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Dr Nicholas Tucker

Senior Lecturer

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

2009-Present, Lecturer in Molecular Microbiology, University of Strathclyde
2005-2009, Post-doctoral fellow, John Innes Centre, Norwich 
2002-2005 PhD. Molecular microbiology, University of East Anglia 
1999-2000 MSc. Human Molecular Genetics, Imperial College, London. 
1996-99 BSc. (Hons.) Biochemistry, Heriot-Watt University, Edinburgh.

The unifying theme across my research is bacterial gene regulation. Bacteria must be able to efficiently respond to changes in their environment by altering the expression of specific genes. This is most commonly achieved at the transcriptional level by proteins that either activate or repress the activity of RNA-polymerase.

Research Areas:

1. Gene regulation and signaling by bacterial enhancer binding proteins
2. Nitric oxide sensing and metalloproteins (Rrf2 family)
3. Pseudomonas aeruginosa pathogenicity
4. E. coli and Streptomyces coelicolor nitrogen metabolism

Nitric oxide is a toxic radical gas that is produced by macrophage cells as a broad range antibiotic. Bacterial pathogens have evolved a number of systems for detoxifying nitric oxide such as flavorubredoxin and flavohemoglobin in E. coli . The expression of the genes encoding these proteins is nitric oxide dependent and is controlled by the transcriptional regulators NorR and NsrR respectively. Both proteins sense nitric oxide via metal centres that control their ability to activate or repress gene expression.

Publications

Genomics of antibiotic-resistance prediction in Pseudomonas aeruginosa
Jeukens Julie, Freschi Luca, Kukavica-Ibrulj Irena, Emond-Rheault Jean-Guillaume, Tucker Nicholas P, Levesque Roger C
Annals of the New York Academy of Sciences, (2017)
http://dx.doi.org/10.1111/nyas.13358
Discovery, characterisation and in vivo activity of pyocin SD2, a protein antibiotic from Pseudomonas aeruginosa
McCaughey Laura C., Josts Inokentijs, Grinter Rhys, White Paul, Byron Olwyn, Tucker Nicholas P., Matthews Jacqueline M., Kleanthous Colin, Whitchurch Cynthia B., Walker Daniel
Biochemical journal Vol 473, pp. 2345-2358, (2016)
http://dx.doi.org/10.1042/BCJ20160470
Genes required for free phage production are essential for pseudomonas aeruginosa chronic lung infections
Lemieux Andrée-Ann, Jeukens Julie, Kukavica-Ibrulj Irena, Fothergill Joanne L., Boyle Brian, Laroche Jérôme, Tucker Nicholas P., Winstanley Craig, Levesque Roger C.
Journal of Infectious Diseases Vol 213, pp. 395-402, (2016)
http://dx.doi.org/10.1093/infdis/jiv415
Clinical utilization of genomics data produced by the international Pseudomonas aeruginosa consortium
Freschi Luca, Jeukens Julie, Kukavica-Ibrulj Irena, Boyle Brian, Dupont Marie-Josée, Laroche Jérôme, Larose Stéphane, Maaroufi Halim, Fothergill Joanne L., Moores Matthew, Winsor Geoffrey L., Aaron Shawn D., Barbeau Jean, Bell Scott C., Burns Jane L., Camara Miguel, Cantin André, Charette Steve J., Dewar Ken, Déziel Éric, Grimwood Keith, Hancock Robert E. W., Harrison Joe J., Heeb Stephan, Jelsbak Lars, Jia Baofeng, Kenna Dervla T., Kidd Timothy J., Klockgether Jens, Lam Joseph S., Lamont Iain L., Lewenza Shawn, Loman Nick, Malouin François, Manos Jim, McArthur Andrew G., McKeown Josie, Milot Julie, Naghra Hardeep, Nguyen Dao, Pereira Sheldon K., Perron Gabriel G., Pirnay Jean-Paul, Rainey Paul B., Rousseau Simon, Santos Pedro M., Stephenson Anne, Taylor Véronique, Turton Jane F., Waglechner Nicholas, Williams Paul, Thrane Sandra W., Wright Gerard D., Brinkman Fiona S. L., Tucker Nicholas P., Tümmler Burkhard, Winstanley Craig, Levesque Roger C.
Frontiers in Microbiology Vol 6, (2015)
http://dx.doi.org/10.3389/fmicb.2015.01036
Phenotypic and genotypic characteristics of small colony variants and their role in chronic infection
Johns Benjamin E., Purdy Kevin J., Tucker Nicholas P., Maddocks Sarah E.
Microbiology Insights Vol 8, pp. 15-23, (2015)
http://dx.doi.org/10.4137/MBI.S25800
Revolutionizing prokaryotic systematics through next-generation sequencing
Sangal Vartul, Nieminen Leena, Tucker Nicholas P., Hoskisson Paul A.
New Approaches to Prokaryotic SystematicsMethods in Microbiology Vol 41, (2014)
http://dx.doi.org/10.1016/bs.mim.2014.07.001

more publications

Professional activities

BBSRC (Biotech & Biological Sciences Research Council) (External organisation)
Member
12/2014
Comparative genomics of Pseudomonas aeruginosa
Contributor
10/2013
SULSA Symposium 2013
Member of programme committee
9/9/2013
Pseudomonas 2013
Participant
7/9/2013
Antonie van Leeuwenhoek: International Journal of General and Molecular Microbiology (Journal)
Editorial board member
28/5/2013
Advances in Biology (Journal)
Editorial board member
28/5/2013

more professional activities

Projects

A comparative multi-omics platform for accelerated antibiotic drug discovery from ancient Polar bacteria
Duncan, Katherine (Principal Investigator) Tucker, Nicholas (Co-investigator)
Period 01-Oct-2017 - 30-Sep-2018
Accelerating clinical introduction of novel antibacterial drugs
Tucker, Nicholas (Principal Investigator) Burley, Glenn (Co-investigator) Scott, Fraser (Co-investigator)
Period 01-Nov-2016 - 31-Oct-2017
BBSRC Doctoral Training Grant (DTG) | Bellota-Anton, Cesar
Tucker, Nicholas (Principal Investigator) Hunt, Neil (Co-investigator) Bellota-Anton, Cesar (Research Co-investigator)
Period 01-Dec-2011 - 01-Dec-2014
Lung infection monitor for chronic disease patients
Connolly, Patricia (Principal Investigator) Tucker, Nicholas (Co-investigator)
Period 01-Nov-2015 - 31-Oct-2018
Comparative transcriptomic and metabolomic analysis of engineered bacteria
Tucker, Nicholas (Principal Investigator) Edrada-Ebel, Ruangelie (Co-investigator)
Analysis of industrial biotech strains produced by Ingenza
Period 18-Nov-2014 - 18-Nov-2015
Ultrafast Laser Facility for Advanced Spectroscopy Applications
McKee, David (Principal Investigator) Ackemann, Thorsten (Co-investigator) Fedorov, Maxim (Co-investigator) Hoskisson, Paul (Co-investigator) Hunt, Neil (Co-investigator) Tucker, Nicholas (Co-investigator)
Equipment sharing grant, £36,0000
Period 01-Jan-2012 - 30-Jun-2012

more projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Hamnett Wing John Arbuthnott Building

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