Professor Gwyn Gould
Strathclyde Institute of Pharmacy and Biomedical Sciences
Personal statement
Gwyn did his undergraduate Biochemistry degree at the University of Southampton. He followed this with a PhD at the same institution with Professor Tony Lee on the biophysics of membrane protein/lipid interactions, graduating in 1986. He then moved to Dartmouth Medical School in New Hampshire, working with Professor Gustav E. Lienhard, where he began his interest in glucose transport. He moved to the University of Glasgow in 1989 developing his interest in the structure and function of glucose transporters and the cell biology of membrane trafficking. He and his laboratory moved to SIPBS in October 2019.
Studies in Gwyn’s group seek to understand the cellular and molecular mechanisms which regulate glucose transport in adipocytes, cardiomyocytes and skeletal muscle. Studies focus upon identifying the molecular machinery that control GLUT4 function, defining how this machinery interacts with the insulin signalling system, and defining how these processes are impaired in disease.
In particular we are interested in using cutting edge imaging approaches to study the behaviour of gluocse transporters in health and disease.
Lab web site: https://gwyngould.wixsite.com/strathclydelab
Prize And Awards
- Wellcome Trust Research Leave Award
- Recipient
- 2004
- Lister Institute of Preventive Medicine Research Fellowship
- Recipient
- 1/6/1992
Publications
- CHC22 clathrin mediates traffic from early secretory compartments for human GLUT4 pathway biogenesis
- Camus Stéphane M, Camus Marine D, Figueras-Novoa Carmen, Boncompain Gaelle, Sadacca L Amanda, Esk Christopher, Bigot Anne, Gould Gwyn W, Kioumourtzoglou Dimitrios, Perez Franck, Bryant Nia J, Mukherjee Shaeri, Brodsky Frances M
- Journal of Cell Biology Vol 219 (2019)
- https://doi.org/10.1083/jcb.201812135
- GLUT4 expression and glucose transport in human induced pluripotent stem cell-derived cardiomyocytes
- Bowman Peter R T, Smith Godfrey L, Gould Gwyn W
- PLoS One Vol 14 (2019)
- https://doi.org/10.1371/journal.pone.0217885
- The deubiquitinating enzyme USP25 binds tankyrase and regulates trafficking of the facilitative glucose transporter GLUT4 in adipocytes
- Sadler Jessica B A, Lamb Christopher A, Welburn Cassie R, Adamson Iain S, Kioumourtzoglou Dimitrios, Chi Nai-Wen, Gould Gwyn W, Bryant Nia J
- Scientific Reports Vol 9 (2019)
- https://doi.org/10.1038/s41598-019-40596-5
- Animal cell cytokinesis : the role of dynamic changes in the plasma membrane proteome and lipidome
- Gould Gwyn W
- Seminars in Cell and Developmental Biology Vol 53, pp. 64-73 (2016)
- https://doi.org/10.1016/j.semcdb.2015.12.012
- Characterization of VAMP isoforms in 3T3-L1 adipocytes : implications for GLUT4 trafficking
- Sadler Jessica BA, Bryant Nia J, Gould Gwyn W
- Molecular Biology of the Cell Vol 26, pp. 530-536 (2015)
- https://doi.org/10.1091/mbc.E14-09-1368
- Insulin stimulates syntaxin4 SNARE complex assembly via a novel regulatory mechanism
- Kioumourtzoglou Dimitrios, Gould Gwyn W, Bryant Nia J
- Molecular and Cellular Biology Vol 34, pp. 1271-1279 (2014)
- https://doi.org/10.1128/MCB.01203-13
Research Interests
A major consequence of insulin action is a dramatic increase in the rate of glucose transport into fat and muscle. This is achieved by the delivery of the facilitative glucose transporter GLUT4 from insulin-sensitive intracellular stores to the cell surface. Insulin-stimulated glucose transport is impaired in Type-2 diabetes; this is underpinned by reduced delivery of GLUT4 to the cell surface. Metabolic disorders such as Type-2 diabetes are linked to the development of cardiovascular disease. Our lab uses cellular, genetic and systems biology approaches to understand insulin regulated GLUT4 trafficking in different cells.
Studies in our group use a range of experimental systems and approaches. These include genome editing of cultured adipocytes to probe the regulatory pathways controlling GLUT4 trafficking and activity, cutting-edge imaging techniques including STED-FCS and dSTORM, analysis of signalling and trafficking in subcellular fractions and analysis of transport kinetics in intact cells. We also employ Saccharomyces cerevisiae as a tool to study membrane trafficking.
Professional Activities
- Cells (Journal)
- Editorial board member
- 2019
- PeerJ (Journal)
- Editorial board member
- 2017
- Scientific Reports (Journal)
- Editorial board member
- 2017
- 26th EASD OXFORD WORKSHOP
- Participant
- 20/8/2023
- 26th EASD OXFORD WORKSHOP
- Participant
- 19/8/2023
- 26th EASD OXFORD WORKSHOP
- Speaker
- 19/8/2023
Projects
- How does EFR3 control insulin-stimulated plasma membrane dispersal of GLUT4?
- Gould, Gwyn (Principal Investigator) Li, David (Co-investigator) McConnell, Gail (Co-investigator) Van de Linde, Sebastian (Co-investigator)
- 15-Jan-2023 - 14-Jan-2026
- Novel approaches to GLUT4 trafficking in genome edited adipocytes (International Exchanges 2022 Cost Share (JSPS and NSTC))
- Gould, Gwyn (Principal Investigator)
- 10-Jan-2023 - 09-Jan-2025
- DTP 2224 University of Strathclyde | Brown, Mollie
- McConnell, Gail (Principal Investigator) Gould, Gwyn (Co-investigator) Brown, Mollie (Research Co-investigator)
- 01-Jan-2022 - 01-Jan-2026
- SPRINT: A SuPer-Resolution time-resolved ImagiNg and specTroscopy facility for rapid biomolecular analysis
- Li, David (Principal Investigator) Chamberlain, Luke (Co-investigator) Chen, Yu (Co-investigator) Cunningham, Margaret Rose (Co-investigator) Gould, Gwyn (Co-investigator) Hoskisson, Paul (Co-investigator) McConnell, Gail (Co-investigator) Rattray, Zahra (Co-investigator) Van de Linde, Sebastian (Co-investigator)
- 01-Jan-2021 - 31-Jan-2023
- What do membranes really look like? New approaches to 3D multiplexed imaging of the cell surface (New Horizons)
- Gould, Gwyn (Principal Investigator) Van de Linde, Sebastian (Co-investigator)
- 01-Jan-2021 - 29-Jan-2023
- Obesity and Neuroinflammation: The Impact of Adipocyte-derived Extracellular Vesicles on Inflammatory Signalling Pathways of Microglia
- Colvin, Chiara (Post Grad Student) Gould, Gwyn (Co-investigator) Rattray, Zahra (Co-investigator) Cunningham, Margaret Rose (Principal Investigator)
- 01-Jan-2020 - 30-Jan-2021
Contact
Professor
Gwyn
Gould
Strathclyde Institute of Pharmacy and Biomedical Sciences
Email: gwyn.gould@strath.ac.uk
Tel: 548 4805