Dr Vania Moreira

Strathclyde Chancellor's Fellow

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

 

ORCID: 0000-0001-6169-5035

 

CURRENT POSITIONS

** University Lecturer

Chancellor's Research Fellow in Medicinal Chemistry

Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, United Kingdom

 

**Adjunct Professor & Principal Investigator

Drug Discovery Programme, Faculty of Pharmacy, University of Helsinki, Finland

 

EDUCATION AND DEGREES AWARDED

**Fellow of the Higher Education Academy, UK (FHEA), 2017

**Title of “Docent” (Adjunct Professor) in Pharmaceutical Chemistry, University of Helsinki, Finland, 2015

**Ph.D. in Pharmaceutical Organic Chemistry, University of Coimbra, Portugal & University of Maryland, USA, (highest-scoring grade, “Passed with Distinction and Honours”), 2008

**Degree in Pharmaceutical Sciences (Pharm.D.), University of Coimbra, Portugal, Grade 17 out of 20 (First-class honours), awarded with the “ Sociedade Farmacêutica Lusitana Award” (best student of Pharmaceutical Sciences of the year in Portugal), 2003

 

RESEARCH AREAS

Drug Discovery, Medicinal Chemistry, Natural Products, Antimicrobial and anti-biofilm agents & materials, Neglected diseases, Cancer, (Neuro)inflammation

 

MAJOR FUNDING SOURCES

The Finnish Funding Agency for Innovation (TEKES); Huonekalusäätio; University of Helsinki Research Funds; Magnus Ehrnrooth Foundation; Portuguese Science and Technology Foundation (FCT); FP7-HEALTH-2013-INNOVATION-1 (European Funding); Academy of Finland; Tenovus Sctoland

 

CURRENT COMPOSITION OF RESEARCH GROUP

Doctoral students

Declan Mullen (Oct 2018 - ); Next generation bio-based antimicrobial agents

Ghada Hassan (Sep 2016-); Sustainable antimicrobial coatings

Tiina Ahonen (Sep 2014-); New drugs for chronic pain

Nina Forsman (co-supervisor; Sep 2016-); Sustainable multifunctional coatings for textiles and other cellulosic materials

 

FORMER RESEARCH GROUP MEMBERS

Post-doctoral researchers

Dr. Xing Wan (May 2017- Jan 2018); Sustainable antimicrobial coatings

Dr. Leena Keurulainen (Sep 2016 - Apr 2017); Sustainable antimicrobial coatings

Doctoral students

Dr. Laura Kolsi (main supervisor, graduated 2019); Synthesis of Abietane-Type Diterpenoids with Anticancer Activity

Dr. Raisa Haavikko (co-supervisor; graduated 2015); Synthesis of betulins with new bioactivities

Dr. Nehad El-Salamouni (visiting doctoral student; graduated 2013); Design and synthesis of some novel phenolic compounds and their quinone oxidation products of potential biological activities

 

M.Sc. students

M.Sc. Ruaraidh MacGregor (main supervisor, graduated 2018), Cellulose antimicrobial solutions

M.Sc. Graeme Lester (main supervisor, graduated 2018), The anticancer activity of picealactones

M.Sc. Declan Mullen (main supervisor, graduated 2018); Targeting metabolic serine hydrolases for the development of new anti-inflammatory drug leads

M.Sc. Henni-Karoliina Ropponen (main supervisor, graduated 2018); Exploiting the Potential of Abietane-type Diterpenoids for the Design and Synthesis of Antimicrobial and Anti-biofilm Agents

M.Sc. Peter Grutschreiber (co-supervisor, graduated 2017); Synthesis and characterisation of morphine derivatives as intermediates in development of new compounds for treatment of chronic pain

M.Sc. Tiina Mäenpää (co-supervisor, graduated 2017); Derivatives of abietic acid and their bioactivity

M.Sc. Eunice Cavalheiro (co-supervisor, graduated 2017); Synthesis of 5-methylene(thio)ureas (thio)barbiturates as potential xanthine oxidase inhibitors

M.Sc. Sara Krogerus (co-supervisor, graduated 2016); Benzylic oxidations of dehydroabietic acid derivatives at positions 7 and 15

M.Sc. Ghada Hassan (main supervisor, graduated 2016); Synthesis of abietic and dehydroabietic acid derivatives to target bacterial biofilms

M.Sc. Augustin Long (co-supervisor, graduated 2014); Modification of resin acids for the production of biologically active molecules

M.Sc. Anna-Kaarina Palomäki (co-supervisor; graduated 2013); Lääkeaineisiin ja rohdoksiin liittyvien tutkimuksellisten kokeellisten töiden kehittäminen lukion kemianopetukseen

 

