Dr Paul Coats
Lecturer
Strathclyde Institute of Pharmacy and Biomedical Sciences
Personal statement
Studying how the human body works helps us to understand the many processes that maintain health and find better treatment for diseases. Through excellent research and teaching we can make a difference to future populations by improving our knowledge of health and disease.
Cardiovascular disease is particularly interesting; Heart and vascular health is fundamental to healthy living but nonetheless remains the greatest disease burden in the developed western world and remains a challenging area in biology.
Heart attack, stroke and peripheral vascular disease are all driven by changes in vascular structure and function. The study of blood vessels and blood vessel cell biology in health and disease are central my research groups activity.
Working with colleagues within SIPBS (Biology, Pharmacology, Formulation, Drug Delivery, Pharmacy Practice) and within the wider research community within the University of Strathclyde (Chemistry, Bio-Engineering) ensures our collaborative research work is exciting and truly focusing on real clinical needs.
Area of Expertise
- Vascular organ bath pharmacology
- Pressure Myography
- Primary cell culture
- Vascular Imaging
- Novel drug delivery
Prize And Awards
- Teaching Excellence Award
- Recipient
- 2020
Publications
- Biological performance of electrospun polymer fibres
- Hall Barrientos Ivan Joseph, MacKenzie Graeme R, Wilson Clive G, Lamprou Dimitrios A, Coats Paul
- Materials Vol 12 (2019)
- https://doi.org/10.3390/ma12030363
- Untargeted metabolic profiling cell-based approach of pulmonary artery smooth muscle cells in response to high glucose and the effect of the antioxidant vitamins D and E
- Alamri Abdulwahab, Burzangi Abdulhadi S, Coats Paul, Watson David G
- Metabolites Vol 8 (2018)
- https://doi.org/10.3390/metabo8040087
- Mitochondria has a role in regulating hypoxic-dependent cell proliferation in pulmonary cells and vascular remodelling
- Coats P, Plevin R, Burzangi A
- Heart Vol 103, pp. A6-A7 (2017)
- https://doi.org/10.1136/heartjnl-2017-311433.14
- Mitochondrial regulation of exosomal transported miRNA play a central role in vascular smooth muscle cell proliferation and migration associated with atherogenesis and re-stenosis
- Al Sulti Zuhair, Coats Paul
- Heart Vol 103, pp. A1-A1 (2017)
- https://doi.org/10.1136/heartjnl-2017-311433.1
- The effect of hypoxic mediated pro-mitogenic signalling pro-mitogenic signalling associated with vein graft failure and vascular remodelling
- Huq Molly, Currie Susan, Coats Paul
- Heart Vol 103, pp. A7 (2017)
- https://doi.org/10.1136/heartjnl-2017-311433.15
- Adventitial ablation technique that permits the assessment of adventitial-dependent contribution to microvascular contractile function
- Zainalabidin Satirah, Wadsworth Roger M, Coats Paul
- Analytical Biochemistry Vol 499, pp. 71-77 (2016)
- https://doi.org/10.1016/j.ab.2016.01.009
Research Interests
Dr Paul Coats is an active researcher within cardiovascular research in SIPBS. His research focus is vascular physiology (health) and pathophysiology (disease). The studies of both large and small blood vessels are core to the research directed by Dr Paul Coats.
Specific research work:
- Role of reactive oxygen species in modulating acute vascular contractile responses in the microcirculation
- Effect of chronic ischaemic vascular disease on blood vessel structure and function
- Identifying mechanisms of vascular restenosis in response to stent insertion or balloon angioplasty
- Mechanisms underlying arteriovenous fistula (AVF) stenosis that occurs in people undergoing renal dialysis
Projects
- Prevention of CXCL12 production in cells of the cardiovascular system by IKK alpha inhibition (BHF PhD Studentship)
- Plevin, Robin (Principal Investigator) Coats, Paul (Co-investigator) MacKay, Simon (Co-investigator) Paul, Andrew (Co-investigator)
- 01-Oct-2018 - 30-Mar-2022
- Biomedical Vacation Scholarships
- Coats, Paul (Principal Investigator) Jiang, Hui-Rong (Principal Investigator) Lawrence, Catherine (Principal Investigator) McDonald, James (Principal Investigator) Pickard, Ben (Principal Investigator)
- 09-Jul-2018 - 31-Aug-2018
- Biomedical Vacation Scholarships / R180191-4
- Coats, Paul (Principal Investigator)
- 18-Jun-2018 - 27-Jul-2018
- Biodegradeable dynamic drug delivery systems
- Coats, Paul (Principal Investigator)
- 01-Dec-2014 - 30-Sep-2015
- Imaging changes in mitochondrial architecture and mobility in vascular disease
- McCarron, John (Principal Investigator) Chalmers, Susan (Co-investigator) Coats, Paul (Co-investigator)
- 06-Feb-2012 - 30-Jul-2015
- Vein graft success depends on tissue hypoxia modulating TLR and PLC gamma
- Coats, Paul (Principal Investigator) Wadsworth, Roger (Co-investigator)
- 01-Oct-2011 - 30-Sep-2016
Contact
Dr
Paul
Coats
Lecturer
Strathclyde Institute of Pharmacy and Biomedical Sciences
Email: paul.coats@strath.ac.uk
Tel: 548 5790