Dr Charles Kennedy

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Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Dr Charles Kennedy obtained a B.Sc. Honours in Pharmacology from the University of Aberdeen then a PhD in Pharmacology from University College London where he worked with Professor Geoffrey Burnstock, FRS. Following a postdoctoral position at Michigan State University in America he was a Beit Research Memorial Fellow at the University of Cambridge before joining the lecturing staff at Strathclyde.

Charles is a Fellow of the British Pharmacological Society and represents SIPBS on the society's Committee of Heads of Pharmacology. He is currently an editor of the British Journal of Pharmacology and Autonomic Neuroscience: Basic & Clinical and is on the editorial board of Purinergic Signalling and Automatic & Autocoid Pharmacology. He also chairs the IUPHAR P2X receptor nomenclature sub-committee and is a member of the IUPHAR P2Y receptor nomenclature sub-committee. In addition he has acted as the external examiner of undergraduate degrees at the Universities of Edinburgh, Nottingham and Surrey.

Our research focuses on the functions of ATP and the related nucleotides ADP, UTP and UDP, when acting through the P2X and P2Y nucleotide receptors. These are dynamic research areas with substantial therapeutic implications in areas such as chronic pain, control of blood pressure and urinary bladder dysfunction, and to which we have made significant contributions. We use a range of experimental techniques, including whole cell patch clamp electophysiology, intracellular calcium ion-imaging, molecular biology and organ bath pharmacology on whole tissues dissociated cells and cloned receptors. The lab has an industrious, but friendly atmosphere and comes complete with CD player and digital radio.

Publications

Characterisation of P2Y2 receptors in human vascular endothelial cells using AR-C118925XX, a competitive and selective P2Y2 antagonist
Muoboghare Markie O, Drummond Robert M, Kennedy Charles
British Journal of Pharmacology Vol 176, pp. 2894-2904 (2019)
https://doi.org/10.1111/bph.14715
P2Y1 and P2Y12 receptor heterodimerisation : from recombinant systems to native detection
Safar MA, Wood R, Cunningham MR, Kennedy C
British Journal of Pharmacology Vol 176, pp. 3049 (2019)
https://doi.org/10.1111/bph.14681
Spatially-structured cell populations process multiple sensory signals in parallel in intact vascular endothelium : stimulus-specific sensory cells in the intact vascular endothelium
Lee Matthew D, Wilson Calum, Saunter Christopher D, Kennedy Charles, Girkin John M, McCarron John G
Science Signaling Vol 11 (2018)
https://doi.org/10.1126/scisignal.aar4411
P2Y1and P2Y12 receptor heterodimerisation : from recombinant systems to native detection
Safar Mohammed Adnan A, Wood Rachel Aimee, Tate Rothwelle, Cunningham Margaret Rose, Kennedy Charles
BPS-MPGPCR 2018 (2018)
P2Y1 and P2Y12 receptor heterodimerisation : from recombinant systems to native detection
Safar Mohammed Adnan A, Wood Rachel Aimee, Tate Rothwelle, Cunningham Margaret Rose, Kennedy Charles
BPS-MPGPCR 2018 (2018)
Heterodimerisation of purinergic GPCRs
Safar Mohammed Adnan A, Wood Rachel A, Cunningham Margaret R, Kennedy Charles
Molecular Neuropharmacology in Health and Wellbeing (2018)

more publications

Professional activities

Pharmacology 2014
Participant
16/12/2014
5th BPS Focused Meeting on Cell Signalling
Participant
2014
Glasgow Neuroscience Day, Glasgow, UK.
Participant
2014
PhD External Examiner
External Examiner
2014
British Pharmacological Society Winter Meeting 2013
Participant
2013
IUPS 2013, Birmingham, UK.
Participant
2013

more professional activities

Projects

Inhibitory purinergic signalling in vascular smooth muscle and its alteration in hypertensio
MacMillan, Debbi (Principal Investigator) Kennedy, Charles (Co-investigator) McCarron, John (Co-investigator)
07-Jan-2011 - 06-Jan-2013
The effects of Chinese traditional medicines on P2X receptors in sensory neurones
Kennedy, Charles (Principal Investigator)
01-Jan-2005 - 30-Jan-2007
SIGNALLING MECHANISMS UNDERLYING P2Y RECEPTOR-MEDIATED VASOCONSTRICTION IN PULMONARY ARTERIES
Kennedy, Charles (Principal Investigator)
01-Jan-2004 - 30-Jan-2008

more projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Robertson Wing

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