Dr Rebecca Beveridge
Senior Lecturer
Pure and Applied Chemistry
Personal statement
Rebecca is a Senior Lecturer and UKRI Future Leaders Fellow who joined the University of Strathclyde in June 2020 as a Chancellor's Fellow. She obtained a BSc in biochemistry and chemistry from the University of Leeds in 2011 and completed her PhD at the University of Manchester in 2015. Rebecca spent 4 years at the Institute for Molecular Pathology in Vienna, Austria as a postdoctoral researcher/ Lise Meitner Postdoctoral Fellow. Throughout her career, she has collected experience in a plethora of mass spectrometry methods to study protein structure such as native mass spectrometry, ion mobility, hydrogen-deuterium exchange, and crosslinking.
Rebecca’s current research is centered around the development of native ion mobility mass spectrometry methods to study proteins and protein complexes, particularly those that are challenging to study with conventional biochemistry methods. Such systems include intrinsically disordered proteins that exist in a wide range of different shapes, and protein complexes formed by protein-degrading molecules such as PROTACs, the complex binding modes of which are challenging to delineate.
Publications
- Native mass spectrometry of complexes formed by molecular glues reveals stoichiometric rearrangement of E3 ligases
- Jackson Cara, Beveridge Rebecca
- Analyst (2024)
- https://doi.org/10.1039/d4an00110a
- Native mass spectrometry interrogation of complexes formed during targeted protein degradation
- Ahmed Ikhlas M M, Beveridge Rebecca
- Rapid Communications in Mass Spectrometry Vol 37 (2023)
- https://doi.org/10.1002/rcm.9604
- Ion mobility mass spectrometry unveils global protein conformations in response to conditions that promote and reverse liquid-liquid phase separation
- Robb Christina Glen, Dao Thuy P, Ujma Jakub, Castañeda Carlos A, Beveridge Rebecca
- Journal of the American Chemical Society Vol 145, pp. 12541-12549 (2023)
- https://doi.org/10.1021/jacs.3c00756
- Shuffled ATG8 interacting motifs form an ancestral bridge between UFMylation and autophagy
- Picchianti Lorenzo, Sánchez de Medina Hernández Víctor, Zhan Ni, Irwin Nicholas AT, Groh Roan, Stephani Madlen, Hornegger Harald, Beveridge Rebecca, Sawa‐Makarska Justyna, Lendl Thomas, Grujic Nenad, Naumann Christin, Martens Sascha, Richards Thomas A, Clausen Tim, Ramundo Silvia, Karagöz G Elif, Dagdas Yasin
- The EMBO journal Vol 42 (2023)
- https://doi.org/10.15252/embj.2022112053
- A special issue of Essays in Biochemistry on structural mass spectrometry
- Britt Hannah M, Beveridge Rebecca, Calabrese Antonio N
- Essays in Biochemistry Vol 67, pp. 147-149 (2023)
- https://doi.org/10.1042/ebc20230006
- Insights into the spectrum of activity and mechanism of action of MGB-BP-3
- Hind Charlotte, Clifford Melanie, Woolley Charlotte, Harmer Jane, McGee Leah M C, Tyson-Hirst Izaak, Tait Henry J, Brooke Daniel P, Dancer Stephanie J, Hunter Iain S, Suckling Colin J, Beveridge Rebecca, Parkinson John A, Sutton J Mark, Scott Fraser J
- ACS Infectious Diseases Vol 8, pp. 2552-2563 (2022)
- https://doi.org/10.1021/acsinfecdis.2c00445
Professional Activities
- Ion mobility mass spectrometry analysis of dynamic proteins and protein complexes
- Speaker
- 11/1/2024
- Nature Communications (Journal)
- Peer reviewer
- 1/1/2024
- Ion mobility mass spectrometry analysis of dynamic proteins and protein complexes
- Speaker
- 21/11/2023
- Introduction to native mass spectroemtry
- Speaker
- 9/11/2023
- Ion mobility mass spectrometry analysis of dynamic proteins and protein complexes
- Speaker
- 7/11/2023
- Ion mobility mass spectrometry insights into dynamic protein complexes and conformations
- Speaker
- 3/11/2023
Projects
- DTP 2224 University of Strathclyde | Madoda, Mxolisi
- Beveridge, Rebecca (Principal Investigator) Chow, Shiao (Co-investigator) Madoda, Mxolisi (Research Co-investigator)
- 01-Jan-2023 - 01-Jan-2027
- Intact protein mass measurement
- Beveridge, Rebecca (Principal Investigator)
- 01-Jan-2023 - 31-Jan-2024
- Industrial CASE Account - University of Strathclyde 2022 | Jackson, Cara
- Beveridge, Rebecca (Principal Investigator) Jamieson, Craig (Co-investigator) Jackson, Cara (Research Co-investigator)
- 01-Jan-2022 - 01-Jan-2026
- Development of innovative label-free methods to investigate the binding properties and degradation efficiencies of PROTACs
- Beveridge, Rebecca (Principal Investigator)
- 01-Jan-2022 - 30-Jan-2026
- Identifying chemical probes to characterise intrinsically disordered drug targets through novel ion mobility-based screening capabilities
- Robb, Christina Glen (Researcher) Beveridge, Rebecca (Principal Investigator)
- 01-Jan-2021 - 31-Jan-2025
- Optimising ion mobility mass spectrometry workflows to interrogate the conformational preferences of a target protein for prostate cancer therapies
- Beveridge, Rebecca (Principal Investigator)
- 05-Jan-2021 - 27-Jan-2021
Contact
Dr
Rebecca
Beveridge
Senior Lecturer
Pure and Applied Chemistry
Email: rebecca.beveridge@strath.ac.uk
Tel: Unlisted