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Dr Margaret Rose Cunningham

Strathclyde Chancellor'S Fellow

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Chancellor’s Research Fellow and Lecturer in Pharmacology, Haematology and Drug Discovery

  • RSE Young Academy of Scotland elected member, 2018
  • Ingenious & Enterprising Women Scotland member, 2018
  • Winston Churchill Memorial Trust Fellow, 2018
  • Editor-in-Chief of Pharmacology Matters magazine, 2017-present
  • Postgraduate Diploma in Academic Practice, University of Strathclyde, 2017
  • Academy of Medical Sciences Springboard Awardee, 2016-present
  • Fellow of the Higher Education Academy (HEA), 2016
  • British Heart Foundation PDRA in the Bristol Platelet Group, University of Bristol, 2010-2014
  • AJ Clark PhD Studentship in Pharmacology, University of Strathclyde, 2006-2010
  • First Class BSc (Hons) Biochemistry and Pharmacology, University of Strathclyde, 2004-2006
  • Laboratory Technician in Cardiovascular Research, University of Glasgow, 1999-2004

 

My field of expertise is G protein-coupled receptor (GPCR) regulation and function in health and disease.  My research area broadly spans understanding the molecular mechanisms of GPCR involvement in the processes that underpin platelet function, anti-cancer cardiotoxicity, inflammation and pain.  I am a member of the SIPBS Cellular Basis of Disease  (CBD) Research Group and I co-lead the Cardiovascular and Metabolic Diseases sub-group with Dr Susan Currie.

 

I am the Editor-in-Chief of Pharmacology Matters  magazine and sit on the editorial board for Pharmacology Research & Perspectives journal.

 

Improving attainment, participation and engagement in science is very important to me therefore I mentor students as part of the Social Mobility Foundation and the Strathclyde Cares Widening Access at University of Strathclyde. I am a keen advocate of enhancing STEM education in primary and secondary schools and sit on the University of Strathclyde and SIPBS Outreach committees.  I am a member of the SIPBS Athena SWAN Self-Assessment Team where I lead on the Career Progression working group for training and form part of the Organisation, Culture and Communication working group.          

 

 

Publications

CaMKIIδ interacts directly with IKKβ and modulates NF-kB signalling in adult cardiac fibroblasts
Martin Tamara P., McCluskey Claire, Cunningham Margaret R., Beattie James, Paul Andrew, Currie Susan
Cellular Signalling, (2018)
http://dx.doi.org/10.1016/j.cellsig.2018.07.008
Anti-cancer tyrosine kinase inhibitors increase oxidative stress in primary cardiac fibroblasts
McMullen CJ, McCluskey C, Kim SJ, Laovitthayanggoon S, MacDonald M, Safar M, Wood R, Cunningham MR, Currie S
British Heart Journal Vol 104, (2018)
http://dx.doi.org/10.1136/heartintjnl-2018-SCF22
Conflicting evidence for the role of JNK as a target in breast cancer cell proliferation : comparisons between pharmacological inhibition and selective shRNA knockdown approaches
Wood Rachel A., Barbour Mark J., Gould Gwyn W., Cunningham Margaret R., Plevin Robin J.
Pharmacology Research & Perspectives Vol 6, (2018)
http://dx.doi.org/10.1002/prp2.376
Editorial for Pharmacology Matters
Cunningham Margaret
Pharmacology Matters Vol 10, (2017)
Protease-activated receptor 4 variant p.Tyr157Cys reduces platelet functional responses and alters receptor trafficking
Norman Jane E., Cunningham Margaret R., Jones Matthew L., Walker Mary E., Westbury Sarah K., Sessions Richard B., Mundell Stuart J., Mumford Andrew D.
Arteriosclerosis, Thrombosis, and Vascular Biology Vol 36, pp. 952-960, (2016)
http://dx.doi.org/10.1161/ATVBAHA.115.307102
Proteinase-activated receptors (PARs) as targets for antiplatelet therapy
Cunningham Margaret, McIntosh Kathryn, Bushell Trevor, Sloan Graeme, Plevin Robin
Biochemical Society Transactions Vol 44, pp. 606-612, (2016)
http://dx.doi.org/10.1042/BST20150282

more publications

Teaching

I am a lecturer for Undergraduate Year 3 BM322 Biomedical Pharmacology, BM324 and BM327 Fundamentals of Pharmacology classes and support the delivery of lectures for BM933 Advanced studies in Haematology and BM937 Advanced topics in Biomedical research.  I also provide laboratory based research projects as part of BM432 and BM906.

