Postgraduate research opportunities

Inhibiting amyloid development using natural compounds: a molecular dynamics study

This project will utilise molecular dynamics simulation, exploiting the ARCHIE_WeSt supercomputer at Strathclyde to understand how the inhibitors interact with protein aggregates; how they interfere with the nucleation and growth pathway of the fibrils, and if aggregation can be reversed.

Number of places

One

Opens

17 February 2020

Duration

3 years

Eligibility

Students applying should have (or expect to achieve) a minimum 2.1 undergraduate degree in a relevant engineering/science discipline, and be highly motivated to undertake multidisciplinary research.

Project Details

Amyloid fibrils are highly ordered protein aggregates associated with many neurodegenerative diseases such as Alzheimer’s. Flavanoids, which are polyphenols such as curcumin present in the human diet, have been shown to inhibit fibril formation in tau protein which is abundant in neurons. However, the molecular mechanisms of this inhibition remain elusive. This project will utilise molecular dynamics simulation, exploiting the ARCHIE_WeSt supercomputer at Strathclyde (www.archie-west.ac.uk), to understand how the inhibitors interact with protein aggregates; how do they interfere with the nucleation and growth pathway of the fibrils, and can they reverse aggregation? As appropriate, the work can be complemented with in vitro cytotoxicity testing, with the aim of developing effective aggregation inhibitors with the potential for disease prevention.

In addition to undertaking cutting edge research, students are also registered for the Postgraduate Certificate in Researcher Development (PGCert), which is a supplementary qualification that develops a student’s skills, networks and career prospects.

Funding Details

This PhD project is initially offered on a self-funding basis. It is open to applicants with their own funding, or those applying to funding sources. However, excellent candidates will be eligible to be considered for a University scholarship.

Contact us

Miss Ewa Kosciuk

+44(0) 141 548 2835

chemeng-pg-admissions@strath.ac.uk

James Weir Building, 75 Montrose Street, Glasgow, G1 1XJ

How to apply

Apply for this project here – please quote the project title in your application.

During the application you'll be asked for the following information and evidence uploaded to the application:

  • your full contact details
  • transcripts and certificates of all degrees
  • proof of English language proficiency if you are not from a majority English-speaking country as recognised by UKVI
  • two references, one of which must be academic. Please see our guidance on referees
  • funding or scholarship information
  • international students must declare any previous UK study

By filling these details out as fully as possible, you'll avoid any delay to your application being processed by the University.

Useful resources

Your application and offer

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Fees and funding