Professor Gwyn Gould

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Gwyn did his undergraduate Biochemistry degree at the University of Southampton. He followed this with a PhD at the same institution with Professor Tony Lee on the biophysics and membrane protein/lipid interactions, graduating in 1986. He then moved to Dartmouth Medical School in New Hampshire, working with Professor Gustav E. Lienhard, where he began his interest in glucose transport. He moved to the University of Glasgow in 1989 developing his interest in the structure and function of glucose transporters and the cell biology of membrane trafficking. He and his laboratory moved to SIPBS in October 2019.

Studies in Gwyn’s group seek to understand the cellular and molecular mechanisms which regulate glucose transport in adipocytes, cardiomyocytes and skeletal muscle. Studies focus upon identifying the molecular machinery that control GLUT4 function, defining how this machinery interacts with the insulin signalling system, and defining how these processes are impaired in disease.

Lab web site: https://gwyngould.wixsite.com/strathclydelab 

Publications

CHC22 clathrin mediates traffic from early secretory compartments for human GLUT4 pathway biogenesis
Camus Stéphane M, Camus Marine D, Figueras-Novoa Carmen, Boncompain Gaelle, Sadacca L Amanda, Esk Christopher, Bigot Anne, Gould Gwyn W, Kioumourtzoglou Dimitrios, Perez Franck, Bryant Nia J, Mukherjee Shaeri, Brodsky Frances M
Journal of Cell Biology Vol 219 (2019)
https://doi.org/10.1083/jcb.201812135
GLUT4 expression and glucose transport in human induced pluripotent stem cell-derived cardiomyocytes
Bowman Peter R T, Smith Godfrey L, Gould Gwyn W
PLoS One Vol 14 (2019)
https://doi.org/10.1371/journal.pone.0217885
The deubiquitinating enzyme USP25 binds tankyrase and regulates trafficking of the facilitative glucose transporter GLUT4 in adipocytes
Sadler Jessica B A, Lamb Christopher A, Welburn Cassie R, Adamson Iain S, Kioumourtzoglou Dimitrios, Chi Nai-Wen, Gould Gwyn W, Bryant Nia J
Scientific Reports Vol 9 (2019)
https://doi.org/10.1038/s41598-019-40596-5
Animal cell cytokinesis : the role of dynamic changes in the plasma membrane proteome and lipidome
Gould Gwyn W
Seminars in Cell and Developmental Biology Vol 53, pp. 64-73 (2016)
https://doi.org/10.1016/j.semcdb.2015.12.012
Characterization of VAMP isoforms in 3T3-L1 adipocytes : implications for GLUT4 trafficking
Sadler Jessica BA, Bryant Nia J, Gould Gwyn W
Molecular Biology of the Cell Vol 26, pp. 530-536 (2015)
https://doi.org/10.1091/mbc.E14-09-1368
Insulin stimulates syntaxin4 SNARE complex assembly via a novel regulatory mechanism
Kioumourtzoglou Dimitrios, Gould Gwyn W, Bryant Nia J
Molecular and Cellular Biology Vol 34, pp. 1271-1279 (2014)
https://doi.org/10.1128/MCB.01203-13

More publications

Research interests

A major consequence of insulin action is a dramatic increase in the rate of glucose transport into fat and muscle. This is achieved by the delivery of the facilitative glucose transporter GLUT4 from insulin-sensitive intracellular stores to the cell surface. Insulin-stimulated glucose transport is impaired in Type-2 diabetes; this is underpinned by reduced delivery of GLUT4 to the cell surface. Metabolic disorders such as Type-2 diabetes are linked to the development of cardiovascular disease. Cardiovascular disease represents the single biggest cause of death in T2DM and is independent of concurrent vascular disease. Our lab uses cellular and systems biology approaches to understand insulin-regulated GLUT4 trafficking in different cells.

 

Our lab uses a range of experimental systems and approaches. These include studies of cultured adipocytes and genome-edited adipocytes, and iPSC-derived cardiomyocytes as our work-horse models, and employ approaches including imaging techniques such as confocal microscopy and dSTORM, analysis of signalling and trafficking in subcellular fractions and analysis of transport kinetics in intact cells. We also employ Saccharomyces cerevisiae as a tool to study membrane trafficking.

Professional activities

Cells (Journal)
Editorial board member
2019
PeerJ (Journal)
Editorial board member
2017
Scientific Reports (Journal)
Editorial board member
2017
MSc by thesis, Examination
Examiner
26/3/2021
MSc by thesis, Examination
Examiner
1/8/2020
100 Years of insulin - organising committee
Recipient
1/4/2020

More professional activities

Projects

SPRINT: A SuPer-Resolution time-resolved ImagiNg and specTroscopy facility for rapid biomolecular analysis
Li, David (Principal Investigator) Chamberlain, Luke (Co-investigator) Chen, Yu (Co-investigator) Cunningham, Margaret Rose (Co-investigator) Gould, Gwyn (Co-investigator) Hoskisson, Paul (Co-investigator) McConnell, Gail (Co-investigator) Rattray, Zahra (Co-investigator) Van de Linde, Sebastian (Co-investigator)
01-Jan-2021 - 30-Jan-2022
What do membranes really look like? New approaches to 3D multiplexed imaging of the cell surface (New Horizons)
Van de Linde, Sebastian (Principal Investigator) Gould, Gwyn (Co-investigator)
01-Jan-2021 - 31-Jan-2022
Doctoral Training Partnership 2020-2021 University of Strathclyde | Geiser, Angéline
Gould, Gwyn (Principal Investigator) Currie, Susan (Co-investigator) Geiser, Angéline (Research Co-investigator)
01-Jan-2020 - 01-Jan-2024
Obesity and Neuroinflammation: The Impact of Adipocyte-derived Extracellular Vesicles on Inflammatory Signalling Pathways of Microglia
Colvin, Chiara (Post Grad Student) Gould, Gwyn (Co-investigator) Rattray, Zahra (Co-investigator) Cunningham, Margaret Rose (Principal Investigator)
01-Jan-2020 - 30-Jan-2021
Probing the biology of Zinc alpha-2 glycoprotein
Gould, Gwyn (Principal Investigator) Cunningham, Margaret Rose (Co-investigator)
01-Jan-2020 - 30-Jan-2024
RABEP2 is a novel GSK3 substrate that represents a single therapeutic target to reduce both hyperglycemia and microvascular disease in diabetes
Gould, Gwyn (Principal Investigator)
01-Jan-2020 - 31-Jan-2023

More projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Hamnett Wing

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