Professor Miles Houslay
Research Professor
Strathclyde Institute of Pharmacy and Biomedical Sciences
Personal statement
Miles Houslay is internationally recognised for his work in cell signalling. He is particularly interested in understanding how the functioning of cyclic nucleotide signaling networks are regulated by spatial constraints and cross-talk. His research focus concerns the functional significance of targeted cAMP degradation by PDE4 phosphodiesterase isoforms and developing novel therapeutics for diseases such as COPD, cancer and schizophrenia. He has published over 440 research papers, holds a number of patents and has acted either as a consultant or served on scientific advisory boards of various companies in Asia, Europe, Japan, UK and USA. He has a research publication H-index of 77 (January 2013).
Publications
- Creating a potential diagnostic for prostate cancer risk stratification (InformMDx™) by translating novel scientific discoveries concerning cAMP degrading phosphodiesterase-4D7 (PDE4D7)
- Henderson Dave JP, Houslay Miles D, Bangma Chris H, Hoffmann Ralf
- Clinical Science Vol 133, pp. 269-286 (2019)
- https://doi.org/10.1042/CS20180519
- The role of ventral striatal cAMP signaling in stress-induced behaviors
- Plattner Florian, Hayashi Kanehiro, Hernández Adan, Benavides David R, Tassin Tara C, Tan Chunfeng, Day Jonathan, Fina Maggy W, Yuen Eunice Y, Yan Zhen, Goldberg Matthew S, Nairn Angus C, Greengard Paul, Nestler Eric J, Taussig Ronald, Nishi Akinori, Houslay Miles D, Bibb James A
- Nature Neuroscience Vol 18, pp. 1094-11100 (2015)
- https://doi.org/10.1038/nn.4066
- Nuclear pore complex remodeling by p75(NTR) cleavage controls TGF-β signaling and astrocyte functions
- Schachtrup Christian, Ryu Jae Kyu, Mammadzada Könül, Khan Abdullah S, Carlton Peter M, Perez Alex, Christian Frank, Le Moan Natacha, Vagena Eirini, Baeza-Raja Bernat, Rafalski Victoria, Chan Justin P, Nitschke Roland, Houslay Miles D, Ellisman Mark H, Wyss-Coray Tony, Palop Jorge J, Akassoglou Katerina
- Nature Neuroscience Vol 18, pp. 1077-1080 (2015)
- https://doi.org/10.1038/nn.4054
- Hypertension linked to PDE3A activation
- Houslay Miles
- Nature Genetics Vol 47, pp. 562-563 (2015)
- https://doi.org/10.1038/ng.3316
- Dimerization of cAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domains
- Bolger Graeme B, Dunlop Allan J, Meng Dong, Day Jon P, Klussmann Enno, Baillie George S, Adams David R, Houslay Miles D
- Cellular Signalling Vol 27, pp. 756-769 (2015)
- https://doi.org/10.1016/j.cellsig.2014.12.009
- The cAMP phosphodiesterase-4D7 (PDE4D7) is downregulated in androgen-independent prostate cancer cells and mediates proliferation by compartmentalising cAMP at the plasma membrane of VCaP prostate cancer cells
- Henderson D J P, Byrne A, Dulla K, Jenster G, Hoffmann R, Baillie G S, Houslay M D
- British Journal of Cancer Vol 110, pp. 1278-1287 (2014)
- https://doi.org/10.1038/bjc.2014.22
Projects
- Identifying selective cAMP phosphodiesterase inhibitors for chronic obstructive pulmonary disease
- Houslay, Miles (Principal Investigator)
- 01-Jan-2012 - 30-Jan-2015
- Novel Therapies For COPD - PoC
- Houslay, Miles (Principal Investigator) Pyne, Nigel (Co-investigator)
- 21-Jan-2012 - 08-Jan-2014
Contact
Professor
Miles
Houslay
Research Professor
Strathclyde Institute of Pharmacy and Biomedical Sciences
Email: miles.houslay@strath.ac.uk
Tel: 548 2125