Postgraduate research opportunities Biomedical use of Silk

Apply

Key facts

  • Opens: Thursday 5 March 2020
  • Number of places: 1
  • Duration: 36 Months

Overview

Drug and stem cell delivery using biopolymers
Back to opportunity

Eligibility

First class honours or Master’s degree

THE Awards 2019: UK University of the Year Winner
Back to opportunity

Project Details

We have a particular interest in exploring the use of silk for drug and cell delivery applications. Silk is an approved biopolymer for use in humans and has remarkable physical properties (e.g. it is tougher than any manmade fibre). Silk, a common suture material, has long been recognised for its biocompatibility and biodegradability. We are using silk as a scaffold for tissue engineering and as a biopolymer for drug and cell delivery. Silk can be processed under mild aqueous conditions to generate several biomedically useful formats, including self-assembling silk hydrogels, nanoparticles, films and scaffolds. This PhD study will go beyond the current state-of-the-art to open up an entirely new silk toolbox. This PhD will deliver ambitious and adventurous science as evidenced by high impact publications resulting from this work. The exact project will be tailored according to the specific interest of the PhD candidate and will be informed by the latest discoveries of the Seib lab.

 

Techniques used: A broad range of techniques will be used. These include but are not limited to biopolymer processing, DLS, DSC, FTIR, rheology, SDS-PAGE, RT-PCR, confocal microscopy and mammalian cell culture.

Further information

Holland C, Numata K, Rnjak-Kovacina J, Seib FP (2019). The biomedical use of silk: past, present, future. Advanced Healthcare Materials 8, e1800465 doi:10.1002/adhm.201800465

 

Totten JT, Wongpinyochit T, Carolla J, Duarte I, Seib FP (2019). PEGylation-dependent metabolic rewiring of macrophages with silk fibroin nanoparticles. ACS Applied Materials & Interfaces 11, 14515-14525. doi: 10.1021/acsami.8b18716

Back to opportunity

Funding details

Applicant will need to self-fund, find sponsorship for tuition and bench fees of £15000 per annum for duration of studies

Back to opportunity

Supervisors

Dr Philipp Seib

Senior Lecturer
Strathclyde Institute of Pharmacy and Biomedical Sciences

View profile