Professor Luke Chamberlain
Strathclyde Institute of Pharmacy and Biomedical Sciences
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Publications
- The endoplasmic reticulum-localized enzyme zDHHC6 mediates S-acylation of short transmembrane constructs from multiple type I and II membrane proteins
- Salaun Christine, Tomkinson Nicholas CO, Chamberlain Luke H
- Journal of Biological Chemistry Vol 299 (2023)
- https://doi.org/10.1016/j.jbc.2023.105201
- S-acylation of Sprouty and SPRED proteins by the S-acyltransferase zDHHC17 involves a novel mode of enzyme-substrate interaction
- Butler Liam, Locatelli Carolina, Allagioti Despoina, Lousa Irina, Lemonidis Kimon, Tomkinson Nicholas C O, Salaun Christine, Chamberlain Luke H
- Journal of Biological Chemistry Vol 299 (2023)
- https://doi.org/10.1016/j.jbc.2022.102754
- Development of a novel high-throughput screen for the identification of new inhibitors of protein S-acylation
- Salaun Christine, Takizawa Hiroya, Galindo Alex, Munro Kevin R, McLellan Jayde, Sugimoto Isamu, Okino Tomotaka, Tomkinson Nicholas CO, Chamberlain Luke H
- Journal of Biological Chemistry Vol 298 (2022)
- https://doi.org/10.1016/j.jbc.2022.102469
- Regulatory effects of protein S-acylation on insulin secretion and insulin action
- Chamberlain Luke H, Shipston Michael J, Gould Gwyn W
- Open Biology Vol 11 (2021)
- https://doi.org/10.1098/rsob.210017
- Accessory proteins of the zDHHC family of S-acylation enzymes
- Salaun Christine, Locatelli Carolina, Zmuda Filip, Cabrera González Juan, Chamberlain Luke H
- Journal of Cell Science Vol 133 (2020)
- https://doi.org/10.1242/jcs.251819
- Identification of key features required for efficient S-acylation and plasma membrane targeting of Sprouty-2
- Locatelli Carolina, Lemonidis Kimon, Salaun Christine, Tomkinson Nicholas C O, Chamberlain Luke H
- Journal of Cell Science Vol 133 (2020)
- https://doi.org/10.1242/jcs.249664
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Professional Activities
- Engineering Biology Workshop
- Organiser
- 3/7/2023
- Engineering Biology Workshop
- Organiser
- 2/6/2023
- Krzysztof Wypijewski
- Host
- 21/9/2022
- UKRI Medical Research Council (External organisation)
- Advisor
- 1/9/2021
- UKRI (External organisation)
- Advisor
- 22/3/2021
- SULSA (University Administered) (External organisation)
- Advisor
- 1/1/2020
Projects
- REGULATION OF PANCREATIC BETA CELL PHYSIOLOGY BY THE S-ACYLATION ENZYME ZDHHC17
- Chamberlain, Luke (Principal Investigator) Pickard, Ben (Co-investigator) Allan Cockerill, Jack (Post Grad Student)
- 01-Jan-2023 - 30-Jan-2026
- S-Acylation of transmembrane proteins in the early secretory pathway
- Chamberlain, Luke (Principal Investigator)
- 01-Jan-2023 - 31-Jan-2026
- DTP 2224 University of Strathclyde | Campbell, Iona
- Chamberlain, Luke (Principal Investigator) Pickard, Ben (Co-investigator) Campbell, Iona (Research Co-investigator)
- 01-Jan-2022 - 01-Jan-2026
- Targeting The ZDHHC9-Gcp16 Interaction As A Novel Therapeutic Strategy In Cancer And Neurological Disorders
- Chamberlain, Luke (Principal Investigator) Tomkinson, Nick (Co-investigator)
- 01-Jan-2021 - 30-Jan-2025
- SPRINT: A SuPer-Resolution time-resolved ImagiNg and specTroscopy facility for rapid biomolecular analysis
- Li, David (Principal Investigator) Chamberlain, Luke (Co-investigator) Chen, Yu (Co-investigator) Cunningham, Margaret Rose (Co-investigator) Gould, Gwyn (Co-investigator) Hoskisson, Paul (Co-investigator) McConnell, Gail (Co-investigator) Rattray, Zahra (Co-investigator) Van de Linde, Sebastian (Co-investigator)
- 01-Jan-2021 - 31-Jan-2023
- GlasBioPhys: An integrated facility for the analysis of biomolecular interactions (19ALERT Mid-range equipment initiative)
- Burley, Glenn (Principal Investigator) Chamberlain, Luke (Co-investigator) Faulds, Karen (Co-investigator) Hoskisson, Paul (Co-investigator)
- 11-Jan-2020 - 09-Jan-2021
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Contact
Professor
Luke
Chamberlain
Strathclyde Institute of Pharmacy and Biomedical Sciences
Email: luke.chamberlain@strath.ac.uk
Tel: 548 3719