Professor Mandy MacLean

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Mandy obtained her PhD in Pharmacology from the University of Edinburgh in 1985 and then spend a year in the USA and three years in Cambridge before moving to The University of Glasgow in 1989. Mandy joined SIPBS in 2019. Her research has focused on the role of serotonin in the development of pulmonary arterial hypertension (PAH). As more women get PAH than men, more recently her work has focused on sex effects and oestrogen metabolism in PAH.  She has a BHF programme grant and recently won the 2017 Reynold Spector Award for Clinical Pharmacology from the American Society for Pharmacology and Experimental Therapeutics (ASPET). Other researchawards include a Royal Society Wolfson Research Merit Award in 2010 and a Royal Society Leverhulme Trust Senior Research Fellowship in 2013. In 2013 she was elected as a Fellow of The Royal Society of Edinburgh (FRSE) and awarded the British Pharmacological Society AstraZeneca Prize for Women in Pharmacology. She was elected as an Ordinary Member and Trustee of Council for the Royal Society of Edinburgh and is now Vice-President (Life Sciences) of the Royal Society of Edinburgh. Mandy received an MBE in the 2010 Queen’s New Years Honours list for her career and public engagement activities. She plays a key role in the University’s public engagement agenda including co-hosting monthly events for Glasgow’s Cafe Scientifique (since 2004). In 2018 she was made a Fellow of the Academy of Medical Sciences and has just been appointed the Scottish Champion for the Academy of Medical Sciences. In July 2019 Mandy was awarded the title of 'Distinguished Professor' by The University of Strathclyde. In December 2020 Mandy was elected onto Council of The Academy of Medical Sciences and onto the Board of Glasgow Children's Hospital Charity.

Publications

Insights from the menstrual cycle in pulmonary arterial hypertension
Baird Grayson L, Walsh Thomas, Aliotta Jason, Allahua Melissa, Andrew Ruth, Bourjeily Ghada, Brodsky Alexander S, Denver Nina, Dooner Mark, Harrington Elizabeth O, Klinger James R, MacLean Margaret R, Mullin Christopher J, Pereira Mandy, Poppas Athena, Whittenhall Mary, Ventetuolo Corey E
Annals of the American Thoracic Society Vol 18, pp. 218-228 (2021)
https://doi.org/10.1513/AnnalsATS.202006-671OC
Sex-dependent right ventricular hypertrophic gene changes after methamphetamine treatment in mice
Labazi Hicham, Nilsen Margaret, MacLean Margaret R
European Journal of Pharmacology Vol 900 (2021)
https://doi.org/10.1016/j.ejphar.2021.174066
Sex differences in pulmonary hypertension
Morris Hannah, Denver Nina, Gaw Rosemary, Labazi Hicham, Mair Kirsty, MacLean Margaret R
Clinics in Chest Medicine Vol 42, pp. 217-228 (2021)
https://doi.org/10.1016/j.ccm.2020.10.005
Estrogen signaling and portopulmonary hypertension : the pulmonary vascular complications of liver disease study (PVCLD2)
Al-Naamani Nadine, Krowka Michael J, Forde Kimberly A, Krok Karen L, Feng Rui, Heresi Gustavo A, Dweik Raed A, Bartolome Sonja, Bull Todd M, Roberts Kari E, Austin Eric D, Hemnes Anna R, Patel Mamta J, Oh Jae K, Lin Grace, Doyle Margaret F, Denver Nina, Andrew Ruth, MacLean Margaret R, Fallon Michael B, Kawut Steven M
Hepatology Vol 73, pp. 726-737 (2021)
https://doi.org/10.1002/hep.31314
Direct delivery of microRNA96 to the lungs reduces progression of sugen/hypoxia-induced pulmonary hypertension in the rat
Docherty Craig K, Denver Nina, Fisher Simon, Nilsen Margaret, Hillyard Dianne, Openshaw Rebecca L, Labazi Hicham, MacLean Margaret R
Molecular Therapy - Nucleic Acids Vol 22, pp. 396-405 (2020)
https://doi.org/10.1016/j.omtn.2020.09.002
Obesity, estrogens and adipose tissue dysfunction : implications for pulmonary arterial hypertension
Mair Kirsty M, Gaw Rosemary, MacLean Margaret R
Pulmonary Circulation Vol 10, pp. 1-21 (2020)
https://doi.org/10.1177/2045894020952023

More publications

Professional activities

The Pharmacology of Harry Potter Potions
Speaker
16/8/2021
American Thoracic Society
Speaker
5/2021
British Thoracic Society
Chair
2/2021
American Heart Association
Speaker
11/2020
Potions and Pharmacology: The science behind Harry Potters potions!
Contributor
6/2/2020
Vascular pharmacology (Journal)
Associate Editor
2020

More professional activities

Projects

Doctoral Training Partnership 2020-2021 University of Strathclyde | Coyle, Chelbi
Bushell, Trevor (Principal Investigator) Plevin, Robin (Principal Investigator) Tian, Lian (Principal Investigator) MacLean, Mandy (Co-investigator) Coyle, Chelbi (Research Co-investigator)
01-Jan-2020 - 01-Jan-2024
Oestrogen and oestrogen metabolites in pulmonary arterial hypertension
MacLean, Mandy (Principal Investigator)
01-Jan-2020 - 31-Jan-2024
RG/16/2/32153: Sex and the development of pulmonary arterial hypertension. BHF Programme transfer.
MacLean, Mandy (Principal Investigator)
25-Jan-2019 - 31-Jan-2022

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Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Hamnett Wing

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