Postgraduate research opportunities

Strathclyde Institute of Pharmacy & Biomedical Sciences

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A multidisciplinary approach to elucidate the mechanism of ammonium transport by the ubiquitous family of Amt/Rhesus protein


Opens:31 May 2017

What are the functional features that are important for the ion specificity and ion permeation? What are the structural features that explain the mechanistic difference between Amt (transporter) and Rh (channel)? What are the conformational changes associated with the transport cycle?

Fee status

Subject

Pharmacy and biomedical sciences

Mode of Study

Full Time

Funding

Postgraduate research opportunities

Investigating anti-cancer drug induced cardiotoxicity in different cell types of the heart

This project will investigate how intracellular calcium signalling is affected by selected anti-cancer agents in both contractile and non-contractile cells of the adult heart. It will be important to identify whether common mechanisms underlying toxicity may exist across different cells of the heart.

Number of places

1

Opens

10 January 2020

Eligibility

2:1 UK Honours degree or overseas equivalent

Project Details

Primary adult cardiac fibroblasts and myocytes will be isolated from normal rats and rats subjected to cardiac hypertrophy. Drug-induced hypertrophic remodelling will also be performed on cells in culture in line with NC3Rs. Cells will either be maintained in culture or used on the day of isolation to investigate phenotypic and functional differences in response to drug treatment. In particular, transition of fibroblasts to myofibroblasts (an indication of pathological response) will be monitored as well as intracellular calcium responses in both cell types (altered calcium handling is evident in cardiac myocytes following hypertrophic remodelling) and the effects of specific anti-cancer agents will be assessed. A comparison between anthracycline and tyrosine kinase-induced effects will be made with a view to understanding the susceptibility of hearts with pre-existing pathology to anti-cancer agents. Functional assays to assess viability, proliferation and cell-cell communication will be assessed using cells from normal and hypertrophied hearts. Investigations will be performed using an animal model of reactive hypertrophic and fibrotic cardiac remodelling

Funding Details

Funding is required to be sourced by the applicant including £10k per annum for bench fees

Supervisor

Primary Supervisor: Susan Currie

Email: susan.currie@strath.ac.uk

Webpage: www.strath.ac.uk/research/subjects/pharmacybiomedicalsciences/cardiovasculardisease/

 

Secondary Supervisor: Margaret Cunningham

Email: margaret.cunningham@strath.ac.uk

Webpage: www.strath.ac.uk/research/subjects/pharmacybiomedicalsciences/cardiovasculardisease/

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