Professor Gail McConnell



Intra-colony channel morphology in Escherichia coli biofilms is governed by nutrient availability and substrate stiffness
Bottura Beatrice, Rooney Liam M, Hoskisson Paul A, McConnell Gail
Biofilm Vol 4 (2022)
Light-sheet mesoscopy with the Mesolens provides fast sub-cellular resolution imaging throughout large tissue volumes
Battistella Eliana, Schniete Jan, Wesencraft Katrina, Quintana Juan F, McConnell Gail
iScience Vol 25 (2022)
Application of light-sheet mesoscopy to image host-pathogen interactions in intact organs
Battistella Eliana, Quintana Juan F, McConnell Gail
Frontiers in Cellular and Infection Microbiology : Parasite and Host Vol 12 (2022)
Challenges and advances in optical 3D mesoscale imaging
Munck Sebastian, Cawthorne Christopher, Escamilla‐Ayala Abril, Kerstens Axelle, Gabarre Sergio, Wesencraft Katrina, Battistella Eliana, Craig Rebecca, Reynaud Emmanuel G, Swoger Jim, McConnell Gail
Journal of Microscopy Vol 286, pp. 201-219 (2022)
Enhanced fluorescence from semiconductor quantum dot-labelled cells excited at 280 nm
McFarlane Mollie, Hall Nicholas, McConnell Gail
Methods and Applications in Fluorescence Vol 10 (2022)
Label2label : training a neural network to selectively restore cellular structures in fluorescence microscopy
Kölln Lisa Sophie, Salem Omar, Valli Jessica, Hansen Carsten Gram, McConnell Gail
Journal of Cell Science Vol 135 (2022)

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Research interests

The optical microscope is so important to biomedicine that it is used as an icon to symbolise all science, but in the age of lasers, computers, digital detectors and new photochemistry the basic design of this classic tool of research can be greatly improved. My research involves the development of new optical instruments and technologies for cell and tissue imaging: this includes linear and nonlinear optics, new light sources, and new ways of preparing the specimen for imaging that reveals more structural information than the light microscope can normally provide.

An example of my interests is the Mesolens, where we have redesigned the microscope so that internal details of every cell of the millions present in a biological specimen of more than 100 cubic millimeters in volume can be seen. Our microscope does not use an eyepiece for recording, since the image exceeds the power of the human eye to perceive detail: our image datasets from a volume specimen are typically hundreds of gigabytes in size. We specified the novel optics for screening transgenic mouse embryos to discover human genes that might produce congenital abnormalities, such as vascular disease, which affects approximately one in two hundred human births. However, we are now finding applications throughout bioscience, e.g. in neuroscience and developmental studies. At the Strathclyde Mesolab, a newly created MRC-supported facility, we are working with life, physical and computer scientists worldwide to explore applications of our current technology and to develop new mesoscopic imaging modes that will provide a new insight into development and disease.

Professional activities

Mesoscopic optical imaging with the Mesolens
Exploring the potential of Quantum Bioimging
PhD examination of Anneliese Jarman
Microscience Microscopy Congress 2021
Optical mesoscopy with the Mesolens

More professional activities


New Endoscopic Imaging Technologies for Instantaneous assessment of Vasodilation as an Indicator of Bacterial Infection in Tonsillitis
McConnell, Gail (Principal Investigator)
03-Jan-2022 - 02-Jan-2026
DTP 2224 University of Strathclyde | Brown, Mollie
McConnell, Gail (Principal Investigator) Gould, Gwyn (Co-investigator) Brown, Mollie (Research Co-investigator)
01-Jan-2022 - 01-Jan-2025
Understanding the role of biofilms in otitis media with effusion using fluorescence mesoscopy
McConnell, Gail (Principal Investigator)
01-Jan-2022 - 30-Jan-2023
Understanding the role of bacterial biofilms in otitis media with effusion
McConnell, Gail (Principal Investigator)
01-Jan-2022 - 30-Jan-2023
Understanding the role of fibrin in wound healing after tonsillectomy (MRS vacation scholarship)
McConnell, Gail (Principal Investigator)
05-Jan-2022 - 04-Jan-2022
Making wider-field high quality objective lenses by 3D printing
McConnell, Gail (Principal Investigator)
11-Jan-2022 - 10-Jan-2025

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