Dr Rebecca Beveridge
Senior Lecturer
Pure and Applied Chemistry
Personal statement
Rebecca is a Senior Lecturer and UKRI Future Leaders Fellow who joined the University of Strathclyde in June 2020 as a Chancellor's Fellow. She obtained a BSc in biochemistry and chemistry from the University of Leeds in 2011 and completed her PhD at the University of Manchester in 2015. Rebecca spent 4 years at the Institute for Molecular Pathology in Vienna, Austria as a postdoctoral researcher/ Lise Meitner Postdoctoral Fellow. Throughout her career, she has collected experience in a plethora of mass spectrometry methods to study protein structure such as native mass spectrometry, ion mobility, hydrogen-deuterium exchange, and crosslinking.
Rebecca’s current research is centered around the development of native ion mobility mass spectrometry methods to study proteins and protein complexes, particularly those that are challenging to study with conventional biochemistry methods. Such systems include intrinsically disordered proteins that exist in a wide range of different shapes, and protein complexes formed by protein-degrading molecules such as PROTACs, the complex binding modes of which are challenging to delineate.
Publications
- Amorphous aggregates with a very wide size distribution play a central role in crystal nucleation
- Liao Zhiyu, Das Ankita, Robb Christina Glen, Beveridge Rebecca, Wynne Klaas
- Chemical Science Vol 15, pp. 12420-12430 (2024)
- https://doi.org/10.1039/D4SC00452C
- Strathclyde Minor Groove Binders (S-MGBs) with activity against Acanthamoeba castellanii
- McGee Leah MC, Carpinteyro Sanchez Alemao G, Perieteanu Marina, Eskandari Kaveh, Bian Yan, Mackie Logan, Young Louise, Beveridge Rebecca, Suckling Colin J, Roberts Craig W, Scott Fraser J
- Journal of Antimicrobial Chemotherapy (2024)
- https://doi.org/10.1093/jac/dkae221
- Rapid flow-based synthesis of post-translationally modified peptides and proteins : a case study on MYC's transactivation domain
- Williams Elyse T, Schiefelbein Kevin, Schuster Matthias, Ahmed Ikhlas M M, De vries Marije, Beveridge Rebecca, Zerbe Oliver, Hartrampf Nina
- Chemical Science Vol 15, pp. 8756-8765 (2024)
- https://doi.org/10.1039/D4SC00481G
- Exploiting bi-specific engagement : assessing monovalent vs bivalent binding
- Duxbury Rachel, Beveridge Rebecca, Jamieson Craig, Jones David, Jones Gavin, Rattray Zahra
- Immuno-oncology Summit Europe 2024 (2024)
- Native mass spectrometry of complexes formed by molecular glues reveals stoichiometric rearrangement of E3 ligases
- Jackson Cara, Beveridge Rebecca
- Analyst Vol 149, pp. 3178-3185 (2024)
- https://doi.org/10.1039/d4an00110a
- Improving bi-specific engagement : assessing monovalent vs bivalent binding
- Duxbury Rachel, Beveridge Rebecca, Jamieson Craig, Jones David, Jones Gavin, Rattray Zahra
- 2nd Annual GSK Biopharm Postgraduate Symposium (2024)
Professional Activities
- Ion mobility mass spectrometry analysis of dynamic proteins and protein complexes
- Speaker
- 11/1/2024
- Nature Communications (Journal)
- Peer reviewer
- 1/1/2024
- Ion mobility mass spectrometry analysis of dynamic proteins and protein complexes
- Speaker
- 21/11/2023
- Introduction to native mass spectroemtry
- Speaker
- 9/11/2023
- Ion mobility mass spectrometry analysis of dynamic proteins and protein complexes
- Speaker
- 7/11/2023
- Ion mobility mass spectrometry insights into dynamic protein complexes and conformations
- Speaker
- 3/11/2023
Projects
- DTP 2224 University of Strathclyde | Madoda, Mxolisi
- Beveridge, Rebecca (Principal Investigator) Chow, Shiao (Co-investigator) Madoda, Mxolisi (Research Co-investigator)
- 01-Oct-2023 - 01-Apr-2027
- Intact protein mass measurement
- Beveridge, Rebecca (Principal Investigator)
- 01-Jun-2023 - 31-May-2024
- Understanding the relationship between target affinities of bi-specific antibodies to dual cell-membrane targets and their impact on cell binding and selectivity to improve the accuracy and value of in silico modelling for prediction of the optimal target affinities for effective clinical outcomes
- Rattray, Zahra (Principal Investigator) Beveridge, Rebecca (Principal Investigator) Duxbury, Rachel (Post Grad Student)
- 01-Oct-2022 - 31-Mar-2026
- Development of innovative label-free methods to investigate the binding properties and degradation efficiencies of PROTACs
- Beveridge, Rebecca (Principal Investigator)
- 01-Oct-2022 - 30-Sep-2026
- Industrial CASE Account - University of Strathclyde 2022 | Jackson, Cara
- Beveridge, Rebecca (Principal Investigator) Jamieson, Craig (Co-investigator) Jackson, Cara (Research Co-investigator)
- 01-Oct-2022 - 01-Oct-2026
- Identifying chemical probes to characterise intrinsically disordered drug targets through novel ion mobility-based screening capabilities
- Robb, Christina Glen (Researcher) Beveridge, Rebecca (Principal Investigator)
- 01-Oct-2021 - 31-Mar-2025
Contact
Dr
Rebecca
Beveridge
Senior Lecturer
Pure and Applied Chemistry
Email: rebecca.beveridge@strath.ac.uk
Tel: Unlisted