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Dr RuAngelie Edrada-Ebel

Senior Lecturer

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Dr Edrada-Ebel currently heads the Natural Products Metabolomics Group (NPMG) and is currently author of more than 100 publications and two patents on the topic marine natural products. She referees articles on marine natural products on more than 10 peer-reviewed journals and is a member of the editorial board for Marine Drugs. Her expertise comprises both natural products isolation and structure elucidation with modern spectroscopic techniques. At present, she has a series of on-going projects on the application of metabolomics to identify and biotechnologically optimize the production of bioactive secondary metabolites in marine-derived microorganisms.

Publications

Isolation of petrocidin A, a new cytotoxic cyclic dipeptide from the marine sponge-derived bacterium Streptomyces sp. SBT348
Cheng Cheng, Othman Eman M., Stopper Helga , Edrada-Ebel RuAngelie, Hentschel Ute, Abdelmohsen Usama Ramadan
Marine Drugs Vol 15, (2017)
http://dx.doi.org/10.3390/md15120383
Metabolomics-coupled functional pharmacology of chlorophyll compounds isolated from the leaves of Ficus Exasperata Vahl (Moraceae) provides novel pathways on myometrial activity
Bafor Enitome E., Rowan Edward G., Edrada-Ebel RuAngelie
Reproductive Sciences, (2017)
http://dx.doi.org/10.1177/1933719117732159
P43 The isolation and purification of bioactive metabolites from Ficus carica and their neuroprotective effects in Alzheimer's disease
Khojah Hanan, Edrada-Ebel RuAngelie
Biochemical Pharmacology Vol 139, pp. 140, (2017)
http://dx.doi.org/10.1016/j.bcp.2017.06.044
Characterisation of the antiproliferative constituents and activity of Ficus exasperata (Vahl) on ovarian cancer cells – a preliminary investigation
Bafor Enitome E., McKenna Jennifer, Rowan Edward G., Edrada-Ebel RuAngelie
Natural Product Letters Vol 31, pp. 2164-2168, (2017)
http://dx.doi.org/10.1080/14786419.2016.1277348
Characterisation of sterol biosynthesis and validation of 14α-demethylase as a drug target in Acanthamoeba
Thomson Scott, Rice Christopher A., Zhang Tong, Edrada-Ebel RuAngelie, Henriquez Fiona L., Roberts Craig W.
Scientific Reports Vol 7, (2017)
http://dx.doi.org/10.1038/s41598-017-07495-z
Isolation, purification, and characterization of five active diketopiperazine derivatives from endophytic streptomyces SUK 25 with antimicrobial and cytotoxic activities
Alshaibani Muhanna M, Zin Noraziah, Jalil Juriyati, Sidik Nik M, Ahmad Siti Junaidah, Kamal Nurkhalida, Edrada-Ebel RuAngelie
Journal of Microbiology and Biotechnology Vol 27, pp. 1249-1256, (2017)
http://dx.doi.org/10.4014/jmb.1608.08032

more publications

Research interests

  • Metabolomics of microbial symbionts in collaboration with Prof. Ute Hentschel of the Sponge Microbiology Group at the University of Wuerzburg and partners with SeaBioTech, an FP-7 funded project.
  • Real Time Flux Modeling in Biopharmaceutical Bioprocessing, jointly co-funded by the BBSRC and the EPSRC, a collaborative research on metabolomics and fermentation work as well as further national collaborative work with Scottish medium-scale enterprises on the cultivation of marine microorganism. 
  • Metagenomic approach of optimizing the production of novel antibiotics from Streptomyces
  • Propolis project with Beevital exploring the anti-trypanosomal activity of the African Propolis collection
  • Ecological implications of the production of secondary metabolites in Crustaeceans and alternative application of utilising the waste products of the by-catch in collaboration with the Langoustine Laboratory, University of Glasgow.
  • Dereplication study and metabolomics of sponges and their endozooic microorganism obtained from the Irish and Celtic Sea (in collaboration with Prof. Alan Dobson, Environmental Research Institute, University College Cork)
  • Structure elucidation of biologically active secondary metabolites from sponges, tropical plants, and marine-derived fungi
  • Phytochemistry of biologically active secondary metabolites from tropical plants from Southeast Asia and Africa (in collaboration with Prof. Alan Harvey, SIDR)
  • Mass spectral analysis of marine-derived synthetic pyridinium polymers as novel anti-cancer drugs (in collaboration with Prof. Marcel Jaspars, University of Aberdeen)

Professional activities

Anticancer Potential of Selected Algae of Gulf of Mannar [South-East Coast of Indis]
External Examiner
15/12/2016
Metabolomics for Plant, Human, and Animal Health (2016)
Invited speaker
17/11/2016
Structure elucidation and biological investigation of novel serrulatane diterpenes from a propolis type sourced from Kangaroo Island
External Examiner
8/11/2016
International Conference on Herbal Medicine
Keynote/plenary speaker
6/10/2016
Postgraduate Workshop on Natural Products Metabolomics, Faculty Exchange programme
Invited speaker
12/9/2016
Metabolomics and dereplication-based isolation of novel bioactive natural products from marine sponge-associated actinomycetes
External Examiner
22/7/2016

more professional activities

Projects

Development of high-value compounds from Bacillus licheniformis
Edrada-Ebel, Ruangelie (Principal Investigator) Young, Louise (Co-investigator)
Period 01-Nov-2017 - 28-Feb-2018
Identification of pathway specific anti-cancer compounds from Scottish Marine Microbes
Edrada-Ebel, Ruangelie (Principal Investigator)
This agreement is applicable to only the original MATERIAL for the analyses of chemical contents of a series of research materials originating from Scotland.
Period 29-Nov-2016 - 28-Nov-2018
Potential novel antibiotics from microorganisms of under explored extreme marine habitats
Edrada-Ebel, Ruangelie (Principal Investigator)
Period 25-Jul-2016 - 24-Sep-2016
Escaping Bio-Assay Guided Isolation: Nature's Tools for Chemical Biology
Edrada-Ebel, Ruangelie (Principal Investigator)
Period 01-Sep-2015 - 31-Aug-2018
Comparative transcriptomic and metabolomic analysis of engineered bacteria
Tucker, Nicholas (Principal Investigator) Edrada-Ebel, Ruangelie (Co-investigator)
Analysis of industrial biotech strains produced by Ingenza
Period 18-Nov-2014 - 18-Nov-2015
Grace Reveleris Flash LSD
Edrada-Ebel, Ruangelie (Academic) Watson, David (Academic)
Period 01-Sep-2012

more projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Hamnett Wing John Arbuthnott Building

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