Professor Craig Jamieson

Publications

Synthesis and evaluation of small molecule inhibitors of the androgen receptor N-terminal domain

Henry Martyn C, Riley Christopher M, Hunter Irene, Elwood Jessica M L, Lopez-Fernandez J Daniel, Minty Laura, Coe Diane M, McEwan Iain J, Jamieson Craig

ACS Medicinal Chemistry Letters Vol 14, pp. 1800-1806 (2023)

https://doi.org/10.1021/acsmedchemlett.3c00426

Computer vision as a new paradigm for monitoring of solution and solid phase peptide synthesis

Yan Chunhui, Fyfe Calum, Minty Laura, Barrington Henry, Jamieson Craig, Reid Marc

Chemical Science Vol 14, pp. 11872-11880 (2023)

https://doi.org/10.1039/d3sc01383a

Current and emerging approaches to noncompetitive AR inhibition

Riley Christopher M, Elwood Jessica M L, Henry Martyn C, Hunter Irene, Lopez-Fernandez J Daniel, McEwan Iain J, Jamieson Craig

Medicinal Research Reviews Vol 43, pp. 1701-1747 (2023)

https://doi.org/10.1002/med.21961

Multigram-scale synthesis of a gem-difluoro-substituted 4,5,6,7-tetrahydrobenzo[c]thiophen-4-one heterocycle via oxidative chlorination and radical Smiles rearrangement

Henry Martyn C, Anderson Jack Q, Jamieson Craig

Synlett Vol 34 (2023)

https://doi.org/10.1055/a-2153-7341

Functionalized tetrazoles as latent active esters in the synthesis of amide bonds

Elwood Jessica M L, Henry Martyn C, Lopez-Fernandez J Daniel, Mowat Jenna M, Boyle Mhairi, Buist Benjamin, Livingstone Keith, Jamieson Craig

Organic Letters Vol 24, pp. 9491-9496 (2022)

https://doi.org/10.1021/acs.orglett.2c03971

Identification and optimization of a ligand-efficient benzoazepinone bromodomain and extra terminal (BET) family acetyl-lysine mimetic into the oral candidate quality molecule I-BET432

Humphreys Philip G, Anderson Niall A, Bamborough Paul, Baxter Andrew, Chung Chun-wa, Cookson Rosa, Craggs Peter D, Dalton Toryn, Fournier Julie C L, Gordon Laurie J, Gray Heather F, Gray Matthew W, Gregory Richard, Hirst David J, Jamieson Craig, Jones Katherine L, Kessedjian Hripsimee, Lugo David, McGonagle Grant, Patel Vipulkumar K, Patten Christopher, Poole Darren L, Prinjha Rab K, Ramirez-Molina Cesar, Rioja Inmaculada, Seal Gail, Stafford Kayleigh A J, Shah Rishi R, Tape Daniel, Theodoulou Natalie H, Tomlinson Laura R, Ukuser Sabri, Wall Ian D, Wellaway Natalie, White Gemma

Journal of Medicinal Chemistry Vol 65, pp. 15174-15207 (2022)

https://doi.org/10.1021/acs.jmedchem.2c01102

More publications

Research Interests

Biography

Craig Jamieson earned his BSc (Hons) in Chemistry at the University of Glasgow in 1996. His PhD studies were carried out under the direction of Professor R Ramage at the University of Edinburgh (1999).  Following postdoctoral research under the supervision of Professor S V Ley at the University of Cambridge, in 2001 he was appointed as a Principal Scientist in GlaxoSmithKline's Discovery Medicinal Chemistry group working on a range of exploratory medicinal chemistry programmes.  In 2004, Craig joined Organon Laboratories (later Merck Research Labs) as a Group Leader in the Medicinal Chemistry Department, with responsibility for hit to clincal candidate optimisation.  In August 2010, Craig was appointed as a John Anderson Research Lecturer in Chemical Biology, based in the Department of Pure and Applied Chemistry at the University of Strathclyde where he is currently a Professor in the Chemical Biology and Medicinal Chemistry Research Theme.

Research Interests

A major area of focus for our research continues to be in the Chemistry-Biology-Medicine continuum.  In this regard, we have a number of active programmes centred around hit and lead identification on disease targets and mechanisms in areas of significant societal need.  Allied to our work in the medicinal chemistry sphere, we also have a keen interest in the development of novel, enabling synthetic methodologies to enhance the armamentarium of molecule makers working in our arena.  We collaborate with groups and industrial partners locally, nationally and globally in order to effectively meet our research goals.

Professional Activities

Sequence engineering to improve syringeability of high concentration mAb formulations

Contributor

23/11/2022

Gyros Protein Technologies

Visiting researcher

1/6/2019

Almac Sciences

Visiting researcher

31/5/2019

Aldeyra Therapeutics Inc

Consultant

1/10/2018

Arc Scientific

Consultant

1/1/2016

Syngenta Limited

Visiting researcher

1/1/2014

More professional activities

Projects

A Prosperity Partnership for the Design of Next-Generation Antibody Drug Bioconjugates (Next-Gen ADC)

Burley, Glenn (Principal Investigator) Jamieson, Craig (Co-investigator) Kerr, William (Co-investigator) Nordon, Alison (Co-investigator) Rattray, Zahra (Co-investigator) Tomkinson, Nick (Co-investigator)

15-Jan-2023 - 14-Jan-2028

Developing new bioanalytical pipelines for early-stage assessment of antibody-drug conjugate developability

Rattray, Zahra (Principal Investigator) Jamieson, Craig (Co-investigator) Jolliffe, Sophie (Research Co-investigator)

02-Jan-2023 - 01-Jan-2027

Industrial CASE Account - University of Strathclyde 2022 | McTaggart, Eilidh

Jamieson, Craig (Principal Investigator) Burley, Glenn (Co-investigator) McTaggart, Eilidh (Research Co-investigator)

01-Jan-2023 - 01-Jan-2027

NMR-BASE: Nuclear Magnetic Resonance for Biomolecule Analysis in Supported Environments

Parkinson, John (Principal Investigator) Burley, Glenn (Co-investigator) Dufès, Christine (Co-investigator) Irving, Craig (Co-investigator) Jamieson, Craig (Co-investigator) Scott, Fraser (Co-investigator) Seib, Philipp (Co-investigator) Taladriz Sender, Andrea (Co-investigator)

01-Jan-2023 - 31-Jan-2024

Industrial CASE Account - University of Strathclyde 2022 | Jackson, Cara

Beveridge, Rebecca (Principal Investigator) Jamieson, Craig (Co-investigator) Jackson, Cara (Research Co-investigator)

01-Jan-2022 - 01-Jan-2026

Industrial CASE Account - University of Strathclyde 2021 | Powell, Daniel

Tomkinson, Nick (Principal Investigator) Jamieson, Craig (Co-investigator) Powell, Daniel (Research Co-investigator)

01-Jan-2022 - 01-Jan-2026

More projects