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Dr Paul Coats

Lecturer

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Studying how the human body works helps us to understand the many processes that maintain health and find better treatment for diseases. Through excellent research and teaching we can make a difference to future populations by improving our knowledge of health and disease.

Cardiovascular disease is particularly interesting; Heart and vascular health is fundamental to healthy living but nonetheless remains the greatest disease burden in the developed western world and remains a challenging area in biology.

Heart attack, stroke and peripheral vascular disease are all driven by changes in vascular structure and function. The study of blood vessels and blood vessel cell biology in health and disease are central my research groups activity.

Working with colleagues within SIPBS (Biology, Pharmacology, Formulation, Drug Delivery, Pharmacy Practice) and within the wider research community within the University of Strathclyde (Chemistry, Bio-Engineering) ensures our collaborative research work is exciting and truly focusing on real clinical needs.  

Expertise

Has expertise in:

    • Vascular organ bath pharmacology
    • Pressure Myography
    • Primary cell culture
    • Vascular Imaging
    • Novel drug delivery 

Publications

Mitochondria has a role in regulating hypoxic-dependent cell proliferation in pulmonary cells and vascular remodelling
Coats P, Plevin R, Burzangi A
British Heart Journal Vol 103, pp. A6-A7, (2017)
http://dx.doi.org/10.1136/heartjnl-2017-311433.14
Mitochondrial regulation of exosomal transported miRNA play a central role in vascular smooth muscle cell proliferation and migration associated with atherogenesis and re-stenosis
Al Sulti Zuhair, Coats Paul
British Heart Journal Vol 103, pp. A1-A1, (2017)
http://dx.doi.org/10.1136/heartjnl-2017-311433.1
The effect of hypoxic mediated pro-mitogenic signalling pro-mitogenic signalling associated with vein graft failure and vascular remodelling
Huq Molly, Currie Susan, Coats Paul
British Heart Journal Vol 103, pp. A7, (2017)
http://dx.doi.org/10.1136/heartjnl-2017-311433.15
Adventitial ablation technique that permits the assessment of adventitial-dependent contribution to microvascular contractile function
Zainalabidin Satirah, Wadsworth Roger M., Coats Paul
Analytical Biochemistry Vol 499, pp. 71-77, (2016)
http://dx.doi.org/10.1016/j.ab.2016.01.009
Improving arteriovenous fistula patency : transdermal delivery of diclofenac reduces cannulation-dependent neointimal hyperplasia via AMPK activation
MacAskill Mark G., Watson David G., Ewart Marie-Ann, Wadsworth Roger, Jackson Andrew, Aitken Emma, MacKenzie Graeme, Kingsmore David, Currie Susan, Coats Paul
Vascul Pharmacol Vol 71, pp. 108-115, (2015)
http://dx.doi.org/10.1016/j.vph.2015.02.012
Hypoxia mediated signalling in vein graft remodelling and failure
Huq M, Currie S, Coats P
British Heart Journal Vol 100, (2014)
http://dx.doi.org/10.1136/heartjnl-2014-306916.16

more publications

Research interests

Dr Paul Coats is an active researcher within cardiovascular research in SIPBS. His research focus is vascular physiology (health) and pathophysiology (disease). The studies of both large and small blood vessels are core to the research directed by Dr Paul Coats.

Specific research work:

  • Role of reactive oxygen species in modulating acute vascular contractile responses in the microcirculation
  • Effect of chronic ischaemic vascular disease on blood vessel structure and function
  • Identifying mechanisms of vascular restenosis in response to stent insertion or balloon angioplasty
  • Mechanisms underlying arteriovenous fistula (AVF) stenosis that occurs in people undergoing renal dialysis 

Projects

BBSRC Doctoral Training Grant (DTG) | MacAskill, Mark
Coats, Paul (Principal Investigator) Currie, Susan (Co-investigator)
Period 01-Oct-2010 - 08-Apr-2014
E-Health Informatics Research Centre | Wyper, Grant Mark Andrew
Bennie, Marion (Principal Investigator) Coats, Paul (Co-investigator) Wyper, Grant Mark Andrew (Research Co-investigator)
Period 01-Oct-2014 - 01-Jul-2018
Biodegradeable dynamic drug delivery systems
Coats, Paul (Principal Investigator)
Period 01-Dec-2014 - 30-Sep-2015
Vein graft success depends on tissue hypoxia modulating TLR and PLC gamma
Coats, Paul (Principal Investigator)
Period 01-Oct-2011 - 30-Sep-2016
Regulation of angiogenesis in a human model of perpheral vascular disease
Coats, Paul (Principal Investigator)
Period 01-Aug-2004 - 31-Jul-2008
Oxidant-dependant mechanisms of microvascular tone in health and critical limb ischemia
Coats, Paul (Principal Investigator)
Period 01-Aug-2004 - 01-Aug-2007

more projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Hamnett Wing John Arbuthnott Building

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