Postgraduate research opportunities

Understanding the role of specific immune molecules in the development of multiple sclerosis

Neuroscience, immunology, multiple sclerosis

Number of places

1

Opens

28 February 2020

Deadline

31 July 2020

Duration

36 Months

Eligibility

Degree in the biomedical sciences or related areas

Project Details

Multiple sclerosis (MS) is a disease of all ages but commonly affects adults between the ages of 20 and 40, thus the major cause of non-traumatic neurological disability among working adults. It affects more than two million people worldwide, and UK has higher MS prevalence than many other countries with around 100,000 people suffering from the condition. While the exact cause of MS is not known and currently there is no cure for MS, it is well established that the lesion development in the central nervous system (CNS) in MS patients consistently involves an inflammatory component. Recent research suggest that cytokines including TNF-a and IL-1b not only regulate neuroinflammation but also perform a distinct set of CNS specific functions e.g. CNS homeostasis and repair. Thus understanding the complex modulatory roles of these cytokines in the maintenance of CNS homeostasis (neuroprotection and neurodegeneration) is the key to future effective therapeutic strategies for these diseases. Recently we reported that IL-33 is highly expressed in the CNS and it contributes to the development of CNS inflammation in an animal model of MS disease, suggesting IL-33 may have currently unknown CNS specific functions. This application therefore aims to investigate the roles of specific immune molecules such as IL-33 in the immunopathogenesis of MS disease using both in vitro and in vivo techniques. The findings from this study will provide novel insights into the complex immune-CNS crosstalk during the development of MS disease.

 The students will have access to state-of-the-art equipment during their studies. In addition they will receive the excellent training programme designed for PhD students in SIPBS in: data handling and statistical interpretation, information and database searching, research skills in data presentation and scientific writing

Techniques used:

  • In vitro techniques: cell culture, molecular biology assays (e.g. RNA extraction, real-time PCR), immunohistochemical staining, histology, microscope imaging, various immunoassays such as ELISA, flow cytometry.

In vivo techniques: PIL course training, induction of murine MS disease model, clinical evaluation of disease severity, tissue dissection and processing for specific immunoassays

Funding Details

Applicant will need to self-fund, find sponsorship for tuition and bench fees of £12,000 per annum for duration of studies

Supervisor

Primary Supervisor: Hui-Rong Jiang

Email: huirong.jiang@strath.ac.uk

 

Secondary Supervisor: Trevor Bushell

Email: trevor.bushell@strath.ac.uk

Contact us

Primary Supervisor: Hui-Rong Jiang

Email: huirong.jiang@strath.ac.uk

How to apply

Applicants can apply using the University PEGASUS Application System https://www.strath.ac.uk/science/strathclydeinstituteofpharmacybiomedicalsciences/studywithus-postgraduate/phd/