- Opens: Monday 1 March 2021
- Number of places: One
- Duration: 3 years
OverviewThe project will focus on the applications of latest Small-angle X-ray scattering system in CMAC (EPSRC Centre of excellence in continuous manufacturing and crystallisation) to provide mechanistic understanding of interparticle interaction in dense system under repulsive or attractive interactions.
Students applying should have (or expect to achieve) a minimum 2.1 undergraduate degree in a relevant subject (physics, chemistry, material science or a related subject). Desirable experience in crystallisation, X-ray characterisation, computational, analytical skills, although not essential.
Small-angle X-ray scattering (SAXS) offers various ways to characterize nanoscale structures of pharmaceutical crystal and large molecules. The scattering of X-rays at small angles is (like light scattering) a non-invasive technique which originates from the spatial fluctuations of the electron density within the material. This allows investigating nanoparticles, molecular ordering/packing in the size range of 20 to 100 nm and in addition permits to identify the physical form of API/polymorphs and excipients in drug products. Small amounts of aggregates or crystalline material can be detected and amorphous, liquid crystalline, and crystalline structures be distinguished.
The project will focus on the applications of latest SAXS system in CMAC (EPSRC Centre of excellence in continuous manufacturing and crystallisation) to provide mechanistic understanding of interparticle interaction in dense system under repulsive or attractive interactions. The insight will be applied to optimise pharmaceutical crystallisation process to avoid undesired agglomeration during the process.
This innovative research project works with world leading experts, ideally suited to students with the creativity and drive to pursue doctoral studies at a technologically leading university.
In addition to undertaking cutting edge research, students are also registered for the Postgraduate Certificate in Researcher Development (PGCert), which is a supplementary qualification that develops a student’s skills, networks and career prospects.
This PhD project is initially offered on a self-funding basis. It is open to applicants with their own funding, or those applying to funding sources. However, excellent candidates will be eligible to be considered for University scholarship.
Please quote the project title in your application.
During the application you'll be asked for the following information and evidence uploaded to the application:
- your full contact details
- transcripts and certificates of all degrees
- proof of English language proficiency if you are not from a majority English-speaking country as recognised by UKVI
- two references, one of which must be academic. Please see our guidance on referees
- funding or scholarship information
- international students must declare any previous UK study
By filling these details out as fully as possible, you'll avoid any delay to your application being processed by the University.