Professor Mandy MacLean

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Mandy obtained her PhD in Pharmacology from the University of Edinburgh in 1985 and then spend a year in the USA and three years in Cambridge before moving to The University of Glasgow in 1989. Mandy joined SIPBS in 2019. Her research has focused on the role of serotonin in the development of pulmonary arterial hypertension (PAH). As more women get PAH than men, more recently her work has focused on sex effects and oestrogen metabolism in PAH.  She has a BHF programme grant and recently won the 2017 Reynold Spector Award for Clinical Pharmacology from the American Society for Pharmacology and Experimental Therapeutics (ASPET). Other researchawards include a Royal Society Wolfson Research Merit Award in 2010 and a Royal Society Leverhulme Trust Senior Research Fellowship in 2013. In 2013 she was elected as a Fellow of The Royal Society of Edinburgh (FRSE) and awarded the British Pharmacological Society AstraZeneca Prize for Women in Pharmacology. She was elected as an Ordinary Member and Trustee of Council for the Royal Society of Edinburgh and is now Vice-President (Life Sciences) of the Royal Society of Edinburgh. Mandy received an MBE in the 2010 Queen’s New Years Honours list for her career and public engagement activities. She plays a key role in the University’s public engagement agenda including co-hosting monthly events for Glasgow’s Cafe Scientifique (since 2004). In 2018 she was made a Fellow of the Academy of Medical Sciences and has just been appointed the Scottish Champion for the Academy of Medical Sciences. In July 2019 Mandy was awarded the title of 'Distinguished Professor' by The University of Strathclyde.

Prizes and awards

Academy of Medical Sciences, Regional Champion for Scotland
Recipient
2018
Fellow of the Academy of Medical Sciences
Recipient
2018
Vice-President (Life Sciences) Royal Society of Edinburgh
Recipient
2018
British Pharmacological Society Honorary Fellowship
Recipient
2018
Reynold Spector Award in Clinical Pharmacology given by the American Society for Pharmacology and Experimental Therapeutics
Recipient
2017
Royal Society of Edinburgh Council and Trustee
Recipient
2015

more prizes and awards

Publications

Reduction of the serotonin 5-HT1B and 5-HT2A receptor-mediated contraction of human pulmonary artery by the combined 5-HT1B receptor antagonist and serotonin transporter inhibitor LY393558
Baranowska-Kuczko Marta, Kozłowska Hanna, Schlicker Eberhard, Göthert Manfred, MacLean Margaret R, Kozłowski Mirosław, Kloza Monika, Sadowska Olga, Malinowska Barbara
Pharmacological Reports (2020)
https://doi.org/10.1007/s43440-020-00105-2
Estrogen signaling and portopulmonary hypertension : the pulmonary vascular complications of liver disease study (PVCLD2)
Al-Naamani Nadine, Krowka Michael J, Forde Kimberly A, Krok Karen L, Feng Rui, Heresi Gustavo A, Dweik Raed A, Bartolome Sonja, Bull Todd M, Roberts Kari E, Austin Eric D, Hemnes Anna R, Patel Mamta J, Oh Jae K, Lin Grace, Doyle Margaret F, Denver Nina, Andrew Ruth, MacLean Margaret, Fallon Michael B, Kawut Steven M
Hepatology (2020)
Estrogen metabolites in a small cohort of patients with idiopathic pulmonary arterial hypertension
Denver Nina, Homer Natalie ZM, Andrew Ruth, Harvey Katie Y, Morrell Nicholas, Austin Eric D, MacLean Margaret R
Pulmonary Circulation Vol 10 (2020)
https://doi.org/10.1177/2045894020908783
Understanding longitudinal biventricular structural and functional changes in a pulmonary hypertension Sugen–hypoxia rat model by cardiac magnetic resonance imaging
Jayasekera Geeshath, Wilson Kathryn S, Buist Hanna, Woodward Rosemary, Uckan Aysel, Hughes Colin, Nilsen Margaret, Church A Colin, Johnson Martin K, Gallagher Lindsay, Mullin James, MacLean Mandy R, Holmes William M, Peacock Andrew J, Welsh David J
Pulmonary Circulation Vol 10 (2020)
https://doi.org/10.1177/2045894019897513
Notch3 signalling and vascular remodelling in pulmonary arterial hypertension
Morris Hannah E, Neves Karla B, Montezano Augusto C, MacLean Margaret R, Touyz Rhian M
Clinical Science Vol 133, pp. 2481-2498 (2019)
https://doi.org/10.1042/CS20190835
Current strategies for quantification of estrogens in clinical research
Denver Nina, Khan Shazia, Homer Natalie ZM, MacLean Margaret R, Andrew Ruth
Journal of Steroid Biochemistry and Molecular Biology Vol 192 (2019)
https://doi.org/10.1016/j.jsbmb.2019.04.022

more publications

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Hamnett Wing

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