Dr Stuart Hannah

Research Associate

Biomedical Engineering

Personal statement

My research is interested in the development of diagnostic tests for a range of important conditions such as antimicrobial resistance, cancerous biomarkers, infectious diseases within livestock farming, and detection of clinically important molecules including dopamine and ascorbic acid. I develop novel, low-cost electrode systems, suitable for use at the point of care. These systems typically exploit electrochemical techniques for the rapid detection of either biomarkers, specific molecules or bacterial growth.

Current projects I am involved with include development of a rapid, antibiotic susceptibility test, a low-cost sensor for the detection of clinically important neurotransmitter dopamine, optimisation of a process for detection of infectious diseases within the agricultural sector.

I have experience in the supervision of final year undergraduate students and postgraduate level students.

I joined the department of Biomedical Engineering at Strathclyde in 2018 having previously studied for both my undergraduate degree and PhD degree in Electronic and Electrical Engineering at Strathclyde. My PhD involved the development of force and temperature sensors based on organic field-effect transistors and ferroelectric materials. During my PhD, I optimised the transistor dielectric layer to provide transistors with low-voltage operation, and transferred a fully vacuum evaporated transistor fabrication process onto flexible plastic foils. I also developed force/temperature sensors using ferroelectric material P(VDF-TrFE), and incorporated these sensors with organic transistors to provide signal amplification and a useful readout signal for applications ranging from touch screen interfaces to electronic skin. Following my PhD, I worked as a postdoctoral researcher at Ecole des Mines de Saint-Etienne, Gardanne, France for 14 months working on stretchable electronics for biosensing applications. During this time, I developed a conformable, stretchable sensor to record bladder wall stretch to aid treatment of conditions such as urinary urge incontinence and overactive bladder syndrome.

My work is highly interdisciplinary involving industrial partners, clinicians, and working alongside other academics such as microbiologists, chemists and electronics engineers.  

Publications

Biologically modified microelectrode sensors provide enhanced sensitivity for detection of nucleic acid sequences from Mycobacterium tuberculosis
Blair Ewen O, Hannah Stuart, Vezza Vincent, Avci Hüseyin, Kocagoz Tanil, Hoskisson Paul A, Güzel Fatma D, Corrigan Damion K
Sensors and Actuators Reports Vol 2 (2020)
https://doi.org/10.1016/j.snr.2020.100008
Developments in microscale and nanoscale sensors for biomedical sensing
Hannah Stuart, Blair Ewen, Corrigan Damion K
Current Opinion in Electrochemistry Vol 23, pp. 7-15 (2020)
https://doi.org/10.1016/j.coelec.2020.02.012
Low-cost, thin-film, mass-manufacturable carbon electrodes for detection of the neurotransmitter dopamine
Hannah Stuart, Al-Hatmi Maha, Gray Louise, Corrigan Damion K
Bioelectrochemistry Vol 133 (2020)
https://doi.org/10.1016/j.bioelechem.2020.107480
Establishing a field-effect transistor sensor for the detection of mutations in the tumour protein 53 gene (TP53) : an electrochemical optimisation approach
Crossley Lisa, Attoye Bukola, Vezza Vincent, Blair Ewen, Corrigan Damion K, Hannah Stuart
Biosensors Vol 9 (2019)
https://doi.org/10.3390/bios9040141
Rapid antibiotic susceptibility testing using low-cost, commercially available screen-printed electrodes
Hannah Stuart, Addington Emily, Alcorn David, Shu Wenmiao, Hoskisson Paul A, Corrigan Damion K
Biosensors and Bioelectronics Vol 145 (2019)
https://doi.org/10.1016/j.bios.2019.111696
Conformable, stretchable sensor to record bladder wall stretch
Hannah Stuart, Brige Pauline, Ravichandran Aravind, Ramuz Marc
ACS Omega Vol 4, pp. 1907–1915 (2019)
https://doi.org/10.1021/acsomega.8b02609

more publications

Teaching

In terms of teaching, I contribute to the following undergraduate and masters courses in the department of Biomedical Engineering –

BE428 – Professional Studies and Research Methods in Biomedical Engineering

BE207 – Human Cell Biology 2

Professional activities

Oral Presentation at RSC ABG ECRM 2020 in Glasgow
Speaker
5/3/2020
STV News Interview on Microplate Project
Recipient
24/10/2019
Radio Scotland Interview on Microplate Project
Recipient
24/10/2019
2019 Scotland and North of England Electrochemistry Symposium (Butler Meeting)
Participant
9/4/2019
Fabrication and development of electrode systems for label-free biosensing
Speaker
28/3/2019
Force and Temperature Sensors Based on Organic Thin-Film Transistors and P(VDF-TrFE)
Speaker
27/2/2017

more professional activities

Projects

Improving rational drug prescription: a rapid and low-cost antibiotic susceptibility test for drug resistant/susceptible tuberculosis
Blair, Ewen (Co-investigator) Corrigan, Damion (Principal Investigator) Hannah, Stuart (Co-investigator)
Multidrug resistant TB (MDR-TB) is a significant healthcare challenge. For example, in 2016 there were 558,000 new cases globally. Quoting the World Health Organisation “Multidrug-resistant TB (MDR-TB) is multifactorial and fuelled by improper treatment of patients, poor management of supply and quality of drugs, and airborne transmission of bacteria in public places. Case management becomes difficult and the challenge is compounded by catastrophic economic and social costs that patients incur while seeking help and on treatment”.
A vital aspect of mitigating the health, social and economic costs associated with MDR-TB is the ability to rapidly diagnose the disease and quickly pinpoint which antibiotics will be effective.
DC’s group have been developing a new rapid antibiotic susceptibility test called “Microplate”. This technology was acknowledged with a prestigious Longitude Prize Discovery Award during 2017. We have recently published our first demonstration of the Microplate approach to drug susceptibility testing (with MRSA) and now have the opportunity through this pump-priming scheme to collaborate with groups in India to develop the technology specifically for MDR-TB. The technology is easy to use, low cost, mass manufacturable and fits well with established microbiological methods. It is therefore ideal for deployment in low resource settings.
01-Jan-2020 - 30-Jan-2020
PhD Project - Extended research exchange on electrochemical biosensors
Corrigan, Damion (Principal Investigator) Hannah, Stuart (Co-investigator) Schulte, Albert (Co-investigator) Thaweskulchai, Thana (Post Grad Student)
01-Jan-2019 - 01-Jan-2020
Carnegie Trust - sponsored summer internship - Lisa Crossley
Corrigan, Damion (Principal Investigator) Hannah, Stuart (Co-investigator)
17-Jan-2019 - 31-Jan-2019
CENSIS Project with Biotangents Ltd
Corrigan, Damion (Principal Investigator) Hannah, Stuart (Researcher)
18-Jan-2019 - 18-Jan-2019
Epsrc Doctoral Training Grant | Hannah, Stuart
Gleskova, Helena (Principal Investigator) Uttamchandani, Deepak (Co-investigator) Hannah, Stuart (Research Co-investigator)
01-Jan-2013 - 09-Jan-2017
EPSRC Doctoral Training Grant - DTA, University of Strathclyde | Hannah, Stuart
Gleskova, Helena (Principal Investigator) Uttamchandani, Deepak (Co-investigator) Hannah, Stuart (Research Co-investigator)
01-Jan-2013 - 09-Jan-2017

more projects

Address

Biomedical Engineering
Graham Hills Building

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