Dr Paul Coats

Lecturer

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Studying how the human body works helps us to understand the many processes that maintain health and find better treatment for diseases. Through excellent research and teaching we can make a difference to future populations by improving our knowledge of health and disease.

Cardiovascular disease is particularly interesting; Heart and vascular health is fundamental to healthy living but nonetheless remains the greatest disease burden in the developed western world and remains a challenging area in biology.

Heart attack, stroke and peripheral vascular disease are all driven by changes in vascular structure and function. The study of blood vessels and blood vessel cell biology in health and disease are central my research groups activity.

Working with colleagues within SIPBS (Biology, Pharmacology, Formulation, Drug Delivery, Pharmacy Practice) and within the wider research community within the University of Strathclyde (Chemistry, Bio-Engineering) ensures our collaborative research work is exciting and truly focusing on real clinical needs.

Expertise

Has expertise in:

Vascular organ bath pharmacology
Pressure Myography
Primary cell culture
Vascular Imaging
Novel drug delivery

Prizes and awards

Teaching Excellence Award: Recipient; 2020

More prizes and awards

Publications

Biological performance of electrospun polymer fibres: Hall Barrientos Ivan Joseph, MacKenzie Graeme R, Wilson Clive G, Lamprou Dimitrios A, Coats Paul; Materials Vol 12 (2019); https://doi.org/10.3390/ma12030363
Untargeted metabolic profiling cell-based approach of pulmonary artery smooth muscle cells in response to high glucose and the effect of the antioxidant vitamins D and E: Alamri Abdulwahab, Burzangi Abdulhadi S, Coats Paul, Watson David G; Metabolites Vol 8 (2018); https://doi.org/10.3390/metabo8040087
Mitochondrial regulation of exosomal transported miRNA play a central role in vascular smooth muscle cell proliferation and migration associated with atherogenesis and re-stenosis: Al Sulti Zuhair, Coats Paul; Heart Vol 103, pp. A1-A1 (2017); https://doi.org/10.1136/heartjnl-2017-311433.1
Mitochondria has a role in regulating hypoxic-dependent cell proliferation in pulmonary cells and vascular remodelling: Coats P, Plevin R, Burzangi A; Heart Vol 103, pp. A6-A7 (2017); https://doi.org/10.1136/heartjnl-2017-311433.14
The effect of hypoxic mediated pro-mitogenic signalling pro-mitogenic signalling associated with vein graft failure and vascular remodelling: Huq Molly, Currie Susan, Coats Paul; Heart Vol 103, pp. A7 (2017); https://doi.org/10.1136/heartjnl-2017-311433.15
Adventitial ablation technique that permits the assessment of adventitial-dependent contribution to microvascular contractile function: Zainalabidin Satirah, Wadsworth Roger M, Coats Paul; Analytical Biochemistry Vol 499, pp. 71-77 (2016); https://doi.org/10.1016/j.ab.2016.01.009

More publications

Research interests

Dr Paul Coats is an active researcher within cardiovascular research in SIPBS. His research focus is vascular physiology (health) and pathophysiology (disease). The studies of both large and small blood vessels are core to the research directed by Dr Paul Coats.

Specific research work:

Role of reactive oxygen species in modulating acute vascular contractile responses in the microcirculation
Effect of chronic ischaemic vascular disease on blood vessel structure and function
Identifying mechanisms of vascular restenosis in response to stent insertion or balloon angioplasty
Mechanisms underlying arteriovenous fistula (AVF) stenosis that occurs in people undergoing renal dialysis

Projects

Prevention of CXCL12 production in cells of the cardiovascular system by IKK alpha inhibition (BHF PhD Studentship): Plevin, Robin (Principal Investigator) Coats, Paul (Co-investigator) MacKay, Simon (Co-investigator) Paul, Andrew (Co-investigator); 01-Jan-2018 - 30-Jan-2022
Biomedical Vacation Scholarships: Coats, Paul (Principal Investigator) Jiang, Hui-Rong (Principal Investigator) Lawrence, Catherine (Principal Investigator) McDonald, James (Principal Investigator) Pickard, Ben (Principal Investigator); 09-Jan-2018 - 31-Jan-2018
Biomedical Vacation Scholarships / R180191-4: Coats, Paul (Principal Investigator); 18-Jan-2018 - 27-Jan-2018
Biodegradeable dynamic drug delivery systems: Coats, Paul (Principal Investigator); 01-Jan-2014 - 30-Jan-2015
Imaging changes in mitochondrial architecture and mobility in vascular disease: McCarron, John (Principal Investigator) Chalmers, Susan (Co-investigator) Coats, Paul (Co-investigator); 06-Jan-2012 - 30-Jan-2015
Vein graft success depends on tissue hypoxia modulating TLR and PLC gamma: Coats, Paul (Principal Investigator) Wadsworth, Roger (Co-investigator); 01-Jan-2011 - 30-Jan-2016

More projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Hamnett Wing

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