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Dr Catherine Lawrence

Senior Lecturer

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

My research focuses on the interaction between gastrointestinal (GI) parasitic helminths (worms) and their hosts. Infection with GI helminths parasites has an impact on a number of immunological issues including oral vaccination and dysregulation of immune respones that predispose for intestinal inflammation. This has direct implications for the design and application of anti-parasite therapies and treatments but also has wider importance for immunoregulation in mucosal tissues in general. My work concentrates on two related themes:

Immunopathology - the key mechanisms whereby expulsion of GI nematodes is achieved are still in doubt. It had always been assumed that intestinal pathology was obligatory for expulsion of GIP parasites. However, I have shown that sever pathology is not required for the expulsion of nematode parasites. Recently we showed that mast cell derived cytokines are essential in the promotion of and amplification of the protective and pathological immunes responses associated with infection with GI helminths. This has important implications as it now places mast cells as key cells in the induction, amplification and perpetuation of the Th2 response induced following infection with GI helminths rather than as acting as endpoint effector cells.

Role of mast cells in inflammatory disease - this work is now being further extended to analyse the role of mast cells in inflammatory disorders such as rheumatoid arthritis (in collaboration with Professor I McInnes, University of Glasgow), cardiovascular disease ( Dr P Maffia and S Kennedy, University of Glasgow), and stroke (with Dr H Carswell).

Antiparasiticals

More recently I have been developing research in evaluating novel anthelminthics in collaboration with Dr Chris Carter.

Publications

Perivascular mast cells promote neointimal elastin deposit and suppress chronic vein graft restensosis in hyperlipidaemic mice : mast cells and vein graft remodelling
Wu Junxi, Lawrence Catherine, Wadsworth Roger M., Kennedy Simon
Vessel Plus, (2017)
Mast cells contribute to porphyromonas gingivalis-induced bone loss
Malcolm J., Millington O., Millhouse E., Campbell L., Adrados Planell A., Butcher J. P., Lawrence C., Ross Kirsty, Ramage G., McInnes I. B., Culshaw S.
Journal of Dental Research, (2016)
http://dx.doi.org/10.1177/0022034516634630
Perivascular mast cells regulate vein graft neointimal formation and remodeling
Wu Junxi, Grassia Gianluca, Cambrook Helen, Ialenti Armando, MacRitchie Neil, Carberry Jaclyn, Wadsworth Roger M., Lawrence Catherine, Kennedy Simon, Maffia Pasquale
PeerJ Vol 3, (2015)
http://dx.doi.org/10.7717/peerj.1192
Mast cells promote blood brain barrier breakdown and neutrophil infiltration in a mouse model of focal cerebral ischemia
McKittrick Craig M., Lawrence Catherine E., Carswell Hilary V.O.
Journal of Cerebral Blood Flow and Metabolism Vol 35, pp. 638-647, (2015)
http://dx.doi.org/10.1038/jcbfm.2014.239
Mast cells and vascular diseases
Kennedy Simon, Wu Junxi, Wadsworth Roger, Lawrence Catherine, Maffia Pasquale
Pharmacology and Therapeutics Vol 138, pp. 53-65, (2013)
http://dx.doi.org/10.1016/j.pharmthera.2013.01.001
Protective role of MAP kinase phosphatase 2 (MKP-2) in a model of collagen antibody induced arthritis
Schroeder J., Ross K., Alexander J., Lawrence C. E., Plevin R.
Immunology Vol 137, pp. 585-585, (2012)
http://dx.doi.org/10.1111/imm.12002

more publications

Professional activities

British Society for Parasitology
Organiser
2012
British Society for Parasitology
Organiser
2012
British Society for Parasitology
Organiser
2011
British Society for Parasitology
Organiser
2010
British Society for Parasitology
Organiser
2009
XI International Congress of Parasitology , UK
Chair
1/2008

more professional activities

Projects

Biomedical Vacation Scholarships / R180191-2
Lawrence, Catherine (Principal Investigator)
Period 02-Jul-2018 - 25-Aug-2018
Biomedical Vacation Scholarships
Coats, Paul (Principal Investigator) Jiang, Hui-Rong (Principal Investigator) Lawrence, Catherine (Principal Investigator) McDonald, James (Principal Investigator) Pickard, Benjamin (Principal Investigator)
Period 09-Jul-2018 - 31-Aug-2018
Use of Immunohistochemistry and co-culture model systems to investigating the contribution of M2 macrophages towards chemotherapy resistance in patients with Acute Myeloid leukaemia
Lawrence, Catherine (Principal Investigator)
Period 15-May-2017 - 14-May-2020
RE:ACTIVE The Apples for All Project
Ross, Kirsty (Researcher) Lawrence, Catherine (Academic) Laycock, Martin (CoI)
The RE:ACTIVE funding was designed to create an ongoing legacy from the Commonwealth Games held in Glasgow in 2014. The Apples for All project aimed to engage nurseries from some of Glasgow's most deprived areas by supplying them with free Scottish heritage apples trees. As a result, 140 nurseries were invited to the University or Glasgow Botanic Gardens to collect their trees and take part in interactive activities around apples.
Period 17-Jun-2014 - 31-May-2015
Role of mast cells in inflammatory arthritis
Lawrence, Catherine (Principal Investigator)
Period 09-Jun-2014 - 01-Aug-2014
Quantitative analysis of the regulation of gene expression, changes in posttranslational protein modifications and protein:protein interactions
Lawrence, Catherine (Co-investigator) Pyne, Susan (Co-investigator) Pyne, Nigel (Co-investigator) Roberts, Craig (Co-investigator)
Period 01-Mar-2003 - 28-Feb-2008

more projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Hamnett Wing

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