
Dr Marie Boyd
Reader
Strathclyde Institute of Pharmacy and Biomedical Sciences
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Winner of Dragons den event at research day 2011 and 2012 Recipient 2011 NCRI ‚Radiation Research Recipient 2009 Invited Trustee and Scientific Advisory Committee of the LH Gray Trust Recipient 2008 Secretary of Association for radiation research Recipient 2006
Prize And Awards
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Evaluating nanoparticle localisation in glioblastoma multicellular tumour spheroids by surface enhanced Raman scattering McCabe Samantha M, Wallace Gregory Q, Sloan-Dennison Sian, Tipping William J, Shand Neil C, Graham Duncan, Boyd Marie, Faulds Karen Analyst Vol 148, pp. 3247-3256 (2023) https://doi.org/10.1039/D3AN00751K Understanding radiation response and cell cycle variation in brain tumour cells using Raman spectroscopy Hill Iona E, Boyd Marie, Milligan Kirsty, Jenkins Cerys A, Sorensen Annette, Jirasek Andrew, Graham Duncan, Faulds Karen Analyst Vol 148, pp. 2594-2608 (2023) https://doi.org/10.1039/D3AN00121K Comparing trastuzumab-related cardiotoxicity between elderly and younger patients with breast cancer : a prospective cohort study Aladwani A, Mullen A, Alrashidi M, Alfarisi O, Alterkait F, Aladwani A, Kumar A, Boyd M, Eldosouky ME European Review for Medical and Pharmacological Sciences Vol 25, pp. 7643-7653 (2021) https://doi.org/10.26355/eurrev_202112_27611 Determining the prognostic significance of IKKα in prostate cancer Montes Melania, MacKenzie Lewis, McAllister Milly J, Roseweir Antonia, McCall Pamela, Hatziieremia Sophia, Underwood Mark A, Boyd Marie, Paul Andrew, Plevin Robin, MacKay Simon P, Edwards Joanne The Prostate Vol 80, pp. 1188-1202 (2020) https://doi.org/10.1002/pros.24045 Plasma metabolomics identifies lipid and amino acid markers of weight loss in patients with upper gastrointestinal cancer Miller Janice, Alshehri Ahmed, Ramage Michael I, Stevens Nathan A, Mullen Alexander B, Boyd Marie, Ross James A, Wigmore Stephen J, Watson David G, Skipworth Richard JE Cancers Vol 11 (2019) https://doi.org/10.3390/cancers11101594 Focused very high-energy electron beams as a novel radiotherapy modality for producing high-dose volumetric elements Kokurewicz K, Brunetti E, Welsh G H, Wiggins S M, Boyd M, Sorensen A, Chalmers A J, Schettino G, Subiel A, DesRosiers C, Jaroszynski D A Scientific Reports Vol 9 (2019) https://doi.org/10.1038/s41598-019-46630-w
Publications
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Aberdeen Cancer Network (External organisation) Advisor 1/9/2022 Gliomodel (External organisation) Member 1/4/2022 Management Science (Organisational unit) Member 2020 Dusquene University Visiting researcher 1/2015 Duquesne University Visiting researcher 1/2015 Paediatric Formulation of Medicines Participant 2014
Developing Aberdeen's Cancer Research Network Spiers, Valerie (Principal Investigator) kiltie, anne (Principal Investigator) Gomez-Roman, Natividad (Co-investigator) Boyd, Marie (Co-investigator) Tomlinson, Ian P M (Principal Investigator) Gourley, Charlie (Co-investigator) Machesky, Laura (Co-investigator) Chalmers, Anthony (Principal Investigator) Broche, Lionel (Co-investigator) Stansfield, Ian (Co-investigator) The aim of this proposal is to encourage new collaborative research and innovation in these fields, through working with colleagues in the CRUK Scotland Centre based in Edinburgh and Glasgow, broadening the range of cancer research being conducted in Scotland. 01-Jan-2022 - 30-Jan-2023 Moving North, expanding the use of the chick embryo model in cancer research to a multiuser facility at the University of Strathclyde Boyd, Marie (Principal Investigator) Mullen, Alexander (Co-investigator) 01-Jan-2021 - 31-Jan-2023 Preventing the damaging effects of cancer chemotherapy and radiation treatment on human endothelial cells targeting the JNK pathway Plevin, Robin (Principal Investigator) Boyd, Marie (Co-investigator) McIntosh, Kathryn (Co-investigator) Preventing the damaging effects of cancer chemotherapy and radiation treatment on human endothelial cells targeting the JNK pathway 01-Jan-2019 - 31-Jan-2023 Advancing first-in-class IKKalpha inhibitors to commercialisation and clinical application Boyd, Marie (Principal Investigator) 01-Jan-2017 - 31-Jan-2020 Laser-driven radiation beamlines at SCAPA (EPSRC Capital Equipment Portfolio) McKenna, Paul (Principal Investigator) Boyd, Marie (Co-investigator) Gray, Ross (Co-investigator) Hidding, Bernhard (Co-investigator) Jaroszynski, Dino (Co-investigator) McArthur, Stephen (Co-investigator) Sheng, Zheng-Ming (Co-investigator) We propose to create new capability and capacity for collaborative high power laser-plasma research to underpin the development and application of laser-driven radiation sources, using three new beamlines and experiment stations at the Scottish Centre for the Application of Plasma-based Accelerators, SCAPA. Each of the beamlines will be configured in a unique way and with a focus on a specific category of laser-plasma interactions and secondary sources, to create a complementary suite of dedicated beamlines. This approach is required to enable the development and optimisation of laser-plasma sources from the realms of scientific investigation to real-world applications. It enables long-term investment in the optimisation and stabilisation of the beams and largely eliminates downtime for rebuilding experiments, thus enabling efficient and effective use of high power laser beam time.
