Personal statement
Gwyn did his undergraduate Biochemistry degree at the University of Southampton. He followed this with a PhD at the same institution with Professor Tony Lee on the biophysics of membrane protein/lipid interactions, graduating in 1986. He then moved to Dartmouth Medical School in New Hampshire, working with Professor Gustav E. Lienhard, where he began his interest in glucose transport. He moved to the University of Glasgow in 1989 developing his interest in the structure and function of glucose transporters and the cell biology of membrane trafficking. He and his laboratory moved to SIPBS in October 2019.
Studies in Gwyn’s group seek to understand the cellular and molecular mechanisms which regulate glucose transport in adipocytes, cardiomyocytes and skeletal muscle. Studies focus upon identifying the molecular machinery that control GLUT4 function, defining how this machinery interacts with the insulin signalling system, and defining how these processes are impaired in disease.
In particular we are interested in using cutting edge imaging approaches to study the behaviour of gluocse transporters in health and disease.
Lab web site: https://gwyngould.wixsite.com/strathclydelab
Research interests
A major consequence of insulin action is a dramatic increase in the rate of glucose transport into fat and muscle. This is achieved by the delivery of the facilitative glucose transporter GLUT4 from insulin-sensitive intracellular stores to the cell surface. Insulin-stimulated glucose transport is impaired in Type-2 diabetes; this is underpinned by reduced delivery of GLUT4 to the cell surface. Metabolic disorders such as Type-2 diabetes are linked to the development of cardiovascular disease. Our lab uses cellular, genetic and systems biology approaches to understand insulin regulated GLUT4 trafficking in different cells.
Studies in our group use a range of experimental systems and approaches. These include genome editing of cultured adipocytes to probe the regulatory pathways controlling GLUT4 trafficking and activity, cutting-edge imaging techniques including STED-FCS and dSTORM, analysis of signalling and trafficking in subcellular fractions and analysis of transport kinetics in intact cells. We also employ Saccharomyces cerevisiae as a tool to study membrane trafficking.
Professional activities
- Cells (Journal)
- Editorial board member
- 2019
- PeerJ (Journal)
- Editorial board member
- 2017
- Scientific Reports (Journal)
- Editorial board member
- 2017
- PhD thesis viva
- Examiner
- 2/3/2022
- Simeon Omale
- Host
- 15/11/2021
- PeerJ- the Journal of Life and Environmental Sciences (Journal)
- Advisory Board Member
- 1/10/2021
More professional activities
Projects
- DTP 2224 University of Strathclyde | Brown, Mollie
- McConnell, Gail (Principal Investigator) Gould, Gwyn (Co-investigator) Brown, Mollie (Research Co-investigator)
- 01-Jan-2022 - 01-Jan-2026
- What do membranes really look like? New approaches to 3D multiplexed imaging of the cell surface (New Horizons)
- Gould, Gwyn (Principal Investigator) Van de Linde, Sebastian (Co-investigator)
- 01-Jan-2021 - 31-Jan-2023
- SPRINT: A SuPer-Resolution time-resolved ImagiNg and specTroscopy facility for rapid biomolecular analysis
- Li, David (Principal Investigator) Chamberlain, Luke (Co-investigator) Chen, Yu (Co-investigator) Cunningham, Margaret Rose (Co-investigator) Gould, Gwyn (Co-investigator) Hoskisson, Paul (Co-investigator) McConnell, Gail (Co-investigator) Rattray, Zahra (Co-investigator) Van de Linde, Sebastian (Co-investigator)
- 01-Jan-2021 - 28-Jan-2023
- Obesity and Neuroinflammation: The Impact of Adipocyte-derived Extracellular Vesicles on Inflammatory Signalling Pathways of Microglia
- Colvin, Chiara (Post Grad Student) Gould, Gwyn (Co-investigator) Rattray, Zahra (Co-investigator) Cunningham, Margaret Rose (Principal Investigator)
- 01-Jan-2020 - 30-Jan-2021
- Probing the biology of Zinc alpha-2 glycoprotein
- Gould, Gwyn (Principal Investigator) Cunningham, Margaret Rose (Co-investigator)
- 01-Jan-2020 - 30-Jan-2024
- Doctoral Training Partnership 2020-2021 University of Strathclyde | Geiser, Angéline
- Gould, Gwyn (Principal Investigator) Currie, Susan (Co-investigator) Geiser, Angéline (Research Co-investigator)
- 01-Jan-2020 - 01-Jan-2024
More projects
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Strathclyde Institute of Pharmacy and Biomedical Sciences
Hamnett Wing
Hamnett Wing
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