eric J N, Granatosky Eve A, Glukhov Evgenia, Ryffel Florian, Houson Hailey, Mohimani Hosein, Kharbush Jenan J, Zeng Yi, Vorholt Julia A, Kurita Kenji L, Charusanti Pep, McPhail Kerry L, Nielsen Kristian Fog, Vuong Lisa, Elfeki Maryam, Traxler Matthew F, Engene Niclas, Koyama Nobuhiro, Vining Oliver B, Baric Ralph, Silva Ricardo R, Mascuch Samantha J, Tomasi Sophie, Jenkins Stefan, Macherla Venkat, Hoffman Thomas, Agarwal Vinayak, Williams Philip G, Dai Jingqui, Neupane Ram, Gurr Joshua, Rodríguez Andrés M C, Lamsa Anne, Zhang Chen, Dorrestein Kathleen, Duggan Brendan M, Almaliti Jehad, Allard Pierre-Marie, Phapale Prasad, Nothias Louis-Felix, Alexandrov Theodore, Litaudon Marc, Wolfender Jean-Luc, Kyle Jennifer E, Metz Thomas O, Peryea Tyler, Nguyen Dac-Trung, VanLeer Danielle, Shinn Paul, Jadhav Ajit, Müller Rolf, Waters Katrina M, Shi Wenyuan, Liu Xueting, Zhang Lixin, Knight Rob, Jensen Paul R, Palsson Bernhard Ø, Pogliano Kit, Linington Roger G, Gutiérrez Marcelino, Lopes Norberto P, Gerwick William H, Moore Bradley S, Dorrestein Pieter C, Bandeira Nuno
Nature Biotechnology Vol 34, pp. 828-37, (2016)
http://dx.doi.org/10.1038/nbt.3597
Competitive strategies differentiate closely related species of marine actinobacteria
Patin Nastassia V, Duncan Katherine R, Dorrestein Pieter C, Jensen Paul R
ISME Journal Vol 10, pp. 478-90, (2016)
http://dx.doi.org/10.1038/ismej.2015.128
Using molecular networking for microbial secondary metabolite bioprospecting
Purves Kevin, Macintyre Lynsey, Brennan Debra, Hreggviðsson Guðmundur Ó., Kuttner Eva, Ásgeirsdóttir Margrét E., Young Louise C., Green David H., Edrada-Ebel Ruangelie, Duncan Katherine
Metabolites Vol 6, (2016)
http://dx.doi.org/10.3390/metabo6010002

more publications

Professional activities

Chemistry & Biology of Natural Products. Warwick University
Participant
28/6/2018
The Microbiology Society Annual Conference, 2018
Participant
13/4/2018
Omics guided antibiotic discovery from our Oceans
Speaker
4/2018
Understanding the Chemical Language of Marine Bacteria
Speaker
4/2018
An Ocean of Chemical Diversity
Speaker
3/2018
IBioIC Annual Conference
Participant
25/1/2018

more professional activities

Projects

Doctoral Training Partnership (DTP 2016-2017 University of Strathclyde) | Addington, Emily
Hoskisson, Paul (Principal Investigator) Duncan, Katherine (Co-investigator) Addington, Emily (Research Co-investigator)
Period 01-Jan-2018 - 01-Jul-2021
Microbiology Society Harry Smith Internship
Duncan, Katherine (Principal Investigator)
Period 14-May-2018 - 16-Jul-2018
Understanding the chemical warfare of actinomycetes across taxonomic and phylogenetic boundaries for accelerated antibiotic discovery
Duncan, Katherine (Principal Investigator)
Period 01-Oct-2017 - 30-Sep-2020
Santander Visiting Academic Fellowship, Chile
Duncan, Katherine (Principal Investigator)
Period 15-Mar-2018 - 22-Mar-2018
The Use of Narrow Band LED Light in Photobioreactors and Comparative Metabolomics to Aid the Development of Marine Microalgae for Biotechnology
Duncan, Katherine (Principal Investigator) Hoskisson, Paul (Principal Investigator)
Period 01-Oct-2017 - 30-Sep-2021
Characterizing novel marine microbial chemistry to combat antimicrobial resistance AMR
Duncan, Katherine (Principal Investigator)
Period 28-May-2018 - 22-Jul-2018

more projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Hamnett Wing

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