Professor Glenn Burley
Pure and Applied Chemistry
Personal statement
Personal statement
Glenn A. Burley (GAB) is Professor of Chemical Biology at the University of Strathclyde. The main focus of GAB’s research programme is the development of molecular probes to further our understanding of processes involved in gene expression. GAB was awarded a Bachelor of Medicinal Chemistry (Hon. I) and a PhD in Organic Chemistry from the University of Wollongong, Australia. GAB was a post-doctoral fellow in the Fullerene Science Centre at the University of Sussex (2001-2003) and an Alexander von Humboldt Fellow at the University of Munich (2004-2006). GAB began his independent career as an EPSRC Advanced Fellow in 2007 at the University of Leicester, before moving to Strathclyde in 2011.
More information can be found at: www.burleylabs.co.uk
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Publications
- Quantifying antibody binding : techniques and therapeutic implications
- Lodge James, Kajtar Lewis, Duxbury Rachel, Hall David, Burley Glenn A, Cordy Joanna, Yates James WT, Rattray Zahra
- mAbs Vol 17 (2025)
- https://doi.org/10.1080/19420862.2025.2459795
- Factors to consider for synthesis in 1536-well plates - an amide coupling case study for PROTAC synthesis
- Stevens Rebecca, Palmer Harry E P, Miah Afjal H, Burley Glenn A
- Journal of Organic Chemistry Vol 90, pp. 2192-2200 (2025)
- https://doi.org/10.1021/acs.joc.4c02456
- Expanding the reaction toolbox for nanoscale direct-to-biology PROTAC synthesis and biological evaluation
- Stevens Rebecca, Shrives Harry J, Cryan Jenni, Klimaszewska Diana, Stacey Peter, Burley Glenn A, Harling John D, Battersby David J, Miah Afjal H
- RSC Medicinal Chemistry (2024)
- https://doi.org/10.1039/D4MD00760C
- Biocatalytic synthesis of ribonucleoside analogues using nucleoside transglycosylase-2
- Salihovic Admir, Ascham Alex, Rosenqvist Petja S, Taladriz-Sender Andrea, Hoskisson Paul A, Hodgson David R W, Grogan Gideon, Burley Glenn A
- Chemical Science Vol 16, pp. 1302-1307 (2024)
- https://doi.org/10.1039/D4SC07521H
- Germanyl triazoles as a platform for CuAAC diversification and chemoselective orthogonal cross-coupling
- Halford-McGuff John M, Richardson Thomas M, McKay Aidan P, Peschke Frederik, Burley Glenn A, Watson Allan J B
- Beilstein Journal of Organic Chemistry Vol 20, pp. 3198-3204 (2024)
- https://doi.org/10.3762/bjoc.20.265
- Assessing the manufacturability and critical quality attribute profiles of anti-IL-8 immunoglobulin G mutant variants
- Armstrong Georgina Bethany, Burley Glenn A, Lewis William, Rattray Zahra
- Molecular Pharmaceutics Vol 21, pp. 6423–6432 (2024)
- https://doi.org/10.1021/acs.molpharmaceut.4c01010
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Research Interests
The Burley group (www.burleylabs.co.uk) applies a problem-based ethos that utilizes synthetic organic chemistry, biosynthesis and physical organic chemistry to explore regulatory mechanisms of transcription and RNA processing. In collaboration with bio-engineers, the group is constructing a new generation of nucleic acid-programmed nano-assemblies for diagnostic and light-harvesting applications.
Three nodes of research are currently being pursued:
- Chemical Biology of alternative RNA splicing (in collaboration with Prof. Ian Eperon, University of Leicester) – Alternative RNA splicing is a major contributor to protein diversity and genetic regulation operating in eukaryotic cells, yet the mechanisms by which it is regulated are poorly understood. This research programme is aimed at unravelling fundamental issues associated with splice site selection using small molecule and large molecule (oligonucleotides and protein hybrids) probes. These methods are being applied to further our understanding in diseases such as Spinal Muscular Atrophy (SMA) and Prostate Cancer.
