Professor Glenn Burley

Pure and Applied Chemistry

Personal statement

Glenn A. Burley (GAB) is Professor of Chemical Biology at the University of Strathclyde. The main focus of GAB’s research programme is the development of molecular probes to further our understanding of processes involved in gene expression. GAB was awarded a Bachelor of Medicinal Chemistry (Hon. I) and a PhD in Organic Chemistry from the University of Wollongong, Australia. GAB was a post-doctoral fellow in the Fullerene Science Centre at the University of Sussex (2001-2003) and an Alexander von Humboldt Fellow at the University of Munich (2004-2006). GAB began his independent career as an EPSRC Advanced Fellow in 2007 at the University of Leicester, before moving to Strathclyde in 2011.

Publications

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Publications

Evidence for a Cu(II)-catalysed CuAAC reaction : a combined experimental and computational study: Andrews Matthew J, Richardson Thomas M, Roberts Dean D, Maestro Aitor, Hilton Timothy A, Sotorrios Lia, Martín‐Fernández Carlos, Craciunescu Luca, Peschke Frederik, McKay Aidan P, Macgregor Stuart A, Burley Glenn A, Watson Allan J B; Angewandte Chemie International Edition (2026); https://doi.org/10.1002/anie.3647018
Influence of DNA mispairing and abasic sites on duplex dynamics : a temperature-jump infrared spectroscopy study: Hunt Neil T, Kendall-Price Sophie E T, Phelps Ryan, Greetham Gregory M, Burley Glenn A; Journal of Physical Chemistry Letters Vol 17, pp. 7111-7119 (2026); https://doi.org/10.1021/acs.jpclett.6c00991
Fluorous-directed clamping stabilizes triple-helical DNA: Taladriz-Sender Andrea, Brazzill Michael, Withers Jamie M, Clark Alasdair W, Burley Glenn A, Rusling David A; ACS Omega Vol 11, pp. 33983–33990 (2026); https://doi.org/10.1021/acsomega.6c00803
Quantifying antibody binding : techniques and therapeutic implications: Lodge James, Kajtar Lewis, Duxbury Rachel, Hall David, Burley Glenn A, Cordy Joanna, Yates James WT, Rattray Zahra; mAbs Vol 17 (2025); https://doi.org/10.1080/19420862.2025.2459795
Split-APEX implicates splicing factor SRSF1 and splicing helicases in ribosomal biogenesis: Paschalis Vasileios, Wills Max F K, De Gusmao Araujo Philippe, Lucas Christian, Tubasum Sumera, Cui Shijie, Kara Hesna, Bueno-Alejo Carlos, Santana-Vega Marina, Taladriz-Sender Andrea, Zhao Zhengyun, Axer Alexander, Dominguez Cyril, Clark Alasdair W, Burley Glenn A, Hudson Andrew J, Eperon Ian C; Frontiers in Molecular Biosciences Vol 12 (2025); https://doi.org/10.3389/fmolb.2025.1714378
The great escape : defining the molecular basis of cellular uptake and endosomal escape of ADCs: Graham Harriet, McWhinnie Fergus, Burley Glenn, Rattray Zahra; 16th PharmSci International Conference (2025)

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Research

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Research Interests

The Burley group (www.burleylabs.co.uk) applies a problem-based ethos that utilizes synthetic organic chemistry, biocatalysisand physical organic chemistry to explore regulatory mechanisms of transcription and RNA processing. A second research area of interest is the development of bio-orthogonal chemistries to prepare bioconjugates for cell selective drug delivery.