Dr Neil Hunt

Reader

Physics

Personal statement

Neil is a Reader working in the Biomolecular and Chemical Physics group, part of the Nanoscience division. Research in Neil’s Multidimensional Spectroscopy Group concentrates on applying ultrafast two dimensional infrared (2D-IR) spectroscopy to the study of biological systems. Recently, he obtained a high profile ERC Starting Investigator Grant to extend this technique to allow the observation of real-time changes in molecular structure during reactions.  Neil also collaborates closely with the Central Laser Facility at the STFC Rutherford Appleton Laboratory on developing 2D-IR and transient 2D-IR methods for studying biological systems.

Publications

2D-IR spectroscopy shows that optimised DNA minor groove binding of Hoechst33258 follows an induced fit model
Ramakers Lennart A. I., Hithell Gordon, May John J., Greetham Gregory M., Donaldson Paul M., Towrie Michael, Parker Anthony W., Burley Glenn, Hunt Neil
Journal of Physical Chemistry B, (2017)
http://dx.doi.org/10.1021/acs.jpcb.7b00345
Encapsulating Subsite analogues of the [FeFe]-hydrogenases in micelles enables direct water interactions
Fritzsch Robby, Brady Owen, Adair Elaine, Wright Joseph A., Pickett Christopher J., Hunt Neil
Journal of Physical Chemistry Letters Vol 7, pp. 2838-2843, (2016)
http://dx.doi.org/10.1021/acs.jpclett.6b01338
Combining random forest and 2D correlation analysis to identify serum spectral signatures for neuro-oncology
Smith Benjamin Richard, Ashton Katherine M., Brodbelt Andrew, Dawson Timothy, Jenkinson Michael D., Hunt Neil T., Palmer David S., Baker Matthew J.
Analyst Vol 141, pp. 3668-3678, (2016)
http://dx.doi.org/10.1039/C5AN02452H
Long-range vibrational dynamics are directed by Watson-Crick base-pairing in duplex DNA
Hithell Gordon, Shaw Daniel J., Donaldson Paul M., Greetham Gregory M., Towrie Michael, Burley Glenn A., Parker Anthony W., Hunt Neil T.
Journal of Physical Chemistry B, (2016)
http://dx.doi.org/10.1021/acs.jpcb.6b02112
Detection of transient intermediates generated from subsite analogues of [FeFe]-hydrogenases
Hunt Neil, Wright Joseph, Pickett Christopher
Inorganic Chemistry Vol 2016, pp. 399-410, (2015)
http://dx.doi.org/10.1021/acs.inorgchem.5b02477
Multidimensional infrared spectroscopy reveals the vibrational and solvation dynamics of isoniazid
Shaw Daniel J., Adamczyk Katrin, Frederix Pim W. J. M., Simpson Niall, Robb Kirsty, Greetham Gregory M., Towrie Michael, Parker Anthony W., Hoskisson Paul A., Hunt Neil T.
Journal of Chemical Physics Vol 142, (2015)
http://dx.doi.org/10.1063/1.4914097

more publications

Professional activities

Austin Symposium on Molecular Structure and Dynamics, Dallas, USA,
Member
1/3/2016
Pacifichem Congress, Honolulu, Hawaii, USA
Member
17/12/2015
DfG Roundtable Meeting on Photoreceptors, Munich, Germany
Member
10/10/2015
Advances in Structure and Dynamics, Bangalore, India
Member
6/1/2015
Laserlab Europe, Lasers for Life Meeting, London
Member
15/6/2014
CCP9 Workshop "Electronic excitations and dynamics in macromolecules and extended systems"
Member
28/9/2013

more professional activities

Projects

Determining the molecular-level origin of Isoniazid susceptibility and resistance in Mycobacterium tuberculosis using Two-Dimensional Infrared Spectroscopy
Simpson, Niall (Principal Investigator) Hoskisson, Paul (Co-investigator) Hunt, Neil (Co-investigator)
Period 01-Dec-2015 - 30-Nov-2016
Determining the molecular-level origin of Isoniazid susceptibility and resistance in Mycobacterium tuberculosis using Two-Dimensional Infrared Spectroscopy
Simpson, Niall (Principal Investigator) Hoskisson, Paul (Co-investigator) Hunt, Neil (Co-investigator)
Period 01-Dec-2015 - 30-Nov-2016
Advanced data analysis tools for 2D-IR spectroscopy
Hunt, Neil (Principal Investigator) Baker, Matthew (Co-investigator)
Period 01-Oct-2015 - 30-Sep-2018
Advanced data analysis tools for 2D-IR spectroscopy
Hunt, Neil (Principal Investigator) Baker, Matthew (Co-investigator)
Period 01-Oct-2015 - 30-Sep-2018
Advanced data analysis tools for 2D-IR spectroscopy
Hunt, Neil (Principal Investigator) Baker, Matthew (Co-investigator)
Period 01-Oct-2015 - 30-Sep-2018

more projects