Dr Catherine Lawrence

Senior Lecturer

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

My research focuses on the interaction between gastrointestinal (GI) parasitic helminths (worms) and their hosts. Infection with GI helminths parasites has an impact on a number of immunological issues including oral vaccination and dysregulation of immune respones that predispose for intestinal inflammation. This has direct implications for the design and application of anti-parasite therapies and treatments but also has wider importance for immunoregulation in mucosal tissues in general. My work concentrates on two related themes:

Immunopathology - the key mechanisms whereby expulsion of GI nematodes is achieved are still in doubt. It had always been assumed that intestinal pathology was obligatory for expulsion of GIP parasites. However, I have shown that sever pathology is not required for the expulsion of nematode parasites. Recently we showed that mast cell derived cytokines are essential in the promotion of and amplification of the protective and pathological immunes responses associated with infection with GI helminths. This has important implications as it now places mast cells as key cells in the induction, amplification and perpetuation of the Th2 response induced following infection with GI helminths rather than as acting as endpoint effector cells.

Role of mast cells in inflammatory disease - this work is now being further extended to analyse the role of mast cells in inflammatory disorders such as rheumatoid arthritis (in collaboration with Professor I McInnes, University of Glasgow), cardiovascular disease ( Dr P Maffia and S Kennedy, University of Glasgow), and stroke (with Dr H Carswell).

Antiparasiticals

More recently I have been developing research in evaluating novel anthelminthics in collaboration with Dr Chris Carter.

Publications

UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment : questionnaire and workshop proceedings
McFall Aisling, Hietamies Tuuli M, Bernard Ashton, Aimable Margaux, Allan Stuart M, Bath Philip M, Brezzo Gaia, Carare Roxana O, Carswell Hilary V, Clarkson Andrew N, Currie Gillian, Farr Tracy D, Fowler Jill H, Good Mark, Hainsworth Atticus H, Hall Catherine, Horsburgh Karen, Kalaria Rajesh, Kehoe Patrick, Lawrence Catherine, Macleod Malcolm, McColl Barry W, McNeilly Alison, Miller Alyson A, Miners Scott, Mok Vincent, O’Sullivan Michael, Platt Bettina, Sena Emily S, Sharp Matthew, Strangeward Patrick, Szymkowiak Stefan, Touyz Rhian M, Trueman Rebecca C, White Claire, McCabe Chris, Work Lorraine M, Quinn Terence J
Journal of Cerebral Blood Flow and Metabolism Vol 40, pp. 1402-1414 (2020)
https://doi.org/10.1177/0271678X20910552
Isolation of a novel flavanonol and an alkylresorcinol with highly potent anti-trypanosomal activity from Libyan propolis
Siheri Weam, Ebiloma Godwin U, Igoli John O, Gray Alexander I, Biddau Marco, Akrachalanont Pilaslak, Samya Sh M D Alenezi Samya, Alwashih Mohammad A, Edrada Ebel RuAngelie, Müller Sylke, Lawrence Catherine E, Fearnley James, Watson David G, De Koning Harry P
Molecules Vol 24 (2019)
https://doi.org/10.3390/molecules24061041
Novel protective role for MAP kinase phosphatase 2 in inflammatory arthritis
Schroeder Juliane, Ross Kirsty, McIntosh Kathryn, Jabbar Shilan Khayrula Jabbar, Woods Stuart, Crowe Jenny, Patterson-Kane Janet C, Alexander James, Lawrence Catherine, Plevin Robin
RMD Open Vol 5, pp. e000711 (2019)
https://doi.org/10.1136/rmdopen-2018-000711
Perivascular mast cells promote neointimal elastin deposit and suppress chronic vein graft restensosis in hyperlipidaemic mice : mast cells and vein graft remodelling
Wu Junxi, Lawrence Catherine, Wadsworth Roger M, Kennedy Simon
Vessel Plus Vol 1, pp. 137-144 (2017)
https://doi.org/10.20517/2574-1209.2017.15
Mast cells contribute to porphyromonas gingivalis-induced bone loss
Malcolm J, Millington O, Millhouse E, Campbell L, Adrados Planell A, Butcher J P, Lawrence C, Ross Kirsty, Ramage G, McInnes I B, Culshaw S
Journal of Dental Research Vol 95, pp. 704-710 (2016)
https://doi.org/10.1177/0022034516634630
Perivascular mast cells regulate vein graft neointimal formation and remodeling
Wu Junxi, Grassia Gianluca, Cambrook Helen, Ialenti Armando, MacRitchie Neil, Carberry Jaclyn, Wadsworth Roger M, Lawrence Catherine, Kennedy Simon, Maffia Pasquale
PeerJ Vol 3 (2015)
https://doi.org/10.7717/peerj.1192

More publications

Professional activities

Biomedical Science degree programme - International Medical University, Malaysia
Examiner
1/10/2020
Immunology - University of Manchester
Examiner
1/10/2020
Knowledge Exchange and Research projects - the capstone experience
Speaker
29/4/2020
Biomedical Science degree- University of Lancaster
Examiner
1/10/2019
STEMFest Glasgow 2018
Contributor
21/11/2018
Research led teaching and project provision
Speaker
25/4/2017

More professional activities

Projects

Biomedical Vacation Scholarships
Coats, Paul (Principal Investigator) Jiang, Hui-Rong (Principal Investigator) Lawrence, Catherine (Principal Investigator) McDonald, James (Principal Investigator) Pickard, Ben (Principal Investigator)
09-Jan-2018 - 31-Jan-2018
Biomedical Vacation Scholarships / R180191-2
Lawrence, Catherine (Principal Investigator)
02-Jan-2018 - 25-Jan-2018
Use of Immunohistochemistry and co-culture model systems to investigating the contribution of M2 macrophages towards chemotherapy resistance in patients with Acute Myeloid leukaemia
Lawrence, Catherine (Principal Investigator) Williams, Mark (Co-investigator)
15-Jan-2017 - 14-Jan-2020
RE:ACTIVE The Apples for All Project
Ross, Kirsty (Researcher) Jackson, Claire (Administrator) Lawrence, Catherine (Academic) Laycock, Martin (CoI) McInnes, Iain (Principal Investigator) Suau, Cristian (Principal Investigator)
The RE:ACTIVE funding was designed to create an ongoing legacy from the Commonwealth Games held in Glasgow in 2014. The Apples for All project aimed to engage nurseries from some of Glasgow's most deprived areas by supplying them with free Scottish heritage apples trees. As a result, 140 nurseries were invited to the University or Glasgow Botanic Gardens to collect their trees and take part in interactive activities around apples.
17-Jan-2014 - 31-Jan-2015
Role of mast cells in inflammatory arthritis
Lawrence, Catherine (Principal Investigator)
09-Jan-2014 - 01-Jan-2014
Role of mast cells in inducing and perpetuating arthritis
Lawrence, Catherine (Principal Investigator)
01-Jan-2010 - 31-Jan-2015

More projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Hamnett Wing

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