Professor Daniel Markl
Strathclyde Institute of Pharmacy and Biomedical Sciences
Personal statement
Daniel Markl’s research focuses on developing predictive systems, in-silico design methods and self-driving labs for drug product development and manufacturing that accelerate the pace at which new medicines are developed and delivered. He obtained a BSc (2010) and MSc (2012) in telematics with a focus on neural networks and a PhD (2015) in chemical engineering from Graz University of Technology. Daniel secured an Erasmus Mundus in 2010, which allowed him to study modelling and control system design for one year during his MSc at Lund University. During his PhD he was employed by the Research Center Pharmaceutical Engineering (RCPE) GmbH, where he was in the group Process and Manufacturing Science and involved in several projects at the interface of pharmaceutical engineering, materials science and process modelling. He continued as Senior Scientist and Scientific Project Leader at RCPE after completing his PhD. In 2016 he joined Professor Zeitler’s group (Terahertz Applications Group) as a postdoctoral research associate at the University of Cambridge. Daniel worked for two years in the Terahertz Applications Group before becoming a Chancellor’s Fellow and Lecturer/Assistant Professor at the University of Strathclyde in the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS).
Daniel is Associate Director at CMAC (www.cmac.ac.uk), Training Director of the EPSRC Centre of Doctoral Training in Cyberphysical Systems for Medicines Development and Manufacturing and leads the MHRA-funded Centre of Excellence in Regulatory Science and Innovation (CERSI) for the digital transformation of medicines development and manufacturing.
Prize And Awards
- Fellowship of Higher Education
- Recipient
- 2020
- President of Pharmaceutical Solid State Research Cluster
- Recipient
- 2020
- AAPS Pharmaceutical Research Meritorious Manuscript Award
- Recipient
- 2019
- Best Poster Award
- Recipient
- 2016
- Erasmus Mundus
- Recipient
- 2010
Publications
- Transient hydrate formation during disintegration of film-coated pharmaceutical tablets
- Ma Mingrui, Zeng Xiaorui, Powell Daniel, Nassar Marwa, Teckoe Jason, Markl Daniel, Zeitler J Axel
- International Journal of Pharmaceutics Vol 701 (2026)
- https://doi.org/10.1016/j.ijpharm.2026.127136
- Accelerating the formulation development for directly compressed tablets via automated sessile drop testing
- Ma Mingrui, Abbas Faisal, Armstrong John, Gahler Daniel, Soltani Pooria, Salehian Mohammad, Markl Daniel
- STYL’ONE User Group 2026 (2026)
- From simplicity to complexity : how excipients shape stability and disintegration of immediate-release tablets
- Ibrahim Isra, Mann James, Winge Fredrik, Davis Adrian, Hens Bart, Khadra Ibrahim, Virrankoski Milena, DeAngelis Austin, Markl Daniel
- International Journal of Pharmaceutics Vol 701 (2026)
- https://doi.org/10.1016/j.ijpharm.2026.127130
- Accelerated drug development using a digital formulator and a self-driving tableting data factory
- Abbas Faisal, Salehian Mohammad, Hou Peter, Moores Jonathan, Goldie Jonathan, Tsioutsios Alexandros, Tait Theo, Portela Victor, Boulay Quentin, Thiolliere Roland, Stark Ashley, Schwartz Jean-Jacques, Guerin Jerome, Maloney Andrew GP, Moldovan Alexandru A, Reynolds Gavin, Mantanus Jérôme, Clark Catriona, Chapman Paul, Florence Alastair, Markl Daniel
- Nature Communications Vol 17 (2026)
- https://doi.org/10.1038/s41467-026-71204-6
- Revisiting strain rate sensitivity : the role of feed frame-induced lubrication in tablet tensile strength loss during scale-up
- Osman Musab, Reynolds Gavin, Yates Catherine, Markl Daniel, Upadhyay Pratik P, Pitt Kendal, Robertson John
- International Journal of Pharmaceutics Vol 697 (2026)
- https://doi.org/10.1016/j.ijpharm.2026.126867
- Empowering the pharmaceutical workforce for the digital future
- Maclean Natalie, Abrahmsén-Alami Susanna, Clark Catriona, Dörr Frederik, Florence Alastair, Ketolainen Jarkko, Lindow Morten, Mantanus Jérôme, Rantanen Jukka, Reynolds Gavin, Robertson Amy, Markl Daniel
- European Journal of Pharmaceutical Sciences Vol 220 (2026)
- https://doi.org/10.1016/j.ejps.2026.107449
Research Interests
Our laboratory conducts multidisciplinary research at the intersection of materials, processes, products, and performance, with the goal of transforming how medicines are designed, developed, and manufactured. We seek to establish a fundamental, predictive understanding of how material properties and processing conditions jointly determine product structure, quality, and performance.
