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Dr Paul Hoskisson

Reader

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Laboratory webpage is here http://paulhoskisson.weebly.com

Research in my group is focussed on the synthesis of antibiotics and the evolution of bacterial pathogens, using a range of techniques from molecular biology and biochemistry through to mathematical modelling and image analysis. The bacterial genus Streptomyces is the main focus of work in my Research Group due to its industrial importance, being responsible for producing around two thirds of all commercially important antibiotics as well as numerous anti-fungal, anti-helminthic and anti-cancer drugs. 

We also have an interest in evolution of metabolism, evolution of bacterial pathogens, genomics of actinobacteria and the exploitation of amphibian proteins for biotechnology. 

We use a range of techniques to study the biology of actinobacteria including molecular genetics, protein biochemistry, genomics, microscopy, physiology, advanced spectroscopy, mathematical modeling and bioinformatics.

I was elected as a member of the Royal Society of Edinburgh Young Academy of Scotland in 2014 and a Fellow of the Royal Society of Biology (FRSB) in 2016.

I am a member of the Microbiology Society, the American Society of Microbiology, the Biochemical Society, The Royal Society of Biology and British Herpetological Society.

I am a managing editor for Antonie van Leeuwenhoek International Journal of Microbiology, and sit on the editorial board for Microbial Genomics, Frontiers in Antimicrobials, resistance and chemotherapy, Frontiers in Microbial Physiology and Metabolism, Frontiers in Synthetic Biology and Metabolism and Nature Scientific Data and Nature Scientific Reports.I am a former Editor in Chief of Microbiology Today.

I am a Fellow of the Higher Education Academy.

I am interested in the use of Social media for communication of science and you can follow on Twitter @paulhoskisson

Publications

Applying the Mesolens to microbiology : investigating the structural organisation of bacterial biofilms
Rooney Liam M., McCann Lee, Hoskisson Paul A., McConnell Gail
RMS Frontiers in Bioimaging 2018, (2018)
Merging in-solution X-ray and neutron scattering data allows fine structural analysis of membrane-protein detergent complexes
Dias Mirandela Gaëtan, Tamburrino Giulia, Ivanović Miloš T., Strnad Felix M., Byron Olwyn, Rasmussen Tim, Hoskisson Paul A., Hub Jochen S., Zachariae Ulrich, Gabel Frank, Javelle Arnaud
Journal of Physical Chemistry Letters, pp. 3910–3914, (2018)
http://dx.doi.org/10.1021/acs.jpclett.8b01598
Gene exchange drives the ecological success of a multi-host bacterial pathogen
Richardson Emily J., Bacigalupe Rodrigo, Harrison Ewan M., Weinert Lucy A., Lycett Samantha, Vrieling Manouk, Robb Kirsty, Hoskisson Paul A., Holden Matthew TG, Feil Edward J., Patterson Gavin K., Tong Steven YC, Shittu Adebayo, van Wamel Willen, Aanensen David M., Parkhill Julian, Peacock Sharon J., Corander Jukka, Holmes Mark, Fitzgerald J. Ross
Nature Ecology & Evolution, pp. 1-43, (2018)
Applying the mesolens to microbiology : visualising biofilm architecture and substructure
Rooney Liam M., McCann Lee, Hoskisson Paul A., McConnell Gail
ELMI 2018, (2018)
Dispatches from the land of the morning calm : special issue papers from the 18th International Symposium on the Biology of Actinomycetes
Hoskisson Paul A., van Wezel Gilles P.
Antonie van Leeuwenhoek Vol 111, pp. 639-639, (2018)
http://dx.doi.org/10.1007/s10482-018-1077-x
Sporulation-specific cell division defects in ylmE mutants of Streptomyces coelicolor are rescued by additional deletion of ylmD
Zhang Le, Willemse Joost, Hoskisson Paul A., van Wezel Gilles P.
Scientific Reports Vol 8, pp. 1-13, (2018)
http://dx.doi.org/10.1038/s41598-018-25782-1

more publications

Professional activities

Generating metabolic robustness for antibiotic biosynthesis though the expansion of primary metabolism in Streptomyces
Speaker
5/3/2018
Frogs, Foam and foiling antibiotic resistant infections
Speaker
10/11/2017
Generating metabolic robustness for antibiotic biosynthesis though the expansion of primary metabolism in Streptomyces
Speaker
26/10/2017
Generating metabolic robustness for antibiotic biosynthesis though the expansion of primary metabolism in Streptomyces
Speaker
18/9/2017
Generating metabolic robustness for antibiotic biosynthesis though the expansion of primary metabolism in Streptomyces
Speaker
14/9/2017
Small Talk: Communicating microbiology in the digital age
Speaker
1/9/2017

more professional activities

Projects

Fast-tracking Health Innovation for NHS Scotland. MRC Confidence in Concept / R180246-103
Corrigan, Damion (Principal Investigator) Hoskisson, Paul (Co-investigator) Shu, Will (Co-investigator)
Period 01-Mar-2018 - 28-Feb-2020
Can epistasis be exploited to understand industrial antibiotic production in Streptomyces
Hoskisson, Paul (Principal Investigator)
Period 19-Feb-2018 - 18-Aug-2018
MycoChip - A rapid onchip antibiotic susceptibility test for Mycobacterium tuberculosis (Newton Fund)
Corrigan, Damion (Principal Investigator) Hoskisson, Paul (Co-investigator)
Period 12-Feb-2018 - 14-Feb-2020
Microplate - shrinking culture plates onto a microchip for a rapid antibiotic susceptibility test
Corrigan, Damion (Principal Investigator) Hoskisson, Paul (Co-investigator) Shu, Will (Co-investigator)
Period 01-Sep-2017 - 31-Aug-2018
EPSRC Centre for Doctoral Training in Medical Devices and Health Technologies | Vezza, Vincent James
Corrigan, Damion (Principal Investigator) Hoskisson, Paul (Co-investigator) Vezza, Vincent James (Research Co-investigator)
Period 01-Oct-2016 - 01-Oct-2020
Microfluidic manufacturing and development of a novel clostridium difficile oral vaccine | Forbes, Neil Liam Andrew
Perrie, Yvonne (Principal Investigator) Hoskisson, Paul (Co-investigator) Forbes, Neil Liam Andrew (Research Co-investigator)
Period 01-Oct-2016 - 01-Oct-2019

more projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Hamnett Wing John Arbuthnott Building

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