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Dr Chris John Price

Epsrc Manufacturing Fellow

Chemical and Process Engineering

Personal statement

I am passionate about particles, especially how we can influence their formation by controlling crystallization to deliver particles with physical attributes designed to deliver optimal performance in formulated products. I have recently moved from managing particle science related innovation and product development in the pharmaceutical industry to pursue fundamental research in crystallization focussing on enhancing the purification of organic molecules by active intervention during the crystal growth process.

Publications

The effect of ultrasound on the crystallisation of paracetamol in the presence of structurally similar impurities
Nguyen Thai T. H., Khan Azeem, Bruce Layla M., Forbes Clarissa, O'Leary Richard, Price Chris J.
Crystals, (2017)
http://dx.doi.org/10.3390/cryst7100294
Addressing the challenges of continuous filtration, washing and drying
Price Chris John, Ottoboni Sara
Continuous manufacturing 2017, (2017)
Development of a novel continuous filtration unit for pharmaceutical process development and manufacturing : a case study using paracetamol
Ottoboni S., Price C. J., Steven C., Meehan E., Barton A., Mitchell A.
Filtech, (2016)
The impact of paracetamol impurities on face-specific properties : investigating the surface of single crystals using TOF-SIMS
Ottoboni Sara, Chrubasik Michael, Mir Bruce Layla, Nguyen Thai Thu Hien, Johnston Blair, Florence Alastair, Price Chris John
Crystal Growth of Organic Materials, (2016)
The impact of solvent systems, process conditions and structurally related impurities on the growth rate and morphologies of paracetamol crystals
Price Chris John, Mir Bruce Layla, Nguyen Thai Thu Hien, Hadil Hailani
Crystal Growth of Organic Materials, (2016)
Adipic acid primary nucleation kinetics from probability distributions in droplet-based systems under stagnant and flow conditions
Rossi Damiano, Gavriilidis Asterios, Kuhn Simon, Candel Miguel Ardid, Jones Alan G., Price Chris, Mazzei Luca
Crystal Growth and Design Vol 15, pp. 1784-1791, (2015)
http://dx.doi.org/10.1021/cg501836e

more publications

Professional activities

What the pharmaceutical industry needs from fine particles
Contributor
7/2/2017
Industrial Crystallization: Batch & Continuous
Contributor
17/1/2017
Impurities: A neglected challenge
Contributor
1/12/2016
Crystallizing and isolating pharmaceuticals: Addressing some of the remaining challenges
Contributor
26/10/2016
Talk to your crystallographer - Essential conversations and critical relationships for partners in Directed Assembly
Contributor
20/7/2016
How does the pharmaceutical industry bring a new drug to market. Why crystallize it continuously? What is the role of ultrasound?
Contributor
25/5/2016

more professional activities

Projects

Doctoral Training Partnership (DTP 2016-2017 University of Strathclyde) | Shahid, Muhid
Price, Chris John (Principal Investigator) Lue, Leo (Co-investigator) Shahid, Muhid (Research Co-investigator)
Period 01-Oct-2017 - 01-Oct-2020
AZ compounds for evaluation in Continuous Filtration Device
Price, Chris John (Principal Investigator)
Period 05-Oct-2017 - 07-Mar-2018
Future Continuous Manufacturing and Advanced Crystallisation Research Hub (CMAC Hub)
Florence, Alastair (Principal Investigator) Halbert, Gavin (Co-investigator) Johnston, Blair (Co-investigator) Nordon, Alison (Co-investigator) Price, Chris John (Co-investigator) Sefcik, Jan (Co-investigator) Ter Horst, Joop (Co-investigator)
"Our Hub research is driven by the societal need to produce medicines and materials for modern living through novel manufacturing processes. The enormous value of the industries manufacturing these high value products is estimated to generate £50 billion p.a. in the UK economy. To ensure international competitiveness for this huge UK industry we must urgently create new approaches for the rapid design of these systems, controlling how molecules self-assemble into small crystals, in order to best formulate and deliver these for patient and customer. We must also develop the engineering tools, process operations and control methods to manufacture these products in a resource-efficient way, while delivering the highest quality materials. Changing the way in which these materials are made, from what is called batch crystallisation (using large volume tanks) to continuous crystallisation (a more dynamic, flowing process), gives many advantages, including smaller facilities, more efficient use of expensive ingredients such as solvents, reducing energy requirements, capital investment, working capital, minimising risk and variation and, crucially, improving control over the quality and performance of the particles making them more suitable for formulation into final products. The vision is to quickly and reliably design a process to manufacture a given material into the ideal particle using an efficient continuous process, and ensure its effective delivery to the consumer. This will bring precision medicines and other highly customisable projects to market more quickly. An exemplar is the hubs exciting innovation partnership with Cancer Research UK. Our research will develop robust design procedures for rapid development of new particulate products and innovative processes, integrate crystallisation and formulation to eliminate processing steps and develop reconfiguration strategies for flexible production. This will accelerate innovation towards redistributed anufacturing, more personalisation of products, and manufacturing closer to the patient/customer. We will develop a modular MicroFactory for integrated particle engineering, coupled with a fully integrated, computer-modelling approach to guide the design of processes and materials at molecule, particle and formulation levels. This will help optimise what we call the patient-centric supply chain and provide customisable products. We will make greater use of targeted experimental design, prediction and advanced computer simulation of new formulated materials, to control and optimise the processes to manufacture them. Our talented team of scientists will use the outstanding capabilities in the award winning £34m CMAC National Facility at Strathclyde and across our 6 leading university spokes (Bath, Cambridge, Imperial, Leeds, Loughborough, Sheffield). This builds on existing foundations independently recognised by global industry as 'exemplary collaboration between industry, academia and government which represents the future of pharmaceutical manufacturing and supply chain framework'. Our vision will be translated from research into industry through partnership and co-investment of £31m. This includes 10 of world's largest pharmaceutical companies (eg AstraZeneca, GSK), chemicals and food companies (Syngenta, Croda, Mars) and 19 key technology companies (Siemens, 15 SMEs) Together, with innovation spokes eg Catapult (CPI) we aim to provide the UK with the most advanced, integrated capabilities to deliver continuous manufacture, leading to better materials, better value, more sustainable and flexible processes and better health and well-being for the people of the UK and worldwide. CMAC will create future competitive advantage for the UK in medicines manufacturing and chemicals sector and is strongly supported by industry / government bodies, positioning the UK as the investment location choice for future investments in research and manufacturing."
Period 01-Jan-2017 - 31-Dec-2023
Doctoral Training Centre In Continuous Manufacturing And Crystallisation | Ottoboni, Sara
Price, Chris John (Principal Investigator) Nordon, Alison (Co-investigator) Ottoboni, Sara (Research Co-investigator)
Period 01-Oct-2014 - 01-Oct-2018
Assessment of continuous filter unit and assessment of filter cake washing efficiency (student secondment)
Price, Chris John (Principal Investigator)
Period 23-Nov-2015 - 22-Nov-2017
KTP - Alconbury Weston
Price, Chris John (Principal Investigator) Mulheran, Paul (Co-investigator)
Period 18-Apr-2016 - 01-Oct-2018

more projects

Address

Chemical and Process Engineering
James Weir Building

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