Professor Gail McConnell

Physics

Publications

An evaluation of multi-excitation-wavelength standing-wave fluorescence microscopy (TartanSW) to improve sampling density in studies of the cell membrane and cytoskeleton
Schniete Jana K, Tinning Peter W, Scrimgeour Ross C, Robb Gillian, Kölln Lisa S, Wesencraft Katrina, Paul Nikki R, Bushell Trevor J, McConnell Gail
Scientific Reports Vol 11 (2021)
https://doi.org/10.1038/s41598-020-78282-6
Three-dimensional in situ morphometrics of Mycobacterium tuberculosis infection within lesions by optical mesoscopy and novel acid-fast staining
Francis Robert J, Robb Gillian, McCann Lee, Khatri Bhagwati, Keeble James, Dagg Belinda, Amos Brad, Salguero Francisco J, Ho Mei Mei, Bullen Anwen, McConnell Gail, MacLellan-Gibson Kirsty
Scientific Reports Vol 10 (2020)
https://doi.org/10.1038/s41598-020-78640-4
Intra-colony channels in E. coli function as a nutrient uptake system
Rooney Liam M, Amos William B, Hoskisson Paul A, McConnell Gail
ISME Journal Vol 14, pp. 2461-2473 (2020)
https://doi.org/10.1038/s41396-020-0700-9
Characterisation of a deep-ultraviolet light-emitting diode emission pattern via fluorescence
McFarlane Mollie, McConnell Gail
Measurement Science and Technology Vol 31 (2020)
https://doi.org/10.1088/1361-6501/ab78c1
Three-dimensional observations of an aperiodic oscillatory gliding motility behaviour in Myxococcus xanthus using confocal interference reflection microscopy
Rooney Liam M, Kölln Lisa S, Scrimgeour Ross, Amos William B, Hoskisson Paul A, McConnell Gail
mSphere Vol 5 (2020)
https://doi.org/10.1128/mSphere.00846-19
Of microscopes and microbes : characterising a novel nutrient uptake system in Escherichia coli biofilms
Rooney Liam M, Hoskisson Paul A, McConnell Gail
FEMS 2019 (2019)

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Research interests

The optical microscope is so important to biomedicine that it is used as an icon to symbolise all science, but in the age of lasers, computers, digital detectors and new photochemistry the basic design of this classic tool of research can be greatly improved. My research involves the development of new optical instruments and technologies for cell and tissue imaging: this includes linear and nonlinear optics, new light sources, and new ways of preparing the specimen for imaging that reveals more structural information than the light microscope can normally provide.

An example of my interests is the Mesolens, where we have redesigned the microscope so that internal details of every cell of the millions present in a biological specimen of more than 100 cubic millimeters in volume can be seen. Our microscope does not use an eyepiece for recording, since the image exceeds the power of the human eye to perceive detail: our image datasets from a volume specimen are typically hundreds of gigabytes in size. We specified the novel optics for screening transgenic mouse embryos to discover human genes that might produce congenital abnormalities, such as vascular disease, which affects approximately one in two hundred human births. However, we are now finding applications throughout bioscience, e.g. in neuroscience and developmental studies. At the Strathclyde Mesolab, a newly created MRC-supported facility, we are working with life, physical and computer scientists worldwide to explore applications of our current technology and to develop new mesoscopic imaging modes that will provide a new insight into development and disease.

Professional activities

Applying the Mesolens to Microbiology; Visualising Biofilm Architecture and Substructure
Contributor
13/4/2018
Applying the Mesolens to Microbiology; Visualising Biofilm Architecture and Substructure
Contributor
22/11/2017
Sensors and their Applications XVI (Event)
Member
12/9/2011
Institute of Physics and Engineering in Medicine (External organisation)
Member
1/1/2011
Institute of Physics (External organisation)
Member
1/1/2010
Sensors and their Applications XVI (Event)
Member
4/10/2009

More professional activities

Projects

FASPRI:a new method for increased spatial resolution in surface plasmon imaging of unlabelled living cells.
McConnell, Gail (Principal Investigator)
01-Jan-2021 - 31-Jan-2022
Structural investigation of the Candida albicans/Staphylococcus aureus dual biofilm by Mesolens 3D imaging
BAXTER, Katherine (Co-investigator) Hoskisson, Paul (Principal Investigator) McConnell, Gail (Co-investigator)
01-Jan-2020 - 31-Jan-2023
Structural investigation of the Candida albicans/Staphylococcus aureus dual biofilm by Mesolens 3D imaging (Fellowship for Katherine Baxter)
Hoskisson, Paul (Principal Investigator) McConnell, Gail (Co-investigator)
01-Jan-2020 - 31-Jan-2023
Assessing the role of biofilm spatial structure and mechanics in pathogenic recurrent tonsillitis using mesoscopy
McConnell, Gail (Principal Investigator)
01-Jan-2020 - 30-Jan-2023
Doctoral Training Partnership 2020-2021 University of Strathclyde | Craig, Rebecca
Patton, Brian (Principal Investigator) McConnell, Gail (Co-investigator) Craig, Rebecca (Research Co-investigator)
01-Jan-2020 - 01-Jan-2024
Prosperity Partnership Call 2 Strategic Students-Weir Group and University of Strathclyde | Drais, Sara
Phoenix, Vernon (Principal Investigator) McConnell, Gail (Co-investigator) Pytharouli, Stella (Co-investigator) White, Chris (Co-investigator) Drais, Sara (Research Co-investigator)
01-Jan-2019 - 01-Jan-2024

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