Professor Glenn Burley

Pure and Applied Chemistry

Personal statement

Glenn A. Burley (GAB) is Professor of Chemical Biology at the University of Strathclyde. The main focus of GAB’s research programme is the development of molecular probes to further our understanding of processes involved in gene expression. GAB was awarded a Bachelor of Medicinal Chemistry (Hon. I) and a PhD in Organic Chemistry from the University of Wollongong, Australia. GAB was a post-doctoral fellow in the Fullerene Science Centre at the University of Sussex (2001-2003) and an Alexander von Humboldt Fellow at the University of Munich (2004-2006).  GAB began his independent career as an EPSRC Advanced Fellow in 2007 at the University of Leicester, before moving to Strathclyde in 2011.

Publications

S-adenosyl methionine cofactor modifications enhance the biocatalytic repertoire of small molecule C-alkylation
McKean Iain, Sadler Joanna, Cuetos Anibal, Frese Amina, Humphreys Luke, Grogan Gideon, Hoskisson Paul, Burley Glenn
Angewandte Chemie International Edition (2019)
https://doi.org/10.1002/anie.201908681
Molecular construction of sulfonamide antisense oligonucleotides
Korotkovs Valerijs, Reichenbach Linus F, Pescheteau Clémentine, Burley Glenn A, Liskamp Rob M J
Journal of Organic Chemistry Vol 84, pp. 10635-10648 (2019)
https://doi.org/10.1021/acs.joc.9b00941
Splice-switching small molecules : a new therapeutic approach to modulate gene expression
Taladriz-Sender Andrea, Campbell Emma, Burley Glenn A
Methods Vol 167, pp. 134-142 (2019)
https://doi.org/10.1016/j.ymeth.2019.06.011
Whisky tasting using a bimetallic nanoplasmonic tongue
Macias Gerard, Sperling Justin Ryan, Peveler William J, Burley Glenn A, Neale Steven L, Clark Alasdair W
Nanoscale Vol 11, pp. 15216-15223 (2019)
https://doi.org/10.1039/C9NR04583J
Sequence-selective minor groove recognition of a DNA duplex containing synthetic genetic components
Padroni Giacomo, Withers Jamie M, Taladriz Sender Andrea, Reichenbach Linus F, Parkinson John A, Burley Glenn A
Journal of the American Chemical Society Vol 141, pp. 9555-9563 (2019)
https://doi.org/10.1021/jacs.8b12444
PROTAC-mediated degradation of Bruton's tyrosine kinase is inhibited by covalent binding
Tinworth Christopher P, Lithgow Hannah, Dittus Lars, Bassi Zuni I, Hughes Sophie E, Muelbaier Marcel, Dai Han, Smith Ian E D, Kerr William J, Burley Glenn A, Bantscheff Marcus, Harling John D
ACS Chemical Biology Vol 14, pp. 342-347 (2019)
https://doi.org/10.1021/acschembio.8b01094

more publications

Research interests

The Burley group applies a problem-based ethos that utilizes synthetic organic chemistry, biosynthesis and physical organic chemistry to explore regulatory mechanisms of transcription and RNA processing. In collaboration with bio-engineers, the group is constructing a new generation of nucleic acid-programmed nano-assemblies for diagnostic and light-harvesting applications.  

Three nodes of research are currently being pursued:

  1. Chemical Biology of alternative RNA splicing (in collaboration with Prof. Ian Eperon & Dr Cyril Dominguez, University of Leicester) – Alternative RNA splicing is a major contributor to protein diversity and genetic regulation operating in eukaryotic cells, yet the mechanisms by which it is regulated are poorly understood. This research programme is aimed at unravelling fundamental issues associated with splice site selection using small molecule and large molecule (oligonucleotides and protein hybrids) probes. These methods are being applied to further our understanding in diseases such as Spinal Muscular Atrophy (SMA) and Prostate Cancer.
  2. DNA-based construction of molecular devices (in collaboration with Prof. Richard Cogdell FRS & Dr Alasdair Clark, University of Glasgow) - We are currently developing self-assembly approaches for the construction of DNA-programmed optoelectronic and light-harvesting devices. DNA-binding molecules are being developed that read the genetic code of DNA and direct the assembly of noble metal nanoparticles and light-harvesting proteins in defined positions along a DNA nanostructure. We are now applying this technology to build DNA-programmed light-harvesting devices and plasmonic waveguides for molecular electronics and medical diagnostic applications.
  3. Synthetic Organic Chemistry (in collaboration with Dr Allan Watson, University of St. Andrews) - New bioconjugation methodology is being developed using ynamines as a new generation of click chemistry reagents. These functional groups display unique reactivity relative to their alkyne cognates enabling the efficient and chemoselective construction of bioconjugates and as target identificaiton and validation tools in chemical biology.

See www.burleylabs.co.uk for further details.

Professional activities

Dynamic Biosensors User Meeting
Speaker
5/6/2019
Visiting Professorship
Recipient
1/6/2019
Copper-Catalysed Modification of Biomolecules: Mechanistic Insights and Applications
Speaker
4/4/2019
External examiner
Examiner
1/2/2019
Invited talk
Speaker
10/10/2018
XXIII INTERNATIONAL ROUNDTABLE ON NUCLEOSIDES, NUCLEOTIDES AND NUCLEIC ACIDS
Participant
26/8/2018

more professional activities

Projects

Industrial Case Account - University of Strathclyde 2019 | Abate, Immacolata
Burley, Glenn (Principal Investigator) Tomkinson, Nick (Co-investigator) Abate, Immacolata (Research Co-investigator)
01-Jan-2019 - 01-Jan-2023
Industrial CASE Account - University of Strathclyde 2017 | Mowat, Jenna
Jamieson, Craig (Principal Investigator) Burley, Glenn (Co-investigator) Mowat, Jenna (Research Co-investigator)
01-Jan-2019 - 01-Jan-2023
Doctoral Training Partnership 2018-19 University of Strathclyde | Mowat, Jenna
Jamieson, Craig (Principal Investigator) Burley, Glenn (Co-investigator) Mowat, Jenna (Research Co-investigator)
01-Jan-2019 - 01-Jan-2023
BBSRC Pathfinder: A new genetically-encoded catalytic platform for RNA imaging
Burley, Glenn (Principal Investigator)
09-Jan-2019 - 08-Jan-2019
Macromolecular construction of DNA networks directed by the flourous effect
Burley, Glenn (Principal Investigator)
01-Jan-2018 - 31-Jan-2021
Industrial CASE Account - University of Strathclyde 2018 | Bunschoten, Roderick
Burley, Glenn (Principal Investigator) Jamieson, Craig (Co-investigator) Bunschoten, Roderick (Research Co-investigator)
01-Jan-2018 - 01-Jan-2022

more projects

Address

Pure and Applied Chemistry
Thomas Graham Building

Location Map

View University of Strathclyde in a larger map