Professor Mandy MacLean

Strathclyde Institute of Pharmacy and Biomedical Sciences


Personal statement

Mandy obtained her PhD in Pharmacology from the University of Edinburgh in 1985 and then spend a year in the USA and three years in Cambridge before moving to The University of Glasgow in 1989. Mandy joined SIPBS in 2019. Her research has focused on the role of serotonin in the development of pulmonary arterial hypertension (PAH). As more women get PAH than men, more recently her work has focused on sex effects and oestrogen metabolism in PAH.  She has a BHF programme grant and recently won the 2017 Reynold Spector Award for Clinical Pharmacology from the American Society for Pharmacology and Experimental Therapeutics (ASPET). Other researchawards include a Royal Society Wolfson Research Merit Award in 2010 and a Royal Society Leverhulme Trust Senior Research Fellowship in 2013. In 2013 she was elected as a Fellow of The Royal Society of Edinburgh (FRSE) and awarded the British Pharmacological Society AstraZeneca Prize for Women in Pharmacology. She was elected as an Ordinary Member and Trustee of Council for the Royal Society of Edinburgh and was Vice-President (Life Sciences) of the Royal Society of Edinburgh. Mandy received an MBE in the 2010 Queen’s New Years Honours list for her career and public engagement activities. She plays a key role in the University’s public engagement agenda and co-hosted monthly events for Glasgow’s Cafe Scientifique (2004-2023). In 2018 she was made a Fellow of the Academy of Medical Sciences and was the Scottish Champion for the Academy of Medical Sciences in 2018-19. In July 2019 Mandy was awarded the title of 'Distinguished Professor' by The University of Strathclyde. In December 2020 Mandy was elected onto Council of The Academy of Medical Sciences and  is their Council EDI champion and Chair of their Mentoring Advisory Group. Mandy is also a trustee of, and sits on the Board of, the Glasgow Children's Hospital Charity.

Back to staff profile


A pilot study to examine association of BMI with functional class and 6 min walk distance in idiopathic and heritable PAH : possible association with estrogen metabolism
MacLean Margaret R, Pandya Divya, Swietlik Emilia M, Denver Nina, Mair Kirsty, Morrell Nicholas W, Gräf Stefan
Pulmonary Circulation Vol 12 (2022)
Serotonin and pulmonary hypertension; sex and drugs and ROCK and Rho
MacLean Margaret R, Fanburg Barry, Hill Nicolas, Lazarus Howard M, Pack Thomas F, Palacios Michelle, Penumatsa Krishna C, Wring Stephen A
Comprehensive Physiology Vol 12, pp. 1-16 (2022)
Sex dependent changes in pulmonary hypertension and penetrance mediated by a high fat diet in transgenic mice with a human BMPR2 mutation (R899X)
Labazi H, Aitchison G, Mair K, Denver N, Nilsen M, Laforest S, Gebril A, Maclean MR
American Journal of Respiratory and Critical Care Medicine Vol 205, pp. A1173-A1173 (2022)
Insights from the menstrual cycle in pulmonary arterial hypertension
Baird Grayson L, Walsh Thomas, Aliotta Jason, Allahua Melissa, Andrew Ruth, Bourjeily Ghada, Brodsky Alexander S, Denver Nina, Dooner Mark, Harrington Elizabeth O, Klinger James R, MacLean Margaret R, Mullin Christopher J, Pereira Mandy, Poppas Athena, Whittenhall Mary, Ventetuolo Corey E
Annals of the American Thoracic Society Vol 18, pp. 218-228 (2021)
Sex-dependent right ventricular hypertrophic gene changes after methamphetamine treatment in mice
Labazi Hicham, Nilsen Margaret, MacLean Margaret R
European Journal of Pharmacology Vol 900 (2021)
Sex differences in pulmonary hypertension
Morris Hannah, Denver Nina, Gaw Rosemary, Labazi Hicham, Mair Kirsty, MacLean Margaret R
Clinics in Chest Medicine Vol 42, pp. 217-228 (2021)

More publications

Back to staff profile

Professional Activities

The Pharmacology of Harry Potter Potions
American Thoracic Society
British Thoracic Society
American Heart Association
Potions and Pharmacology: The science behind Harry Potters potions!
British Heart Foundation BHF (External organisation)

More professional activities


Obesity and estrogen metabolism in pulmonary arterial hypertension
MacLean, Mandy (Principal Investigator)
01-Jan-2022 - 31-Jan-2026
High Resolution Mass Spectrometry to enhance hormonal profiling across the lifespan (BBSRC ALERT Mid-range Equipment)
MacLean, Mandy (Principal Investigator)
01-Jan-2021 - 31-Jan-2022
Blood flow dynamics in women with pulmonary arterial hypertension: A numerical investigation into the effects of pulmonary vascular resistance based on 4D flow magnetic resonance imaging
Kazakidi, Asimina (Principal Investigator) MacLean, Mandy (Co-investigator) Dolean Maini, Victorita (Co-investigator) Boumpouli, Maria (Co-investigator) Hall Barrientos, Pauline (Co-investigator)
EPSC STEM Equals Pump Priming grant, part of the EPSRC Inclusion Matters grant (EP/S012133/1). Award: £5,000
01-Jan-2020 - 31-Jan-2021
Doctoral Training Partnership 2020-2021 University of Strathclyde | Coyle, Chelbi
Tian, Lian (Principal Investigator) MacLean, Mandy (Co-investigator) Coyle, Chelbi (Research Co-investigator)
01-Jan-2020 - 01-Jan-2024
Oestrogen and oestrogen metabolites in pulmonary arterial hypertension
MacLean, Mandy (Principal Investigator)
01-Jan-2020 - 30-Jan-2024
RG/16/2/32153: Sex and the development of pulmonary arterial hypertension. BHF Programme transfer.
MacLean, Mandy (Principal Investigator)
25-Jan-2019 - 18-Jan-2022

More projects

Back to staff profile


Professor Mandy MacLean
Strathclyde Institute of Pharmacy and Biomedical Sciences

Tel: 548 4286