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Control of mixing in continuous crystallisation of pharmaceuticals

The project investigates continuous mixing in pharmaceutical crystallisation and introduce rational design principles into development of mixing-controlled industrial crystallisation processes. Collaboration with CMAC industrial partners GlaxoSmithKline, AstraZeneca, Bayer, Lilly, Novartis, Pfizer, Roche, Takeda.

Number of places

1

Funding

Home fee, Stipend

Opens

12 February 2018

Deadline

31 May 2018

Duration

3.5 years

Eligibility

Applicants must have the equivalent of a good honours or masters degree in chemical engineering, physics, chemistry or a related subject. The application deadline is 31 May 2018, but the position will be filled as soon as a suitable candidate is found.

Project Details

Crystallisation is widely used for purification of pharmaceuticals, fine chemicals and advanced materials. It is well known that many mixing-induced crystallisation processes are strongly dependent on how mixing is performed. However, there is a very limited understanding of mixing phenomena in crystallisation processes. The aim of this project is to develop a fundamental understanding of continuous mixing of miscible liquids involved in mixing-induced crystallisation. This knowledge will help to introduce rational design principles into development of mixing-controlled industrial crystallisation processes.

The project will take a combined experimental and modelling approach to investigate mixing processes in continuous static mixers under steady state conditions, using a suite of advanced characterisation techniques, including Raman spectroscopy and near-IR hyperspectral imaging. Microscale diffusion models and mesoscale mixing models will be developed to provide accurate quantitative description of mixing processes over a wide range of flow conditions applicable to industrial manufacturing conditions.

The project is a collaboration with CMAC industrial partners GlaxoSmithKline, AstraZeneca, Bayer, Lilly, Novartis, Pfizer, Roche and Takeda.

The project will be based in CMAC, a world-class international hub for manufacturing research and training. The PhD researcher will benefit from the vibrant research environments in CMAC Doctoral Training Centre (www.cmac.ac.uk). The supervisors will be Prof. Jan Sefcik and Dr. Leo Lue in the Department of Chemical and Process Engineering (CPE). CPE has a strong commitment to outreach and students are encouraged to take part in public engagement and communication. CPE is committed to equal opportunities and we hold a Bronze Athena SWAN award for our efforts to tackle gender inequality. The University of Strathclyde is situated in Glasgow, a vibrant and friendly city in Scotland with a wide range of cultural activities and the amazing natural beauty of Scottish Highlands and Islands nearby. 

In addition to undertaking cutting edge research, students are also registered for the Postgraduate Certificate in Researcher Development (PGCert), which is a supplementary qualification that develops a student’s skills, networks and career prospects.

Funding Details

Only UK and EU citizens are eligible for this studentship, which covers UK/EU tuition fees and an annual stipend of over £14500 (tax free). The start date of this 3.5 year studentship will be 1st October 2018.

Contact us

Ms Jacqueline Brown

+44(0) 141 574 5319

chemeng-pg-admissions@strath.ac.uk

James Weir Building, 75 Montrose Street, Glasgow, G1 1XJ

How to apply

Apply for this PhD project here.

Please quote the project title in your application.