Professor Mandy MacLean

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Mandy obtained her PhD in Pharmacology from the University of Edinburgh in 1985 and then spend a year in the USA and three years in Cambridge before moving to The University of Glasgow in 1989. Mandy joined SIPBS in 2019. Her research has focused on the role of serotonin in the development of pulmonary arterial hypertension (PAH). As more women get PAH than men, more recently her work has focused on sex effects and oestrogen metabolism in PAH.  She has a BHF programme grant and recently won the 2017 Reynold Spector Award for Clinical Pharmacology from the American Society for Pharmacology and Experimental Therapeutics (ASPET). Other researchawards include a Royal Society Wolfson Research Merit Award in 2010 and a Royal Society Leverhulme Trust Senior Research Fellowship in 2013. In 2013 she was elected as a Fellow of The Royal Society of Edinburgh (FRSE) and awarded the British Pharmacological Society AstraZeneca Prize for Women in Pharmacology. She was elected as an Ordinary Member and Trustee of Council for the Royal Society of Edinburgh and is now Vice-President (Life Sciences) of the Royal Society of Edinburgh. Mandy received an MBE in the 2010 Queen’s New Years Honours list for her career and public engagement activities. She plays a key role in the University’s public engagement agenda including co-hosting monthly events for Glasgow’s Cafe Scientifique (since 2004). In 2018 she was made a Fellow of the Academy of Medical Sciences and has just been appointed the Scottish Champion for the Academy of Medical Sciences. In July 2019 Mandy was awarded the title of 'Distinguished Professor' by The University of Strathclyde.

Prizes and awards

Academy of Medical Sciences, Regional Champion for Scotland
Recipient
2018
Vice-President (Life Sciences) Royal Society of Edinburgh
Recipient
2018
Fellow of the Academy of Medical Sciences
Recipient
2018
British Pharmacological Society Honorary Fellowship
Recipient
2018
Reynold Spector Award in Clinical Pharmacology given by the American Society for Pharmacology and Experimental Therapeutics
Recipient
2017
Royal Society of Edinburgh Council and Trustee
Recipient
2015

more prizes and awards

Publications

Current strategies for quantification of estrogens in clinical research
Denver Nina, Khan Shazia, Homer Natalie ZM, MacLean Margaret R, Andrew Ruth
Journal of Steroid Biochemistry and Molecular Biology Vol 192 (2019)
https://doi.org/10.1016/j.jsbmb.2019.04.022
Data for analysis of catechol estrogen metabolites in human plasma by liquid chromatography tandem mass spectrometry
Denver Nina, Khan Shazia, Stasinopoulos Ioannis, Church Colin, Homer Natalie ZM, MacLean Margaret R, Andrew Ruth
Data in Brief Vol 23 (2019)
https://doi.org/10.1016/j.dib.2019.103740
Derivatization enhances analysis of estrogens and their bioactive metabolites in human plasma by liquid chromatography tandem mass spectrometry
Denver Nina, Khan Shazia, Stasinopoulos Ioannis, Church Colin, Homer Natalie ZM, MacLean Margaret R, Andrew Ruth
Analytica Chimica Acta Vol 1054, pp. 84-94 (2019)
https://doi.org/10.1016/j.aca.2018.12.023
Influence of 2-methoxyestradiol and sex on hypoxia-induced pulmonary hypertension and hypoxia-inducible factor-1-α
Docherty Craig K, Nilsen Margaret, MacLean Margaret R
Journal of the American Heart Association Vol 8 (2019)
https://doi.org/10.1161/JAHA.118.011628
The role of sex in the pathophysiology of pulmonary hypertension
Docherty Craig K, Harvey Katie Yates, Mair Kirsty M, Griffin Sinead, Denver Nina, MacLean Margaret R
Sex-Specific Analysis of Cardiovascular Function (2018) (2018)
https://doi.org/10.1007/978-3-319-77932-4_31
Role of the aryl hydrocarbon receptor in sugen 5416-induced experimental pulmonary hypertension
Dean Afshan, Gregorc Teja, Docherty Craig K, Harvey Katie Y, Nilsen Margaret, Morrell Nicholas W, MacLean Margaret R
American Journal of Respiratory Cell and Molecular Biology Vol 58, pp. 320-330 (2018)
https://doi.org/10.1165/rcmb.2017-0260OC

more publications

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Hamnett Wing

Location Map

View University of Strathclyde in a larger map