- DNA-based construction of molecular devices (in collaboration with Prof. Richard Cogdell FRS & Dr Alasdair Clark, University of Glasgow) - We are currently developing self-assembly approaches for the construction of DNA-programmed optoelectronic and light-harvesting devices. DNA-binding molecules are being developed that read the genetic code of DNA and direct the assembly of noble metal nanoparticles and light-harvesting proteins in defined positions along a DNA nanostructure. We are now applying this technology to build DNA-programmed light-harvesting devices and plasmonic waveguides for molecular electronics and medical diagnostic applications.
- Synthetic Organic Chemistry (in collaboration with Dr Allan Watson, University of St. Andrews) - New bioconjugation methodology is being developed using ynamines as a new generation of click chemistry reagents. These functional groups display unique reactivity relative to their alkyne cognates enabling the efficient and chemoselective construction of bioconjugates and as target identificaiton and validation tools in chemical biology.
See www.burleylabs.co.uk for further details.
Professional Activities
- LINXS Chemistry of Life Meeting
- Speaker
- 18/10/2024
- Mechanism inspired ynamine modification of biomolecules
- Speaker
- 9/6/2024
- Invited speaker - School of Chemistry
- Speaker
- 8/5/2024
- 57th Bürgenstock Conference on Stereochemistry
- Participant
- 28/4/2024
- Next-generation oligonucleotide therapies: synthesis, target engagement and chemical biology
- Speaker
- 18/4/2024
- Cpi Innovation Services Limited (External organisation)
- Advisor
- 1/7/2023
Projects
- Predicting and controlling High Order Structures for the development of more effective and safer therapeutic peptides (ICASE)
- Rattray, Zahra (Principal Investigator) Burley, Glenn (Co-investigator)
- 01-Jan-2024 - 30-Jan-2028
- Industrial CASE Account - University of Strathclyde 2024 | Salvadori, Irene
- Rattray, Zahra (Principal Investigator) Burley, Glenn (Co-investigator) Salvadori, Irene (Research Co-investigator)
- 01-Jan-2024 - 01-Jan-2028
- High-Throughput PROTAC Synthesis to Target Synthetic Lethality in Epigenetics
- Burley, Glenn (Principal Investigator)
- 01-Jan-2024 - 31-Jan-2024
- Industrial CASE Account - University of Strathclyde 2024 | Paszczuk, Lauren
- Burley, Glenn (Principal Investigator) Rattray, Zahra (Co-investigator) Paszczuk, Lauren (Research Co-investigator)
- 01-Jan-2024 - 01-Jan-2028
- GLAS-CYTO: AN INTEGRATED FACILITY FOR THE BIOPHYSICAL ANALYSIS OF CELLULAR INTERACTIONS
- Burley, Glenn (Principal Investigator) Chamberlain, Luke (Co-investigator) Chow, Shiao (Co-investigator) Corrigan, Damion (Co-investigator) Cunningham, Margaret Rose (Co-investigator) Faulds, Karen (Co-investigator) Jamieson, Craig (Co-investigator) Rattray, Zahra (Co-investigator) Tomkinson, Nick (Co-investigator) Taladriz Sender, Andrea (Research Co-investigator)
- 01-Jan-2024 - 31-Jan-2025
- A Prosperity Partnership for the Design of Next-Generation Antibody Drug Bioconjugates (Next-Gen ADC)
- Burley, Glenn (Principal Investigator) Jamieson, Craig (Co-investigator) Kerr, William (Co-investigator) Nordon, Alison (Co-investigator) Rattray, Zahra (Co-investigator) Tomkinson, Nick (Co-investigator)
- 15-Jan-2023 - 14-Jan-2028
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Contact
Professor
Glenn
Burley
Pure and Applied Chemistry
Email: glenn.burley@strath.ac.uk
Tel: 548 2792