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Dr David Watson

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Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

My main areas of research involve high resolution mass spectrometry and chromatography applied to metabolomics, bionanalysis and natural products research. There has been a strong focus on metabolomics in the last eight years and I won a bid to host the Metabolomics Society conference in Glasgow where I was local chair and organiser in 2013. Current metabolomics collaborations are as follows: parasite biology (Graham Coombs and Mike Barrett GU), drosophila biology (Julian Dow GU), cancer cell biology (Nigel and Sue Pyne and Hing Leung, Beatson), clinical screening for disease (Hing Leung prostate cancer, Brian Walker and Ruth Andrew, University of Edinburgh, metabolic syndrome), steroids in models of pulmonary hypertension, Mandy MacLean, GU), profiling of mammalian milks (Malcolm Kennedy, GU). I am currently about to establish projects on metabolomics of the microbiome in irritable bowel syndrome and on the impact of exercise on the metabolome. I have other non-collaborative projects on fundamental mechanisms in hydrophilic interaction chromatography and oxidation mechanisms of fatty acids. I am also supervising a BBSRC CASE award project with UCB Celltech on deamidation of monoclonal antibodies. In the area of natural products I am investigating the biological properties of bee venom (with Mark Dufton, Carol Clements and Louise Young)and the activity of propolis against sleeping sickness and leishmaniasis. I am currently primary supervisor of 16 PhD students. I have published 205 full papers and reviews, 80 in the last six years, and have an H factor of 34. I have published two textbooks one of which is the leading undergraduate textbook in the field of pharmaceutical analysis. My teaching currently focuses on the MSc course in Pharmaceutical Analysis although I have taught a wide range of topics within the MPharm curriculum.

Publications

Metabolomic profiling and stable isotope labelling of Trichomonas vaginalis and Tritrichomonas foetus reveal major differences in amino acid metabolism including the production of 2-hydroxyisocaproic acid, cystathionine and S-methylcysteine
Westrop Gareth D., Wang Lijie, Blackburn Gavin J., Zhang Tong, Zheng Liang, Watson David G., Coombs Graham H.
PLoS One Vol 12, (2017)
http://dx.doi.org/10.1371/journal.pone.0189072
Plasma metabolomic profile varies with glucocorticoid dose in patients with congenital adrenal hyperplasia
Alwashih Mohammad A, Watson David G., Andrew Ruth, Stimson Roland H., Alossaimi Manal, Blackburn Gavin, Walker Brian R.
Scientific Reports Vol 7, (2017)
http://dx.doi.org/10.1038/s41598-017-17220-5
Rapid changes in Atlantic grey seal milk from birth to weaning - immune factors and indicators of metabolic strain
Lowe Amanda D., Bawazeer Sami, Watson David G., McGill Suzanne, Burchmore Richard J. S., Pomeroy P. P (Paddy), Kennedy Malcolm W.
Scientific Reports Vol 7, pp. 1-11, (2017)
http://dx.doi.org/10.1038/s41598-017-16187-7
Acute interaction between hydrocortisone and insulin alters the plasma metabolome in humans
Alwashih Mohammad A., Stimson Roland H., Andrew Ruth, Walker Brian R., Watson David G.
Scientific Reports Vol 7, (2017)
http://dx.doi.org/10.1038/s41598-017-10200-9
The chemical and biological properties of propolis
Siheri Weam, Alenezi Sameah, Tusiimire Jonans, Watson David G.
Bee Products - Chemical and Biological PropertiesBee Products - Chemical and Biological Properties, (2017)
http://dx.doi.org/10.1007/978-3-319-59689-1_7
A method for the analysis of sugars in biological systems using reductive amination in combination with hydrophilic interaction chromatography and high resolution mass spectrometry
Bawazeer Sami, Muhsen Ali Ali, Alhawiti Aliyah, Khalaf Abedawn, Gibson Colin, Tusiimire Jonans, Watson David G.
Talanta Vol 166, pp. 75-80, (2017)
http://dx.doi.org/10.1016/j.talanta.2017.01.038

more publications

Professional activities

Metabolomics 2014
Member of programme committee
23/6/2014
Metabolomics 2013
Organiser
1/7/2013
Metabolomics Society conference in Boston
Keynote/plenary speaker
1/2008

more professional activities

Projects

Doctoral Training Centre In Continuous Manufacturing And Crystallisation | Dabrowska, Natalia
Watson, David (Principal Investigator) Florence, Alastair (Co-investigator) Dabrowska, Natalia (Research Co-investigator)
Period 01-Oct-2012 - 10-Feb-2017
Investigating the clinical relevance of post translational modifications such as asparaginyl de-amidation; potential impact on immunogenicity | Maclure, Pauline
Watson, David (Principal Investigator) Oswald, Iain (Co-investigator) Maclure, Pauline (Research Co-investigator)
Period 01-Feb-2012 - 01-Feb-2016
Grace Reveleris Flash LSD
Edrada-Ebel, Ruangelie (Academic) Watson, David (Academic)
Period 01-Sep-2012
Sepacore Flash Chromatography System by Buchi
Edrada-Ebel, Ruangelie (Academic) Watson, David (Academic) Ferro, Valerie (Academic)
Period 01-Jun-2011
Investigating the clinical relevance of post translational modifications such as asparaginyl de-amidation; potential impact on immunogenicity
Watson, David (Principal Investigator)
Period 01-Oct-2011 - 31-Jan-2016
Metabolomic systems biology analysis of differentiation in trypanosomes
Watson, David (Principal Investigator)
Period 01-Jun-2008 - 31-May-2011

more projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Hamnett Wing John Arbuthnott Building

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