Professor Paul Hoskisson

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Laboratory webpage is here http://paulhoskisson.weebly.com

Research in my group is focussed on the synthesis of antibiotics and the evolution of bacterial pathogens, using a range of techniques from molecular biology and biochemistry through to mathematical modelling and image analysis. The bacterial genus Streptomyces is the main focus of work in my Research Group due to its industrial importance, being responsible for producing around two thirds of all commercially important antibiotics as well as numerous anti-fungal, anti-helminthic and anti-cancer drugs. 

We also have an interest in evolution of metabolism, evolution of bacterial pathogens, genomics of actinobacteria and the exploitation of amphibian proteins for biotechnology. 

We use a range of techniques to study the biology of actinobacteria including molecular genetics, protein biochemistry, genomics, microscopy, physiology, advanced spectroscopy, mathematical modeling and bioinformatics.

I was elected as a member of the Royal Society of Edinburgh Young Academy of Scotland in 2014 and a Fellow of the Royal Society of Biology (FRSB) in 2016.

I am a member of the Microbiology Society, the American Society of Microbiology, the Biochemical Society, The Royal Society of Biology and British Herpetological Society.

I am a managing editor for Antonie van Leeuwenhoek International Journal of Microbiology, and sit on the editorial board for Microbial Genomics, Frontiers in Antimicrobials, resistance and chemotherapy, Frontiers in Microbial Physiology and Metabolism, Frontiers in Synthetic Biology and Metabolism and Nature Scientific Data and Nature Scientific Reports.I am a former Editor in Chief of Microbiology Today.

I am a Fellow of the Higher Education Academy.

I am interested in the use of Social media for communication of science and you can follow on Twitter @paulhoskisson

Publications

Expanding, integrating, sensing and responding : the role of Primary metabolism in specialised metabolite production
Fernandez-Martinez Lorena T, Hoskisson Paul A
Current Opinion in Microbiology Vol 51, pp. 16-21 (2019)
https://doi.org/10.1016/j.mib.2019.03.006
The parasitic worm product ES-62 normalises the gut microbiota bone marrow axis in inflammatory arthritis
Doonan James, Tarafdar Anuradha, Pineda Miguel A, Lumb Felicity E, Crowe Jenny, Khan Aneesah M, Hoskisson Paul A, Harnett Margaret M, Harnett William
Nature Communications Vol 10 (2019)
https://doi.org/10.1038/s41467-019-09361-0
The lipid environment determines the activity of the Escherichia coli ammonium transporter AmtB
Dias Mirandela Gaëtan, Tamburrino Giulia, Hoskisson Paul A, Zachariae Ulrich, Javelle Arnaud
FASEB Journal Vol 33, pp. 1989-1999 (2019)
https://doi.org/10.1096/fj.201800782R
Development of a needle shaped microelectrode for electrochemical detection of the sepsis biomarker interleukin-6 (IL-6) in real time
Russell Christopher, Ward Andrew C, Vezza Vincent, Hoskisson Paul, Alcorn David, Steenson D Paul, Corrigan Damion K
Biosensors and Bioelectronics Vol 126, pp. 806-814 (2019)
https://doi.org/10.1016/j.bios.2018.11.053
Characterisation of the mode of action of Aurodox, a type III secretion system inhibitor from streptomyces goldiniensis
McHugh Rebecca E, O'Boyle Nicky, Connolly James P R, Hoskisson Paul A, Roe Andrew J
Infection and Immunity (2018)
https://doi.org/10.1128/IAI.00595-18
Driving the expression of the Salmonella enterica sv Typhimurium flagellum using flhDC from Escherichia coli results in key regulatory and cellular differences
Albanna Ayman, Sim Martin, Hoskisson Paul A, Gillespie Colin, Rao Christopher V, Aldridge Phillip D
Scientific Reports Vol 8, pp. 1-11 (2018)
https://doi.org/10.1038/s41598-018-35005-2

more publications

Professional activities

Applying the Mesolens to Microbiology; Visualising Biofilm Architecture and Substructure
Contributor
13/4/2018
Generating metabolic robustness for antibiotic biosynthesis though the expansion of primary metabolism in Streptomyces
Speaker
5/3/2018
Applying the Mesolens to Microbiology; Visualising Biofilm Architecture and Substructure
Contributor
22/11/2017
Frogs, Foam and foiling antibiotic resistant infections
Speaker
10/11/2017
Generating metabolic robustness for antibiotic biosynthesis though the expansion of primary metabolism in Streptomyces
Speaker
26/10/2017
Generating metabolic robustness for antibiotic biosynthesis though the expansion of primary metabolism in Streptomyces
Speaker
18/9/2017

more professional activities

Projects

Evolutionary genomics for the sustainable exploitation of microbes from Mexican niches: from biodiversity to application (Newton Fund) Newton Advanced Fellowship (Francisco Barona-Gomez)
Hoskisson, Paul (Principal Investigator)
17-Jan-2018 - 16-Jan-2021
Combatting antimicrobial resistance through new software for Natural Products Discovery (Tools and Resources Development Fund)
Duncan, Katherine (Principal Investigator) Hoskisson, Paul (Co-investigator)
01-Jan-2018 - 30-Jan-2020
Industrial CASE Account - University of Strathclyde 2018 | Foylan, Shannan
McConnell, Gail (Principal Investigator) Hoskisson, Paul (Co-investigator) Foylan, Shannan (Research Co-investigator)
01-Jan-2018 - 01-Jan-2022
Doctoral Training Partnership 2018-19 University of Strathclyde | Murray, Jordan
McConnell, Gail (Principal Investigator) Hoskisson, Paul (Co-investigator) Murray, Jordan (Research Co-investigator)
01-Jan-2018 - 01-Jan-2022
Genome sequencing and analysis of Streptomyces strains
Hoskisson, Paul (Principal Investigator)
01-Jan-2018 - 28-Jan-2019
Fast-tracking Health Innovation for NHS Scotland. MRC Confidence in Concept / R180246-103
Corrigan, Damion (Principal Investigator) Hoskisson, Paul (Co-investigator) Shu, Will (Co-investigator)
01-Jan-2018 - 28-Jan-2020

more projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Hamnett Wing

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