The equipment will support an extensive research portfolio in laser-plasma physics and multidisciplinary applications, with an emphasis on radiation sources and healthcare applications. The unique properties of laser-driven radiation sources make them attractive both as tools for science (e.g. femtosecond X-ray sources for probing the structure of matter) and for applications in a variety of sectors including: healthcare (e.g. imaging and radiotherapy); industry (e.g. penetrative probing and assay) and energy (e.g. testing the integrity of stored nuclear waste). The strategic development of this field requires a balanced programme of dedicated university-scale and leading-edge national laser facilities. The proposed beamlines will complement existing and planned expansion of national facilities at the Central Laser Facility, providing new capability and capacity to enable UK research groups to remain at the forefront of this research area and help promote international collaboration.
The research will be performed collaboratively with groups from across the UK and sustained mainly through collaborative research grants. The new suite of beamlines will promote exchanges between academia and industry, and enable engagement of the UK research community with large international projects, such as the Extreme Light Infrastructure, ELI. It will also provide a unique interdisciplinary training platform for researchers. 01-Jan-2017 - 28-Jan-2021 Lab in a bubble Jaroszynski, Dino (Principal Investigator) Boyd, Marie (Co-investigator) Brunetti, Enrico (Co-investigator) Ersfeld, Bernhard (Co-investigator) Hidding, Bernhard (Co-investigator) McKenna, Paul (Co-investigator) Noble, Adam (Co-investigator) Sheng, Zheng-Ming (Co-investigator) Vieux, Gregory (Co-investigator) Welsh, Gregor H. (Co-investigator) Wiggins, Mark (Co-investigator) "The lab in a bubble project is a timely investigation of the interaction of charged particles with radiation inside and in the vicinity of relativistic plasma bubbles created by intense ultra-short laser pulses propagating in plasma. It builds on recent studies carried out by the ALPHA-X team of coherent X-ray radiation from the laser-plasma wakefield accelerator and high field effects where radiation reaction becomes important. The experimental programme will be carried out using high power lasers and investigate new areas of physics where single-particle and collective radiation reaction and quantum effects become important, and where non-linear coupling and instabilities between beams, laser, plasma and induced fields develop, which result in radiation and particle beams with unique properties. Laser-plasma interactions are central to all problems studied and understanding their complex and often highly non-linear interactions gives a way of controlling the bubble and beams therein. To investigate the rich range of physical processes, advanced theoretical and experimental methods will be applied and advantage will be taken of know-how and techniques developed by the teams. New analytical and numerical methods will be developed to enable planning and interpreting results from experiments. Advanced experimental methods and diagnostics will be developed to probe the bubble and characterise the beams and radiation. An important objective will be to apply the radiation and beams in selected proof-of-concept applications to the benefit of society.
The project is involves a large group of Collaborators and Partners, who will contribute to both theoretical and experimental work. The diverse programme is managed through a synergistic approach where there is strong linkage between work-packages, and both theoretical and experiential methodologies are applied bilaterally: experiments are informed by theory at planning and data interpretation stages, and theory is steered by the outcome of experimental studies, which results in a virtuous circle that advances understanding of the physics inside and outside the lab in a bubble. We also expect to make major advances in high field physics and the development of a new generation of compact coherent X-ray sources." 01-Jan-2016 - 31-Jan-2021
Professional Activities
Projects
The equipment will support an extensive research portfolio in laser-plasma physics and multidisciplinary applications, with an emphasis on radiation sources and healthcare applications. The unique properties of laser-driven radiation sources make them attractive both as tools for science (e.g. femtosecond X-ray sources for probing the structure of matter) and for applications in a variety of sectors including: healthcare (e.g. imaging and radiotherapy); industry (e.g. penetrative probing and assay) and energy (e.g. testing the integrity of stored nuclear waste). The strategic development of this field requires a balanced programme of dedicated university-scale and leading-edge national laser facilities. The proposed beamlines will complement existing and planned expansion of national facilities at the Central Laser Facility, providing new capability and capacity to enable UK research groups to remain at the forefront of this research area and help promote international collaboration.
The research will be performed collaboratively with groups from across the UK and sustained mainly through collaborative research grants. The new suite of beamlines will promote exchanges between academia and industry, and enable engagement of the UK research community with large international projects, such as the Extreme Light Infrastructure, ELI. It will also provide a unique interdisciplinary training platform for researchers.
The project is involves a large group of Collaborators and Partners, who will contribute to both theoretical and experimental work. The diverse programme is managed through a synergistic approach where there is strong linkage between work-packages, and both theoretical and experiential methodologies are applied bilaterally: experiments are informed by theory at planning and data interpretation stages, and theory is steered by the outcome of experimental studies, which results in a virtuous circle that advances understanding of the physics inside and outside the lab in a bubble. We also expect to make major advances in high field physics and the development of a new generation of compact coherent X-ray sources."
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Contact
Dr
Marie
Boyd
Reader
Strathclyde Institute of Pharmacy and Biomedical Sciences
Email: marie.boyd@strath.ac.uk
Tel: 548 2263