Research interests
The optical microscope is so important to biomedicine that it is used as an icon to symbolise all science, but in the age of lasers, computers, digital detectors and new photochemistry the basic design of this classic tool of research can be greatly improved. My research involves the development of new optical instruments and technologies for cell and tissue imaging: this includes linear and nonlinear optics, new light sources, and new ways of preparing the specimen for imaging that reveals more structural information than the light microscope can normally provide.
An example of my interests is the Mesolens, where we have redesigned the microscope so that internal details of every cell of the millions present in a biological specimen of more than 100 cubic millimeters in volume can be seen. Our microscope does not use an eyepiece for recording, since the image exceeds the power of the human eye to perceive detail: our image datasets from a volume specimen are typically hundreds of gigabytes in size. We specified the novel optics for screening transgenic mouse embryos to discover human genes that might produce congenital abnormalities, such as vascular disease, which affects approximately one in two hundred human births. However, we are now finding applications throughout bioscience, e.g. in neuroscience and developmental studies. At the Strathclyde Mesolab, a newly created MRC-supported facility, we are working with life, physical and computer scientists worldwide to explore applications of our current technology and to develop new mesoscopic imaging modes that will provide a new insight into development and disease.
Professional activities
- Applying the Mesolens to Microbiology; Visualising Biofilm Architecture and Substructure
- Contributor
- 13/4/2018
- Applying the Mesolens to Microbiology; Visualising Biofilm Architecture and Substructure
- Contributor
- 22/11/2017
- Sensors and their Applications XVI (Event)
- Member
- 12/9/2011
- Institute of Physics and Engineering in Medicine (External organisation)
- Member
- 1/1/2011
- Institute of Physics (External organisation)
- Member
- 1/1/2010
- Sensors and their Applications XVI (Event)
- Member
- 4/10/2009
More professional activities
Projects
- FASPRI:a new method for increased spatial resolution in surface plasmon imaging of unlabelled living cells.
- McConnell, Gail (Principal Investigator)
- 01-Jan-2021 - 31-Jan-2022
- Structural investigation of the Candida albicans/Staphylococcus aureus dual biofilm by Mesolens 3D imaging
- BAXTER, Katherine (Co-investigator) Hoskisson, Paul (Principal Investigator) McConnell, Gail (Co-investigator)
- 01-Jan-2020 - 31-Jan-2023
- Structural investigation of the Candida albicans/Staphylococcus aureus dual biofilm by Mesolens 3D imaging (Fellowship for Katherine Baxter)
- Hoskisson, Paul (Principal Investigator) McConnell, Gail (Co-investigator)
- 01-Jan-2020 - 31-Jan-2023
- Assessing the role of biofilm spatial structure and mechanics in pathogenic recurrent tonsillitis using mesoscopy
- McConnell, Gail (Principal Investigator)
- 01-Jan-2020 - 30-Jan-2023
- Doctoral Training Partnership 2020-2021 University of Strathclyde | Craig, Rebecca
- Patton, Brian (Principal Investigator) McConnell, Gail (Co-investigator) Craig, Rebecca (Research Co-investigator)
- 01-Jan-2020 - 01-Jan-2024
- Prosperity Partnership Call 2 Strategic Students-Weir Group and University of Strathclyde | Drais, Sara
- Phoenix, Vernon (Principal Investigator) McConnell, Gail (Co-investigator) Pytharouli, Stella (Co-investigator) White, Chris (Co-investigator) Drais, Sara (Research Co-investigator)
- 01-Jan-2019 - 01-Jan-2024
More projects
Address
Physics
John Anderson Building
John Anderson Building
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