Dr David Nelson

Senior Lecturer

Pure and Applied Chemistry

Personal statement

We conduct research at the intersection of organic and inorganic chemistry, with our primary aim being to discover, develop, and understand metal-catalysed reactions for organic synthesis. We use the tools of physical organic chemistry, organic and organometallic synthesis, and spectroscopy to achieve our aims. Ongoing projects include:

  • Understanding structure/reactivity relationships in nickel catalysed reactions
  • Quantifying reactivity and site-selectivity in metal catalysed C-H functionalisation reactions
  • The design of new ligands and quantification of their properties

We are grateful to have received generous funding from organisations including the EPSRC, the Carnegie Trust, GSK, AstraZeneca, Syngenta, the Leverhulme Trust, and the Royal Society.

Further details can be found on our website at http://personal.strath.ac.uk/david.nelson/.

In addition to research and teaching, I organise colloquia for research students and staff in the Catalysis & Synthesis and Chemical Biology & Medicinal Chemistry sections.

Expertise

Has expertise in:

    Areas

    • Catalysis
    • Cross-coupling
    • C-H activation
    • N-Heterocyclic carbenes
    • Organometallic chemistry
    • Physical organic chemistry

    Techniques

    • Organometallic and organic synthesis
    • Handling of air- and moisture-sensitive compounds
    • NMR and UV/visible spectroscopies
    • Reaction kinetics
    • Reaction simulation using numerical integration software
    • Density functional theory (DFT)

Qualifications

Qualifications and Experience

  • Senior Lecturer, University of Strathclyde, 2018 - Present
  • Chancellor's Fellow and Lecturer, University of Strathclyde, 2014 - 2018
  • Research Fellow (with Prof. S. P. Nolan FRSE), University of St Andrews, 2012 - 2014
  • PhD in Pure and Applied Chemistry (with Prof. J. M. Percy), University of Strathclyde, 2008 - 2012
  • MChem in Chemistry with Industrial Experience, University of Edinburgh, 2003 - 2008

Memberships

  • Member of the Royal Society of Chemistry
  • Member of the Americal Chemical Society
  • Member of the Society of Chemical Industry
  • Member of the Society of Chemical Industry Young Chemists' Panel
  • Fellow of the Higher Education Academy

 

Publications

Nickel versus palladium in cross-coupling catalysis : on the role of substrate coordination to zerovalent metal complexes
Cooper Alasdair K, Burton Paul M, Nelson David J
Synthesis (2019)
Metabolomic profiling of the immune stimulatory effect of eicosenoids on PMA-differentiated THP-1 cells
Alqarni Abdulmalik M, Dissanayake Tharushi, Nelson David J, Parkinson John A, Dufton Mark J, Ferro Valerie A, Watson David G
Vaccines Vol 7 (2019)
https://doi.org/10.3390/vaccines7040142
The electrophilic fluorination of enol esters using SelectFluor : a polar two-electron process
Wood Susanna H, Etridge Stephen, Kennedy Alan R, Percy Jonathan M, Nelson David J
Chemistry - A European Journal Vol 25, pp. 5574-5585 (2019)
https://doi.org/10.1002/chem.201900029
An N-heterocyclic carbene with a saturated backbone and spatially-defined steric impact
Laidlaw Gillian, Wood Susanna H, Kennedy Alan R, Nelson David J
Zeitschrift fur Anorganische und Allgemeine Chemie (2018)
https://doi.org/10.1002/zaac.201800423
Steric effects determine the mechanisms of reactions between bis(N-heterocyclic carbene)-nickel(0) complexes and aryl halides
Nelson David J, Maseras Feliu
Chemical Communications, pp. 1-3 (2018)
Insights into mechanism and selectivity in ruthenium(II)-catalysed ortho-arylation reactions directed by Lewis basic groups
McIntyre Jamie, Mayoral-Soler Irene, Salvador Sedano Pedro, Poater Albert, Nelson David James
Catalysis Science and Technology (2018)
https://doi.org/10.1039/C8CY00592C

more publications

Teaching

Current Teaching

CH450/8 Distance Learning Course - Reaction Mechanisms. [2014/15 - Present] This distance learning course is completed by MChem students on placement. The aims of the course are to: develop knowledge and understanding of reaction mechanisms, particularly in organic chemistry; develop skills in analysing reaction mechanisms; extend powers of analysis and deduction, and relate these to the choice of appropriate experiments in the study of reaction mechanisms; and show how knowledge of reaction mechanisms is related to synthetic chemistry and the understanding of processes both in the laboratory or production plant and in living systems.

CH508/9 Advanced and Modern Methods in Organic Synthesis. [2017/18 - Present] This course covers a range of state-of-the-art techniques in organic synthesis, including: palladium, copper, iridium, ruthenium, and gold-catalysis, organocatalysis, and asymmetric synthesis. Several lectures are devoted to the study of physical organic chemistry in the understanding of these reactions.

