Dr David Watson

Reader

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

My main areas of research involve high resolution mass spectrometry and chromatography applied to metabolomics, bionanalysis and natural products research. There has been a strong focus on metabolomics in the last eight years and I won a bid to host the Metabolomics Society conference in Glasgow where I was local chair and organiser in 2013. Current metabolomics collaborations are as follows: parasite biology (Graham Coombs and Mike Barrett GU), drosophila biology (Julian Dow GU), cancer cell biology (Nigel and Sue Pyne and Hing Leung, Beatson), clinical screening for disease (Hing Leung prostate cancer, Brian Walker and Ruth Andrew, University of Edinburgh, metabolic syndrome), steroids in models of pulmonary hypertension, Mandy MacLean, GU), profiling of mammalian milks (Malcolm Kennedy, GU). I am currently about to establish projects on metabolomics of the microbiome in irritable bowel syndrome and on the impact of exercise on the metabolome. I have other non-collaborative projects on fundamental mechanisms in hydrophilic interaction chromatography and oxidation mechanisms of fatty acids. I am also supervising a BBSRC CASE award project with UCB Celltech on deamidation of monoclonal antibodies. In the area of natural products I am investigating the biological properties of bee venom (with Mark Dufton, Carol Clements and Louise Young)and the activity of propolis against sleeping sickness and leishmaniasis. I am currently primary supervisor of 16 PhD students. I have published 205 full papers and reviews, 80 in the last six years, and have an H factor of 34. I have published two textbooks one of which is the leading undergraduate textbook in the field of pharmaceutical analysis. My teaching currently focuses on the MSc course in Pharmaceutical Analysis although I have taught a wide range of topics within the MPharm curriculum.

Publications

Untargeted metabolomics profiling of an 80.5 km simulated treadmill ultramarathon
Howe Christopher C F, Alshehri Ahmed, Muggeridge David, Mullen Alexander B, Boyd Marie, Spendiff Owen, Moir Hannah J, Watson David G
Metabolites Vol 8 (2018)
https://doi.org/10.3390/metabo8010014
Treatment of active Crohn's disease with an ordinary food-based diet that replicates exclusive enteral nutrition
Svolos V, Hansen R, Nichols B, Quince C, Ijaz UZ, Papadopoulou RT, Edwards CA, Watson D, Alghamdi A, Brejnrod A, Ansalone C, Duncan H, Gervais L, Tayler R, Salmond J, Bolognini D, Klopfleisch R, Gaya DR, Milling S, Russell RK, Gerasimidis K
Gastroenterology (2018)
https://doi.org/10.1053/j.gastro.2018.12.002
Untargeted metabolic profiling cell-based approach of pulmonary artery smooth muscle cells in response to high glucose and the effect of the antioxidant vitamins D and E
Alamri Abdulwahab, Burzangi Abdulhadi S, Coats Paul, Watson David G
Metabolites Vol 8 (2018)
https://doi.org/10.3390/metabo8040087
Untargeted metabolomics of extracts from faecal samples demonstrates distinct differences between paediatric Crohn's disease patients and healthy controls but no significant changes resulting from exclusive enteral nutrition treatment
Alghamdi Adel, Gerasimidis Konstantinos, Blackburn Gavin, Akinci Didem, Edwards Christine, Russell Richard K, Watson David G
Metabolites Vol 8 (2018)
https://doi.org/10.3390/metabo8040082
Effect of melittin on metabolomic profile and cytokine production in PMA-differentiated THP-1 cells
Alqarni Abdulmalik M, Ferro Valerie A, Parkinson John A, Dufton Mark J, Watson David G
Vaccines Vol 6 (2018)
https://doi.org/10.3390/vaccines6040072
The chemical and biological properties of propolis
Siheri Weam, Alenezi Sameah, Tusiimire Jonans, Watson David G
Bee Products - Chemical and Biological Properties (2017) (2017)
https://doi.org/10.1007/978-3-319-59689-1_7

more publications

Professional activities

Metabolomics 2014
Member of programme committee
23/6/2014
Metabolomics 2013
Organiser
1/7/2013
Metabolomics Society conference in Boston
Keynote/plenary speaker
1/2008

more professional activities

Projects

Doctoral Training Centre In Continuous Manufacturing And Crystallisation | Dabrowska, Natalia
Watson, David (Principal Investigator) Florence, Alastair (Co-investigator) Dabrowska, Natalia (Research Co-investigator)
01-Jan-2012 - 10-Jan-2017
Grace Reveleris Flash LSD
Edrada-Ebel, Ruangelie (Academic) Clements, Carol (Academic) Watson, David (Academic)
01-Jan-2012
Investigating the clinical relevance of post translational modifications such as asparaginyl de-amidation; potential impact on immunogenicity
Watson, David (Principal Investigator)
01-Jan-2011 - 31-Jan-2016
Sepacore Flash Chromatography System by Buchi
Edrada-Ebel, Ruangelie (Academic) Watson, David (Academic) Ferro, Valerie (Academic)
01-Jan-2011
Metabolomic systems biology analysis of differentiation in trypanosomes
Watson, David (Principal Investigator)
01-Jan-2008 - 31-Jan-2011
Metabolic Analysis of Clinical Samples
Watson, David (Principal Investigator)
01-Jan-2007 - 31-Jan-2010

more projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Hamnett Wing

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