I coordinate and deliver the Organisational and Staff Development Unit (OSDU) Research Bidding and Design - Getting Started class with Dr Emma Compton-Daw and Dr Katherine Duncan to help support early career researchers with grantmanship. 

My laboratory welcomes placements as part of the Erasmus programme so please contact me for further information and details of project opportunities available. 

I actively engage with primary and secondary schools to help devise and deliver their STEM-related activities and participate in their career carousel events. I offer work experience to secondary school students to give them a taste of laboratory life.    

Research interests

My research is highly collaborative and multidisciplinary with ongoing projects in my laboratory including:

 

I have an open-door policy and offer a supportive environment for highly motivated students to progress in their studies and develop their research skills. 

 

I welcome all informal enquiries to discuss potential opportunities to join my research team!

 

*Lab group website in development

 

Professional activities

Young Life Scientists Symposium
Organiser
1/6/2018
Career pathways in Science - Biology Week
Presenter
10/2017

more professional activities

Projects

The Biochemical Society Summer Vacation Studentship: Project ‘The role of PAR4 in EAE models of Multiple Sclerosis’
Barbour, Mark (Principal Investigator) Cunningham, Margaret Rose (Academic) Jiang, Hui-Rong (Academic)
PI: Dr Rachel Wood, Co-applicants: Dr Mark Barbour, Dr Margaret Cunningham and Dr Hui-Rong Jiang £1600, 2018
Student: Mr Ryan McEwan
Period 01-Jun-2018 - 31-Jul-2018
'Young Life Scientists' Symposium - Molecular Neuropharmacology in Health and Wellbeing’
Cunningham, Margaret Rose (Academic)
YLS Symposia organization ‘Molecular Neuropharmacology in Health and Wellbeing’ in collaboration with University of Glasgow, Biochemical Society, The Physiological Society, British Pharmacological Society hosted at the Strathclyde Technology and Innovation Centre on Thursday 19th November (£3000, 2018).

Organisation Committee:
Dr Margaret Rose Cunningham (UoS)
Dr Mark Barbour (UoS)
Dr Rachel Wood (UoS)
Mr Moa Safar (UoS, PhD candidate)

Dr Sophie Bradley (UoG)
Dr Mario Rossi (UoG)
Ms Sarah Hesse (UoG, PhD candidate)
Ms Miriam Scarpa (UoG, PhD candidate)
Period 01-Jun-2018 - 15-Nov-2018
British Society for Cell Biology Vacation Studentship - Investigating the cellular complexity of drug-induced cardiotoxicity by fingerprinting single cell mass spectral information using ToF-SIMS
Cunningham, Margaret Rose (Principal Investigator) Chrubasik, Michael (Researcher)
Period 25-Jun-2018 - 18-Aug-2018
Winston Churchill Memorial Fellowship
Cunningham, Margaret Rose (Principal Investigator)
The aim of the project is to establish firm and authentic contacts with numerous educational institutions world-wide to create a hub of primary and secondary schools across different continents that can digitally collaborate to form a global STEM club. I already have existing professional connections in North & South America, Africa and Europe, therefore this fellowship seeka to develop ties to STEM ambassadors in schools in Asia and Australasia, namely Japan and Australia respectively. In doing so I hope to: 1. Work with new ambassadors to share ideas on STEM outreach to gain insight into their best practices and how they strive to achieve equity in attainment in their local area. 2. Create a Wikispace classroom to host and organise collaborative interschool activities. 3. Establish a global network for schools in the West Dunbartonshire area to foster knowledge exchange (STEM or otherwise) 4. Communicate progress via school blogs, learned societies and publication.
Period 01-Apr-2018 - 31-Mar-2019
AWERB 3Rs grant 2016
Cunningham, Margaret Rose (Co-investigator) Currie, Susan (Principal Investigator)
Period 01-Aug-2016
BPS Vacation Studentship - Investigating biophysical interactions of PAR inhibitors at the cell membrane using Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS)
Cunningham, Margaret Rose (Principal Investigator)
Period 26-Jun-2017 - 01-Sep-2017

more projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Hamnett Wing John Arbuthnott Building

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