Professor Glenn Burley
Pure and Applied Chemistry
Personal statement
Personal statement
Glenn A. Burley (GAB) is Professor of Chemical Biology at the University of Strathclyde. The main focus of GAB’s research programme is the development of molecular probes to further our understanding of processes involved in gene expression. GAB was awarded a Bachelor of Medicinal Chemistry (Hon. I) and a PhD in Organic Chemistry from the University of Wollongong, Australia. GAB was a post-doctoral fellow in the Fullerene Science Centre at the University of Sussex (2001-2003) and an Alexander von Humboldt Fellow at the University of Munich (2004-2006). GAB began his independent career as an EPSRC Advanced Fellow in 2007 at the University of Leicester, before moving to Strathclyde in 2011.
More information can be found at: www.burleylabs.co.uk
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Publications
- Gram-scale enzymatic synthesis of 2′-deoxyribonucleoside analogues using nucleoside transglycosylase-2
- Salihovic Admir, Ascham Alex, Taladriz-Sender Andrea, Bryson Samantha, Withers Jamie M, Mckean Iain J W, Hoskisson Paul A, Grogan Gideon, Burley Glenn A
- Chemical Science (2024)
- https://doi.org/10.1039/D4SC04938A
- A first insight into the developability of an Immunoglobulin G3 : a combined computational and experimental approach
- Armstrong Georgina B, Lewis Alan, Shah Vidhi, Taylor Paul, Jamieson Craig J, Burley Glenn A, Lewis Will, Rattray Zahra
- ACS Pharmacology & Translational Science Vol 7, pp. 2439-2451 (2024)
- https://doi.org/10.1021/acsptsci.4c00271
- A framework for the biophysical screening of antibody mutations targeting solvent-accessible hydrophobic and electrostatic patches for enhanced viscosity profiles
- Armstrong Georgina B, Shah Vidhi, Sanches Paula, Patel Mitul, Casey Ricky, Jamieson Craig, Burley Glenn A, Lewis William, Rattray Zahra
- Computational and Structural Biotechnology Journal Vol 23, pp. 2345-2357 (2024)
- https://doi.org/10.1016/j.csbj.2024.05.041
- Mechanistic basis of the Cu(OAc)2 catalyzed azide-ynamine (3+2)cycloaddition reaction
- Bunschoten Roderick P, Peschke Frederik, Taladriz-Sender Andrea, Alexander Emma, Andrews Matthew J, Kennedy Alan R, Fazakerley Neal J, Lloyd Jones Guy C, Watson Allan J B, Burley Glenn A
- Journal of the American Chemical Society Vol 146, pp. 13558-13570 (2024)
- https://doi.org/10.1021/jacs.4c03348
- Innovative, combinatorial and high-throughput approaches to degrader synthesis
- Stevens Rebecca, Thompson James D F, Fournier Julie C L, Burley Glenn A, Battersby David J, Miah Afjal H
- Chemical Society Reviews Vol 53, pp. 4838-4861 (2024)
- https://doi.org/10.1039/d3cs01127e
- 2′- 19 F labelling of ribose in RNAs: a tool to analyse RNA/protein interactions by NMR in physiological conditions
- Kara Hesna, Axer Alexander, Muskett Frederick W, Bueno-Alejo Carlos J, Paschalis Vasileios, Taladriz-Sender Andrea, Tubasum Sumera, Vega Marina Santana, Zhao Zhengyun, Clark Alasdair W, Hudson Andrew J, Eperon Ian C, Burley Glenn A, Dominguez Cyril
- Frontiers in Molecular Biosciences Vol 11 (2024)
- https://doi.org/10.3389/fmolb.2024.1325041
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Research Interests
The Burley group (www.burleylabs.co.uk) applies a problem-based ethos that utilizes synthetic organic chemistry, biosynthesis and physical organic chemistry to explore regulatory mechanisms of transcription and RNA processing. In collaboration with bio-engineers, the group is constructing a new generation of nucleic acid-programmed nano-assemblies for diagnostic and light-harvesting applications.
Three nodes of research are currently being pursued:
- Chemical Biology of alternative RNA splicing (in collaboration with Prof. Ian Eperon, University of Leicester) – Alternative RNA splicing is a major contributor to protein diversity and genetic regulation operating in eukaryotic cells, yet the mechanisms by which it is regulated are poorly understood. This research programme is aimed at unravelling fundamental issues associated with splice site selection using small molecule and large molecule (oligonucleotides and protein hybrids) probes. These methods are being applied to further our understanding in diseases such as Spinal Muscular Atrophy (SMA) and Prostate Cancer.
