Professor Gail McConnell

Strathclyde Institute of Pharmacy and Biomedical Sciences

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Publications

Printing, characterizing, and assessing transparent 3D printed lenses for optical imaging
Rooney Liam M, Christopher Jay, Watson Ben, Susir Kumar Yash, Copeland Laura, Walker Lewis D, Foylan Shannan, Amos William B, Bauer Ralf, McConnell Gail
Advanced Materials Technologies (2024)
https://doi.org/10.1002/admt.202400043
An easy to use tool for the analysis of subcellular mRNA transcript colocalisation in smFISH data
Bentley-Abbot Calum, Heslop Rhiannon, Pirillo Chiara, Chandrasegaran Praveena, McConnell Gail, Roberts Ed, Hutchinson Edward, MacLeod Annette
Scientific Reports Vol 14 (2024)
https://doi.org/10.1038/s41598-024-58641-3
Low-cost 3D printed lenses for brightfield and fluorescence microscopy
Christopher Jay, Rooney Liam M, Donnachie Mark, Uttamchandani Deepak, McConnell Gail, Bauer Ralf
Biomedical Optics Express Vol 15, pp. 2224-2237 (2024)
https://doi.org/10.1364/BOE.514653
Multimodal optical mesoscopy reveals the quantity and spatial distribution of gram-positive biofilms in ex vivo tonsils
Clapperton Megan, Kunanandam Tash, Florea Catalina D, Douglas Catriona M, McConnell Gail
Journal of Microscopy (2024)
https://doi.org/10.1111/jmi.13266
Construction and characterisation of a structured, tuneable, and transparent 3D culture platform for soil bacteria
Rooney Liam M, Dupuy Lionel X, Hoskisson Paul A, McConnell Gail
Microbiology Vol 170 (2024)
https://doi.org/10.1099/mic.0.001429
Time-lapse mesoscopy of Candida albicans and Staphylococcus aureus dual-species biofilms reveals a structural role for the hyphae of C. albicans in biofilm formation
Baxter Katherine J, Sargison Fiona A, Fitzgerald J Ross, McConnell Gail, Hoskisson Paul A
Microbiology Vol 170 (2024)
https://doi.org/10.1099/mic.0.001426

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Research Interests

The optical microscope is so important to biomedicine that it is used as an icon to symbolise all science, but in the age of lasers, computers, digital detectors and new photochemistry the basic design of this classic tool of research can be greatly improved. My research involves the development of new optical instruments and technologies for cell and tissue imaging: this includes linear and nonlinear optics, new light sources, and new ways of preparing the specimen for imaging that reveals more structural information than the light microscope can normally provide.

An example of my interests is the Mesolens, where we have redesigned the microscope so that internal details of every cell of the millions present in a biological specimen of more than 100 cubic millimeters in volume can be seen. Our microscope does not use an eyepiece for recording, since the image exceeds the power of the human eye to perceive detail: our image datasets from a volume specimen are typically hundreds of gigabytes in size. We specified the novel optics for screening transgenic mouse embryos to discover human genes that might produce congenital abnormalities, such as vascular disease, which affects approximately one in two hundred human births. However, we are now finding applications throughout bioscience, e.g. in neuroscience and developmental studies. At the Strathclyde Mesolab, a newly created MRC-supported facility, we are working with life, physical and computer scientists worldwide to explore applications of our current technology and to develop new mesoscopic imaging modes that will provide a new insight into development and disease.

Professional Activities

Strathclyde Optical Microscopy Course
Organiser
4/8/2024
ELMI
Organiser
4/6/2024
MBL Lightsheet Conference and Workshop
Participant
6/5/2024
Searching for biomarkers of tonsillar disease
Contributor
7/11/2023
Optica Webinar
Participant
7/11/2023
MIFOBIO
Participant
11/2023

More professional activities

Projects

3D-printed transmissive adaptive optics for microscopy (BBSRC 23TRT)
Bauer, Ralf (Principal Investigator) Cunningham, Margaret Rose (Co-investigator) McConnell, Gail (Co-investigator)
01-Jan-2024 - 30-Jan-2025
Industrial Case Account - University of Strathclyde 2023 | Walker, Lewis
McConnell, Gail (Principal Investigator) Patton, Brian (Co-investigator) Walker, Lewis (Research Co-investigator)
01-Jan-2023 - 01-Jan-2026
DTP 2224 University of Strathclyde | Copeland, Laura
McConnell, Gail (Principal Investigator) Patton, Brian (Co-investigator) Copeland, Laura (Research Co-investigator)
01-Jan-2023 - 01-Jan-2027
Label-free intraoperative histological imaging (icase)
McConnell, Gail (Principal Investigator)
01-Jan-2023 - 30-Jan-2027
How does EFR3 control insulin-stimulated plasma membrane dispersal of GLUT4?
Gould, Gwyn (Principal Investigator) Li, David (Co-investigator) McConnell, Gail (Co-investigator) Van de Linde, Sebastian (Co-investigator)
15-Jan-2023 - 14-Jan-2026
Development of Therapeutic Strategies to Regenerate Pancreatic Beta Cells: Towards a Disease-Modifying Treatment for Type 1 Diabetes.
McConnell, Gail (Principal Investigator)
24-Jan-2023 - 23-Jan-2027

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Contact

Professor Gail McConnell
Strathclyde Institute of Pharmacy and Biomedical Sciences

Email: g.mcconnell@strath.ac.uk
Tel: 548 3059