Dr David Watson

Reader

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

My main areas of research involve high resolution mass spectrometry and chromatography applied to metabolomics, bionanalysis and natural products research. There has been a strong focus on metabolomics in the last eight years and I won a bid to host the Metabolomics Society conference in Glasgow where I was local chair and organiser in 2013. Current metabolomics collaborations are as follows: parasite biology (Graham Coombs and Mike Barrett GU), drosophila biology (Julian Dow GU), cancer cell biology (Nigel and Sue Pyne and Hing Leung, Beatson), clinical screening for disease (Hing Leung prostate cancer, Brian Walker and Ruth Andrew, University of Edinburgh, metabolic syndrome), steroids in models of pulmonary hypertension, Mandy MacLean, GU), profiling of mammalian milks (Malcolm Kennedy, GU). I am currently about to establish projects on metabolomics of the microbiome in irritable bowel syndrome and on the impact of exercise on the metabolome. I have other non-collaborative projects on fundamental mechanisms in hydrophilic interaction chromatography and oxidation mechanisms of fatty acids. I am also supervising a BBSRC CASE award project with UCB Celltech on deamidation of monoclonal antibodies. In the area of natural products I am investigating the biological properties of bee venom (with Mark Dufton, Carol Clements and Louise Young)and the activity of propolis against sleeping sickness and leishmaniasis. I am currently primary supervisor of 16 PhD students. I have published 205 full papers and reviews, 80 in the last six years, and have an H factor of 34. I have published two textbooks one of which is the leading undergraduate textbook in the field of pharmaceutical analysis. My teaching currently focuses on the MSc course in Pharmaceutical Analysis although I have taught a wide range of topics within the MPharm curriculum.

Publications

Development of a derivatization method for investigating testosterone and dehydroepiandrosterone using tandem mass spectrometry in saliva samples from young professional soccer players pre- and post-training
Alzahrani Mansour A, Alshuwaier Ghareeb O, Aljaloud Khalid S, Gibson Colin, Khalaf Abedawn, Alhawiti Aliyah S, Watson David G
Scientia Pharmaceutica Vol 87 (2019)
https://doi.org/10.3390/scipharm87020011
Propolis exerts an anti-inflammatory effect on PMA-differentiated THP-1 cells via inhibition of purine nucleoside phosphorylase
Alqarni Abdulmalik M, Niwasabutra Kanidta, Sahlan Muhamad, Fearnley Hugo, Fearnley James, Ferro Valerie A, Watson David G
Metabolites Vol 9 (2019)
https://doi.org/10.3390/metabo9040075
Plasma free satty acids metabolic profile with LC-MS and appetite-related hormones in South Asian and white European men in relation to adiposity, physical activity and cardiorespiratory fitness : a cross-sectional study
Benedetti Simone, Al-Tannak Naser F, Alzharani Mansour, Moir Hannah J, Stensel David J, Thackray Alice E, Naughton Declan P, Dorak Mehmet T, Spendif Owen, Hill Natasha, Watson David, Allgrove Judith
Metabolites Vol 9 (2019)
https://doi.org/10.3390/metabo9040071
Deletion of TSPO resulted in change of metabolomic profile in retinal pigment epithelial cells
Alamri Abdulwahab, Biswas Lincoln, Watson David G, Shu Xinhua
International Journal of Molecular Sciences Vol 20 (2019)
https://doi.org/10.3390/ijms20061387
Isolation of a novel flavanonol and an alkylresorcinol with highly potent anti-trypanosomal activity from Libyan propolis
Siheri Weam, Ebiloma Godwin U, Igoli John O, Gray Alexander I, Biddau Marco, Akrachalanont Pilaslak, Samya Sh M D Alenezi Samya, Alwashih Mohammad A, Edrada Ebel RuAngelie, Müller Sylke, Lawrence Catherine E, Fearnley James, Watson David G, De Koning Harry P
Molecules Vol 24 (2019)
https://doi.org/10.3390/molecules24061041
Treatment of active Crohn's disease with an ordinary food-based diet that replicates exclusive enteral nutrition
Svolos V, Hansen R, Nichols B, Quince C, Ijaz UZ, Papadopoulou RT, Edwards CA, Watson D, Alghamdi A, Brejnrod A, Ansalone C, Duncan H, Gervais L, Tayler R, Salmond J, Bolognini D, Klopfleisch R, Gaya DR, Milling S, Russell RK, Gerasimidis K
Gastroenterology (2018)
https://doi.org/10.1053/j.gastro.2018.12.002

more publications

Professional activities

Metabolomics 2014
Member of programme committee
23/6/2014
Metabolomics 2013
Organiser
1/7/2013
Metabolomics Society conference in Boston
Keynote/plenary speaker
1/2008

more professional activities

Projects

Doctoral Training Centre In Continuous Manufacturing And Crystallisation | Dabrowska, Natalia
Watson, David (Principal Investigator) Florence, Alastair (Co-investigator) Dabrowska, Natalia (Research Co-investigator)
01-Jan-2012 - 10-Jan-2017
Grace Reveleris Flash LSD
Edrada-Ebel, Ruangelie (Academic) Clements, Carol (Academic) Watson, David (Academic)
01-Jan-2012
Investigating the clinical relevance of post translational modifications such as asparaginyl de-amidation; potential impact on immunogenicity
Watson, David (Principal Investigator)
01-Jan-2011 - 31-Jan-2016
Sepacore Flash Chromatography System by Buchi
Edrada-Ebel, Ruangelie (Academic) Watson, David (Academic) Ferro, Valerie (Academic)
01-Jan-2011
Metabolomic systems biology analysis of differentiation in trypanosomes
Watson, David (Principal Investigator)
01-Jan-2008 - 31-Jan-2011
Metabolic Analysis of Clinical Samples
Watson, David (Principal Investigator)
01-Jan-2007 - 31-Jan-2010

more projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Hamnett Wing

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