Postgraduate research opportunities

Molecular probes for lysosomal accumulation, release and environmental sensing

The design, synthesis and evaluation of small molecules to understand the function and disease states of lysosomes.

Number of places

1

Funding

Home fee, Equipment costs, Travel costs, Stipend

Opens

12 February 2021

Deadline

1 June 2021

Duration

48 months

Eligibility

  • Full Time Studying
  • EU Fee Status
  • Rest of UK Fee Status

UKRI Studentship Eligibility

The eligibility criteria for UKRI funding has changed for studentships commencing in the 2021/22 academic year. Now, all home and international students are eligible to apply for UKRI funding which will cover the full stipend and tuition fees at the home rate (not the international rate). Under the new criteria, UKRI have stipulated a maximum percentage of international students that can be recruited each year against individual training grants. This will be managed at the institutional level for all EPSRC DTP and ICASE grants. For EPSRC CDT grants, this will be managed by the individual CDT administrative/management team. For ESRC and AHRC studentships the final funding decision will be made by the respective grant holder.

 

To be classed as a home student, applicants must meet the following criteria:

  • Be a UK national (meeting residency requirements), or
  • Have settled status, or
  • Have pre-settled status (meeting residency requirements), or
  • Have indefinite leave to remain or enter.

 

The residency requirements are based on the Education (Fees and Awards) (England) Regulations 2007 and subsequent amendments. Normally to be eligible for a full award a student must have no restrictions on how long they can stay in the UK and have been ordinarily resident in the UK for at least 3 years prior to the start of the studentship (with some further constraint regarding residence for education).

If a student does not meet the criteria above, they will be classed as an international student. The international portion of the tuition fee cannot be funded by the UKRI grant and must be covered from other sources. International students are permitted to self-fund the difference between the home and international fee rates.

Project Details

Lysosomes are membrane bound organelles characterised by a low pH, which contain hydrolytic enzymes that function as part of the cellular recycling system.  The low pH associated with these organelles provides a unique opportunity for accumulation, release, and sensing using small molecules, permitting an understanding of this chemical environment and its relationship to disease.  We will design, synthesise, and monitor small molecules that are able to examine each of these areas using bioinformatics to process and interpret the imaging data generated.

 

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