Professor Gail McConnell

Strathclyde Institute of Pharmacy and Biomedical Sciences

Publications

A 340/380 nm light emitting diode illuminator for Fura-2 AM ratiometric Ca2+ imaging of live cells with better than 5 nM precision
Tinning Peter W., Franssen Aimee J. P. M., Hridi Shehla U., Bushell Trevor J., McConnell Gail
Journal of Microscopy, (2017)
A 340/380 nm light emitting diode illuminator for Fura-2 AM ratiometric Ca2+ imaging of live cells with better than 5 nM precision
Tinning Peter William, Franssen Aimee, Hridi Shehla Unaiza, Bushell Trevor, McConnell Gail
MMC (2017), (2017)
A 340/380 nm light emitting diode illuminator for Fura-2 AM ratiometric Ca2+ imaging of live cells with better than 5 nM precision
Tinning Peter William, Franssen Aimee, Hridi Shehla Unaiza, Bushell Trevor, McConnell Gail
Photonex, (2017)
Increased expression of IL-16 in the brain of experimental autoimmune encephalomyelitis
Hridi Shehla Unaiza, McCann Lee, McConnell Gail, Bushell Trevor J, Jiang Hui-Rong
Brain and Neuroscience Advances, (2017)
Tumor regression after intravenous administration of targeted vesicles entrapping the vitamin E α-tocotrienol
Karim Reatul, Somani Sukrut, Al Robaian Majed, Mullin Margaret, Amor Rumelo, McConnell Gail, Dufès Christine
Journal of Controlled Release Vol 246, pp. 79-87, (2017)
http://dx.doi.org/10.1016/j.jconrel.2016.12.014
A femtosecond Raman generator for long wavelength two-photon and third harmonic generation imaging
Trägårdh J., Schniete J., Parsons M., McConnell G.
APL Photonics Vol 1, (2016)
http://dx.doi.org/10.1063/1.4962207

more publications

Research interests

The optical microscope is so important to biomedicine that it is used as an icon to symbolise all science, but in the age of lasers, computers, digital detectors and new photochemistry the basic design of this classic tool of research can be greatly improved. My research involves the development of new optical instruments and technologies for cell and tissue imaging: this includes linear and nonlinear optics, new light sources, and new ways of preparing the specimen for imaging that reveals more structural information than the light microscope can normally provide.

An example of my interests is the Mesolens, where we have redesigned the microscope so that internal details of every cell of the millions present in a biological specimen of more than 100 cubic millimeters in volume can be seen. Our microscope does not use an eyepiece for recording, since the image exceeds the power of the human eye to perceive detail: our image datasets from a volume specimen are typically hundreds of gigabytes in size. We specified the novel optics for screening transgenic mouse embryos to discover human genes that might produce congenital abnormalities, such as vascular disease, which affects approximately one in two hundred human births. However, we are now finding applications throughout bioscience, e.g. in neuroscience and developmental studies. At the Strathclyde Mesolab, a newly created MRC-supported facility, we are working with life, physical and computer scientists worldwide to explore applications of our current technology and to develop new mesoscopic imaging modes that will provide a new insight into development and disease.

Professional activities

Sensors and their Applications XVI (Event)
Member
12/9/2011
Institute of Physics and Engineering in Medicine (External organisation)
Member
1/1/2011
Institute of Physics (External organisation)
Member
1/1/2010
Sensors and their Applications XVI (Event)
Member
4/10/2009
Institute of Physics and Engineering in Medicine (External organisation)
Member
1/10/2009
European Light Microscopy Initiative conference
Organiser
2009

more professional activities

Projects

EFucci and atlas of proliferation to reduce mouse usage in embryonic proliferation assays
McConnell, Gail (Principal Investigator)
Period 01-Oct-2014 - 30-Sep-2015
David Begg Studentship | Chen, Haochang
Li, David (Principal Investigator) McConnell, Gail (Co-investigator) Chen, Haochang (Research Co-investigator)
Period 01-Nov-2014 - 01-May-2018
TartanSW: a new method for spectrally-resolved standing wave cell microscopy and mesoscopy
McConnell, Gail (Principal Investigator) Bushell, Trevor (Co-investigator)
Period 01-Aug-2017 - 31-Oct-2018
Cost-effective medical hyperspectral imaging
Marshall, Stephen (Principal Investigator) McConnell, Gail (Co-investigator) McKee, David (Co-investigator) Ren, Jinchang (Co-investigator)
Period 01-Jul-2016 - 30-Jun-2018
Doctoral Training Partnership (DTA - University of Strathclyde) | Chen, Haochang
Li, David (Principal Investigator) McConnell, Gail (Co-investigator) Chen, Haochang (Research Co-investigator)
Period 01-Oct-2014 - 01-Oct-2017
EPSRC Doctoral Training Grant | Keatings, Stefanie Renaud
Riis, Erling (Principal Investigator) McConnell, Gail (Co-investigator)
Period 01-Oct-2007 - 27-Apr-2011

more projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Hamnett Wing John Arbuthnott Building

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