Dr RuAngelie Edrada-Ebel

Senior Lecturer

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Dr Edrada-Ebel currently heads the Natural Products Metabolomics Group (NPMG) and is currently author of more than 100 publications and two patents on the topic marine natural products. She referees articles on marine natural products on more than 10 peer-reviewed journals and is a member of the editorial board for Marine Drugs. Her expertise comprises both natural products isolation and structure elucidation with modern spectroscopic techniques. At present, she has a series of on-going projects on the application of metabolomics to identify and biotechnologically optimize the production of bioactive secondary metabolites in marine-derived microorganisms.

Expertise

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Prize And Awards

Thieme Award 2018 for the Most Innovative Planta Medica Original Paper: Recipient; 6/7/2018
RMIT FOUNDATION INTERNATIONAL VISITING FELLOWSHIP: Recipient; 1/11/2017

More prizes and awards

Qualifications

Positions Held:

2015 to date Senior Lecturer in Pharmaceutical Analysis, Strathclyde Institute of Pharmacy and Biomedical Sciences

2008 to 2014 Lecturer in Pharmaceutical Analysis, Strathclyde Institute of Pharmacy and Biomedical Sciences

2007 to 2008 NMR and MS Facility Manager, Strathclyde Institute of Pharmacy and Biomedical Sciences

2005 to 2007 Research Scientist (part-time), BioMar, Düsseldorf Life Science Centre

2001 to 2007 Senior Researcher and Instructor, Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine Universität Düsseldorf

1999 to 2001 Research Fellow (Post Doctorate), Department of Chemistry, University of California Santa Cruz

1998 to 1999 Research Fellow, Department of Chemistry and Biochemistry, University of Oklahoma

1989 to 1993 Instructor, College of Pharmacy, University of the Philippines

Educational Background:

1994 – 1998 Doctorate degree in Pharmaceutical Biology, Julius Maximillians-University of Würzburg, Germany, Magna cum Laude, Dissertation: “Isolation and structure elucidation of bioactive secondary metabolites from Philippine marine sponges and soft corals.” Adviser: Prof. Dr. Peter Proksch, Date of Graduation: 18 June 1998

1989 - 1992 Master of Science degree in Pharmacy, University of the Philippines, Manila, Philippines, Thesis: “The biological and chemical investigation of the colored constituents of Kokoona ochracea (Elm) Merrill (Fam. Celastraceae).”

Publications

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Publications

Targeted isolation of antibiofilm compounds from halophytic endophyte Bacillus velezensis 7NPB-3B using LC-HR-MS-based metabolomics: Singh Sanju, Nwagwu Elizabeth, Young Louise, Kumar Pankaj, Shinde Pramod B, Edrada-Ebel RuAngelie; Microorganisms Vol 12 (2024); https://doi.org/10.3390/microorganisms12020413
Annotation of GC-MS Data of Antimicrobial Constituents in the Antarctic Seaweed Phaeurus antarcticus by Molecular Networking: Dos Santos Gustavo Souza, Teixeira Maria Valdeline Sousa, Clementino Leandro da Costa, Gama-Filho Péricles Abreu, Pereira Luiz Miguel, Teixeira Thaiz Rodrigues, Furtado Niege Araçari Jacometti Cardoso, Yatsuda Ana Patrícia, da Silva Graminha Marcia Aparecida, Colepicolo-Neto Pio, Edrada-Ebel RuAngelie, Debonsi Hosana Maria; Chemistry and Biodiversity Vol 20 (2023); https://doi.org/10.1002/cbdv.202300429
Pseudomonassin, a new bioactive ribosomally synthesised and post-translationally modified peptide from Pseudomonas sp. SST3: Miranda Kevin Jace, Jaber Saif, Atoum Dana, Arjunan Subha, Ebel Rainer, Jaspars Marcel, Edrada-Ebel RuAngelie; Microorganisms Vol 11 (2023); https://doi.org/10.3390/microorganisms11102563
Anti‐inflammatory activity of Lauraceae plant species and prediction models based on their metabolomics profiling data: de Alcântara Bianca Gonçalves Vasconcelos, Neto Albert Katchborian, Garcia Daniela Aparecida, Casoti Rosana, Oliveira Tiago Branquinho, de Paula Ladvocat Ana Claudia Chagas, Edrada-Ebel RuAngelie, Soares Marisi Gomes, Dias Danielle Ferreira, Chagas de Paula Daniela Aparecida; Chemistry and Biodiversity Vol 20 (2023); https://doi.org/10.1002/cbdv.202300650
Use of multivariate analysis to unravel the differences between two chamomile varieties and their anticancer and antioxidant activities: Atoum Dana, Fernandez-Pastor Ignacio, Young Louise, Edrada-Ebel RuAngelie; Plants Vol 12 (2023); https://doi.org/10.3390/plants12122297
Understanding the seasonal effect of metabolite production in Terminalia catappa L. leaves through a concatenated MS- and NMR-based metabolomics approach: Zanatta Ana C, Vieira Natália Carolina, Dantas-Medeiros Renato, Vilegas Wagner, Edrada-Ebel RuAngelie; Metabolites Vol 13 (2023); https://doi.org/10.3390/metabo13030349

