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Professor Miles Houslay

Research Professor

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Miles Houslay is internationally recognised for his work in cell signalling. He is particularly interested in understanding how the functioning of cyclic nucleotide signaling networks are regulated by spatial constraints and cross-talk. His research focus concerns the functional significance of targeted cAMP degradation by PDE4 phosphodiesterase isoforms and developing novel therapeutics for diseases such as COPD, cancer and schizophrenia. He has published over 440 research papers, holds a number of patents and has acted either as a consultant or served on scientific advisory boards of various companies in Asia, Europe, Japan, UK and USA. He has a research publication H-index of 77 (January 2013).

Publications

Hypertension linked to PDE3A activation
Houslay Miles
Nature Genetics Vol 47, pp. 562-563, (2015)
http://dx.doi.org/10.1038/ng.3316
Dimerization of cAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domains
Bolger Graeme B., Dunlop Allan J., Meng Dong, Day Jon P., Klussmann Enno, Baillie George S., Adams David R., Houslay Miles D.
Cellular Signalling Vol 27, pp. 756-769, (2015)
http://dx.doi.org/10.1016/j.cellsig.2014.12.009
The cAMP phosphodiesterase-4D7 (PDE4D7) is downregulated in androgen-independent prostate cancer cells and mediates proliferation by compartmentalising cAMP at the plasma membrane of VCaP prostate cancer cells
Henderson D J P, Byrne A, Dulla K, Jenster G, Hoffmann R, Baillie G S, Houslay M D
British Journal of Cancer Vol 110, pp. 1278-1287, (2014)
http://dx.doi.org/10.1038/bjc.2014.22
Oxygen-dependent cleavage of the p75 neurotrophin receptor triggers stabilization of HIF-1α
Le Moan Natacha, Houslay Daniel, Christian Frank, Houslay Miles, Akassoglou Katerina
Molecular Cell Vol 44, pp. 476-490, (2011)
http://dx.doi.org/10.1016/j.molcel.2011.08.033
DISC1-dependent switch from progenitor proliferation to migration in the developing cortex
Ishizuka Koko, Kamiya Atsushi, Oh Edwin, Kanki Hiroaki, Seshadri Saurav, Robinson Jon, Murdoch Hannah, Dunlop Allan, Kubo Ken-ichiro, Furukori Keiko, Huang Beverly, Zeledon Mariela, Hayashi-Takagi Ariko, Okano Hideyuki, Nakajima Kazunori, Houslay Miles, Katsanis Nicholas, Sawa Akira
Nature Vol 473, pp. 92-96, (2011)
http://dx.doi.org/10.1038/nature09859
Sleep deprivation impairs cAMP signalling in the hippocampus
Vecsey Christopher, Baillie George, Jaganath Devan, Havekes Robbert, Daniels Andrew, Wimmer Mathieu, Huang Ted, Brown Kim, Li Xiang-Yao, Descalzi Giannina, Kim Susan, Chen Tao, Shang Yu-Ze, Zhuo Min, Houslay Miles, Abel Ted
Nature Vol 461, pp. 1122-1125, (2009)
http://dx.doi.org/10.1038/nature08488

more publications

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences

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