Dr Rebecca Beveridge

Senior Lecturer

Pure and Applied Chemistry

Contact

Personal statement

Rebecca is a Senior Lecturer and UKRI Future Leaders Fellow who joined the University of Strathclyde in June 2020 as a Chancellor's Fellow. She obtained a BSc in biochemistry and chemistry from the University of Leeds in 2011 and completed her PhD at the University of Manchester in 2015. Rebecca spent 4 years at the Institute for Molecular Pathology in Vienna, Austria as a postdoctoral researcher/ Lise Meitner Postdoctoral Fellow. Throughout her career, she has collected experience in a plethora of mass spectrometry methods to study protein structure such as native mass spectrometry, ion mobility, hydrogen-deuterium exchange, and crosslinking.

Rebecca’s current research is centered around the development of native ion mobility mass spectrometry methods to study proteins and protein complexes, particularly those that are challenging to study with conventional biochemistry methods. Such systems include intrinsically disordered proteins that exist in a wide range of different shapes, and protein complexes formed by protein-degrading molecules such as PROTACs, the complex binding modes of which are challenging to delineate.

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Publications

Native mass spectrometry interrogation of complexes formed during targeted protein degradation
Ahmed Ikhlas M M, Beveridge Rebecca
Rapid Communications in Mass Spectrometry Vol 37 (2023)
https://doi.org/10.1002/rcm.9604
Ion mobility mass spectrometry unveils global protein conformations in response to conditions that promote and reverse liquid-liquid phase separation
Robb Christina Glen, Dao Thuy P, Ujma Jakub, Castañeda Carlos A, Beveridge Rebecca
Journal of the American Chemical Society Vol 145, pp. 12541-12549 (2023)
https://doi.org/10.1021/jacs.3c00756
Shuffled ATG8 interacting motifs form an ancestral bridge between UFMylation and autophagy
Picchianti Lorenzo, Sánchez de Medina Hernández Víctor, Zhan Ni, Irwin Nicholas AT, Groh Roan, Stephani Madlen, Hornegger Harald, Beveridge Rebecca, Sawa‐Makarska Justyna, Lendl Thomas, Grujic Nenad, Naumann Christin, Martens Sascha, Richards Thomas A, Clausen Tim, Ramundo Silvia, Karagöz G Elif, Dagdas Yasin
The EMBO journal Vol 42 (2023)
https://doi.org/10.15252/embj.2022112053
A special issue of Essays in Biochemistry on structural mass spectrometry
Britt Hannah M, Beveridge Rebecca, Calabrese Antonio N
Essays in Biochemistry Vol 67, pp. 147-149 (2023)
https://doi.org/10.1042/ebc20230006
Insights into the spectrum of activity and mechanism of action of MGB-BP-3
Hind Charlotte, Clifford Melanie, Woolley Charlotte, Harmer Jane, McGee Leah M C, Tyson-Hirst Izaak, Tait Henry J, Brooke Daniel P, Dancer Stephanie J, Hunter Iain S, Suckling Colin J, Beveridge Rebecca, Parkinson John A, Sutton J Mark, Scott Fraser J
ACS Infectious Diseases Vol 8, pp. 2552-2563 (2022)
https://doi.org/10.1021/acsinfecdis.2c00445
Selective anti-Leishmanial Strathclyde minor groove binders using an N-oxide tail group modification
Perieteanu Marina C, McGee Leah MC, Shaw Craig D, MacMillan Donna S, Khalaf Abedawn I, Gillingwater Kirsten, Beveridge Rebecca, Carter Katharine C, Suckling Colin J, Scott Fraser J
International Journal of Molecular Sciences Vol 23 (2022)
https://doi.org/10.3390/ijms231911912

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Professional Activities

Ion Mobility Mass Spectrometry Insights into dynamic protein complexes and conformations
Speaker
7/7/2023
Ion Mobility Mass Spectrometry Reveals the Effect of Small Molecules on Protein Conformation and Stoichiometry
Speaker
21/6/2023
Ion Mobility Mass Spectrometry Insights into dynamic protein complexes and conformations
Speaker
8/6/2023
Ion Mobility Mass Spectrometry Insights into dynamic protein complexes and conformations
Speaker
10/5/2023
Native mass spectrometry analysis of complexes formed by protein degraders
Speaker
27/1/2023
Ion Mobility Mass Spectrometry Insights into dynamic protein complexes and conformations
Speaker
16/11/2022

More professional activities

Projects

DTP 2224 University of Strathclyde | Madoda, Mxolisi
Beveridge, Rebecca (Principal Investigator) Chow, Shiao (Co-investigator) Madoda, Mxolisi (Research Co-investigator)
01-Jan-2023 - 01-Jan-2027
Intact protein mass measurement
Beveridge, Rebecca (Principal Investigator)
01-Jan-2023 - 31-Jan-2024
Industrial CASE Account - University of Strathclyde 2022 | Jackson, Cara
Beveridge, Rebecca (Principal Investigator) Jamieson, Craig (Co-investigator) Jackson, Cara (Research Co-investigator)
01-Jan-2022 - 01-Jan-2026
Development of innovative label-free methods to investigate the binding properties and degradation efficiencies of PROTACs
Beveridge, Rebecca (Principal Investigator)
01-Jan-2022 - 30-Jan-2026
Identifying chemical probes to characterise intrinsically disordered drug targets through novel ion mobility-based screening capabilities
Robb, Christina Glen (Researcher) Beveridge, Rebecca (Principal Investigator)
01-Jan-2021 - 31-Jan-2025
Optimising ion mobility mass spectrometry workflows to interrogate the conformational preferences of a target protein for prostate cancer therapies
Beveridge, Rebecca (Principal Investigator)
05-Jan-2021 - 27-Jan-2021

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Contact

Dr Rebecca Beveridge
Senior Lecturer
Pure and Applied Chemistry

Email: rebecca.beveridge@strath.ac.uk
Tel: Unlisted