Dr Charles Kennedy

Academic Visitor

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Dr Charles Kennedy obtained a B.Sc. Honours in Pharmacology from the University of Aberdeen then a PhD in Pharmacology from University College London where he worked with Professor Geoffrey Burnstock, FRS. Following a postdoctoral position at Michigan State University in America he was a Beit Research Memorial Fellow at the University of Cambridge before joining the lecturing staff at Strathclyde.

Charles is a Fellow of the British Pharmacological Society and represents SIPBS on the society's Committee of Heads of Pharmacology. He is currently an editor of the British Journal of Pharmacology and Autonomic Neuroscience: Basic & Clinical and is on the editorial board of Purinergic Signalling and Automatic & Autocoid Pharmacology. He also chairs the IUPHAR P2X receptor nomenclature sub-committee and is a member of the IUPHAR P2Y receptor nomenclature sub-committee. In addition he has acted as the external examiner of undergraduate degrees at the Universities of Edinburgh, Nottingham and Surrey.

Our research focuses on the functions of ATP and the related nucleotides ADP, UTP and UDP, when acting through the P2X and P2Y nucleotide receptors. These are dynamic research areas with substantial therapeutic implications in areas such as chronic pain, control of blood pressure and urinary bladder dysfunction, and to which we have made significant contributions. We use a range of experimental techniques, including whole cell patch clamp electophysiology, intracellular calcium ion-imaging, molecular biology and organ bath pharmacology on whole tissues dissociated cells and cloned receptors. The lab has an industrious, but friendly atmosphere and comes complete with CD player and digital radio.

Publications

Different responses of the blockade of the P2Y1 receptor with BPTU in human and porcine intestinal tissues and in cell cultures
Traserra Sara, Barber Claudia, MacInnes Jane, Relea Lucia, MacPherson Lewis C, Cunningham Margaret R, Vergara Patri, Accarino Anna, Kennedy Charles, Jimenez Marcel
Neurogastroenterology and Motility Vol 33 (2021)
https://doi.org/10.1111/nmo.14101
The P2Y/P2X divide : how it began
Kennedy Charles
Biochemical Pharmacology Vol 187 (2021)
https://doi.org/10.1016/j.bcp.2021.114408
That was then, this is now : the development of our knowledge and understanding of P2 receptor subtypes
Kennedy Charles
Purinergic Signalling Vol 17, pp. 9-23 (2021)
https://doi.org/10.1007/s11302-021-09763-0
Update of P2X receptor properties and their pharmacology : IUPHAR review 30
Illes Peter, Müller Christa E, Jacobson Kenneth A, Grutter Thomas, Nicke Annette, Fountain Samuel J, Kennedy Charles, Schmalzing Günther, Jarvis Michael F, Stojilkovic Stanko S, King Brian F, Di Virgilio Francesco
British Journal of Pharmacology Vol 178, pp. 489-514 (2021)
https://doi.org/10.1111/bph.15299
Interrogating purinergic P2Y1 and P2Y12 heterodimerisation
Safar Mohammed, Tate Rothwelle, Sapermsap Natakorn, Li David, Cunningham Margaret, Kennedy Charles
3rd ERNEST Conference (2020)
Update of P2Y receptor pharmacology : IUPHAR Review 27
Jacobson Kenneth A, Delicado Esmerilda G, Gachet Christian, Kennedy Charles, von Kügelgen Ivar, Li Beibei, Miras-Portugal M Teresa, Novak Ivana, Schöneberg Torsten, Perez-Sen Raquel, Thor Doreen, Wu Beili, Yang Zhenlin, Müller Christa E
British Journal of Pharmacology Vol 177, pp. 2413–2433 (2020)
https://doi.org/10.1111/bph.15005

More publications

Professional activities

Pharmacology 2014
Participant
16/12/2014
Glasgow Neuroscience Day, Glasgow, UK.
Participant
2014
5th BPS Focused Meeting on Cell Signalling
Participant
2014
PhD External Examiner
External Examiner
2014
5th UK Purine Symposium
Participant
2013
PhD External Examiner
External Examiner
2013

More professional activities

Projects

Inhibitory purinergic signalling in vascular smooth muscle and its alteration in hypertensio
MacMillan, Debbi (Principal Investigator) Kennedy, Charles (Co-investigator) McCarron, John (Co-investigator)
07-Jan-2011 - 06-Jan-2013
The effects of Chinese traditional medicines on P2X receptors in sensory neurones
Kennedy, Charles (Principal Investigator)
01-Jan-2005 - 30-Jan-2007
SIGNALLING MECHANISMS UNDERLYING P2Y RECEPTOR-MEDIATED VASOCONSTRICTION IN PULMONARY ARTERIES
Kennedy, Charles (Principal Investigator)
01-Jan-2004 - 30-Jan-2008

More projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences

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