Dr Nicholas Tucker

Senior Lecturer

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

2009-Present, Lecturer in Molecular Microbiology, University of Strathclyde
2005-2009, Post-doctoral fellow, John Innes Centre, Norwich 
2002-2005 PhD. Molecular microbiology, University of East Anglia 
1999-2000 MSc. Human Molecular Genetics, Imperial College, London. 
1996-99 BSc. (Hons.) Biochemistry, Heriot-Watt University, Edinburgh.

The unifying theme across my research is bacterial gene regulation. Bacteria must be able to efficiently respond to changes in their environment by altering the expression of specific genes. This is most commonly achieved at the transcriptional level by proteins that either activate or repress the activity of RNA-polymerase.

Research Areas:

1. Gene regulation and signaling by bacterial enhancer binding proteins
2. Nitric oxide sensing and metalloproteins (Rrf2 family)
3. Pseudomonas aeruginosa pathogenicity
4. E. coli and Streptomyces coelicolor nitrogen metabolism

Nitric oxide is a toxic radical gas that is produced by macrophage cells as a broad range antibiotic. Bacterial pathogens have evolved a number of systems for detoxifying nitric oxide such as flavorubredoxin and flavohemoglobin in E. coli . The expression of the genes encoding these proteins is nitric oxide dependent and is controlled by the transcriptional regulators NorR and NsrR respectively. Both proteins sense nitric oxide via metal centres that control their ability to activate or repress gene expression.


Differential transcription of expanded gene families in central carbon metabolism of Streptomyces coelicolor A3(2)
Schniete Jana K, Reumerman Richard, Kerr Leena, Tucker Nicholas P, Hunter Iain S, Herron Paul R, Hoskisson Paul A
Access Microbiology (2020)
Emergence of an Australian-like pstS-null vancomycin resistant Enterococcus faecium clone in Scotland
Lemonidis Kimon, Salih Talal S, Dancer Stephanie J, Hunter Iain S, Tucker Nicholas P
PLoS ONE Vol 14 (2019)
Identification and characterisation of Staphylococcus aureus on low cost screen printed carbon electrodes using impedance spectroscopy
Ward AC, Hannah AJ, Kendrick SL, Tucker NP, MacGregor G, Connolly P
Biosensors and Bioelectronics Vol 110, pp. 65-70 (2018)
Genomic characterisation of an international Pseudomonas aeruginosa reference panel indicates that the two major groups draw upon distinct mobile gene pools
Freschi Luca, Bertelli Claire, Jeukens Julie, Moore Matthew P, Kukavica-Ibrulj Irena, Emond-Rheault Jean-Guillaume, Hamel Jérémie, Fothergill Joanne L, Tucker Nicholas P, McClean Siobhán, Klockgether Jens, de Soyza Anthony, Brinkman Fiona SL, Levesque Roger C, Winstanley Craig
FEMS Microbiology Letters (2018)
Community-led comparative genomic and phenotypic analysis of the aquaculture pathogen Pseudomonas baetica a390T sequenced by Ion semiconductor and Nanopore technologies
Beaton Ainsley, Lood Cédric, Cunningham-Oakes Edward, MacFadyen Alison, Mullins Alex J, Bestawy Walid El, Botelho João, Chevalier Sylvie, Coleman Shannon, Dalzell Chloe, Dolan Stephen K, Faccenda Alberto, Ghequire Maarten G K, Higgins Steven, Kutschera Alexander, Murray Jordan, Redway Martha, Salih Talal, da Silva Ana C, Smith Brian A, Smits Nathan, Thomson Ryan, Woodcock Stuart, Welch Martin, Cornelis Pierre, Lavigne Rob, van Noort Vera, Tucker Nicholas P
FEMS Microbiology Letters Vol 365 (2018)
Why antibacterial minor groove binders are a good thing
Suckling Colin J, Khalaf Abedawn, Scott Fraser J, Tucker Nicholas, Niemenen Leena, Lemonidis Kimon, Hunter Iain S
3rd International Electronic Conference on Medicinal Chemistry (2017)

more publications

Professional activities

BBSRC (Biotech & Biological Sciences Research Council) (External organisation)
Comparative genomics of Pseudomonas aeruginosa
SULSA Symposium 2013
Member of programme committee
Pseudomonas 2013
Advances in Biology (Journal)
Editorial board member
Antonie van Leeuwenhoek: International Journal of General and Molecular Microbiology (Journal)
Editorial board member

more professional activities


Investigating a novel class of Gram-negative active antibiotic suitable for clinical use
Scott, Fraser (Principal Investigator) Hunter, Iain (Co-investigator) Suckling, Colin (Co-investigator) Tucker, Nicholas (Co-investigator)
01-Jan-2020 - 31-Jan-2022
Exploiting Pseudomonas for the production of methacrylate for the plastics industry
Tucker, Nicholas (Principal Investigator) Duncan, Katherine (Co-investigator)
01-Jan-2018 - 30-Jan-2022
A comparative multi-omics platform for accelerated antibiotic drug discovery from ancient Polar bacteria
Duncan, Katherine (Principal Investigator) Tucker, Nicholas (Co-investigator)
01-Jan-2017 - 30-Jan-2018
Accelerating clinical introduction of novel antibacterial drugs
Tucker, Nicholas (Principal Investigator) Burley, Glenn (Co-investigator) Scott, Fraser (Co-investigator)
01-Jan-2016 - 31-Jan-2017
Transcriptomics-based strain interrogation. IBioIC Ingenza studentship
Tucker, Nicholas (Principal Investigator)
03-Jan-2016 - 02-Jan-2020
Lung infection monitor for chronic disease patients
Connolly, Patricia (Principal Investigator) Tucker, Nicholas (Co-investigator)
01-Jan-2015 - 28-Jan-2019

more projects


Strathclyde Institute of Pharmacy and Biomedical Sciences
Hamnett Wing

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