Dr David Watson

Reader

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

My main areas of research involve high resolution mass spectrometry and chromatography applied to metabolomics, bionanalysis and natural products research. There has been a strong focus on metabolomics in the last eight years and I won a bid to host the Metabolomics Society conference in Glasgow where I was local chair and organiser in 2013. Current metabolomics collaborations are as follows: parasite biology (Graham Coombs and Mike Barrett GU), drosophila biology (Julian Dow GU), cancer cell biology (Nigel and Sue Pyne and Hing Leung, Beatson), clinical screening for disease (Hing Leung prostate cancer, Brian Walker and Ruth Andrew, University of Edinburgh, metabolic syndrome), steroids in models of pulmonary hypertension, Mandy MacLean, GU), profiling of mammalian milks (Malcolm Kennedy, GU). I am currently about to establish projects on metabolomics of the microbiome in irritable bowel syndrome and on the impact of exercise on the metabolome. I have other non-collaborative projects on fundamental mechanisms in hydrophilic interaction chromatography and oxidation mechanisms of fatty acids. I am also supervising a BBSRC CASE award project with UCB Celltech on deamidation of monoclonal antibodies. In the area of natural products I am investigating the biological properties of bee venom (with Mark Dufton, Carol Clements and Louise Young)and the activity of propolis against sleeping sickness and leishmaniasis. I am currently primary supervisor of 16 PhD students. I have published 205 full papers and reviews, 80 in the last six years, and have an H factor of 34. I have published two textbooks one of which is the leading undergraduate textbook in the field of pharmaceutical analysis. My teaching currently focuses on the MSc course in Pharmaceutical Analysis although I have taught a wide range of topics within the MPharm curriculum.

Publications

A method for the analysis of sugars in biological systems using reductive amination in combination with hydrophilic interaction chromatography and high resolution mass spectrometry
Bawazeer Sami, Muhsen Ali Ali, Alhawiti Aliyah, Khalaf Abedawn, Gibson Colin, Tusiimire Jonans, Watson David G.
Talanta Vol 166, pp. 75-80, (2017)
http://dx.doi.org/10.1016/j.talanta.2017.01.038
The chemical characterization of Nigerian propolis samples and their activity against Trypanosoma brucei
Omar Ruwida, Igoli John O., Zhang Tong, Gray Alexander I., Ebiloma Godwin Unekwuojo, Clements Carol J., Fearnley James, Edrada Ebel RuAngelie, Paget Tim, de Koning Harry P., Watson David G.
Scientific Reports Vol 7, (2017)
http://dx.doi.org/10.1038/s41598-017-01038-2
Metabolomic profiling of the synergistic effects of melittin in combination with cisplatin on ovarian cancer cells
Alonezi Sanad, Tusiimire Jonans, Wallace Jennifer, Dufton Mark J., Parkinson John A., Young Louise C., Clements Carol J., Park Jin-Kyu, Jeon Jong-Woon, Ferro Valerie A., Watson David G.
Metabolites Vol 7, pp. 1-18, (2017)
http://dx.doi.org/10.3390/metabo7020014
Comparison of the metabolism of mephedrone in cultured and in freshly isolated primary rat hepatocytes
Alanazi Ibrahim, Grant M. Helen, Watson David, Henderson Catherine
Applied in Vitro Toxicology Vol 2, pp. 241-241, (2016)
http://dx.doi.org/10.1089/aivt.2016.29007.abstracts
Identification of novel metabolic pathways of sitagliptin (STG) by LC/MS and LC/MS2 after incubations with rat hepatcoytes
Khreit Osama IG, Grant Helen M, Henderson Catherine, Watson David G, Sutcliffe Oliver B
Drug Metabolism and Disposition Vol 7, (2016)
http://dx.doi.org/10.4172/2157-7609.1000220
Specialised information processing deficits and distinct metabolomic profiles following TM-domain disruption of Nrg1
O'Tuathaigh CMP, Mathur N, O'Callaghan MJ, MacIntyre L, Harvey R, Lai D, Waddington JL, Pickard BS, Watson DG, Moran PM
Schizophrenia Bulletin, (2016)

more publications

Professional activities

Metabolomics 2014
Member of programme committee
23/6/2014
Metabolomics 2013
Organiser
1/7/2013
Metabolomics Society conference in Boston
Keynote/plenary speaker
1/2008

more professional activities

Projects

Doctoral Training Centre In Continuous Manufacturing And Crystallisation | Dabrowska, Natalia
Watson, David (Principal Investigator) Florence, Alastair (Co-investigator) Dabrowska, Natalia (Research Co-investigator)
Period 01-Oct-2012 - 10-Feb-2017
Investigating the clinical relevance of post translational modifications such as asparaginyl de-amidation; potential impact on immunogenicity | Maclure, Pauline
Watson, David (Principal Investigator) Oswald, Iain (Co-investigator) Maclure, Pauline (Research Co-investigator)
Period 01-Feb-2012 - 01-Feb-2016
Grace Reveleris Flash LSD
Edrada-Ebel, Ruangelie (Academic) Clements, Carol (Academic) Watson, David (Academic)
Period 01-Sep-2012
Sepacore Flash Chromatography System by Buchi
Edrada-Ebel, Ruangelie (Academic) Watson, David (Academic) Ferro, Valerie (Academic)
Period 01-Jun-2011
Investigating the clinical relevance of post translational modifications such as asparaginyl de-amidation; potential impact on immunogenicity
Watson, David (Principal Investigator)
Period 01-Oct-2011 - 31-Jan-2016
Metabolomic systems biology analysis of differentiation in trypanosomes
Watson, David (Principal Investigator)
Period 01-Jun-2008 - 31-May-2011

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Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Hamnett Wing John Arbuthnott Building

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