Personal statement
2009-Present, Lecturer in Molecular Microbiology, University of Strathclyde
2005-2009, Post-doctoral fellow, John Innes Centre, Norwich
2002-2005 PhD. Molecular microbiology, University of East Anglia
1999-2000 MSc. Human Molecular Genetics, Imperial College, London.
1996-99 BSc. (Hons.) Biochemistry, Heriot-Watt University, Edinburgh.
The unifying theme across my research is bacterial gene regulation. Bacteria must be able to efficiently respond to changes in their environment by altering the expression of specific genes. This is most commonly achieved at the transcriptional level by proteins that either activate or repress the activity of RNA-polymerase.
Research Areas:
1. Gene regulation and signaling by bacterial enhancer binding proteins
2. Nitric oxide sensing and metalloproteins (Rrf2 family)
3. Pseudomonas aeruginosa pathogenicity
4. E. coli and Streptomyces coelicolor nitrogen metabolism
Nitric oxide is a toxic radical gas that is produced by macrophage cells as a broad range antibiotic. Bacterial pathogens have evolved a number of systems for detoxifying nitric oxide such as flavorubredoxin and flavohemoglobin in E. coli . The expression of the genes encoding these proteins is nitric oxide dependent and is controlled by the transcriptional regulators NorR and NsrR respectively. Both proteins sense nitric oxide via metal centres that control their ability to activate or repress gene expression.
Professional activities
- BBSRC (Biotech & Biological Sciences Research Council) (External organisation)
- Member
- 12/2014
- Comparative genomics of Pseudomonas aeruginosa
- Contributor
- 10/2013
- SULSA Symposium 2013
- Member of programme committee
- 9/9/2013
- Pseudomonas 2013
- Participant
- 7/9/2013
- Antonie van Leeuwenhoek: International Journal of General and Molecular Microbiology (Journal)
- Editorial board member
- 28/5/2013
- Advances in Biology (Journal)
- Editorial board member
- 28/5/2013
more professional activities
Projects
- A comparative multi-omics platform for accelerated antibiotic drug discovery from ancient Polar bacteria
- Duncan, Katherine (Principal Investigator) Tucker, Nicholas (Co-investigator)
- Period 01-Oct-2017 - 30-Sep-2018
- Transcriptomics-based strain interrogation. IBioIC Ingenza studentship
- Tucker, Nicholas (Principal Investigator)
- Period 03-Oct-2016 - 02-Oct-2020
- Accelerating clinical introduction of novel antibacterial drugs
- Tucker, Nicholas (Principal Investigator) Burley, Glenn (Co-investigator)
- Period 01-Nov-2016 - 31-Oct-2017
- BBSRC Doctoral Training Grant (DTG) | Bellota-Anton, Cesar
- Tucker, Nicholas (Principal Investigator) Hunt, Neil (Co-investigator)
- Period 01-Dec-2011 - 01-Dec-2014
- Lung infection monitor for chronic disease patients
- Connolly, Patricia (Principal Investigator) Tucker, Nicholas (Co-investigator)
- Period 01-Nov-2015 - 31-Oct-2018
- Comparative transcriptomic and metabolomic analysis of engineered bacteria
- Tucker, Nicholas (Principal Investigator) Edrada-Ebel, Ruangelie (Co-investigator)
- Analysis of industrial biotech strains produced by Ingenza
- Period 18-Nov-2014 - 18-Nov-2015
more projects
Address
Strathclyde Institute of Pharmacy and Biomedical Sciences
Hamnett Wing John Arbuthnott Building
Hamnett Wing John Arbuthnott Building
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