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Dr Paul Hoskisson

Reader

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Laboratory webpage is here http://paulhoskisson.weebly.com

Research in my group is focussed on the synthesis of antibiotics and the evolution of bacterial pathogens, using a range of techniques from molecular biology and biochemistry through to mathematical modelling and image analysis. The bacterial genus Streptomyces is the main focus of work in my Research Group due to its industrial importance, being responsible for producing around two thirds of all commercially important antibiotics as well as numerous anti-fungal, anti-helminthic and anti-cancer drugs. 

We also have an interest in evolution of metabolism, evolution of bacterial pathogens, genomics of actinobacteria and the exploitation of amphibian proteins for biotechnology. 

We use a range of techniques to study the biology of actinobacteria including molecular genetics, protein biochemistry, genomics, microscopy, physiology, advanced spectroscopy, mathematical modeling and bioinformatics.

I was elected as a member of the Royal Society of Edinburgh Young Academy of Scotland in 2014 and a Fellow of the Royal Society of Biology (FRSB) in 2016.

I am a member of the Microbiology Society, the American Society of Microbiology, the Biochemical Society, The Royal Society of Biology and British Herpetological Society.

I am a managing editor for Antonie van Leeuwenhoek International Journal of Microbiology, and sit on the editorial board for Microbial Genomics, Frontiers in Antimicrobials, resistance and chemotherapy, Frontiers in Microbial Physiology and Metabolism, Frontiers in Synthetic Biology and Metabolism and Nature Scientific Data and Nature Scientific Reports.I am a former Editor in Chief of Microbiology Today.

I am a Fellow of the Higher Education Academy.

I am interested in the use of Social media for communication of science and you can follow on Twitter @paulhoskisson

Publications

The E. coli dicarboxylic acid transporters DauA act as a signal transducer by interacting with the DctA uptake system
Karinou Eleni, Hoskisson Paul A., Strecker Alexander, Unden Gottfried, Javelle Arnaud
Scientific Reports, pp. 1-30, (2017)
Genomic analysis of endemic clones of toxigenic and non-toxigenic Corynebacterium diphtheriae in Belarus during and after the major epidemic in 1990s
Grosse-Kock Steffan, Kolodkina Valentina, Schwalbe Edward C., Blom Jochen, Burkovski Andreas, Hoskisson Paul A., Brisse Sylvain , Smith Darren, Sutcliffe Iain C., Titov Leonid, Sangal Vartul
BMC Genomics Vol 18, (2017)
http://dx.doi.org/10.1186/s12864-017-4276-3
Examining the role of protein structural dynamics in drug resistance in Mycobacterium tuberculosis
Shaw Daniel J., Hill Rachel E., Simpson Niall, Husseini Fouad S., Robb Kirsty, Greetham Gregory M., Towrie Michael, Parker Anthony W., Robinson David , Hirst Jonathan D. , Hoskisson Paul, Hunt Neil T.
Chemical Science, (2017)
http://dx.doi.org/10.1039/C7SC03336B
The MtrAB two-component system controls antibiotic production in Streptomyces coelicolor A3(2)
Som Nicolle F., Heine Daniel, Holmes Neil, Knowles Felicity, Chandra Govind, Seipke Ryan F., Hoskisson Paul A, Wilkinson Barrie, Hutchings Matthew I.
Microbiology Vol 163, pp. 1415-1419, (2017)
http://dx.doi.org/10.1099/mic.0.000524
Draft genome sequence of root-associated sugarcane growth-promoting microbispora sp. strain GKU 823
Kruasuwan Worarat, Hoskisson Paul A., Thamchaipenet Arinthip
Genome Announcements Vol 5, (2017)
http://dx.doi.org/10.1128/genomeA.00647-17
Disruption of key NADH-binding pocket residues of the Mycobacterium tuberculosis InhA affects DD-CoA binding ability
Shaw Daniel J., Robb Kirsty, Vetter Beatrice V., Tong Madeline, Molle Virginie, Hunt Neil T., Hoskisson Paul A.
Scientific Reports Vol 7, (2017)
http://dx.doi.org/10.1038/s41598-017-05042-4

more publications

Professional activities

Royal Society of Biology (External organisation)
Member
1/1/2016
BBSRC (Biotech & Biological Sciences Research Council) (External organisation)
Member
1/10/2015
Royal Society of Edinburgh (External organisation)
Member
1/7/2014
Scientific Data (Journal)
Editor
2013
Society for General Microbiology
Participant
9/2012
Society for General Microbiology
Organiser
26/3/2012

more professional activities

Projects

Microplate - shrinking culture plates onto a microchip for a rapid antibiotic susceptibility test
Corrigan, Damion (Principal Investigator) Hoskisson, Paul (Co-investigator) Shu, Will (Co-investigator)
Period 01-Sep-2017 - 31-Aug-2018
EPSRC Centre for Doctoral Training in Medical Devices and Health Technologies | Vezza, Vincent James
Corrigan, Damion (Principal Investigator) Hoskisson, Paul (Co-investigator) Vezza, Vincent James (Research Co-investigator)
Period 01-Oct-2016 - 01-Oct-2020
Microfluidic manufacturing and development of a novel clostridium difficile oral vaccine | Forbes, Neil Liam Andrew
Perrie, Yvonne (Principal Investigator) Hoskisson, Paul (Co-investigator) Forbes, Neil Liam Andrew (Research Co-investigator)
Period 01-Oct-2016 - 01-Oct-2019
Establishing an integrated biocatalytic Friedel-Crafts platform for the alkylation of aromatic small molecules | McKean, Iain
Burley, Glenn (Principal Investigator) Hoskisson, Paul (Co-investigator) McKean, Iain (Research Co-investigator)
Period 01-Oct-2015 - 01-Oct-2019
David Begg Studentship | Brozio, Sarah
Hoskisson, Paul (Principal Investigator) Brozio, Sarah (Research Co-investigator)
Period 01-Oct-2014 - 01-Apr-2018
Assessing the biotechnological potential of Antarctic and sub Arctic sediment cores (MASTS funding)
Duncan, Katherine (Principal Investigator) Hoskisson, Paul (Co-investigator)
Period 05-Dec-2016 - 11-Aug-2017

more projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Hamnett Wing John Arbuthnott Building

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