Professor Clive Wilson
Research Professor
Strathclyde Institute of Pharmacy and Biomedical Sciences
Personal statement
Personal statement
Clive Wilson is the J. P. Todd Professor of Pharmaceutics at Strathclyde University and serves on the European Union Federation of Pharmaceutical Sciences teaching and overseas liaison committee. He completed his Ph.D. with Professor Dennis Parke in drug metabolism at the University of Surrey. His first position was an Asthma Research Council Fellow at the Cardiothoracic Institute, London becoming a Lecturer in Biochemical Pharmacology and moving to Nottingham Medical School to become Reader in Applied Pharmacology.
Major areas of research have been the study of the behaviour of drug formulations in man. With colleagues at Nottingham, he pioneered applications of scintigraphy in the study of physiological and patho-physiological effects on drug absorption following oral, nasal, pulmonary and ophthalmic delivery. In the university, his group collaborates with industry on ophthalmic drug delivery projects especially related to the behaviour of ocular implants. He is a member of the steering group of the IMI OrBiTo programme and co-manages the Strathclyde group with Professor Gavin Halbert. Recent new areas of interest include additive soft and hard matrix technologies for drug delivery, and several programmes in novel therapies for treating ulcerative colitis.
Primary Teaching activities are in the field of Biopharmaceutics and formulation research.
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Steering Group EUFEPS Recipient 1/8/2011 E.F.A.P.S. Recipient 15/8/2010 F.C.R.S. Recipient 3/6/2010 GlaxoSmithKline International Achievement Award Recipient 1/2008
Prize And Awards
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Integration of advanced methods and models to study drug absorption and related processes : an UNGAP perspective Wilson Clive G, Aarons Leon, Augustijns Patrick, Brouwers Joachim, Darwich Adam S, De Waal Tom, Garbacz Grzegorz, Hansmann Simone, Hoc Dagmara, Ivanova Anela, Koziolek Mirko, Reppas Christos, Schick Philipp, Vertzoni Maria, García-Horsman J Arturo European Journal of Pharmaceutical Sciences Vol 172 (2022) https://doi.org/10.1016/j.ejps.2021.106100 Application of in vivo imaging techniques and diagnostic tools in oral drug delivery research Senekowitsch Stefan, Schick Philipp, Abrahamsson Bertil, Augustijns Patrick, Gießmann Thomas, Lennernäs Hans, Matthys Christophe, Marciani Luca, Pepin Xavier, Perkins Alan, Feldmüller Maximilian, Sulaiman Sarah, Weitschies Werner, Wilson Clive G, Corsetti Maura, Koziolek Mirko Pharmaceutics Vol 14 (2022) https://doi.org/10.3390/pharmaceutics14040801 In vitro dissolution testing models of ocular implants for posterior segment drug delivery Adrianto Muhammad Faris, Annuryanti Febri, Wilson Clive G, Sheshala Ravi, Thakur Raghu Raj Singh Drug Delivery and Translational Research (2021) https://doi.org/10.1007/s13346-021-01043-z Impact of gastrointestinal tract variability on oral drug absorption and pharmacokinetics : an UNGAP review Vinarov Zahari, Abdallah Mohammad, Agundez José AG, Allegaert Karel, Basit Abdul W, Braeckmans Marlies, Ceulemans Jens, Corsetti Maura, Griffin Brendan T, Grimm Michael, Keszthelyi Daniel, Koziolek Mirko, Madla Christine M, Matthys Christophe, McCoubrey Laura E, Mitra Amitava, Reppas Christos, Stappaerts Jef, Steenackers Nele, Trevaskis Natalie L, Vanuytsel Tim, Vertzoni Maria, Weitschies Werner, Wilson Clive, Augustijns Patrick European Journal of Pharmaceutical Sciences Vol 162 (2021) https://doi.org/10.1016/j.ejps.2021.105812 Current challenges and future perspectives in oral absorption research : an opinion of the UNGAP network Vinarov Zahari, Abrahamsson Bertil, Artursson Per, Batchelor Hannah, Berben Philippe, Bernkop-Schnürch Andreas, Butler James, Ceulemans Jens, Davies Nigel, Dupont Didier, Flaten Gøril Eide, Fotaki Nikoletta, Griffin Brendan T, Jannin Vincent, Keemink Janneke, Kesisoglou Filippos, Koziolek Mirko, Kuentz Martin, Mackie Alan, Meléndez-Martínez Antonio J, McAllister Mark, Müllertz Anette, O'Driscoll Caitriona M, Parrott Neil, Paszkowska Jadwiga, Pavek Petr, Porter Christopher JH, Reppas Christos, Stillhart Cordula, Sugano Kiyohiko, Toader Elena, Valentová Kateřina, Vertzoni Maria, De Wildt Saskia N, Wilson Clive G, Augustijns Patrick Advanced Drug Delivery Reviews Vol 171, pp. 289-331 (2021) https://doi.org/10.1016/j.addr.2021.02.001 Multidimensional analysis of human intestinal fluid composition Pyper Kate, Brouwers Joachim, Augustijns Patrick, Khadra I, Dunn C, Wilson CG, Halbert GW European Journal of Pharmaceutics and Biopharmaceutics Vol 153, pp. 226-240 (2020) https://doi.org/10.1016/j.ejpb.2020.06.011
