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Dr Charles Kennedy

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Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Dr Charles Kennedy obtained a B.Sc. Honours in Pharmacology from the University of Aberdeen then a PhD in Pharmacology from University College London where he worked with Professor Geoffrey Burnstock, FRS. Following a postdoctoral position at Michigan State University in America he was a Beit Research Memorial Fellow at the University of Cambridge before joining the lecturing staff at Strathclyde.

Charles is a Fellow of the British Pharmacological Society and represents SIPBS on the society's Committee of Heads of Pharmacology. He is currently an editor of the British Journal of Pharmacology and Autonomic Neuroscience: Basic & Clinical and is on the editorial board of Purinergic Signalling and Automatic & Autocoid Pharmacology. He also chairs the IUPHAR P2X receptor nomenclature sub-committee and is a member of the IUPHAR P2Y receptor nomenclature sub-committee. In addition he has acted as the external examiner of undergraduate degrees at the Universities of Edinburgh, Nottingham and Surrey.

Our research focuses on the functions of ATP and the related nucleotides ADP, UTP and UDP, when acting through the P2X and P2Y nucleotide receptors. These are dynamic research areas with substantial therapeutic implications in areas such as chronic pain, control of blood pressure and urinary bladder dysfunction, and to which we have made significant contributions. We use a range of experimental techniques, including whole cell patch clamp electophysiology, intracellular calcium ion-imaging, molecular biology and organ bath pharmacology on whole tissues dissociated cells and cloned receptors. The lab has an industrious, but friendly atmosphere and comes complete with CD player and digital radio.

Publications

P2Y11 receptors : properties, distribution and functions
Kennedy Charles
Advances in Experimental Medicine and Biology, (2017)
ATP as a cotransmitter in the autonomic nervous system
Kennedy Charles
Autonomic Neuroscience: Basic and Clinical Vol 191, pp. 2-15, (2015)
http://dx.doi.org/10.1016/j.autneu.2015.04.004
UTP is not a biased agonist at human P2Y11 receptors
Morrow Gael B., Nicholas Robert A., Kennedy Charles
Purinergic Signalling Vol 10, pp. 581-585, (2014)
http://dx.doi.org/10.1007/s11302-014-9418-3
The Concise Guide to PHARMACOLOGY 2013/14 : overview
Alexander Stephen P H, Benson Helen E, Faccenda Elena, Pawson Adam J, Sharman Joanna L, McGrath John C, Catterall William A, Spedding Michael, Peters John A, Harmar Anthony J, Abul-Hasn N, Anderson C M, Anderson C M H, Araiksinen M S, Arita M, Arthofer E, Barker E L, Barratt C, Barnes N M, Bathgate R, Beart P M, Belelli D, Bennett A J, Birdsall N J M, Boison D, Bonner T I, Brailsford L, Bröer S, Brown P, Calo G, Carter W G, Catterall W A, Chan S L F, Chao M V, Chiang N, Christopoulos A, Chun J J, Cidlowski J, Clapham D E, Cockcroft S, Connor M A, Cox H M, Cuthbert A, Dautzenberg F M, Davenport A P, Dawson P A, Dent G, Dijksterhuis J P, Dollery C T, Dolphin A C, Donowitz M, Dubocovich M L, Eiden L, Eidne K, Evans B A, Fabbro D, Fahlke C, Farndale R, Fitzgerald G A, Fong T M, Fowler C J, Fry J R, Funk C D, Futerman A H, Ganapathy V, Gaisnier B, Gershengorn M A, Goldin A, Goldman I D, Gundlach A L, Hagenbuch B, Hales T G, Hammond J R, Hamon M, Hancox J C, Hauger R L, Hay D L, Hobbs A J, Hollenberg M D, Holliday N D, Hoyer D, Hynes N A, Inui K-I, Ishii S, Jacobson K A, Jarvis G E, Jarvis M F, Jensen R, Jones C E, Jones R L, Kaibuchi K, Kanai Y, Kennedy C, Kerr I D, Khan A A, Klienz M J, Kukkonen J P, Lapoint J Y, Leurs R, Lingueglia E, Lippiat J, Lolait S J, Lummis S C R, Lynch J W, MacEwan D, Maguire J J, Marshall I L, May J M, McArdle C A, McGrath J C, Michel M C, Millar N S, Miller L J, Mitolo V, Monk P N, Moore P K, Moorhouse A J, Mouillac B, Murphy P M, Neubig R R, Neumaier J, Niesler B, Obaidat A, Offermanns S, Ohlstein E, Panaro M A, Parsons S, Pwrtwee R G, Petersen J, Pin J-P, Poyner D R, Prigent S, Prossnitz E R, Pyne N J, Pyne S, Quigley J G, Ramachandran R, Richelson E L, Roberts R E, Roskoski R, Ross R A, Roth M, Rudnick G, Ryan R M, Said S I, Schild L, Sanger G J, Scholich K, Schousboe A, Schulte G, Schulz S, Serhan C N, Sexton P M, Sibley D R, Siegel J M, Singh G, Sitsapesan R, Smart T G, Smith D M, Soga T, Stahl A, Stewart G, Stoddart L A, Summers R J, Thorens B, Thwaites D T, Toll L, Traynor J R, Usdin T B, Vandenberg R J, Villalon C, Vore M, Waldman S A, Ward D T, Willars G B, Wonnacott S J, Wright E, Ye R D, Yonezawa A, Zimmermann M, null null
British Journal of Pharmacology Vol 170, pp. 1449-58, (2013)
http://dx.doi.org/10.1111/bph.12444
P2X and P2Y nucleotide receptors as targets in cardiovascular disease
Kennedy Charles, Chootip Krongkarn, Mitchell Callum, Syed Nawazish-I-Husain, Tengah Asrin
Future Medicinal Chemistry Vol 5, pp. 431-439, (2013)
http://dx.doi.org/10.4155/fmc.13.6
The importance of drug discovery for treatment of cardiovascular diseases.
Kennedy Charles
Future Medicinal Chemistry Vol 5, pp. 355-357, (2013)
http://dx.doi.org/10.4155/fmc.13.20

more publications

Professional activities

Pharmacology 2014
Participant
16/12/2014
5th BPS Focused Meeting on Cell Signalling
Participant
2014
Glasgow Neuroscience Day, Glasgow, UK.
Participant
2014
PhD External Examiner
External Examiner
2014
British Journal of Pharmacology (Journal)
Editor
2013
5th UK Purine Symposium
Participant
2013

more professional activities

Projects

SIGNALLING MECHANISMS UNDERLYING P2Y RECEPTOR-MEDIATED VASOCONSTRICTION IN PULMONARY ARTERIES
Kennedy, Charles (Principal Investigator)
Period 01-Oct-2004 - 30-Sep-2008
Inhibitory purinergic signalling in vascular smooth muscle and its alteration in hypertensio
Kennedy, Charles (Co-investigator) McCarron, John (Co-investigator)
Period 07-Mar-2011 - 06-Mar-2013
The effects of Chinese traditional medicines on P2X receptors in sensory neurones
Kennedy, Charles (Principal Investigator)
Period 01-Oct-2005 - 30-Sep-2007

more projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
John Arbuthnott Building Robertson Wing

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