Professor Gail McConnell



Optical mesoscopy, machine learning, and computational microscopy enable high information content diagnostic imaging of blood films
Shaw Michael, Claveau Rémy, Manescu Petru, Elmi Muna, Brown Biobele J, Scrimgeour Ross, Kölln Lisa S, McConnell Gail, Fernandez‐Reyes Delmiro
Journal of Pathology Vol 255, pp. 62-71 (2021)
Investigating the response of skeletal muscle to prosthesis-related loading conditions : an ex vivo animal model
Graser Marisa, Wark Alastair, Day Sarah, Sandison Mairi, McConnell Gail, Buis Arjan
International Society for Prosthetics and Orthotics 18th World Congress (2021)
ScRNA transcription profile of adult zebrafish podocytes using a novel reporter strain
Brown Cara, Mullins Linda J, Wesencraft Katrina, McConnell Gail, Beltran Mariana, Henderson Neil C, Conway Bryan, Hoffmann Scott, Rider Sebastian, Mullins John J
Cellular Physiology and Biochemistry Vol 55, pp. 35-47 (2021)
An evaluation of multi-excitation-wavelength standing-wave fluorescence microscopy (TartanSW) to improve sampling density in studies of the cell membrane and cytoskeleton
Schniete Jana K, Tinning Peter W, Scrimgeour Ross C, Robb Gillian, Kölln Lisa S, Wesencraft Katrina, Paul Nikki R, Bushell Trevor J, McConnell Gail
Scientific Reports Vol 11 (2021)
Three-dimensional in situ morphometrics of Mycobacterium tuberculosis infection within lesions by optical mesoscopy and novel acid-fast staining
Francis Robert J, Robb Gillian, McCann Lee, Khatri Bhagwati, Keeble James, Dagg Belinda, Amos Brad, Salguero Francisco J, Ho Mei Mei, Bullen Anwen, McConnell Gail, MacLellan-Gibson Kirsty
Scientific Reports Vol 10 (2020)
Intra-colony channels in E. coli function as a nutrient uptake system
Rooney Liam M, Amos William B, Hoskisson Paul A, McConnell Gail
ISME Journal Vol 14, pp. 2461-2473 (2020)

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Research interests

The optical microscope is so important to biomedicine that it is used as an icon to symbolise all science, but in the age of lasers, computers, digital detectors and new photochemistry the basic design of this classic tool of research can be greatly improved. My research involves the development of new optical instruments and technologies for cell and tissue imaging: this includes linear and nonlinear optics, new light sources, and new ways of preparing the specimen for imaging that reveals more structural information than the light microscope can normally provide.

An example of my interests is the Mesolens, where we have redesigned the microscope so that internal details of every cell of the millions present in a biological specimen of more than 100 cubic millimeters in volume can be seen. Our microscope does not use an eyepiece for recording, since the image exceeds the power of the human eye to perceive detail: our image datasets from a volume specimen are typically hundreds of gigabytes in size. We specified the novel optics for screening transgenic mouse embryos to discover human genes that might produce congenital abnormalities, such as vascular disease, which affects approximately one in two hundred human births. However, we are now finding applications throughout bioscience, e.g. in neuroscience and developmental studies. At the Strathclyde Mesolab, a newly created MRC-supported facility, we are working with life, physical and computer scientists worldwide to explore applications of our current technology and to develop new mesoscopic imaging modes that will provide a new insight into development and disease.

Professional activities

Mesoscopic optical imaging with the Mesolens
Exploring the potential of Quantum Bioimging
PhD examination of Anneliese Jarman
Microscience Microscopy Congress 2021
Optical mesoscopy with the Mesolens

More professional activities


Imaris for 3D reconstruction and analysis of mesoscopy and microscopy image datasets
McConnell, Gail (Principal Investigator)
01-Jan-2021 - 30-Jan-2022
SPRINT: A SuPer-Resolution time-resolved ImagiNg and specTroscopy facility for rapid biomolecular analysis
Li, David (Principal Investigator) Chamberlain, Luke (Co-investigator) Chen, Yu (Co-investigator) Cunningham, Margaret Rose (Co-investigator) Gould, Gwyn (Co-investigator) Hoskisson, Paul (Co-investigator) McConnell, Gail (Co-investigator) Rattray, Zahra (Co-investigator) Van de Linde, Sebastian (Co-investigator)
01-Jan-2021 - 30-Jan-2022
FASPRI:a new method for increased spatial resolution in surface plasmon imaging of unlabelled living cells.
McConnell, Gail (Principal Investigator)
01-Jan-2021 - 31-Jan-2022
Structural investigation of the Candida albicans/Staphylococcus aureus dual biofilm by Mesolens 3D imaging
BAXTER, Katherine (Co-investigator) Hoskisson, Paul (Principal Investigator) McConnell, Gail (Co-investigator)
01-Jan-2020 - 31-Jan-2023
Structural investigation of the Candida albicans/Staphylococcus aureus dual biofilm by Mesolens 3D imaging (Fellowship for Katherine Baxter)
Hoskisson, Paul (Principal Investigator) McConnell, Gail (Co-investigator)
01-Jan-2020 - 31-Jan-2023
Assessing the role of biofilm spatial structure and mechanics in pathogenic recurrent tonsillitis using mesoscopy
McConnell, Gail (Principal Investigator)
01-Jan-2020 - 30-Jan-2023

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