Publications
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European Federation of Pharmaceutical Sciences (External organisation) Chair 2009 34th Controlled Release Society Conference, USA Keynote/plenary speaker 1/2008 EUFEPS Conference on Bioavailability and Bioequivalence , Greece Keynote/plenary speaker 1/2008 10th Rotterdam Glaucoma Symposium, Netherlands Keynote/plenary speaker 1/2008 Philips Medimetrics (External organisation) Advisor 1/2008 CRS Book Series Editorial Board Editorial board member 1/2008
Retinal Drug Delivery Khadra, Ibrahim (Principal Investigator) Wilson, Clive (Principal Investigator) Dunn, Claire (Researcher) The Allergan project focuses on API infused PLGA implants for ocular drug delivery. These implants are bio-degradable meaning there is no need for surgical removal of the implant. The research currently focuses on investigating the degradation of the implants at 37oC (body temperature) and 50oC (to develop an accelerated degradation model) and observing if agitation has a significant effect on degradation rate. Implants were then fully characterised to determine the physical and chemical degradation effects. 01-Jan-2017 - 31-Jan-2019 EPSRC Doctoral Training Grant - DTA, University of Strathclyde | Brownlee, William John Seib, Philipp (Principal Investigator) Wilson, Clive (Co-investigator) Brownlee, William John (Research Co-investigator) 01-Jan-2015 - 11-Jan-2019 Medical Devices Doctoral Training Centre Renewal | Hall Barrientos, Ivan Wilson, Clive (Principal Investigator) Black, Richard Anthony (Co-investigator) Hall Barrientos, Ivan (Research Co-investigator) 01-Jan-2013 - 29-Jan-2018 Optical and Magnetic Non-Invasive Flow and manipulation platform for controlling nanomanufacture of pharmaceuticals, nanoparticles, and other nanostructured materials Haw, Mark (Principal Investigator) Wilson, Clive (Co-investigator) Zagnoni, Michele (Co-investigator) Wark, Alastair (Co-investigator) micromanipulation non-invasively in nanomaterial manufacture processes, to enhance direct control of nucleation, growth and structure development. Nucleation and assembly are the first stage of engineering nanostructured materials in applications including drug crystallisation, nanoparticle and nanoporous catalyst manufacture, and metal-organic frameworks for molecular storage. There is significant evidence that these complex microscale nucleation and assembly processes are strongly affected by local conditions such as flow. Our understanding of how flow and local (at the micron-scale) forces affect and thus could be used to control nanostructure nucleation is limited, because nucleation is inherently a local process while flow and external forces are usually applied globally. Therefore our novel, versatile OMNIFlow experimental platform will non-invasively impose local micron-scale flows by manipulating optically and magnetically trapped particles, generating local flow fields in the nucleating or assembling suspension. The project brings together Strathclyde expertise in microfluidics, optical and magnetic manipulation and quantitative dynamic microscopy, and focusses on applications in the key Strathclyde research strength of advanced nanomaterial engineering and science for innovative industrial applications. It will provide a unique experimental platform to highlight Strathclyde’s developing central role in this area. 01-Jan-2013 - 02-Jan-2013 Oral Biopharmaceutics "Orbito" Khadra, Ibrahim (Principal Investigator) Wilson, Clive (Principal Investigator) Halbert, Gavin (Principal Investigator) Through partnership, collaboration and data sharing, we will develop our fundamental knowledge of the gastrointestinal environment to deliver innovative biopharmaceutics tools which will accurately predict product performance over a range of clinically relevant conditions. The integration of in vitro and in silico approaches will provide a biopharmaceutics toolkit, validated using clinical data, to accelerate drug development 01-Jan-2012 - 01-Jan-2019 ORBITO: EU Innovative Medicines Initiative In Vivo Predictive Biopharmaceutical Tools Halbert, Gavin (Principal Investigator) Wilson, Clive (Co-investigator) 01-Jan-2012 - 30-Jan-2018
Research Interests
Steering Group, European Federation for Pharmaceutical Sciences
Professional Activities
Projects
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Contact
Professor
Clive
Wilson
Research Professor
Strathclyde Institute of Pharmacy and Biomedical Sciences
Email: c.g.wilson@strath.ac.uk
Tel: Unlisted