Professional activities
- 7th EuCheMS Chemistry Congress
- Speaker
- 26/8/2018
- 12th Fluorofest International Workshop
- Participant
- 24/4/2017
- Bit's 5th Annual Conference on Protein and Peptide
- Invited speaker
- 23/3/2012
- 12 International Conference on Methods and Applications of Fluorescence
- Invited speaker
- 11/9/2011
- RSC, Chemistry World News Article
- Contributor
- 2/2011
- Invited seminar, Laboratory for Biomolecular Dynamics, Katolieke Universiteit Leuven, Belgium
- Invited speaker
- 10/2009
More professional activities
Projects
- EPSRC Doctoral Training Grant - DTA, University of Strathclyde | Mancini, Onorio Claudio
- Mulheran, Paul (Principal Investigator) Rolinski, Olaf (Co-investigator) Mancini, Onorio Claudio (Research Co-investigator)
- 01-Jan-2013 - 09-Jan-2018
- EPSRC Science and Innovation Nanometrology for Molecular Science, Medicine and Manufacture
- Birch, David (Principal Investigator) Dawson, Martin (Co-investigator) Faulds, Karen (Co-investigator) Girkin, John (Co-investigator) Graham, Duncan (Co-investigator) Martin, Robert (Co-investigator) O'Donnell, Kevin (Co-investigator) Rolinski, Olaf (Co-investigator) Smith, William (Co-investigator) Wynne, Klaas (Co-investigator)
- The lack of capacity for advancing the emerging field of nanometrology can only be addressed through stra-tegic interdisciplinary collaborations that provide a stimulating and innovative research environment to catalyse and sustain a new dimension in UK research capability. In a major strategic initiative, Strathclyde University (SU) has founded a Centre for Molecular Nanometrology (2005 - to our knowledge, the first in the world) with facilities supported by the Wolfson Foundation and the Science Research Infrastructure Fund. This Centre has the ultimate goal of recording real-time images of dynamical interactions of single molecules in-situ. With the award of a Science and In-novation Award the Centre will facilitate the high quality, innovative, multidisciplinary research environment required to nurture and develop the extra capacity needed to make the UK a leader in nanometrology. A Science and Innovation Award will also bring together the Centre and medical collaborators at King's College London (KCL), bridging the molecular measurement gap to innovation in emerging areas of strategic impor-tance such as disease pathology, diagnostic tools in nanomedicine, the design of new drug treatments and new structural materials while facilitating knowledge transfer into the healthcare and chemical industries.
- 01-Jan-2008 - 31-Jan-2012
- YOCTOMOLE FLUORESCENCE SENSING OF SINGLE METAL IONS
- Rolinski, Olaf (Principal Investigator) Birch, David (Co-investigator)
- Metal ions play both functional and toxic role in biological systems. Many enzymes require metal cations as co-factors, for example, Se, Zn and Ca, are essential components of glutathione peroxidase, insulin and calmodulin, respectively. Yet excessive Cu and Zn have deleterious effects in that they contribute to the oxidative stress and inflammation in the central nervous system. The presence of metal ions in our environment, e.g. surface waters, also has important influence on our health. Therefore, monitoring the levels of metal ions in living oranisms and the environment is a key analytical issue in life sciences with links to clinical medicine and in pollution control. At present, monitoring metal ions is mainly based on measurement of average concentration, which enables detection of 1 ion in the sample consisting of few billions of other molecules. We propose developing a new approach for single molecule detection, which would allow finding 1 ion in one mole of other molecules. This step improvement in sensitivity can offer a new insight into the research on ion interactions on molecular level, as it removes the complexity associated with ensemble-averaged macroscopic measurements. The goal can be achieved by combining single molecule detection techniques, enabling observation of the volume as small as ~1 micrometer^3, with fluorescence technique based on counting single photons. The aim is to develop the sensor to be able to recognise a specific single metal ion by using an ion-selective molecular mechanism, namely fluorescence resonance energy transfer (FRET).
- 01-Jan-2006 - 31-Jan-2010
- Sol-gel pore nanomorphology using fluorescence resonance energy transfer
- Birch, David (Principal Investigator) Rolinski, Olaf (Co-investigator)
- 01-Jan-2004 - 30-Jan-2007
More projects
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Physics
John Anderson Building
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