Professor Gwyn Gould

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Gwyn did his undergraduate Biochemistry degree at the University of Southampton. He followed this with a PhD at the same institution with Professor Tony Lee on the biophysics and membrane protein/lipid interactions, graduating in 1986. He then moved to Dartmouth Medical School in New Hampshire, working with Professor Gustav E. Lienhard, where he began his interest in glucose transport. He moved to the University of Glasgow in 1989 developing his interest in the structure and function of glucose transporters and the cell biology of membrane trafficking. He and his laboratory moved to SIPBS in October 2019.

Studies in Gwyn’s group seek to understand the cellular and molecular mechanisms which regulate glucose transport in adipocytes, cardiomyocytes and skeletal muscle. Studies focus upon identifying the molecular machinery that control GLUT4 function, defining how this machinery interacts with the insulin signalling system, and defining how these processes are impaired in disease.

Lab web site: https://gwyngould.wixsite.com/strathclydelab 

Publications

Building GLUT4 vesicles : CHC22 clathrin's human touch
Gould Gwyn W, Brodsky Frances M, Bryant Nia J
Trends in Cell Biology Vol 30, pp. 705-719 (2020)
https://doi.org/10.1016/j.tcb.2020.05.007
Insulin-stimulated GLUT4 translocation – size is not everything!
Bryant Nia J, Gould Gwyn W
Current Opinion in Cell Biology Vol 65, pp. 28-34 (2020)
https://doi.org/10.1016/j.ceb.2020.02.006
Characterisation of GLUT4 trafficking in HeLa cells : comparable kinetics and orthologous trafficking mechanisms to 3T3-L1 adipocytes
Morris Silke, Geoghan Niall D, Sadler Jessica BA, Koester Anna M, Black Hannah L, Laub Marco, Miller Lucy, Heffernan Linda, Simpson Jeremy C, Mastic Cynthia C, Cooper Jon, Gadegaard Nikolaj, Bryant Nia J, Gould Gwyn W
PeerJ Vol 8 (2020)
https://doi.org/10.7717/peerj.8751
Cardiac SNARE expression in health and disease
Bowman Peter R T, Smith Godfrey L, Gould Gwyn W
Frontiers in Endocrinology Vol 10 (2019)
https://doi.org/10.3389/fendo.2019.00881
CHC22 clathrin mediates traffic from early secretory compartments for human GLUT4 pathway biogenesis
Camus Stéphane M, Camus Marine D, Figueras-Novoa Carmen, Boncompain Gaelle, Sadacca L Amanda, Esk Christopher, Bigot Anne, Gould Gwyn W, Kioumourtzoglou Dimitrios, Perez Franck, Bryant Nia J, Mukherjee Shaeri, Brodsky Frances M
Journal of Cell Biology Vol 219 (2019)
https://doi.org/10.1083/jcb.201812135
The human-specific and smooth muscle cell-enriched LncRNA SMILR promotes proliferation by regulating mitotic CENPF mRNA and drives cell-cycle progression which can be targeted to limit vascular remodeling
Mahmoud Amira D, Ballantyne Margaret D, Miscianinov Vladislav, Pinel Karine, Hung John, Scanlon Jessica P, Iyinikkel Jean, Kaczynski Jakub, Tavares Adriana S, Bradshaw Angela C, Mills Nicholas L, Newby David E, Caporali Andrea, Gould Gwyn W, George Sarah J, Ulitsky Igor, Sluimer Judith C, Rodor Julie, Baker Andrew H
Circulation Research Vol 125, pp. 535-551 (2019)
https://doi.org/10.1161/CIRCRESAHA.119.314876

More publications

Research interests

A major consequence of insulin action is a dramatic increase in the rate of glucose transport into fat and muscle. This is achieved by the delivery of the facilitative glucose transporter GLUT4 from insulin-sensitive intracellular stores to the cell surface. Insulin-stimulated glucose transport is impaired in Type-2 diabetes; this is underpinned by reduced delivery of GLUT4 to the cell surface. Metabolic disorders such as Type-2 diabetes are linked to the development of cardiovascular disease. Cardiovascular disease represents the single biggest cause of death in T2DM and is independent of concurrent vascular disease. Our lab uses cellular and systems biology approaches to understand insulin-regulated GLUT4 trafficking in different cells.

 

Our lab uses a range of experimental systems and approaches. These include studies of cultured adipocytes and genome-edited adipocytes, and iPSC-derived cardiomyocytes as our work-horse models, and employ approaches including imaging techniques such as confocal microscopy and dSTORM, analysis of signalling and trafficking in subcellular fractions and analysis of transport kinetics in intact cells. We also employ Saccharomyces cerevisiae as a tool to study membrane trafficking.

Professional activities

MPhil by thesis, Examination
Examiner
15/11/2019
Cells (Journal)
Editorial board member
2019
Development of a model of insulin-stimulated glucose transport in human cardiomyocytes
Recipient
1/12/2018
Edinburgh International Science festival
Recipient
2018
Scientific Reports (Journal)
Editorial board member
2017
PeerJ (Journal)
Editorial board member
2017

More professional activities

Projects

RABEP2 is a novel GSK3 substrate that represents a single therapeutic target to reduce both hyperglycemia and microvascular disease in diabetes
Gould, Gwyn (Principal Investigator)
01-Jan-2020 - 31-Jan-2023
Development of a model of insulin-stimulated glucose transport in human cardiomyocytes (Transfer from UoG)
Gould, Gwyn (Principal Investigator)
07-Jan-2019 - 30-Jan-2020

More projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Hamnett Wing

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