Dr Nicholas Tucker

Senior Lecturer

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Research in the Tucker lab is focussed on the application of genomics to the following areas: 1. Exploiting Pseudomonas for industrial biotechnology and the sustainable production of plastics 2. Investigating the mode of action of DNA binding antibiotics and their impact on transcription 3. Using metagenomics to identify useful microorganisms from the environment 4. Pathogen genomics and antimicrobial resistance

Publications

The genetics of prey susceptibility to myxobacterial predation : a review, including an investigation into pseudomonas aeruginosa mutations affecting predation by Myxococcus xanthus: Sydney Natashia, Swain Martin T, So Jeffery MT, Hoiczyk Egbert, Tucker Nicholas P, Whitworth David E; Microbial Physiology (2021); https://doi.org/10.1159/000515546
Transmission, adaptation and geographical spread of the Pseudomonas aeruginosa Liverpool epidemic strain: Moore Matthew P, Lamont Iain L, Williams David, Paterson Steve, Kukavica-Ibrulj Irena, Tucker Nicholas P, Kenna Dervla TD, Turton Jane F, Jeukens Julie, Freschi Luca, Wee Brian A, Loman Nicholas J, Holden Stephen, Manzoor Susan, Hawkey Peter, Southern Kevin W, Walshaw Martin J, Levesque Roger C, Fothergill Joanne L, Winstanley Craig; Microbial Genomics Vol 7 (2021); https://doi.org/10.1099/mgen.0.000511
Microbes Against Humanity, a workshop game for horrible students : using a creative card game in higher education microbiology teaching: Efthimiou Georgios, Tucker Nicholas P; Access Microbiology (2020); https://doi.org/10.1099/acmi.0.000186
Genomic plasticity of pathogenic Escherichia coli mediates D-serine tolerance via multiple adaptive mechanisms: O'Boyle Nicky, Connolly James P R, Tucker Nicholas P, Roe Andrew J; Proceedings of the National Academy of Sciences of the United States of America Vol 117, pp. 22484-22493 (2020); https://doi.org/10.1073/pnas.2004977117
Differential transcription of expanded gene families in central carbon metabolism of Streptomyces coelicolor A3(2): Schniete Jana K, Reumerman Richard, Kerr Leena, Tucker Nicholas P, Hunter Iain S, Herron Paul R, Hoskisson Paul A; Access Microbiology (2020); https://doi.org/10.1099/acmi.0.000122
Emergence of an Australian-like pstS-null vancomycin resistant Enterococcus faecium clone in Scotland: Lemonidis Kimon, Salih Talal S, Dancer Stephanie J, Hunter Iain S, Tucker Nicholas P; PLoS ONE Vol 14 (2019); https://doi.org/10.1371/journal.pone.0218185

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Professional activities

BBSRC (Biotech & Biological Sciences Research Council) (External organisation): Member; 12/2014
Comparative genomics of Pseudomonas aeruginosa: Contributor; 10/2013
SULSA Symposium 2013: Member of programme committee; 9/9/2013
Pseudomonas 2013: Participant; 7/9/2013
Advances in Biology (Journal): Editorial board member; 28/5/2013
Antonie van Leeuwenhoek: International Journal of General and Molecular Microbiology (Journal): Editorial board member; 28/5/2013

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Projects

Investigating a novel class of Gram-negative active antibiotic suitable for clinical use: Scott, Fraser (Principal Investigator) Hunter, Iain (Co-investigator) Suckling, Colin (Co-investigator) Tucker, Nicholas (Co-investigator); 01-Jan-2020 - 31-Jan-2022
Environmental enrichment culture as a route to the biosynthesis of platform chemicals for the plastics industry.: Tucker, Nicholas (Principal Investigator); 01-Jan-2020 - 30-Jan-2024
Doctoral Training Partnership 2020-2021 University of Strathclyde | McGee, Leah: Scott, Fraser (Principal Investigator) Tucker, Nicholas (Co-investigator) McGee, Leah (Research Co-investigator); 01-Jan-2020 - 01-Jan-2024
Exploiting Pseudomonas for the production of methacrylate for the plastics industry: Tucker, Nicholas (Principal Investigator) Duncan, Katherine (Co-investigator); 01-Jan-2018 - 30-Jan-2022
Research Excellence Award - Innovation in mass spectrometry to accelerate drug discovery - Castano Espriu, Laia: Duncan, Katherine (Principal Investigator) Tucker, Nicholas (Co-investigator); 01-Jan-2017 - 30-Jan-2020
A comparative multi-omics platform for accelerated antibiotic drug discovery from ancient Polar bacteria: Duncan, Katherine (Principal Investigator) Tucker, Nicholas (Co-investigator); 01-Jan-2017 - 30-Jan-2018

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Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Hamnett Wing

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