Dr Fiona Murphy
Lecturer
Strathclyde Institute of Pharmacy and Biomedical Sciences
Personal statement
Personal statement
My research focuses on identifying the hazards to human health posed by inhalation exposure to aerosolised particles and nanomaterials. Recent focus is on the development of physiologically-relevant in vitro models to reduce the reliance on rodent models for hazard assessment of novel materials and to improve our understanding of the underlying mechanism of particle-related lung disease.
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Publications
- Non-cyclic nucleotide EPAC1 activators suppress lipopolysaccharide-regulated gene expression, signalling and intracellular communication in differentiated macrophage-like THP-1 cells
- Wiejak Jolanta, Murphy Fiona A, Barker Graeme, Maffia Pasquale, Yarwood Stephen J
- Cellular Signalling Vol 124 (2024)
- https://doi.org/10.1016/j.cellsig.2024.111444
- Differential roles for the oxygen sensing enzymes PHD1 and PHD3 in the regulation of neutrophil metabolism and function
- Watts Emily, Willison Joseph, Arienti Simone, Sadiku Pranvera, Coelho Patricia, Sanchez-Garcia Manuel, Zhang Ailiang, Murphy Fiona, Dickinson Rebecca, Mirchandani Ananda, Morrison Tyler, Lewis Amy, Vermaelen Wesley, Ghesquiere Bart, Carmeliet Peter, Mazzone Massimilliano, Maxwell Patrick, Pugh Christopher, Dockrell David, Whyte Moira, Walmsley Sarah
- Wellcome Open Research Vol 8 (2024)
- https://doi.org/10.12688/wellcomeopenres.19915.2
- Humanising nanotoxicology : moving towards animal-free approaches for hazard assessment of nanomaterials
- Murphy Fiona
- Society of Toxicology (2024)
- Similarity of multicomponent nanomaterials in a safer-by-design context : the case of core–shell quantum dots
- Di Battista Veronica, Sanchez-Lievanos Karla R, Jeliazkova Nina, Murphy Fiona, Tsiliki Georgia, Zabeo Alex, Gajewicz-Skretna Agnieszka, Mikołajczyk Alicja, Hristozov Danail, Stone Vicki, Schmid Otmar, Hunt Neil, Oomen Agnes G, Wohlleben Wendel
- Environmental Science: Nano Vol 11, pp. 924-941 (2024)
- https://doi.org/10.1039/D3EN00338H
- Vascular smooth muscle cells enhance immune/vascular interplay in a 3-cell model of vascular inflammation
- Wiejak Jolanta, Murphy Fiona A, Maffia Pasquale, Yarwood Stephen J
- Scientific Reports Vol 13 (2023)
- https://doi.org/10.1038/s41598-023-43221-8
- How to formulate hypotheses and IATAs to support grouping and read-across of nanoforms
- Murphy Fiona A, Johnston Helinor J, Dekkers Susan, Bleeker Eric AJ, Oomen Agnes G, Fernandes Teresa F, Rasmussen Kirsten, Jantunen Paula, Rauscher Hubert, Hunt Neil, di Cristo Luisana, Braakhuis Hedwig M, Haase Andrea, Hristozov Danail, Wohlleben Wendel, Sabella Stefania, Stone Vicki
- Altex Vol 40, pp. 125-140 (2023)
- https://doi.org/10.14573/altex.2203241
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Professional Activities
- SIPBS Open Doors Day
- Chair
- 8/6/2024
- NC3Rs NAMs-Net Launch
- Participant
- 30/4/2024
- MSci external examiner
- Examiner
- 22/3/2024
- Society of Toxicology
- Speaker
- 2024
- Animal Free Research UK Scientific Conference
- Speaker
- 4/10/2023
- NC3Rs Galleria mellonella worksop
- Speaker
- 13/9/2023
Projects
- Validation of Scinora serum-free media formulations and Xplace supplement for the development of animal-free NAMs for nanotoxicology
- Murphy, Fiona (Principal Investigator)
- 01-Oct-2024 - 31-Mar-2025
- DTP 2224 University of Strathclyde | McAllister, Katie
- Perrie, Yvonne (Principal Investigator) Murphy, Fiona (Co-investigator) McAllister, Katie (Research Co-investigator)
- 01-Oct-2024 - 01-Apr-2028
- Generation of physiologically-reelevant mesothelioma tumour spheroids using tunable hydrogel scaffolds for improved preclinical drug screening
- Murphy, Fiona (Principal Investigator)
- 01-Aug-2024 - 31-Jul-2025
- Developing the Chick Chorioallantoic Membrane (CAM) model for hazard assessment of High Aspect Ratio Nanomaterials
- Murphy, Fiona (Principal Investigator)
- 07-Jan-2024 - 06-Jan-2025
- Development of a physiologically-relevant in vitro model of the lung alveolar space, incorporating novel peptide hydrogels as biomimetic extracellular matrix scaffolds
- Murphy, Fiona (Principal Investigator)
- 01-May-2023 - 30-Apr-2024
- Development of a physiologically-relevant in vitro model of the lung alveolar space, incorporating novel peptide hydrogels as biomimetic extracellular matrix scaffolds
- Murphy, Fiona (Principal Investigator)
- 01-Sep-2022 - 31-Jul-2024
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Contact
Dr
Fiona
Murphy
Lecturer
Strathclyde Institute of Pharmacy and Biomedical Sciences
Email: f.murphy@strath.ac.uk
Tel: Unlisted