Dr Marie Boyd

Reader

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Dr Marie Boyd joined SIPBS from the CRUK Beatson Laboratories in July 2009 as a SULSA Reader in Translational Biology. Dr Boyd was awarded a CRUK Senior Cancer Research Fellowship in 2005 to investigate targeted radionuclide therapy for cancer. Targeted radionuclide therapy utilised radiation like a drug, that is molecules which are accrued specifically in tumours have a radioactive molecule attached, and once the radiopharmaceutical is injected into the body and it gets concentrated only in tumour cells. This results in irradiation specifically to tumour cells sparing normal tissues and thus reduction of toxic side effects. Our research group focuses on expansion of this form of radiotherapy to more tumour types by investigation and development of novel radiopharmaceuticals and targets as well as by adopting gene therapy techniques.

The group also investigates the basic biology of cellular response to radiotherapy and have a large area of research into combining radiotherapy with novel and existing drugs and interrogation of cell signaling and mechanisms using traditional and “Omics” based approaches. The Boyd group have already translated some therapeutic schemes into clinical trial and other promising schemes based upon repurposing of existing drugs, are underway with Industrial partners including AstraZeneca.

 Since the transfer to Strathclyde, the group has established several cross-disciplinary links within the TIC themes in areas of advanced Sciences and Technologies, Bionanotechnology, and Health Technologies at Strathclyde. These collaborations are formed around the need to establish multidisciplinary approaches to the development of cancer therapy. Our work fosters the marriage of cancer biology and radiobiology with platform technologies such as Laser Plasma Wakefield Accelerators, microfluidics, biogels and the combinations of novel and existing drugs and nanomaterials in the SU pipeline with chemo- and radiotherapy produced by a variety of radiation sources. The group will also be integral to the new TIC building hosting the SCAPA (Scottish centre for applied particle accelerators) facility. This research environment is a resource which is unique to Strathclyde University.

The Group is highly active within the recently established RICAS (Research In Cancer at Strathclyde) initiative, has been highly successful in achieving multi-disciplinary, Industry and clinical linked funding. The breadth of research has also recently expanded by involvement in the SIPBS led multi-university programme in pharmacoepidemiology. With our partners we are interrogating prescribing databases to interrogate questions which may lead to the development of better and more personalised cancer therapeutics. The group is also involved with several drug discovery programmes within and outwith the university and has developed phenotypic assay cascades to aid these programmes.

Dr Boyd's group is highly active in the research, industrial and clinical arena and the lab hosts senior fellows, Post docs, PhD students, research assistants, undergraduate and students from within SIPBS and from other University Departments (Physics, chemistry, EEE). The Boyd group will also host vertically Integrated Studentships (VIPs) within the lab, which are being run in collaboration with Chemistry and EEE and we are becoming partners in the Laser Plasma Accelerator Doctoral training centre spearheaded by the university.

Links:

http://www.strath.ac.uk/impact/turningelectronsintoopportunities/

http://www.strath.ac.uk/ricas/

http://www.strath.ac.uk/viprojects/

Publications

On-chip formation of 3D spheroids for patient-derived tissue screening
Christ T., Payne S., Yan Y., Ren J., Edwards J., Boyd M., Zagnoni M.
20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016), pp. 577-578, (2016)
From emulsion to single-phase microfluidics : an integrated approach to culture and perfusion of multicellular spheroids
McMillan Kay S, Boyd Marie, Zagnoni Michele
20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016), pp. 399-400, (2016)
Transitioning from multi-phase to single-phase microfluidics for long-term culture and treatment of multicellular spheroids
McMillan Kay S., Boyd Marie, Zagnoni Michele
Lab on a Chip Vol 16, pp. 3548-3557, (2016)
http://dx.doi.org/10.1039/C6LC00884D
Synthesis and evaluation of a radioiodinated tracer with specificity for poly(ADP-ribose) polymerase-1 (PARP-1) in vivo
Zmuda Filip, Malviya Gaurav, Blair Adele, Boyd Marie, Chalmers Anthony J., Sutherland Andrew, Pimlott Sally L.
Journal of Medicinal Chemistry Vol 58, pp. 8683-8693, (2015)
http://dx.doi.org/10.1021/acs.jmedchem.5b01324
New sulphated flavonoids from Wissadula periplocifolia (L.) C. Presl (Malvaceae)
Teles Yanna C. F., Horta Carolina Campolina Rebello, Agra Maria de Fátima, Siheri Weam, Boyd Marie, Igoli John O., Gray Alexander I., de Souza Maria de Fátima Vanderlei
Molecules Vol 20, pp. 20161-20172, (2015)
http://dx.doi.org/10.3390/molecules201119685
Emulsion technologies for multicellular tumour spheroid radiation assays
McMillan Kay S., McCluskey Anthony G., Sorensen Annette, Boyd Marie, Zagnoni Michele
Analyst Vol 141, pp. 100-110, (2015)
http://dx.doi.org/10.1039/c5an01382h

more publications

Professional activities

Duquesne University
Visiting researcher
1/2015
Dusquene University
Visiting researcher
1/2015
Paediatric Formulation of Medicines
Participant
2014
Austrian Drug Screening Institute
Visiting researcher
2014
Medicinal Chemistry : Current Research (Journal)
Peer reviewer
2013
International preventative research Institute (External organisation)
Member
30/6/2011

more professional activities

Projects

Laser-driven radiation beamlines at SCAPA (EPSRC Capital Equipment Portfolio)
McKenna, Paul (Principal Investigator) Boyd, Marie (Co-investigator) Gray, Ross (Co-investigator) Hidding, Bernhard (Co-investigator) Jaroszynski, Dino (Co-investigator) McArthur, Stephen (Co-investigator) Sheng, Zheng-Ming (Co-investigator)
Period 01-Apr-2017 - 31-Mar-2020
BBSRC Doctoral Training Grant (DTG) | McGinely, Nicola Louise
Boyd, Marie (Principal Investigator) McGinely, Nicola Louise (Research Co-investigator)
Period 01-Oct-2011 - 29-Apr-2016
Epsrc Doctoral Training Grant | McMillan, Kay
Zagnoni, Michele (Principal Investigator) Boyd, Marie (Co-investigator) McMillan, Kay (Research Co-investigator)
Period 01-Oct-2012 - 23-Jan-2017
Lab in a bubble
Jaroszynski, Dino (Principal Investigator) Boyd, Marie (Co-investigator) Brunetti, Enrico (Co-investigator) Ersfeld, Bernhard (Co-investigator) Hidding, Bernhard (Co-investigator) McKenna, Paul (Co-investigator) Noble, Adam (Co-investigator) Sheng, Zheng-Ming (Co-investigator) Vieux, Gregory (Co-investigator) Welsh, Gregor (Co-investigator) Wiggins, Samuel (Co-investigator)
Period 01-Apr-2016 - 31-Mar-2020
Development of oral wafers as medicines for use in the treatment of pain in children with cancer
Mullen, Alexander (Principal Investigator) Boyd, Marie (Co-investigator)
Period 01-Apr-2016 - 31-Mar-2018
Radiosensitisation of Glioblastoma multiforme (GBM)
Sorensen, Annette (Principal Investigator) Boyd, Marie (Co-investigator) Faulds, Karen (Co-investigator) Graham, Duncan (Co-investigator)
Period 01-Feb-2015 - 31-Mar-2017

more projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Hamnett Wing John Arbuthnott Building

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