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Dr Margaret Rose Cunningham

Strathclyde Chancellor'S Fellow

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Chancellor’s Research Fellow and Lecturer in Pharmacology, Haematology and Drug Discovery

  • Winston Churchill Memorial Trust Fellow, 2018

  • Academy of Medical Sciences Springboard Awardee, 2016-present

  • Postgraduate Diploma in Academic Practice, University of Strathclyde, 2015-2017

  • Fellow of the Higher Education Academy (HEA), 2016

  • British Heart Foundation PDRA in the Bristol Platelet Group, University of Bristol, 2010-2014

  • AJ Clark PhD Studentship in Pharmacology, University of Strathclyde, 2006-2010

  • First Class BSc (Hons) Biochemistry and Pharmacology, University of Strathclyde, 2004-2006

  • Research Technician in Cardiovascular Research, University of Glasgow, 1999-2004

 

My field of expertise is G protein-coupled receptor (GPCR) regulation and function in health and disease.  My research area broadly spans understanding the molecular mechanisms of GPCR involvement in the processes that underpin platelet function, anti-cancer cardiotoxicity, inflammation and pain. 

I am the Editor-in-Chief of Pharmacology Matters  and sit on the editorial board for Pharmacology Research & Perspectives journal.

Improving attainment, participation and engagement in science is very important to me therefore I mentor students as part of the Social Mobility Foundation and Widening Access at University of Strathclyde. I am a keen advocate of enhancing STEM education in primary and secondary schools. 

 

 

Publications

Anti-cancer tyrosine kinase inhibitors increase oxidative stress in primary cardiac fibroblasts
McMullen CJ, McCluskey C, Kim SJ, Laovitthayanggoon S, MacDonald M, Safar M, Wood R, Cunningham MR, Currie S
British Heart Journal Vol 104, (2018)
http://dx.doi.org/10.1136/heartintjnl-2018-SCF22
Conflicting evidence for the role of JNK as a target in breast cancer cell proliferation : comparisons between pharmacological inhibition and selective shRNA knockdown approaches
Wood Rachel A., Barbour Mark J., Gould Gwyn W., Cunningham Margaret R., Plevin Robin J.
Pharmacology Research & Perspectives Vol 6, (2018)
http://dx.doi.org/10.1002/prp2.376
Editorial for Pharmacology Matters
Cunningham Margaret
Pharmacology Matters Vol 10, (2017)
Protease-activated receptor 4 variant p.Tyr157Cys reduces platelet functional responses and alters receptor trafficking
Norman Jane E., Cunningham Margaret R., Jones Matthew L., Walker Mary E., Westbury Sarah K., Sessions Richard B., Mundell Stuart J., Mumford Andrew D.
Arteriosclerosis, Thrombosis, and Vascular Biology Vol 36, pp. 952-960, (2016)
http://dx.doi.org/10.1161/ATVBAHA.115.307102
Proteinase-activated receptors (PARs) as targets for antiplatelet therapy
Cunningham Margaret, McIntosh Kathryn, Bushell Trevor, Sloan Graeme, Plevin Robin
Biochemical Society Transactions Vol 44, pp. 606-612, (2016)
http://dx.doi.org/10.1042/BST20150282
Protease-activated receptor 2 : are common functions in glial and immune cells linked to inflammation-related CNS disorders?
Bushell Trevor J., Cunningham Margaret R., McIntosh Kathryn A., Moudio Serge, Plevin Robin
Current Drug Targets Vol 17, pp. 1861-1870, (2016)
http://dx.doi.org/10.2174/1389450117666151209115232

more publications

Teaching

I am a lecturer for Undergraduate Year 3 BM324 and BM327 Fundamentals of Pharmacology classes and support the delivery of lectures for BM933 Postgraduate Studies in Haematology and BM937 Postgraduate Studies in Drug Discovery modules.

My laboratory welcomes placements as part of the Erasmus programme so please contact me for further information and details of project opportunities available. 

I actively engage with primary and secondary schools to help devise and deliver their STEM-related activities and participate in their career carousel events. 

 

Research interests

My research is highly collaborative and multidisciplinary with ongoing projects in my laboratory including:

 

I have an open-door policy and offer a supportive environment for highly motivated students to progress in their studies and develop their research skills. 

 

I welcome all informal enquiries to discuss potential opportunities to join my research team!

 

*Lab group website in development

 

Professional activities

Pharmacology Matters (Journal)
Editor
1/7/2017
The Academy of Medical Sciences (AMS) - Shaping your career in research
Invited speaker
6/6/2017
Lennox Primary Career Week
Contributor
4/2017
The Royal Society Engaging with Schools Programme
Participant
2/3/2017
20th Scottish Cardiovascular Forum
Participant
4/2/2017
The Biochemical Society - Engaging with outreach: funding opportunities for schools
Invited speaker
6/1/2017

more professional activities

Projects

AWERB 3Rs grant 2016
Cunningham, Margaret Rose (Co-investigator) Currie, Susan (Principal Investigator)
Period 01-Aug-2016
BPS Vacation Studentship - Investigating biophysical interactions of PAR inhibitors at the cell membrane using Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS)
Cunningham, Margaret Rose (Principal Investigator)
Period 26-Jun-2017 - 01-Sep-2017
The role of gelsolin family proteins in GPCR regulation
Cunningham, Margaret Rose (Principal Investigator)
Period 01-Sep-2015 - 01-Jun-2016
A multi-disciplinary approach to thrombin receptor research - A focus on the interrogation of the Proteinase-activated Receptor 4 (PAR4) interactome
Cunningham, Margaret Rose (Principal Investigator)
Period 01-Aug-2016 - 31-Jul-2018
Using proteomics to study novel function-disrupting PAR4 variants harboured in patient cohorts with platelet dysfunction
Cunningham, Margaret Rose (Principal Investigator)
Period 01-Jun-2015 - 29-Feb-2016

more projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Hamnett Wing John Arbuthnott Building

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