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Dr Vania Moreira

Strathclyde Chancellor's Fellow

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

 

ORCID: 0000-0001-6169-5035

 

CURRENT POSITIONS

** University Lecturer & Chancellor's Research Fellow in Medicinal Chemistry

Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, United Kingdom

 

**Adjunct Professor & Principal Investigator

Drug Discovery Programme, Faculty of Pharmacy, University of Helsinki, Finland

 

EDUCATION AND DEGREES AWARDED

**Title of “Docent” (Adjunct Professor) in Pharmaceutical Chemistry, University of Helsinki, Finland, 2015

**Ph.D. in Pharmaceutical Organic Chemistry, University of Coimbra, Portugal & University of Maryland, USA, (highest-scoring grade, “Passed with Distinction and Honours”), 2008

**Degree in Pharmaceutical Sciences (Pharm.D.), University of Coimbra, Portugal, Grade 17 out of 20 (First-class honours), awarded with the “ Sociedade Farmacêutica Lusitana Award” (best student of Pharmaceutical Sciences of the year in Portugal), 2003

 

RESEARCH AREAS

Drug Discovery, Medicinal Chemistry, Natural Products, Antimicrobial and anti-biofilm agents & materials, Neglected diseases, Cancer, (Neuro)inflammation

 

MAJOR FUNDING SOURCES

The Finnish Funding Agency for Innovation (TEKES); Huonekalusäätio; University of Helsinki Research Funds; Magnus Ehrnrooth Foundation; Portuguese Science and Technology Foundation (FCT); FP7-HEALTH-2013-INNOVATION-1 (European Funding); Academy of Finland

 

CURRENT COMPOSITION OF RESEARCH GROUP

Doctoral students

Declan Mullen (Oct 2018 - )

Ghada Hassan (Sep 2016-); Sustainable antimicrobial coatings

Laura Kolsi (May 2014-); New diterpenoids with anti-inflammatory and antitumoral activity

Tiina Ahonen (Sep 2014-); New drugs for chronic pain

Nina Forsman (co-supervisor; Sep 2016-); Sustainable multifunctional coatings for textiles and other cellulosic materials

M.Sc. students

Ruaraidh MacGregor (May - Aug 2018), Cellulose antimicrobial solutions

Graeme Lester (May - Aug 2018), The anticancer activity of picealactones

 

FORMER RESEARCH GROUP MEMBERS

Post-doctoral researchers

Xing Wan (May 2017- Jan 2018); Sustainable antimicrobial coatings

Dr. Leena Keurulainen (Sep 2016 - Apr 2017); Sustainable antimicrobial coatings

Doctoral students

Dr. Raisa Haavikko (co-supervisor; graduated 2015); Synthesis of betulins with new bioactivities

Dr. Nehad El-Salamouni (visiting doctoral student; graduated 2013); Design and synthesis of some novel phenolic compounds and their quinone oxidation products of potential biological activities

 

M.Sc. students

M.Sc. Declan Mullen (main supervisor, graduated 2018); Targeting metabolic serine hydrolases for the development of new anti-inflammatory drug leads

M.Sc. Henni-Karoliina Ropponen (main supervisor, graduated 2018); Exploiting the Potential of Abietane-type Diterpenoids for the Design and Synthesis of Antimicrobial and Anti-biofilm Agents

M.Sc. Peter Grutschreiber (co-supervisor, graduated 2017); Synthesis and characterisation of morphine derivatives as intermediates in development of new compounds for treatment of chronic pain

M.Sc. Tiina Mäenpää (co-supervisor, graduated 2017); Derivatives of abietic acid and their bioactivity

M.Sc. Eunice Cavalheiro (co-supervisor, graduated 2017); Synthesis of 5-methylene(thio)ureas (thio)barbiturates as potential xanthine oxidase inhibitors

M.Sc. Sara Krogerus (co-supervisor, graduated 2016); Benzylic oxidations of dehydroabietic acid derivatives at positions 7 and 15

M.Sc. Ghada Hassan (main supervisor, graduated 2016); Synthesis of abietic and dehydroabietic acid derivatives to target bacterial biofilms

M.Sc. Augustin Long (co-supervisor, graduated 2014); Modification of resin acids for the production of biologically active molecules

M.Sc. Anna-Kaarina Palomäki (co-supervisor; graduated 2013); Lääkeaineisiin ja rohdoksiin liittyvien tutkimuksellisten kokeellisten töiden kehittäminen lukion kemianopetukseen

 

