Dr Yu Chen

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Physics

Personal statement

Dr. Yu Chen received her PhD from Birmingham University in nanoscale physics in 2000 and subsequently was appointed to a lectureship in molecular nanometrology at Strathclyde University in 2007 funded by an EPSRC Science and Innovation Award. She is a fellow of the Royal Microscopical Society, a member of the European Microscopy Society, the Institute of Physics, the American Chemical Society, and the Nanotechnology Knowledge Transfer Network. She serves as an expert panel member for the European Cooperation in Science and Technology, a referee for top international journals, an invited speaker and a committee member for a number of international conferences and workshops.

Dr Chen’s main research activities lie in the creation and characterization of nanoscale structures for their unique physical and chemical properties, utilizing both optical and electron microscopy and spectroscopy. Her recent research in Photophysics Group focuses on surface plasmon enhanced effect, including two-photon luminescence, energy transfer and SERRS from noble metal nanoparticles, arrays and porous media, with strong links to biomedical imaging and sensing, as well as nanoparticle-cell interaction and cytotoxicity. Other work includes 3D visualization of nanoparticles, stability of Au nanoparticles, and creating nanostructures using chemical lithography and direct writing.

Publications

Lysozyme encapsulated gold nanoclusters for probing the early stage of lysozyme aggregation under acidic conditions
Alkudaisi Nora, Russell Ben Allan, Birch David J S, Chen Yu
Journal of Photochemistry and Photobiology B: Biology Vol 197 (2019)
https://doi.org/10.1016/j.jphotobiol.2019.111540
Synthesis of small gold nanorods and their subsequent functionalization with hairpin single stranded DNA
Mbalaha Zendesha S, Edwards Paul R, Birch David JS, Chen Yu
ACS Omega Vol 4, pp. 13740-13746 (2019)
https://doi.org/10.1021/acsomega.9b01200
Critical role of tyrosine-20 in formation of gold nanoclusters within lysozyme : a molecular dynamics study
Russell Ben A, Kubiak-Ossowska Karina, Chen Yu, Mulheran Paul A
Physical Chemistry Chemical Physics Vol 21, pp. 4907-4911 (2019)
https://doi.org/10.1039/C8CP06374E
Detecting Lysozyme unfolding via the fluorescence of Lysozyme encapsulated gold nanoclusters
Alkudaisi Nora, Russell Ben A, Jachimska Barbara, Birch David J S, Chen Yu
Journal of Materials Chemistry B, pp. 1-10 (2019)
Polyallylamine hydrochloride coating enhances the fluorescence emission of human serum albumin encapsulated gold nanoclusters
Russell Ben Allan, Jachimska Barbara, Chen Yu
Journal of Photochemistry and Photobiology B: Biology Vol 187, pp. 131-135 (2018)
https://doi.org/10.1016/j.jphotobiol.2018.08.018
Sudlow site II of human serum albumin remains functional after gold nanocluster encapsulation : a fluorescence-based drug binding study of L-Dopa
Russell Ben A, Garton Ashley, Alshammari Abeer Saeed, Birch David J S, Chen Yu
Methods and Applications in Fluorescence Vol 6 (2018)
https://doi.org/10.1088/2050-6120/aacdee

more publications

Professional activities

Invited editor for a book to the Nanoscience and Nanotechnology Book Series published by the Royal Society of Chemistry
Guest editor
2011
5th international conference on bioinformatics and miomedical engineering
Organiser
2011
FluoroFest
Invited speaker
2010
International Communication Association Annual Conference 2014
Invited speaker
2010
Expert in Round Table Group, Washington, DC, USA
Advisor
2010
European Cooperation in Science and Technology (External organisation)
Advisor
2010

more professional activities

Projects

A new tool for rapid RNA detection in single cells_pathfinder
Chen, Yu (Principal Investigator)
08-Jan-2019 - 07-Jan-2019
Smart flow cytometry for cancer diagnosis using silicon single-photon sensors and nanoprobes
Li, David (Principal Investigator) Chen, Yu (Research Co-investigator) Xiao, Dong (Researcher)
01-Jan-2018 - 30-Jan-2022
Doctoral Training Partnership (DTP 2016-2017 University of Strathclyde) | Adelt, Milan
Chen, Yu (Principal Investigator) Birch, David (Co-investigator) Adelt, Milan (Research Co-investigator)
01-Jan-2017 - 01-Jan-2021
New Application of a DNA-nanorod Platform for Vaccine Development
Yu, Jun (Principal Investigator) Chen, Yu (Co-investigator) Roberts, Craig (Co-investigator)
01-Jan-2017 - 30-Jan-2018
Fluorescent mRNA nanoprobes for rapid cancer detection: Application to single cells and clinical trials
Chen, Yu (Principal Investigator)
01-Jan-2017 - 31-Jan-2020
UK Quantum Technology Hub in Quantum Enhanced Imaging (Quantic) / R140296-202
Birch, David (Principal Investigator) Chen, Yu (Co-investigator) Li, David (Co-investigator)
01-Jan-2014 - 30-Jan-2019

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