Professor Susan Pyne

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Awards:

1993-2001 Wellcome Trust Senior Research Fellow

2014 Laurens van Deenen Lecture (awarded by ICBL for out-standing and long-term contributions to lipid research)

2018 Fellowship Royal Society of Biology

 

SIPBS Roles & Responsibilities:

Director of Equality & Diversity

 

Research interests (in collaboration with Nigel Pyne)

  • Sphingosine 1-phosphate signalling in health and disease - at a cellular level (cell division, migration, survival) in model cell lines; in vascular function (e.g. regulation of vascular tone, cardioprotection); in disease (e.g. cancer of the breast, prostate, colon etc.).
  • Isoform diversity, regulation and spatial signalling involving sphingosine kinases
  • Isoform diversity and regulation of lipid phosphate phosphatases

Sphingosine 1-phosphate (S1P) is a biologically active lipid that acts as both an agonist and as an intracellular second messenger. It is key to a number of important physiological processes including formation of blood vessels, migration of immune cells, vascular permeability etc. It is formed by sphingosine kinase-catalysed phosphorylation of sphingosine whereas S1P removal is either by dephosphorylation, which may involve lipid phosphate phosphatases, or cleavage by S1P lyase.

The overall aim of research in the laboratory is to understand the molecular mechanisms by which S1P affects cell function in health and disease.

We make use of molecular, biochemical, cellular biological techniques together with disease models and patient biopsy samples.

Recent research in this laboratory has received support from the British Heart Foundation, Scottish Universities Life Sciences Alliance (SULSA), Cancer Research UK (and WeCan), Biotechnology and Biological Sciences Research Council.

Expressions of interest in joining the research activity of the lab are always welcome.

Teaching Activity: lectures, workshops and tutorials to undergraduates of the BSc, MSci  (both in various biological sciences) and MPharm (pharmacy) teaching programmes. Instruction of laboratory based research projects at both undergraduate and postgraduate (MSc, MRes, PhD) level.

Publications

Short periods of hypoxia upregulate Sphingosine Kinase 1 and increase vasodilation of arteries to Sphingosine 1-Phosphate via S1P3
Alganga Husman, Almabrouk Tarek A M, Katwan Omar J, Daly Craig J, Pyne Susan, Pyne Nigel J, Kennedy Simon
Journal of Pharmacology and Experimental Therapeutics (2019)
https://doi.org/10.1124/jpet.119.257931
Ceramide and sphingosine 1-phosphate in adipose dysfunction
Fang Zijian, Pyne Susan, Pyne Nigel J
Progress in Lipid Research Vol 74, pp. 145-159 (2019)
https://doi.org/10.1016/j.plipres.2019.04.001
Topographical mapping of isoform-selectivity determinants for J-channel-binding inhibitors of sphingosine kinases 1 and 2
Adams David R, Tawati Salha, Berretta Giacomo, Rivas Paula Lopez, Baiget Jessica, Jiang Zhong, Alsfouk Aisha, MacKay Simon P, Pyne Nigel J, Pyne Susan
Journal of Medicinal Chemistry Vol 62, pp. 3658-3676 (2019)
https://doi.org/10.1021/acs.jmedchem.9b00162
Requirement for sphingosine kinase 1 in mediating phase 1 of the hypotensive response to anandamide in the anaesthetised mouse
Greig Fiona H, Nader Katrin, Ballantyne Margaret D, Kazi Zeshan H, Alganga Husam, Ewart Marie-Ann, Zaborska Karolina E, Fertig Bracy, Pyne Nigel J, Pyne Susan, Kennedy Simon
European Journal of Pharmacology Vol 842, pp. 1-9 (2019)
https://doi.org/10.1016/j.ejphar.2018.10.027
Native and polyubiquitinated forms of dihydroceramide desaturase are differentially linked to human embryonic kidney cell survival
Alsanafi Mariam, Kelly Samuel L, Jubair Karawan, McNaughton Melissa, Tate Rothwelle J, Merrill Jr. Alfred H, Pyne Susan, Pyne Nigel J
Molecular and Cellular Biology Vol 38 (2018)
https://doi.org/10.1128/MCB.00222-18
Does the sphingosine 1-phosphate receptor-1 provide a better or worse prognostic outcome for breast cancer patients?
Pyne Nigel J, Pyne Susan
Frontiers in Oncology Vol 8, pp. 1-3 (2018)
https://doi.org/10.3389/fonc.2018.00417

more publications

Professional activities

FASEB Lysophospholipids and Related Lipids in Biology and Diseases, Portugal
Invited speaker
7/2019
FEBS Special Meeting in Sphingolipid Biology, Portugal
Invited speaker
5/2019
7th International Pharmacy Conference, Kuwait
Invited speaker
3/2019
Division of Life Sciences, Hong Kong University of Science and Technology, HK
Speaker
2019
Tenovus Scotland (West) (External organisation)
Advisor
2019
Workshop on Bioactive Lipid Signalling Systems, Singapore
Participant
2019

more professional activities

Projects

STEM Equals (EPSRC Inclusion Matters)
MacGregor, Scott (Principal Investigator) Carter, Sara (Co-investigator) Lunn, Rebecca (Co-investigator) Pyne, Susan (Co-investigator) Renshaw, Joanna (Co-investigator) Rivers, Ian (Co-investigator) Shipton, Zoe (Co-investigator)
01-Jan-2018 - 30-Jan-2021
Identification of pre-clinical SK1 inhibitors for the treatment of Pulmonary Hypertension
Pyne, Nigel (Principal Investigator) MacKay, Simon (Co-investigator) Pyne, Susan (Co-investigator)
26-Jan-2013 - 25-Jan-2014
The Role Of S1P4 And SK1 In Triple Negative Breast Cancer
Pyne, Nigel (Principal Investigator) Dufès, Christine (Co-investigator) Pyne, Susan (Co-investigator)
06-Jan-2013 - 05-Jan-2014
Sphingosine kinase 1 and pulmonary hypertension
Pyne, Nigel (Principal Investigator) Pyne, Susan (Co-investigator)
01-Jan-2012 - 31-Jan-2015
The role of sphingosine 1-phosphate in colorectal cancer
Pyne, Susan (Principal Investigator) Pyne, Nigel (Co-investigator)
16-Jan-2011 - 31-Jan-2014
The role of S1P in HER2-dependent breast cancer
Pyne, Susan (Principal Investigator) Pyne, Nigel (Co-investigator)
01-Jan-2008 - 31-Jan-2009

more projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Robertson Wing

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