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Research

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Research Interests

Natural products metabolomics to optimise production of secondary metabolites in their microbial sources as well as using metabolomics tools in targeting the isolation of bioactive metabolites from their natural sources. Collaboration has been established with Professor Ron Quinn of the Griffith Institute for Drug Discovery, Griffith University and Professor Fernando da Costa of the School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo.
Metabolomics of microbial symbionts in collaboration with Professor Ute Hentschel of the Sponge Microbiology Group at the GEOMAR Helmholtz Centre for Ocean Research Kiel and partners with SeaBioTech, an FP-7 funded project.
Real Time Flux Modeling in Biopharmaceutical Bioprocessing, jointly co-funded by the BBSRC and the EPSRC, a collaborative research on metabolomics and fermentation work as well as further national collaborative work with Scottish medium-scale enterprises on the cultivation of marine microorganism.
Metagenomic approach of optimizing the production of novel antibiotics from Streptomyces
Propolis project with Beevital exploring the anti-trypanosomal activity of the African Propolis collection
Ecological implications of the production of secondary metabolites in Crustaeceans and alternative application of utilising the waste products of the by-catch in collaboration with the Langoustine Laboratory, University of Glasgow.
Dereplication study and metabolomics of sponges and their endozooic microorganism obtained from the Irish and Celtic Sea (in collaboration with Prof. Alan Dobson, Environmental Research Institute, University College Cork)
Structure elucidation of biologically active secondary metabolites from sponges, tropical plants, and marine-derived fungi
Phytochemistry of biologically active secondary metabolites from tropical plants from Southeast Asia and Africa (in collaboration with Prof. Alan Harvey, SIDR)
Mass spectral analysis of marine-derived synthetic pyridinium polymers as novel anti-cancer drugs (in collaboration with Prof. Marcel Jaspars, University of Aberdeen)

Professional Activities

Krystle Angelique Santiago: Host; 15/9/2018
Dr Asmaa BOUFRIDI: Host; 6/7/2018
Jake Coyle: Host; 2/7/2018
Accelerate Chemistry Challenge Programme for Secondary Schools in Scotland: S@S Accelerate 2018: Education Challenge: Invited speaker; 27/6/2018
AHMET SADIK GÜLGEÇ: Host; 15/6/2018
Euroindoamerican Natural Products Meeting: Keynote/plenary speaker; 31/5/2018

More professional activities

Projects

Fucoidan from Seaweed-commercial development pathway: Edrada-Ebel, Ruangelie (Principal Investigator); 20-Jan-2022 - 31-Jan-2023
Discovery of New Drug Leads from Red Sea Marine Fungi: Edrada-Ebel, Ruangelie (Principal Investigator); 12-Jan-2021 - 11-Jan-2022
Development of high-value compounds from Bacillus licheniformis: Edrada-Ebel, Ruangelie (Principal Investigator) Young, Louise (Co-investigator); 01-Jan-2017 - 28-Jan-2018
Identification of pathway specific anti-cancer compounds from Scottish Marine Microbes: Edrada-Ebel, Ruangelie (Principal Investigator); This agreement is applicable to only the original MATERIAL for the analyses of chemical contents of a series of research materials originating from Scotland.; 29-Jan-2016 - 28-Jan-2018
Potential novel antibiotics from microorganisms of under explored extreme marine habitats: Edrada-Ebel, Ruangelie (Principal Investigator); 25-Jan-2016 - 24-Jan-2016
Comparative transcriptomic and metabolomic analysis of engineered bacteria: Tucker, Nicholas (Principal Investigator) Edrada-Ebel, Ruangelie (Co-investigator); Analysis of industrial biotech strains produced by Ingenza; 18-Jan-2014 - 18-Jan-2015