Dr Ruangelie Edrada-Ebel

Senior Lecturer

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Dr Edrada-Ebel currently heads the Natural Products Metabolomics Group (NPMG) and is currently author of more than 100 publications and two patents on the topic marine natural products. She referees articles on marine natural products on more than 10 peer-reviewed journals and is a member of the editorial board for Marine Drugs. Her expertise comprises both natural products isolation and structure elucidation with modern spectroscopic techniques. At present, she has a series of on-going projects on the application of metabolomics to identify and biotechnologically optimize the production of bioactive secondary metabolites in marine-derived microorganisms.

Prizes and awards

Thieme Award 2018 for the Most Innovative Planta Medica Original Paper
Recipient
6/7/2018
RMIT FOUNDATION INTERNATIONAL VISITING FELLOWSHIP
Recipient
1/11/2017

more prizes and awards

Qualifications

Positions Held:

2015 to date Senior Lecturer in Pharmaceutical Analysis, Strathclyde Institute of Pharmacy and Biomedical Sciences

2008 to 2014 Lecturer in Pharmaceutical Analysis, Strathclyde Institute of Pharmacy and Biomedical Sciences

2007 to 2008 NMR and MS Facility Manager, Strathclyde Institute of Pharmacy and Biomedical Sciences

2005 to 2007 Research Scientist (part-time), BioMar, Düsseldorf Life Science Centre

2001 to 2007 Senior Researcher and Instructor, Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine Universität Düsseldorf

1999 to 2001 Research Fellow (Post Doctorate), Department of Chemistry, University of California Santa Cruz

1998 to 1999 Research Fellow, Department of Chemistry and Biochemistry, University of Oklahoma

1989 to 1993 Instructor, College of Pharmacy, University of the Philippines

Educational Background: 

1994 – 1998  Doctorate degree in Pharmaceutical Biology, Julius Maximillians-University of Würzburg, Germany, Magna cum Laude, Dissertation: “Isolation and structure elucidation of bioactive secondary metabolites from Philippine marine sponges and soft corals.” Adviser:  Prof. Dr. Peter Proksch, Date of Graduation: 18 June 1998

1989 - 1992  Master of Science degree in Pharmacy, University of the Philippines, Manila, Philippines,  Thesis: “The biological and chemical investigation of the colored constituents of Kokoona ochracea (Elm) Merrill (Fam. Celastraceae).”

Publications

Morphological, genotypic and metabolomic signatures confirm interfamilial hybridization between the ubiquitous kelps Macrocystis (Arthrothamnaceae) and Lessonia (Lessoniaceae)
Murúa Pedro, Edrada-Ebel Ru Angelie, Muñoz Liliana, Soldatou Sylvia, Legrave Nathalie, Müller Dieter G, Patiño David J, can West Pieter, Küpper Frithjof C, Westermeier Renato, Ebel Rainer, Peters Akira F
Scientific Reports Vol 10 (2020)
https://doi.org/10.1038/s41598-020-65137-3
Metabolomic tools used in marine natural product drug discovery
Stuart Kevin Andrew, Welsh Keira, Walker Molly Clare, Edrada-Ebel RuAngelie
Expert Opinion on Drug Discovery Vol 15, pp. 499-522 (2020)
https://doi.org/10.1080/17460441.2020.1722636
Microbiome-derived carnitine mimics as previously unknown mediators of gut-brain axis communication
Hulme Heather, Meikle Lynsey M, Strittmatter Nicole, van der Hooft Justin J J, Swales John, Bragg Ryan A, Villar Victor H, Ormsby Michael J, Barnes Stephanie, Brown Sheila L, Dexter Alex, Kamat Maya T, Komen Jasper C, Walker Daniel, Milling Simon, Osterweil Emily K, MacDonald Andrew S, Schofield Chris J, Tardito Saverio, Bunch Josephine, Douce Gillian, Edgar Julia M, Edrada-Ebel RuAngelie, Goodwin Richard JA, Burchmore Richard, Wall Daniel M
Science Advances Vol 6 (2020)
https://doi.org/10.1126/sciadv.aax6328
Metabolomics-guided isolation of anti-trypanosomal compounds from endophytic fungi of the mangrove plant Avicennia lanata
Mazlan Noor Wini, Tate Rothwelle, Yusoff Yusnaini Md, Clements Carol, Edrada-Ebel RuAngelie
Current Medicinal Chemistry Vol 27, pp. 1815-1835 (2020)
https://doi.org/10.2174/0929867326666190704130105
Bioassay- and metabolomics-guided screening of bioactive soil actinomycetes from the ancient city of Ihnasia, Egypt
Sebak Mohamed, Saafan Amal E, AbdelGhani Sameh, Bakeer Walid, El-Gendy Ahmed O, Castaño Espriu Laia, Duncan Katherine, Edrada-Ebel RuAngelie
PLOS One Vol 14 (2019)
https://doi.org/10.1371/journal.pone.0226959
Comprehensive multivariate correlations between climatic effect, metabolite-profile, antioxidant capacity and antibacterial activity of Brazilian red propolis metabolites during seasonal study
do Nascimento Ticiano Gomes, dos Santos Arruda Rodolfo Elleson, da Cruz Almeida Erika Tayse, dos Santos Oliveira José Marcos, Basílio-Júnior Irinaldo Diniz, Celerino de Moraes Porto Isabel Cristina, Rodrigues Sabino Adilson, Tonholo Josealdo, Gray Alexander, Edrada Ebel RuAngelie, Clements Carol, Zhang Tong, Watson David George
Scientific Reports Vol 9, pp. 1-16 (2019)
https://doi.org/10.1038/s41598-019-54591-3

