Professor Gail McConnell

Physics

Publications

TartanSW : filling the information gap in standing wave microscopy
Tinning P W, Schniete J K, Scrimgeour R, McConnell G
Photonex (2019)
Fast optical sectioning for widefield fluorescence mesoscopy with the mesolens based on HiLo microscopy
Schniete Jan, Franssen Aimee, Dempster John, Bushell Trevor J, Amos William Bradshaw, McConnell Gail
Scientific Reports Vol 8 (2018)
https://doi.org/10.1038/s41598-018-34516-2
Applying the Mesolens to microbiology : investigating the structural organisation of bacterial biofilms
Rooney Liam M, McCann Lee, Hoskisson Paul A, McConnell Gail
RMS Frontiers in Bioimaging 2018 (2018)
Interference reflection microscopy shows novel insights to bacterial gliding motility
Rooney Liam M, Hoskisson Paul A, McConnell Gail
ELMI 2018 (2018)
Standing wave microscopy of red blood cell membrane morphology with high temporal resolution
Tinning Peter W, Scrimgeour Ross, McConnell Gail
ELMI 2018 (2018)
Applying the mesolens to microbiology : visualising biofilm architecture and substructure
Rooney Liam M, McCann Lee, Hoskisson Paul A, McConnell Gail
ELMI 2018 (2018)

more publications

Research interests

The optical microscope is so important to biomedicine that it is used as an icon to symbolise all science, but in the age of lasers, computers, digital detectors and new photochemistry the basic design of this classic tool of research can be greatly improved. My research involves the development of new optical instruments and technologies for cell and tissue imaging: this includes linear and nonlinear optics, new light sources, and new ways of preparing the specimen for imaging that reveals more structural information than the light microscope can normally provide.

An example of my interests is the Mesolens, where we have redesigned the microscope so that internal details of every cell of the millions present in a biological specimen of more than 100 cubic millimeters in volume can be seen. Our microscope does not use an eyepiece for recording, since the image exceeds the power of the human eye to perceive detail: our image datasets from a volume specimen are typically hundreds of gigabytes in size. We specified the novel optics for screening transgenic mouse embryos to discover human genes that might produce congenital abnormalities, such as vascular disease, which affects approximately one in two hundred human births. However, we are now finding applications throughout bioscience, e.g. in neuroscience and developmental studies. At the Strathclyde Mesolab, a newly created MRC-supported facility, we are working with life, physical and computer scientists worldwide to explore applications of our current technology and to develop new mesoscopic imaging modes that will provide a new insight into development and disease.

Professional activities

Applying the Mesolens to Microbiology; Visualising Biofilm Architecture and Substructure
Contributor
13/4/2018
Applying the Mesolens to Microbiology; Visualising Biofilm Architecture and Substructure
Contributor
22/11/2017
Sensors and their Applications XVI (Event)
Member
12/9/2011
Institute of Physics and Engineering in Medicine (External organisation)
Member
1/1/2011
Institute of Physics (External organisation)
Member
1/1/2010
Sensors and their Applications XVI (Event)
Member
4/10/2009

more professional activities

Projects

Doctoral Training Partnership 2018-19 University of Strathclyde | Pistoni, Sofia
Patton, Brian (Principal Investigator) McConnell, Gail (Co-investigator) Pistoni, Sofia (Research Co-investigator)
01-Jan-2018 - 01-Jan-2022
Applications of high-brightness 280nm light emitting diodes in biomedical optical imaging
McConnell, Gail (Principal Investigator)
01-Jan-2018 - 30-Jan-2022
EPSRC iCASE NPL S Foylan: Quantitative optical mesoscopy for screening of novel antimicrobial compounds
McConnell, Gail (Principal Investigator)
01-Jan-2018 - 30-Jan-2022
Industrial CASE Account - University of Strathclyde 2018 | Foylan, Shannan
McConnell, Gail (Principal Investigator) Hoskisson, Paul (Co-investigator) Foylan, Shannan (Research Co-investigator)
01-Jan-2018 - 01-Jan-2022
Doctoral Training Partnership 2018-19 University of Strathclyde | Murray, Jordan
McConnell, Gail (Principal Investigator) Hoskisson, Paul (Co-investigator) Murray, Jordan (Research Co-investigator)
01-Jan-2018 - 01-Jan-2022
Doctoral Training Partnership (DTP 2016-2017 University of Strathclyde) | Herdly, Lucas
McConnell, Gail (Principal Investigator) Van de Linde, Sebastian (Co-investigator) Herdly, Lucas (Research Co-investigator)
01-Jan-2017 - 01-Jan-2021

more projects