Professor Nigel Pyne

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Awards: 1995 Sandoz Prize in Pharmacology (awarded by the British Pharmacological Society)

              2010 Elected Member of Academy of Sciences of the Institute of Bologna (affilated with the University of Bologna, founded in 1690)

              2017 Elected Fellow of the Royal Society of Biology (FRSB)

 

Research interests

  • Lysolipid (sphingosine 1-phosphate, lysophoshatidic acid) receptor signalling in health and disease with specific focus on cancer and cardiovascular/inflammatory disease
  • Cross talk regulation between lysolipid receptors and growth factor receptors/oncogenes (e.g. PDGFR, HER2, EGFR and TRK A)
  • Translational biology of lysolipids (e.g. drug discovery and biomarker identification)
  • Cyclic AMP/cyclic GMP signalling

The overall aim of research is to investigate the molecular mechanisms by which lysolipid receptors regulate cell biology; to determine how these mechanisms become altered in diseases and to evaluate the potential of receptors and enzymes involved in lysolipid signalling as drugable targets. Techniques in the laboratory range from in vitro cell based assays, imaging, mass spectroscopic analysis and proteomics to in vivo analysis. Recent research in this laboratory has received support from Cancer Research UK, British Heart Foundation, Biotechnology and Biological Sciences Research Council and industry.

194 papers published with an H index of 58 and with 11100 citations (Google Scholar Citations).

Co-founder of Mironid Ltd

Executive member, SULSA

Head of Research, SIPBS (Aug 2006-Sept 2008)

Teaching Activity: lectures, workshops and tutorials to undergraduates of the BSc (various biological science) and MPharm (pharmacy) teaching programmes. Supervision of laboratory based research projects at both undergraduate and postgraduate (PhD) level.

Publications

Dihydroceramide desaturase functions as an inducer and rectifier of apoptosis : effect of retinol derivatives, antioxidants and phenolic compounds
Alsanafi Mariam, Brown Ryan D R, Oh Jeongah, Adams David R, Torta Federico, Pyne Nigel J, Pyne Susan
Cell Biochemistry and Biophysics (2021)
https://doi.org/10.1007/s12013-021-00990-1
A new model for regulation of sphingosine kinase 1 translocation to the plasma membrane in breast cancer cells
Brown Ryan DR, Veerman Ben EP, Oh Jeongah, Tate Rothwelle J, Torta Federico, Cunningham Margaret R, Adams David R, Pyne Susan, Pyne Nigel J
Journal of Biological Chemistry (2021)
https://doi.org/10.1016/j.jbc.2021.100674
Validation of highly selective Sphingosine kinase 2 inhibitors SLM6031434 and HWG-35D as effective anti-fibrotic treatment options in a mouse model of tubulointerstitial fibrosis
Schwalm Stephanie, Beyer Sandra, Hafizi Redona, Traufmann Sandra, Geisslinger Gerd, Adams David R, Pyne Susan, Pyne Nigel, Schaefer Liliana, Huwiler Andrea, Pfeilschifter Josef
Cellular Signalling Vol 79 (2021)
https://doi.org/10.1016/j.cellsig.2020.109881
Structure-function analysis of lipid substrates and inhibitors of sphingosine kinases
Adams David R, Pyne Susan, Pyne Nigel J
Cellular Signalling Vol 76 (2020)
https://doi.org/10.1016/j.cellsig.2020.109806
Recent advances in the role of Sphingosine 1-phosphate in cancer
Pyne Nigel J, Pyne Susan
FEBS Letters Vol 594, pp. 3583-3601 (2020)
https://doi.org/10.1002/1873-3468.13933
A novel selective sphingosine kinase 2 inhibitor, HWG-35D, ameliorates the severity of imiquimod-induced psoriasis model by blocking Th17 differentiation of naïve CD4 T lymphocytes
Shin Sun-Hye, Kim Hee-Yeon, Yoon Hee-Soo, Park Woo-Jae, Adams David R, Pyne Nigel J, Pyne Susan, Park Joo-Won
International Journal of Molecular Sciences Vol 21 (2020)
https://doi.org/10.3390/ijms21218371

More publications

Professional activities

61st Advances in Biological Regulation
Speaker
5/10/2020
FASEB meeting on Lysolipids
Speaker
29/7/2019
FASEB Meeting on Lysoplipids (Portugal)
Chair
29/7/2019
Role of Sphingosine 1-phosphate in disease
Speaker
20/4/2019
Collaborative Research workshop between SU and HKUST
Participant
12/4/2019
Lipid signalling Systems
Speaker
4/4/2019

More professional activities

Projects

Identification of pre-clinical SK1 inhibitors for the treatment of Pulmonary Hypertension
Pyne, Nigel (Principal Investigator) MacKay, Simon (Co-investigator) Pyne, Susan (Co-investigator)
26-Jan-2013 - 25-Jan-2014
The Role Of S1P4 And SK1 In Triple Negative Breast Cancer
Pyne, Nigel (Principal Investigator) Dufès, Christine (Co-investigator) Pyne, Susan (Co-investigator)
06-Jan-2013 - 05-Jan-2014
Sphingosine kinase 1 and pulmonary hypertension
Pyne, Nigel (Principal Investigator) Pyne, Susan (Co-investigator)
01-Jan-2012 - 31-Jan-2015
Novel Therapies For COPD - PoC
Houslay, Miles (Principal Investigator) Pyne, Nigel (Co-investigator)
21-Jan-2012 - 08-Jan-2014
The role of sphingosine 1-phosphate in colorectal cancer
Pyne, Susan (Principal Investigator) Pyne, Nigel (Co-investigator)
16-Jan-2011 - 31-Jan-2014
The role of S1P in HER2-dependent breast cancer
Pyne, Susan (Principal Investigator) Pyne, Nigel (Co-investigator)
01-Jan-2008 - 31-Jan-2009

More projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Robertson Wing

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