more publications

Research interests

  • Natural products metabolomics to optimise production of secondary metabolites in their microbial sources as well as using metabolomics tools in targeting the isolation of bioactive metabolites from their natural sources. Collaboration has been established with Professor Ron Quinn of the Griffith Institute for Drug Discovery, Griffith University and Professor  Fernando da Costa of the School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo.
  • Metabolomics of microbial symbionts in collaboration with Professor Ute Hentschel of the Sponge Microbiology Group at the GEOMAR Helmholtz Centre for Ocean Research Kiel and partners with SeaBioTech, an FP-7 funded project.
  • Real Time Flux Modeling in Biopharmaceutical Bioprocessing, jointly co-funded by the BBSRC and the EPSRC, a collaborative research on metabolomics and fermentation work as well as further national collaborative work with Scottish medium-scale enterprises on the cultivation of marine microorganism. 
  • Metagenomic approach of optimizing the production of novel antibiotics from Streptomyces
  • Propolis project with Beevital exploring the anti-trypanosomal activity of the African Propolis collection
  • Ecological implications of the production of secondary metabolites in Crustaeceans and alternative application of utilising the waste products of the by-catch in collaboration with the Langoustine Laboratory, University of Glasgow.
  • Dereplication study and metabolomics of sponges and their endozooic microorganism obtained from the Irish and Celtic Sea (in collaboration with Prof. Alan Dobson, Environmental Research Institute, University College Cork)
  • Structure elucidation of biologically active secondary metabolites from sponges, tropical plants, and marine-derived fungi
  • Phytochemistry of biologically active secondary metabolites from tropical plants from Southeast Asia and Africa (in collaboration with Prof. Alan Harvey, SIDR)
  • Mass spectral analysis of marine-derived synthetic pyridinium polymers as novel anti-cancer drugs (in collaboration with Prof. Marcel Jaspars, University of Aberdeen)

Professional activities

Krystle Angelique Santiago
Host
15/9/2018
Dr Asmaa BOUFRIDI
Host
6/7/2018
Jake Coyle
Host
2/7/2018
Accelerate Chemistry Challenge Programme for Secondary Schools in Scotland: S@S Accelerate 2018: Education Challenge
Invited speaker
27/6/2018
AHMET SADIK GÜLGEÇ
Host
15/6/2018
Euroindoamerican Natural Products Meeting
Keynote/plenary speaker
31/5/2018

more professional activities

Projects

Doctoral Training Partnership (DTP 2016-2017 University of Strathclyde) | Hislop, Ewan
Edrada-Ebel, Ruangelie (Principal Investigator) Graham, Duncan (Principal Investigator) Faulds, Karen (Co-investigator) Young, Louise (Co-investigator) Hislop, Ewan (Research Co-investigator)
01-Jan-2018 - 01-Jan-2022
Development of high-value compounds from Bacillus licheniformis
Edrada-Ebel, Ruangelie (Principal Investigator) Young, Louise (Co-investigator)
01-Jan-2017 - 28-Jan-2018
Identification of pathway specific anti-cancer compounds from Scottish Marine Microbes
Edrada-Ebel, Ruangelie (Principal Investigator)
This agreement is applicable to only the original MATERIAL for the analyses of chemical contents of a series of research materials originating from Scotland.
29-Jan-2016 - 28-Jan-2018
Potential novel antibiotics from microorganisms of under explored extreme marine habitats
Edrada-Ebel, Ruangelie (Principal Investigator)
25-Jan-2016 - 24-Jan-2016
Escaping Bio-Assay Guided Isolation: Nature's Tools for Chemical Biology
Edrada-Ebel, Ruangelie (Principal Investigator)
01-Jan-2015 - 31-Jan-2018
Comparative transcriptomic and metabolomic analysis of engineered bacteria
Tucker, Nicholas (Principal Investigator) Edrada-Ebel, Ruangelie (Co-investigator)
Analysis of industrial biotech strains produced by Ingenza
18-Jan-2014 - 18-Jan-2015

more projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Hamnett Wing

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