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Dr Colin Gibson

Senior Lecturer

Pure and Applied Chemistry

Personal statement

Colin Gibson was born in the Scottish border town of Hawick, famous for its rugby football and knitting industry. The family moved to Godalming near Guildford in deepest Southern England when he was ten years old.

He went to Southampton University for his B.Sc. studies and stayed there to carry out Ph.D research with Professor Ray Baker, FRS. This work involved initially the analysis of insect hormones but mainly involved the total synthesis of a number of natural products.

After Southampton, Colin was awarded a University of Melbourne research fellowship in Australia. Here he spent a very enjoyable two years working with Professor Don Cameron on the synthesis of quinone natural products as well as visiting relatives.

On returning to the UK he took up a post doctoral research associateship with Professor Sir Alan Battersby, FRS at the University Chemical Laboratory in Cambridge on the synthesis of putative intermediates in vitamin B12 biosynthesis. This was followed by a Senior Research Fellowship at Christ's College, Cambridge.

The heady heights of Cambridge were followed by short interlude at Surrey University as a member of Faculty.

In 1991 he made the move back to Scotland and joined the Strathclyde Chemistry Department.

In his spare time he enjoys watching Hawick RFC playing, drinking wine, cycling (occasional mountain biking) and walking, particularly on the Island of Arran.

Publications

A method for the analysis of sugars in biological systems using reductive amination in combination with hydrophilic interaction chromatography and high resolution mass spectrometry
Bawazeer Sami, Muhsen Ali Ali, Alhawiti Aliyah, Khalaf Abedawn, Gibson Colin, Tusiimire Jonans, Watson David G.
Talanta Vol 166, pp. 75-80, (2017)
http://dx.doi.org/10.1016/j.talanta.2017.01.038
Structure based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1
Khalaf Abedawn I, Huggan Judith, Suckling Colin J, Gibson Colin L, Stewart Kirsten, Giordani Federica , Barrett Michael P., Wong Pui Ee, Barrack Keri L , Hunter William N
Journal of Medicinal Chemistry Vol 57, pp. 6479-6494, (2014)
http://dx.doi.org/10.1021/jm500483b
Communication between the zinc and tetrahydrobiopterin binding sites in nitric oxide synthase
Chreifi Georges, Li Huiying, McInnes Craig, Gibson Colin, Suckling Colin, Poulos Thomas L
Biochemistry, (2014)
http://dx.doi.org/10.1021/bi5003986
Tetrahydrobiopterin and electron transfer in NO synthase
Daff Simon, Gazur Ben, Papale Davide, McInnes Craig, Morthala Raghavendar R., Gibson Colin L., Suckling Colin J.
Nitric Oxide: Biology and Chemistry Vol 27, pp. S5-S5, (2012)
http://dx.doi.org/10.1016/j.niox.2012.04.019
23rd International Conference on Heterocyclic Chemistry (ICHC-23), Glasgow, UK, 31 July-4 August 2011
Gibson Colin
Pure and Applied Chemistry Vol 84, pp. iv-iv, (2012)
Diversity oriented synthesis : substitution at C5 in unreactive pyrimidines by Claisen rearrangement and reactivity in nucleophilic substitution at C2 and C4 in pteridines and pyrido[2,3-d]pyrimidines
Adcock Jonathan Paul, Gibson Colin, Huggan Judith, Suckling Colin
Tetrahedron Vol 67, pp. 3226-3237, (2011)
http://dx.doi.org/10.1016/j.tet.2011.03.011

more publications

Professional activities

Synthesis of Inhibitors and Activators of Pterin Related Enzymes
Contributor
13/6/2012
Pure and applied chemistry (Journal)
Guest editor
1/7/2011
Sustainable Laboratory Chemistry
Keynote/plenary speaker
14/6/2010
ICHC 2011 Conference
Chair
1/2008
Current Org. Synth.
Editorial board member
1/2008
Examiner for Ph.D. degree, Manchester, St. Andrews and Faisalabad
External Examiner
1/2008

more professional activities

Projects

Impact Acceleration Account - University Of Strathclyde 2012 / RA8926
Gibson, Colin (Principal Investigator)
Period 01-Feb-2015 - 30-Sep-2015
ANTI-PARASITIC PYRROLOPYRIMIDINES
Suckling, Colin (Principal Investigator) Gibson, Colin (Co-investigator)
Parasitic diseases, including malaria, leishmaniasis, and trypanosomiasis are amongst the most prevalent diseases world wide collectively with the poorest availability of effective drugs. Human African trypanosomiasis (HAT) has been reported to have a greater morbidity and mortality than HIV/AIDS in some locations. Parasitic disease is difficult to treat because the parasites become closely connected with the living host and it is therefore difficult to find drugs that attack only the parasite. Available drugs are few and are also toxic to humans. In laboratory experiments, we have shown that novel compounds designed and prepared in at the University of Strathclyde and University of Dundee are potentially able to fill the gap in drug availability. Our project is to optimise the effectiveness of our compounds to provide candidate drugs for full clinical development.
Period 01-Oct-2010 - 31-Dec-2013

more projects

Address

Pure and Applied Chemistry
Thomas Graham Building

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