Professor Paul Hoskisson

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Laboratory webpage is here http://paulhoskisson.weebly.com

Research in my group is focussed on the synthesis of antibiotics and the evolution of bacterial pathogens, using a range of techniques from molecular biology and biochemistry through to mathematical modelling and image analysis. The bacterial genus Streptomyces is the main focus of work in my Research Group due to its industrial importance, being responsible for producing around two thirds of all commercially important antibiotics as well as numerous anti-fungal, anti-helminthic and anti-cancer drugs. 

We also have an interest in evolution of metabolism, evolution of bacterial pathogens, genomics of actinobacteria and the exploitation of amphibian proteins for biotechnology. 

We use a range of techniques to study the biology of actinobacteria including molecular genetics, protein biochemistry, genomics, microscopy, physiology, advanced spectroscopy, mathematical modeling and bioinformatics.

I was elected as a member of the Royal Society of Edinburgh Young Academy of Scotland in 2014 and a Fellow of the Royal Society of Biology (FRSB) in 2016.

I am a member of the Microbiology Society, the American Society of Microbiology, the Biochemical Society, The Royal Society of Biology and British Herpetological Society.

I am a managing editor for Antonie van Leeuwenhoek International Journal of Microbiology, and sit on the editorial board for Microbial Genomics, Frontiers in Antimicrobials, resistance and chemotherapy, Frontiers in Microbial Physiology and Metabolism, Frontiers in Synthetic Biology and Metabolism and Nature Scientific Data and Nature Scientific Reports.I am a former Editor in Chief of Microbiology Today.

I am a Fellow of the Higher Education Academy.

I am interested in the use of Social media for communication of science and you can follow on Twitter @paulhoskisson

Publications

The parasitic worm product ES-62 promotes health- and life-span in a high calorie diet accelerated mouse model of ageing
Crowe Jenny, Lumb Felicity E, Doonan James, Broussard Margaux, Tarafdar Anuradha, Pineda Miguel A, Landabaso Carmen, Mulvey Lorna, Hoskisson Paul A, Babayan Simon A, Selman Colin, Harnett William, Harnett Margaret M
PLOS Pathogens Vol 16 (2020)
https://doi.org/10.1371/journal.ppat.1008391
Differential transcription of expanded gene families in central carbon metabolism of Streptomyces coelicolor A3(2)
Schniete Jana K, Reumerman Richard, Kerr Leena, Tucker Nicholas P, Hunter Iain S, Herron Paul R, Hoskisson Paul A
Access Microbiology (2020)
Three-dimensional observations of an aperiodic oscillatory gliding motility behaviour in Myxococcus xanthus using confocal interference reflection microscopy
Rooney Liam M, Kölln Lisa S, Scrimgeour Ross, Amos William B, Hoskisson Paul A, McConnell Gail
mSphere Vol 5 (2020)
https://doi.org/10.1128/mSphere.00846-19
S-adenosyl methionine cofactor modifications enhance the biocatalytic repertoire of small molecule C-alkylation
McKean Iain J W, Sadler Joanna C, Cuetos Anibal, Frese Amina, Humphreys Luke D, Grogan Gideon, Hoskisson Paul A, Burley Glenn A
Angewandte Chemie International Edition Vol 58, pp. 17583-17588 (2019)
https://doi.org/10.1002/anie.201908681
Rapid antibiotic susceptibility testing using low-cost, commercially available screen-printed electrodes
Hannah Stuart, Addington Emily, Alcorn David, Shu Wenmiao, Hoskisson Paul A, Corrigan Damion K
Biosensors and Bioelectronics Vol 145 (2019)
https://doi.org/10.1016/j.bios.2019.111696
Awakening ancient polar actinobacteria : diversity, evolution and specialized metabolite potential
Millán-Aguiñaga Natalie, Soldatou Sylvia, Brozio Sarah, Munnoch John T, Howe John, Hoskisson Paul A, Duncan Katherine R
Microbiology Vol 165, pp. 1169-1180 (2019)
https://doi.org/10.1099/mic.0.000845

more publications

Professional activities

Meet the Researcher- MRS 2019
Speaker
27/2/2019
Applying the Mesolens to Microbiology; Visualising Biofilm Architecture and Substructure
Contributor
13/4/2018
Generating metabolic robustness for antibiotic biosynthesis though the expansion of primary metabolism in Streptomyces
Speaker
5/3/2018
Applying the Mesolens to Microbiology; Visualising Biofilm Architecture and Substructure
Contributor
22/11/2017
Frogs, Foam and foiling antibiotic resistant infections
Speaker
10/11/2017
Generating metabolic robustness for antibiotic biosynthesis though the expansion of primary metabolism in Streptomyces
Speaker
26/10/2017

more professional activities

Projects

Chance and Necessity: Evolution guided antibiotic improvement and discovery
Hoskisson, Paul (Principal Investigator)
01-Jan-2019 - 30-Jan-2022
Understanding the development of Industrial strain lineages (IBIOIC Studentship)
Hoskisson, Paul (Principal Investigator)
01-Jan-2019 - 30-Jan-2023
Re-engineering robustness in to industrial antibiotic producing Streptomyces strains (Super Follow on Fund)
Hoskisson, Paul (Principal Investigator) Hunter, Iain (Co-investigator)
01-Jan-2019 - 30-Jan-2021
Doctoral Training Partnership 2018-19 University of Strathclyde | Bottura, Beatrice
McConnell, Gail (Principal Investigator) Hoskisson, Paul (Co-investigator) Bottura, Beatrice (Research Co-investigator)
01-Jan-2019 - 01-Jan-2023
Evolutionary genomics for the sustainable exploitation of microbes from Mexican niches: from biodiversity to application (Newton Fund) Newton Advanced Fellowship (Francisco Barona-Gomez)
Hoskisson, Paul (Principal Investigator)
17-Jan-2018 - 16-Jan-2021
Combatting antimicrobial resistance through new software for Natural Products Discovery (Tools and Resources Development Fund)
Duncan, Katherine (Principal Investigator) Hoskisson, Paul (Co-investigator)
01-Jan-2018 - 30-Jan-2020

more projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Hamnett Wing

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