Professor Gail McConnell



Application of light-sheet mesoscopy to image host-pathogen interactions in intact organs
Battistella Eliana, Quintana Juan F, McConnell Gail
Frontiers in Cellular and Infection Microbiology : Parasite and Host Vol 12 (2022)
Challenges and advances in optical 3D mesoscale imaging
Munck Sebastian, Cawthorne Christopher, Escamilla‐Ayala Abril, Kerstens Axelle, Gabarre Sergio, Wesencraft Katrina, Battistella Eliana, Craig Rebecca, Reynaud Emmanuel G, Swoger Jim, McConnell Gail
Journal of Microscopy Vol 286, pp. 201-219 (2022)
Enhanced fluorescence from semiconductor quantum dot-labelled cells excited at 280 nm
McFarlane Mollie, Hall Nicholas, McConnell Gail
Methods and Applications in Fluorescence Vol 10 (2022)
Label2label : training a neural network to selectively restore cellular structures in fluorescence microscopy
Kölln Lisa Sophie, Salem Omar, Valli Jessica, Hansen Carsten Gram, McConnell Gail
Journal of Cell Science Vol 135 (2022)
Investigating the response of skeletal muscle to prosthesis-related loading conditions : an ex vivo animal model
Graser Marisa, Wark Alastair, Day Sarah, Sandison Mairi, McConnell Gail, Buis Arjan
International Society for Prosthetics and Orthotics 18th World Congress (2021)
Optical mesoscopy, machine learning, and computational microscopy enable high information content diagnostic imaging of blood films
Shaw Michael, Claveau Rémy, Manescu Petru, Elmi Muna, Brown Biobele J, Scrimgeour Ross, Kölln Lisa S, McConnell Gail, Fernandez‐Reyes Delmiro
Journal of Pathology Vol 255, pp. 62-71 (2021)

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Research interests

The optical microscope is so important to biomedicine that it is used as an icon to symbolise all science, but in the age of lasers, computers, digital detectors and new photochemistry the basic design of this classic tool of research can be greatly improved. My research involves the development of new optical instruments and technologies for cell and tissue imaging: this includes linear and nonlinear optics, new light sources, and new ways of preparing the specimen for imaging that reveals more structural information than the light microscope can normally provide.

An example of my interests is the Mesolens, where we have redesigned the microscope so that internal details of every cell of the millions present in a biological specimen of more than 100 cubic millimeters in volume can be seen. Our microscope does not use an eyepiece for recording, since the image exceeds the power of the human eye to perceive detail: our image datasets from a volume specimen are typically hundreds of gigabytes in size. We specified the novel optics for screening transgenic mouse embryos to discover human genes that might produce congenital abnormalities, such as vascular disease, which affects approximately one in two hundred human births. However, we are now finding applications throughout bioscience, e.g. in neuroscience and developmental studies. At the Strathclyde Mesolab, a newly created MRC-supported facility, we are working with life, physical and computer scientists worldwide to explore applications of our current technology and to develop new mesoscopic imaging modes that will provide a new insight into development and disease.

Professional activities

Mesoscopic optical imaging with the Mesolens
Exploring the potential of Quantum Bioimging
PhD examination of Anneliese Jarman
Microscience Microscopy Congress 2021
Optical mesoscopy with the Mesolens

More professional activities


Understanding the role of bacterial biofilms in otitis media with effusion
McConnell, Gail (Principal Investigator)
01-Jan-2022 - 30-Jan-2023
Understanding the role of biofilms in otitis media with effusion using fluorescence mesoscopy
McConnell, Gail (Principal Investigator)
01-Jan-2022 - 30-Jan-2023
Making wider-field high quality objective lenses by 3D printing
McConnell, Gail (Principal Investigator)
11-Jan-2022 - 10-Jan-2025
Investigating the growth dynamics of multispecies biofilms on medical grade silicone by Mesoscopy
BAXTER, Katherine (Principal Investigator) Hoskisson, Paul (Co-investigator) McConnell, Gail (Co-investigator)
14-Jan-2022 - 13-Jan-2023
A deep view into the parasite-transmitting tsetse fly
McConnell, Gail (Principal Investigator)
01-Jan-2021 - 30-Jan-2023
SPRINT: A SuPer-Resolution time-resolved ImagiNg and specTroscopy facility for rapid biomolecular analysis
Li, David (Principal Investigator) Chamberlain, Luke (Co-investigator) Chen, Yu (Co-investigator) Cunningham, Margaret Rose (Co-investigator) Gould, Gwyn (Co-investigator) Hoskisson, Paul (Co-investigator) McConnell, Gail (Co-investigator) Rattray, Zahra (Co-investigator) Van de Linde, Sebastian (Co-investigator)
01-Jan-2021 - 30-Jan-2022

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