Tumour Targeted Gene Delivery System

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Background

Cancer is still a leading cause of death worldwide – accounting for about 13% of all deaths. Gene therapy could be highly effective in the treatment of cancer, but is limited by the lack of safe and efficacious delivery systems able to deliver therapeutic genes selectively to tumours by intravenous administration, without secondary effects to healthy tissues. Current gene delivery systems provide only low levels of protein expression in tumours and, in the case of viruses, have been associated with significant toxicity problems. Non-viral delivery systems generally deliver therapeutic DNA to the lung and the liver, but not to the tumours, after intravenous administration.

Technology

Researchers at the University of Strathclyde have identified a technique for delivering therapeutic genes to hard-to-reach tumours by intravenous administration without harming healthy tissue. During lab tests the "seek-and-destroy" therapy resulted in 90% of skin cancer tumours disappearing altogether. The team is now investigating the technique's effectiveness at treating different forms of the disease. 

Key Benefits

  • Delivers therapeutic genes efficiently and selectively to tumours following intravenous administration.
  • Leaves healthy cells unaffected.
  • Fewer side-effects than traditional chemotherapy.

Markets / Applications

Cancer Treatment. Global cancer prevalence rates are on the rise owing to an aging population and changing lifestyle.

Licensing & Development

This technology is protected by a patent application filed by the University of Strathclyde. Contact is welcomed from organisations interested in developing, licensing or exploiting this technology.

For further information, please contact Research & Knowledge Exchange Services on rkes@strath.ac.uk     t: 0141 548 3707       f: 0141 552 4409

 

Contact Information

For further information please contact the Knowledge Exchange Hub:

0141  548 4759

ke-hub@strath.ac.uk

If your query relates to medical devices, please contact

 

Contact us

For further information please contact Research & Knowledge Exchange Services on 0141 548 3707 or email rkes@strath.ac.uk