Publications

Dehydroabietic oximes halt pancreatic cancer cell growth in the G1 phase through induction of p27 and downregulation of cyclin D1
Kolsi Laura E., Leal Ana S., Yli-Kauhaluoma Jari, Liby Karen T., Moreira Vania M.
Scientific Reports, (2018)
Catalytic, tunable, one-step bismuth(III) triflate reaction with alcohols : dehydration vs dimerization
Kolsi Laura E., Yli-Kauhaluoma Jari, Moreira Vania M.
ACS Omega Vol 3, pp. 8836–8842, (2018)
http://dx.doi.org/10.1021/acsomega.8b01401
Synthesis of 7β-hydroxy-8-ketone opioid derivatives with antagonist activity at the mu- and delta- opioid receptors
Ahonen Tiina J., Rinne Maiju, Grutschreiber Peter, Mätlik Kert, Airavaara Mikko, Schaarschmidt Dieter, Lang Heinrich, Reiss David, Xhaard Henri, Gavériaux-Ruff Claire, Yli-Kauhaluoma Jari, Moreira Vânia M.
European Journal of Medicinal Chemistry, (2018)
http://dx.doi.org/10.1016/j.ejmech.2018.02.074
Trisubstituted barbiturates and thiobarbiturates : synthesis and biological evaluation as xanthine oxidase inhibitors, antioxidants, antibacterial and antiproliferative agents
Figueiredo Joana, Serrano João L., Cavalheiro Eunice, Keurulainen Leena, Yli-Kauhaluoma Jari, Moreira Vânia M., Ferreira Susana, Domingues Fernanda C., Silvestre Samuel, Almeida Paulo
European Journal of Medicinal Chemistry Vol 143, pp. 829-842, (2018)
http://dx.doi.org/10.1016/j.ejmech.2017.11.070
Pyrazine-fused triterpenoids block transient receptor potential ankyrin-1 (TRPA1) ion channel in vitro and inhibit TRPA1-mediated acute inflammation in vivo
Mäki-Opas Ilari, Hämäläinen Mari, Moilainen Lauri J, Haavikko Raisa, Ahonen Tiina, Alakurtti Sami, Moreira Vania, Muraki Katsuhiko, Yli-Kauhaluoma Jari Tapani, Moilainen Eeva
Acta Rheumatologica Scandinavica Vol 46, (2017)
http://dx.doi.org/10.1080/03009742.2017.1330441
Regioselective benzylic oxidation of aromatic abietanes : application to the semisynthesis of the naturally occurring picealactones A, B and C
Kolsi Laura Elisa, Krogerus Sara, Brito Vanessa, Rüffer Tobias, Lang Heinrich, Yli-Kauhaluoma Jari Tapani, Silvestre Samuel, Moreira Vânia M.
ChemistrySelect Vol 2, pp. 7008-7012, (2017)
http://dx.doi.org/10.1002/slct.201701477

more publications

Professional activities

Bio-based hybrid antimicrobial surfaces
Speaker
4/7/2018
Internal Examiner to doctoral thesis (Yahia Tabaza)
Examiner
3/2018
Resin-acids based antimicrobial and anti-biofilm solutions
Speaker
3/12/2017
Strathclyde Institute of Pharmacy and Biomedical Sciences
Visiting researcher
5/2017
Faculty of Pharmacy, University of Helsinki, FI-0014 Helsinki, Finland (External organisation)
Advisor
2017
XXIV EFMC International Symposium on Medicinal Chemistry (EFMC-ISMC)
Participant
28/8/2016

more professional activities

Projects

Betulins, abietanes and resin acids as novel lead compounds for cancer
Moreira, Vania (Co-investigator)
Period 01-Sep-2011 - 31-Dec-2015
Forestcluster Ltd. & Tekes: Future Biorefinery - FuBio Joint Research 2
Moreira, Vania (Co-investigator)
Period 01-Jun-2011 - 31-May-2014
Design, Synthesis and Biological Evaluation of New Diterpenoids with Potential for the Treatment of Cancer
Moreira, Vania (Principal Investigator)
Period 01-May-2012 - 30-Apr-2013
Wood diterpenes as leads to new anti-biofilm strategies
Moreira, Vania (Co-investigator)
Period 01-Jan-2013 - 31-Dec-2015
Synthesis of Oxamniquine Derivatives for Cancer Treatment. A Drug Repositioning Approach
Moreira, Vania (Research Co-investigator) Bimbo, Luis (Co-investigator)
Period 01-Mar-2013 - 28-Feb-2014
EC-FP7-HEALTH-2013-INNOVATION-1: Understanding chronic pain and new druggable targets: Focus on glial-opioid receptor interface (GLORIA)
Moreira, Vania (Research Co-investigator)
Period 01-Nov-2013 - 31-Oct-2018

more projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Hamnett Wing

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