- DNA-based construction of molecular devices (in collaboration with Prof. Richard Cogdell FRS & Dr Alasdair Clark, University of Glasgow) - We are currently developing self-assembly approaches for the construction of DNA-programmed optoelectronic and light-harvesting devices. DNA-binding molecules are being developed that read the genetic code of DNA and direct the assembly of noble metal nanoparticles and light-harvesting proteins in defined positions along a DNA nanostructure. We are now applying this technology to build DNA-programmed light-harvesting devices and plasmonic waveguides for molecular electronics and medical diagnostic applications.
- Synthetic Organic Chemistry (in collaboration with Dr Allan Watson, University of St. Andrews) - New bioconjugation methodology is being developed using ynamines as a new generation of click chemistry reagents. These functional groups display unique reactivity relative to their alkyne cognates enabling the efficient and chemoselective construction of bioconjugates and as target identificaiton and validation tools in chemical biology.
See www.burleylabs.co.uk for further details.
Professional Activities
- LINXS Chemistry of Life Meeting
- Speaker
- 18/10/2024
- Mechanism inspired ynamine modification of biomolecules
- Speaker
- 9/6/2024
- Invited speaker - School of Chemistry
- Speaker
- 8/5/2024
- 57th Bürgenstock Conference on Stereochemistry
- Participant
- 28/4/2024
- Next-generation oligonucleotide therapies: synthesis, target engagement and chemical biology
- Speaker
- 18/4/2024
- Cpi Innovation Services Limited (External organisation)
- Advisor
- 1/7/2023
Projects
- GLAS-CYTO: AN INTEGRATED FACILITY FOR THE BIOPHYSICAL ANALYSIS OF CELLULAR INTERACTIONS
- Burley, Glenn (Principal Investigator) Chamberlain, Luke (Co-investigator) Chow, Shiao (Co-investigator) Corrigan, Damion (Co-investigator) Cunningham, Margaret Rose (Co-investigator) Faulds, Karen (Co-investigator) Jamieson, Craig (Co-investigator) Rattray, Zahra (Co-investigator) Tomkinson, Nick (Co-investigator) Taladriz Sender, Andrea (Research Co-investigator)
- 01-Aug-2024 - 31-Jul-2025
- A Prosperity Partnership for the Design of Next-Generation Antibody Drug Bioconjugates (Next-Gen ADC)
- Burley, Glenn (Principal Investigator) Jamieson, Craig (Co-investigator) Kerr, William (Co-investigator) Nordon, Alison (Co-investigator) Rattray, Zahra (Co-investigator) Tomkinson, Nick (Co-investigator)
- 15-Nov-2023 - 14-Nov-2028
- Industrial CASE Account - University of Strathclyde 2022 | Otyakmaz, Ayse Birsen
- Burley, Glenn (Principal Investigator) Tomkinson, Nick (Co-investigator) Otyakmaz, Ayse Birsen (Research Co-investigator)
- 01-Oct-2023 - 01-Oct-2027
- Industrial Case Account - University of Strathclyde 2023 | Anderson, Jack
- Burley, Glenn (Principal Investigator) Tomkinson, Nick (Co-investigator) Anderson, Jack (Research Co-investigator)
- 01-Oct-2023 - 01-Oct-2027
- Industrial CASE Account - University of Strathclyde 2022 | McTaggart, Eilidh
- Jamieson, Craig (Principal Investigator) Burley, Glenn (Co-investigator) McTaggart, Eilidh (Research Co-investigator)
- 01-Sep-2023 - 01-Sep-2027
- NMR-BASE: Nuclear Magnetic Resonance for Biomolecule Analysis in Supported Environments
- Parkinson, John (Principal Investigator) Burley, Glenn (Co-investigator) Dufès, Christine (Co-investigator) Irving, Craig (Co-investigator) Jamieson, Craig (Co-investigator) Scott, Fraser (Co-investigator) Seib, Philipp (Co-investigator) Taladriz Sender, Andrea (Co-investigator)
- 01-Aug-2023 - 31-Jul-2024
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Contact
Professor
Glenn
Burley
Pure and Applied Chemistry
Email: glenn.burley@strath.ac.uk
Tel: 548 2792