Publications

Dehydroabietylamine-based cellulose nanofibril films : a new class of sustainable biomaterials for highly efficient, broad-spectrum antimicrobial effects
Hassan Ghada, Forsman Nina, Wan Xing, Keurulainen Leena, Bimbo Luis M, Sisko-Johansson Leena, Sipari Nina, Yli-Kauhaluoma Jari, Zimmernann Ralf, Stehl Susanne, Werner Carsten, Saris Per, Osterberg Monika, Moreira Vania M
ACS Sustainable Chemistry and Engineering (2019)
https://doi.org/10.1021/acssuschemeng.8b05658
Catalytic, tunable, one-step bismuth(III) triflate reaction with alcohols : dehydration vs dimerization
Kolsi Laura E, Yli-Kauhaluoma Jari, Moreira Vania M
ACS Omega Vol 3, pp. 8836–8842 (2018)
https://doi.org/10.1021/acsomega.8b01401
Synthesis of 7β-hydroxy-8-ketone opioid derivatives with antagonist activity at the mu- and delta- opioid receptors
Ahonen Tiina J, Rinne Maiju, Grutschreiber Peter, Mätlik Kert, Airavaara Mikko, Schaarschmidt Dieter, Lang Heinrich, Reiss David, Xhaard Henri, Gavériaux-Ruff Claire, Yli-Kauhaluoma Jari, Moreira Vânia M
European Journal of Medicinal Chemistry Vol 151, pp. 495-507 (2018)
https://doi.org/10.1016/j.ejmech.2018.02.074
Discovery of 12-thiazole abietanes as selective inhibitors of the human metabolic serine hydrolase hABHD16A
Ahonen Tiina J, Savinainen Juha R, Yli-Kauhaluoma Jari, Kalso Eija, Laitinen Jarmo T, Moreira Vânia M
ACS Medicinal Chemistry Letters Vol 9, pp. 1269-1273 (2018)
https://doi.org/10.1021/acsmedchemlett.8b00442
Dehydroabietic oximes halt pancreatic cancer cell growth in the G1 phase through induction of p27 and downregulation of cyclin D1
Kolsi Laura E, Leal Ana S, Yli-Kauhaluoma Jari, Liby Karen T, Moreira Vania M
Scientific Reports Vol 8 (2018)
https://doi.org/10.1038/s41598-018-34131-1
Trisubstituted barbiturates and thiobarbiturates : synthesis and biological evaluation as xanthine oxidase inhibitors, antioxidants, antibacterial and antiproliferative agents
Figueiredo Joana, Serrano João L, Cavalheiro Eunice, Keurulainen Leena, Yli-Kauhaluoma Jari, Moreira Vânia M, Ferreira Susana, Domingues Fernanda C, Silvestre Samuel, Almeida Paulo
European Journal of Medicinal Chemistry Vol 143, pp. 829-842 (2018)
https://doi.org/10.1016/j.ejmech.2017.11.070

more publications

Professional activities

Bio-based hybrid antimicrobial surfaces
Speaker
4/7/2018
Internal Examiner to doctoral thesis (Yahia Tabaza)
Examiner
3/2018
Faculty of Pharmacy, University of Helsinki, FI-0014 Helsinki, Finland (External organisation)
Advisor
2017
Strathclyde Institute of Pharmacy and Biomedical Sciences
Visiting researcher
5/2017
Resin-acids based antimicrobial and anti-biofilm solutions
Speaker
3/12/2017
XXIV EFMC International Symposium on Medicinal Chemistry (EFMC-ISMC)
Participant
28/8/2016

more professional activities

Projects

Diterpenoid-based scaffolds for enabling skin repair
Moreira, Vania (Principal Investigator)
01-Jan-2019 - 31-Jan-2021
DTP 2018-19 University of Strathclyde | Mullen, Declan
Moreira, Vania (Principal Investigator) Parkinson, John (Co-investigator) Mullen, Declan (Research Co-investigator)
01-Jan-2018 - 01-Jan-2021
Sustainable Hydrophobic Materials for Antimicrobial Coatings
Moreira, Vania (Principal Investigator)
01-Jan-2016 - 31-Jan-2018
Fully renewable bioactive textiles II
Moreira, Vania (Principal Investigator)
29-Jan-2015 - 31-Jan-2015
Fully renewable bioactive textiles
Moreira, Vania (Principal Investigator)
27-Jan-2014 - 27-Jan-2015
EC-FP7-HEALTH-2013-INNOVATION-1: Understanding chronic pain and new druggable targets: Focus on glial-opioid receptor interface (GLORIA)
Moreira, Vania (Research Co-investigator) Ruff-Gaveriaux, Claire (Co-investigator) Yli-Kauhaluoma, Jari Tapani (Co-investigator) Airavaara, Mikko (Co-investigator) Ahonen, Tiina (Post Grad Student) Xhaard, Henri (Co-investigator) Kalso, Eija (Principal Investigator) Saarma, Mart (Co-investigator)
01-Jan-2013 - 31-Jan-2018

more projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Hamnett Wing

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