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Prof Neil Hunt

Physics

Personal statement

NTH is a Professor in Physics at the University of Strathclyde. Supported by funding from the EPSRC, the European Research Council, BBSRC and the Leverhulme Trust, his research has focused on developing ultrafast two-dimensional infrared (2D-IR) spectroscopy methods. In particular, NTH’s research has been motivated by a desire to understand the way in which dynamic molecular processes influence the function of biological molecules including reactions in enzyme active sites and the binding of small molecules to proteins and DNA.

A significant contributor to this work has been the close collaboration between the NTH group and the STFC Central Laser Facility (CLF) based at the Rutherford Appleton Laboratory. This collaboration has successfully made 2D-IR spectroscopy available on three internationally-leading laser systems (PIRATE, ULTRA and LifeTIME) for the benefit of the UK scientific community.

Publications

Quantifying secondary structure changes in Calmodulin using 2D-IR spectroscopy: Minnes Lucy, Shaw Daniel J., Cossins Benjamin P., Donaldson Paul M., Greetham Gregory M., Towrie Michael, Parker Anthony W., Baker Matthew J., Henry Alistair J., Taylor Richard J., Hunt Neil T.; Analytical Chemistry Vol 89, pp. 10898-10906, (2017); http://dx.doi.org/10.1021/acs.analchem.7b02610
Examining the role of protein structural dynamics in drug resistance in Mycobacterium tuberculosis: Shaw Daniel J., Hill Rachel E., Simpson Niall, Husseini Fouad S., Robb Kirsty, Greetham Gregory M., Towrie Michael, Parker Anthony W., Robinson David , Hirst Jonathan D. , Hoskisson Paul, Hunt Neil T.; Chemical Science, (2017); http://dx.doi.org/10.1039/C7SC03336B
Disruption of key NADH-binding pocket residues of the Mycobacterium tuberculosis InhA affects DD-CoA binding ability: Shaw Daniel J., Robb Kirsty, Vetter Beatrice V., Tong Madeline, Molle Virginie, Hunt Neil T., Hoskisson Paul A.; Scientific Reports Vol 7, (2017); http://dx.doi.org/10.1038/s41598-017-05042-4
Ultrafast 2D-IR and optical Kerr effect spectroscopy reveal the impact of duplex melting on the structural dynamics of DNA: Hithell Gordon, González-Jiménez Mario, Greetham Gregory M., Donaldson Paul M., Towrie Michael, Parker Anthony W., Burley Glenn A., Wynne Klaas, Hunt Neil; Physical Chemistry Chemical Physics, (2017)
2D-IR spectroscopy shows that optimised DNA minor groove binding of Hoechst33258 follows an induced fit model: Ramakers Lennart A. I., Hithell Gordon, May John J., Greetham Gregory M., Donaldson Paul M., Towrie Michael, Parker Anthony W., Burley Glenn, Hunt Neil; Journal of Physical Chemistry B, (2017); http://dx.doi.org/10.1021/acs.jpcb.7b00345
Using experimental and computational energy equilibration to understand hierarchical self-assembly of Fmoc-dipeptide amphiphiles: Sasselli I.R., Pappas C. G., Matthews E., Wang T., Hunt Neil, Ulijn Rein, Tuttle Christopher; Soft Matter Vol 2016, pp. 8307-8315, (2016); http://dx.doi.org/10.1039/c6sm01737a

more publications

Professional activities

Telluride Symposium on Vibrational Dynamics: Speaker; 2017
Laser imaging and microscopy/spectroscopy workshop, University of Stellenbosch: Speaker; 2017
Austin Symposium on Molecular Structure and Dynamics, Dallas, USA,: Invited speaker; 1/3/2016
Pacifichem Congress, Honolulu, Hawaii, USA: Invited speaker; 17/12/2015
DfG Roundtable Meeting on Photoreceptors, Munich, Germany: Invited speaker; 10/10/2015
Advances in Structure and Dynamics, Bangalore, India: Invited speaker; 6/1/2015

more professional activities

Projects

Fast-tracking Health Innovation for NHS Scotland (MRC Confidence in Concept 2017) / R170262-101: Baker, Matthew (Principal Investigator) Hunt, Neil (Co-investigator); Period 01-Mar-2017 - 28-Feb-2019
Impact Acceleration Account - University Of Strathclyde 2012 / R120526-217: Hunt, Neil (Principal Investigator); Period 01-Oct-2012 - 31-Mar-2017
BBSRC Doctoral Training Grant (DTG) | Bellota-Anton, Cesar: Tucker, Nicholas (Principal Investigator) Hunt, Neil (Co-investigator); Period 01-Dec-2011 - 01-Dec-2014
Advanced data analysis tools for 2D-IR spectroscopy: Hunt, Neil (Principal Investigator) Baker, Matthew (Co-investigator); Period 01-Oct-2015 - 30-Sep-2018
Determining the molecular-level origin of Isoniazid susceptibility and resistance in Mycobacterium tuberculosis using Two-Dimensional Infrared Spectroscopy: Hoskisson, Paul (Co-investigator) Hunt, Neil (Co-investigator); Period 01-Dec-2015 - 30-Nov-2016
Bridging the Gap Grant - In silico to in clinic-o: Baker, Matthew (Principal Investigator) Palmer, David (Co-investigator) Hunt, Neil (Co-investigator); Period 02-Mar-2015 - 02-Jun-2015

Address

Physics
John Anderson Building

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