CH538: Molecular Catalysis. [2019/20] This course covers various topics in homogeneous catalysis, including the use of organometallic complexes, enzymes, and main group complexes. Students learn about applications, underlying mechanisms, techniques for interrogating reactions, and techniques for catalyst separation and recycling.

CH721: Well defined complexes of gold: synthesis, properties and homogeneous catalysis. [2014/15, 2016/17, 2018/19] This course for MPhil and PhD students is delivered in January/February of odd-numbered years. The course covers a range of organic and organometallic chemistry, with a special focus on catalysis, including: the history of gold catalysis; the properties of gold including favoured oxidation states, ligands and geometries; fundamental reactivity of organogold complexes; the synthesis of modern gold complexes as homogeneous catalysts (Au(I) and Au(III)); synthesis of related gold complexes, such as hydroxides, peroxides, di-, tri- and poly-gold complexes; and C-H activation/functionalisation and cross-coupling with gold.

 

Previous Teaching Activities

CH107 Chemistry: Principles and Practice 2 - Organic Chemistry. [2016/17, 2017/18] This first year undergraduate course provides students with the understanding of key reactions, concepts, and principles that are relevant to the study and use of organic chemistry. These include: nucleophiles, electrophiles, and radicals; alkenes and their reactions; epoxides and their reactions; carbonyl compounds and their oxidation, reduction, and reactions.

CH208 Fundamental Organic Chemistry - Aromatic Chemistry. [2016/17] This second year course provides students with the understanding of aromatic molecules and their reactivity, including: identifying aromatic molecules; electrophilic and nucleophilic aromatic substitution; and the generation and reactions of benzyne.

Research interests

Many important reactions in industry today are catalysed by transition metal complexes. Our research focusses on the design, discovery, understanding and optimisation of selective and economical processes, with a specific focus on developing reactions to the point that they can be deployed on scale in industry.

Key Phrases: Catalysis; Organometallic Chemistry; Physical Organic Chemistry; Organic Synthesis

Funding: We are grateful to have received funding and support from the following organisations: Johnson-Matthey/Alfa Aesar; Fluorochem; The Carnegie Trust; The Engineering and Physical Sciences Research Council (EPSRC); Syngenta; AstraZeneca; GlaxoSmithKline; The Leverhulme Trust; The Royal Society.

Detailed Summary: A detailed summary can be found on our group website (http://personal.strath.ac.uk/david.nelson/).

Training: Students within the research group gain training and experience in the synthesis, isolation, characterisation, and study of interesting organic and organometallic compounds. We use a variety of tools and techniques to achieve our aims, including: Schlenk techniques; inert atmosphere gloveboxes; NMR, UV/visible, and IR spectroscopy; GC and GC/mass spectrometry; cyclic voltammetry.

Professional activities

Understanding Oxidative Addition to Nickel(0) for Cross-Coupling Catalysis
Speaker
6/12/2019
Understanding Oxidative Addition to Nickel(0) for Cross-Coupling Catalysis
Speaker
5/12/2019
Understanding Oxidative Addition to Nickel(0) for Cross-Coupling Catalysis
Speaker
4/12/2019
Understanding Oxidative Addition to Nickel(0): Implications for Cross-Coupling Catalysis
Speaker
11/10/2019
Understanding Nickel Catalysis: Reaction Mechanisms and Structure/Reactivity Relationships
Speaker
12/10/2018
Nickel(0) Complexes and Aryl Halides: Reaction Mechanisms and Structure/Reactivity Relationships
Keynote speaker
10/7/2018

more professional activities

Projects

Industrial Case Account - University of Strathclyde 2019 | Sharratt, Hannah
Palmer, David (Principal Investigator) Nelson, David (Co-investigator) Sharratt, Hannah (Research Co-investigator)
01-Jan-2019 - 01-Jan-2023
Kinetics by electrochemistry: understanding oxidative addition to nickel(0) and (I) complexes
Nelson, David (Principal Investigator)
15-Jan-2019 - 14-Jan-2020
Computational Screening Of Nickel Complexes For The Activation Of `Inert? Bonds
Nelson, David (Principal Investigator)
01-Jan-2019 - 01-Jan-2020
Defining, Quantifying, and Understanding Selectivity Paradigms in Iridium-Cataly
Nelson, David (Principal Investigator) Kerr, William (Co-investigator)
01-Jan-2018 - 30-Jan-2021
Industrial CASE Account - University of Strathclyde 2017 | Greaves, Megan
Nelson, David (Principal Investigator) Murphy, John (Co-investigator) Greaves, Megan (Research Co-investigator)
01-Jan-2017 - 01-Jan-2021
AstraZeneca ICASE
Nelson, David (Principal Investigator)
01-Jan-2017 - 30-Jan-2021

more projects

Address

Pure and Applied Chemistry
Thomas Graham Building

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