Professor Jan Sefcik
Head Of Department
Chemical and Process Engineering
Publications
- Integrated continuous process design for crystallisation, spherical agglomeration, and filtration of lovastatin
- Brown Cameron J, McGinty John, Islam Muhammad T, Rajoub Nazer, Arjmandi-Tash Omid, Ottoboni Sara, Shahid Muhid, Urwin Stephanie J, Lee Ye Seol, Chong Magdalene W S, Papathanasiou Foteini, Prakash Aruna S, Prasad Elke, Spence Bronwyn, Sefcik Jan, Robertson John, Smith Rachel, Litster James D, Price Chris J, Nordon Alison, Adjiman Claire S, Florence Alastair J
- Journal of Pharmaceutical Innovation Vol 19 (2024)
- https://doi.org/10.1007/s12247-024-09815-z
- Assessment of GAFF and OPLS force fields for urea : crystal and aqueous solution properties
- Anker Samira, McKechnie David, Mulheran Paul, Sefcik Jan, Johnston Karen
- Crystal Growth and Design Vol 24, pp. 143–158 (2024)
- https://doi.org/10.1021/acs.cgd.3c00785
- Nucleation and growth kinetics of sodium chloride crystallization from water and deuterium oxide
- Flannigan James M, MacIver Daniel, Jolliffe Hikaru, Haw Mark D, Sefcik Jan
- Crystals Vol 13 (2023)
- https://doi.org/10.3390/cryst13091388
- Crystallisation of sodium sulfate
- Muhammad Abdullah, Sefcik Jan, Hamilton Andrea, Johnston Karen
- ISIC 2023 (2023)
- Digital process design to define and deliver pharmaceutical particle attributes
- Urwin Stephanie J, Chong Magdalene WS, Li Wei, McGinty John, Mehta Bhavik, Ottoboni Sara, Pathan Momina, Prasad Elke, Robertson Murray, McGowan Mark, al-Attili Mais, Gramadnikova Ekaterina, Siddique Mariam, Houson Ian, Feilden Helen, Benyahia Brahim, Brown Cameron J, Halbert Gavin W, Johnston Blair, Nordon Alison, Price Chris J, Reilly Chris D, Sefcik Jan, Florence Alastair J
- Chemical Engineering Research and Design Vol 196, pp. 726-749 (2023)
- https://doi.org/10.1016/j.cherd.2023.07.003
- Rapid assessment of crystal nucleation and growth kinetics : comparison of seeded and unseeded experiments
- Cashmore Andrew, Miller Russell, Jolliffe Hikaru, Brown Cameron J, Lee Mei, Haw Mark D, Sefcik Jan
- Crystal Growth and Design Vol 23, pp. 4779-4790 (2023)
- https://doi.org/10.1021/acs.cgd.2c01406
Research Interests
Our research expertise is in particle engineering and nanostructured materials, with focus on design of novel particulate products and efficient processes for their manufacturing, across a wide range of applications from nucleation and crystallisation, to protein and peptide self-assembly, to organic gels and nanocomposites.
Our research in pharmaceutical manufacturing aligned with CMAC seeks to enhance access to medicines by increasing quality and reducing costs with the aim improving people’s health and wellbeing.
We develop experimental workflows for product and process development of particulate systems for pharmaceutical applications to obtain better control of critical quality attributes in medicines manufacturing.
We also develop new methods for extracting valuable real time information from process analytical tools such as imaging and scattering/backscattering to enable intelligent decision support for monitoring and control of particulate systems and processes, including fouling detection and accurate quantitative estimates of particle shape and size distributions from in situ measurements.
Professional Activities
- Evaluation of Methods for Particle Characterisation from In-Situ Sensors
- Contributor
- 6/9/2023
- Evaluation of methods for particle characterisation from in-line imaging and chord length distribution measurements
- Contributor
- 17/11/2022
- Evaluation of methods for particle characterisation from in-line imaging and chord length distribution measurements
- Contributor
- 19/9/2022
- Evaluation of Deep Learning methods for particle characterisation from in-line imaging and chord length distribution measurements
- Contributor
- 18/9/2022
- Multi-sensor Measurements For Quantitative Particle Size And Concentration
- Contributor
- 20/2/2020
- Integrated Filtration and Washing Modelling to Predict Continuous Isolation Performance.
- Contributor
- 2020
Projects
- Industrial Case Account - University of Strathclyde 2023 | Asif, Khadija
- Jorge, Miguel (Principal Investigator) Sefcik, Jan (Co-investigator) Asif, Khadija (Research Co-investigator)
- 01-Jan-2023 - 01-Jan-2027
- Effects of mechanical impact and turbulent flow on secondary nucleation
- Sefcik, Jan (Principal Investigator)
- 01-Jan-2022 - 30-Jan-2026
- Sustainable Pharmaceutical Manufacturing: Computer aided solvent design to minimise solvent use across integrated synthesis, purification & isolation
- Price, Chris John (Principal Investigator) Kerr, William (Co-investigator) Li, Jun (Co-investigator) Lindsay, David (Co-investigator) Sefcik, Jan (Co-investigator)
- 11-Jan-2022 - 10-Jan-2025
- The birth of crystals: new understanding of nucleation by direct measurement
- Haw, Mark (Principal Investigator) Lue, Leo (Co-investigator) Sefcik, Jan (Co-investigator)
- 01-Jan-2020 - 31-Jan-2023
- Doctoral Training Partnership 2020-2021 University of Strathclyde | Anker, Samira
- Johnston, Karen (Principal Investigator) Sefcik, Jan (Co-investigator) Anker, Samira (Research Co-investigator)
- 01-Jan-2020 - 01-Jan-2024
- Catching nucleation in action using surface enhanced Raman spectroscopy
- Johnston, Karen (Principal Investigator) Faulds, Karen (Co-investigator) Sefcik, Jan (Co-investigator)
- 01-Jan-2020 - 30-Jan-2023
Contact
Professor
Jan
Sefcik
Head Of Department
Chemical and Process Engineering
Email: jan.sefcik@strath.ac.uk
Tel: 548 2410