Postgraduate research opportunities PhD in green and sustainable synthetic organic chemistry

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Key facts

  • Opens: Thursday 1 July 2021
  • Deadline: Thursday 30 September 2021
  • Number of places: 1
  • Duration: 4 years
  • Funding: Home fee, Equipment costs, Travel costs, Stipend

Overview

In collaboration with GlaxoSmithKline we have an opportunity to develop novel, green and sustainable synthetic methods of relevance to the pharmaceutical industry.
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Eligibility

First degree in Chemistry 2.1 or above.

THE Awards 2019: UK University of the Year Winner
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Project Details

A specific transformation which requires development is allylic oxidation. Whilst many methods exist for this transformation, the majority of processes require (super)stoichiometric transition metal-based oxidants which are both toxic and expensive.  This project is concerned with addressing these deficiencies through the development of green, efficient and sustainable processes for the conversion of an alkene to an a,b‑unsaturated enone.  Through the development of a mechanistic understanding we will identify and optimise methods for the allylic oxidation of both alkene and arene substrates and apply these to the preparation of pharmaceutically relevant targets.

Further information

For recent example of methodology developed through this collaboration see: Angew. Chem. Int. Ed. 2020, 59, 6740–6744.

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Funding details

Monthly stipend at UKRI rates.

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Supervisors

Primary Supervisor: Prof Nick Tomkinson.

Additional Supervisor/s: Dr Peter Shapland, GlaxoSmithKline

Professor Nicholas Tomkinson

Pure and Applied Chemistry

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Start date: Oct 2021 - Sep 2022

Pure and Applied Chemistry

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Pure and Applied Chemistry

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