Central to our approach is the coupling of self-driving laboratories, advanced measurement techniques, and digital process and product design. By integrating automation, high-throughput experimentation, real-time analytics, and data-driven modeling, we aim to dramatically accelerate development timelines while improving robustness, efficiency, and knowledge generation across the pharmaceutical lifecycle.
Our research includes the development of predictive systems, in-silico design methods, and autonomous experimental platforms for drug product development and manufacturing. These tools enable rapid exploration of complex formulation and process spaces, support rational decision-making, and reduce reliance on trial-and-error experimentation. Ultimately, our work lays the foundation for adaptive, intelligent manufacturing systems that deliver higher-quality medicines more efficiently and reliably.
Professional Activities
- A Digital Particle Engineering Framework: Predicting Product Manufacturability and Performance Attributes From Drug Material Properties
- Contributor
- 12/5/2026
- Accelerated Drug Product Development using a Digital Formulator and a Self-Driving Tableting DataFactory
- Speaker
- 2025
- Self-Driving Tableting DataFactory
- Speaker
- 2025
- Digital CMC Center of Excellence in Regulatory Science & Innovation (CERSI)
- Speaker
- 2025
- A Self-optimised Tableting DataFactory: Accelerating Process and Formulation Development
- Speaker
- 2024
- Accelerating tablet formulation and process development: Synergising a self-driving tableting system with predictive modelling
- Speaker
- 2024
Projects
- AI enabled CMC Datafactory
- Markl, Daniel (Principal Investigator) Florence, Alastair (Co-investigator)
- 01-Jan-2025 - 30-Jan-2026
- CERSI for the Digital Transformation of Medicines Development and Manufacturing
- Markl, Daniel (Principal Investigator) Florence, Alastair (Co-investigator) Johnston, Blair (Co-investigator)
- 01-Jan-2025 - 31-Jan-2026
- INtegrated Spectroscopy and Photonics for Increased productivity and Resource Efficiency in MEDicines manufacture: Sustainable Medicines Manufacturing Expression of Interest
- Nordon, Alison (Principal Investigator) Littlejohn, David (Co-investigator) Markl, Daniel (Co-investigator)
- 01-Jan-2025 - 30-Jan-2025
- DPN-MED: Digital Plug-and-Produce Network for Sustainable Medicines Development and Manufacturing
- Fitzpatrick, Stephen (Principal Investigator) Florence, Alastair (Principal Investigator) Florence, Alastair (Co-investigator) Johnston, Blair (Co-investigator) Markl, Daniel (Co-investigator)
- 01-Jan-2025 - 30-Jan-2025
- NF987
- Markl, Daniel (Principal Investigator) Macdonald, Janine (Co-investigator)
- 25-Jan-2024 - 19-Jan-2024
- Industrial CASE Account - University of Strathclyde 2024 | Jahangir, Reehab
- Markl, Daniel (Principal Investigator) Li, Jun (Co-investigator) Jahangir, Reehab (Research Co-investigator)
- 01-Jan-2024 - 01-Jan-2028
Contact
Professor
Daniel
Markl
Strathclyde Institute of Pharmacy and Biomedical Sciences
Email: daniel.markl@strath.ac.uk
Tel: 444 7115