We conduct research at the intersection of organic and inorganic chemistry, with our primary aim being to discover, develop, and understand metal-catalysed reactions for organic synthesis. We use the tools of physical organic chemistry, organic and organometallic synthesis, and spectroscopy to achieve our aims. Ongoing projects include:
- Understanding structure/reactivity relationships in nickel catalysed reactions of organo (pseudo)halides
- Quantifying reactivity and site-selectivity in metal catalysed C-H functionalisation reactions
- The design of new ligands and quantification of their properties
- Understanding the mechanisms of the reactions of electrophilic fluorinating reagents
We are grateful to have received generous funding from organisations including the EPSRC, the Carnegie Trust, GSK, AstraZeneca, Syngenta, and the Leverhulme Trust.
Further details can be found on our website at http://personal.strath.ac.uk/david.nelson/.
In addition to research and teaching, I organise Synthesis colloquia for research students and staff in the Catalysis & Synthesis and Chemical Biology & Medicinal Chemistry sections.
CH107 Chemistry: Principles and Practice 2 - Organic Chemistry. [2016/17, 2017/18] This first year course provides students with the understanding of key reactions, concepts, and principles that are relevant to the study and use of organic chemistry. These include: nucleophiles, electrophiles, and radicals; alkenes and their reactions; epoxides and their reactions; carbonyl compounds and their oxidation, reduction, and reactions.
CH208 Fundamental Organic Chemistry - Aromatic Chemistry. [2016/17] This second year course provides students with the understanding of aromatic molecules and their reactivity, including: identifying aromatic molecules; electrophilic and nucleophilic aromatic substitution; and the generation and reactions of benzyne.
CH450/8 Distance Learning Course - Reaction Mechanisms. [2014/15 - Present] This distance learning course is completed by MChem students on placement. The aims of the course are to: develop knowledge and understanding of reaction mechanisms, particularly in organic chemistry; develop skills in analysing reaction mechanisms; extend powers of analysis and deduction, and relate these to the choice of appropriate experiments in the study of reaction mechanisms; and show how knowledge of reaction mechanisms is related to synthetic chemistry and the understanding of processes both in the laboratory or production plant and in living systems.
CH508/9 Advanced and Modern Methods in Organic Synthesis. [2017/18] This course covers a range of state-of-the-art techniques in organic synthesis, including: palladium, copper, iridium, ruthenium, and gold-catalysis, organocatalysis, and asymmetric synthesis. Several lectures are devoted to the study of physical organic chemistry in the understanding of these reactions.
CH721: Well defined complexes of gold: synthesis, properties and homogeneous catalysis. [2014/15, 2016/17] This course for MPhil and PhD students is delivered in January/February of odd-numbered years. The course covers a range of organic and organometallic chemistry, with a special focus on catalysis, including: the history of gold catalysis; the properties of gold including favoured oxidation states, ligands and geometries; fundamental reactivity of organogold complexes; the synthesis of modern gold complexes as homogeneous catalysts (Au(I) and Au(III)); synthesis of related gold complexes, such as hydroxides, peroxides, di-, tri- and poly-gold complexes; and C-H activation/functionalisation and cross-coupling with gold.
Many of the most important reactions in industry today are catalysed by transition metal complexes. Our research focusses on the design, discovery, understanding and optimisation of selective and economical processes, with a specific focus on developing reactions to the point that they can be deployed on scale in industry.
Key Phrases: Catalysis; Organometallic Chemistry; Physical Organic Chemistry; Organic Synthesis
Funding: We are grateful to have received funding and support from the following organisations: Johnson-Matthey/Alfa Aesar; Fluorochem; The Carnegie Trust; The Engineering and Physical Sciences Research Council (EPSRC); Syngenta; AstraZeneca; GlaxoSmithKline.
Detailed Summary: A detailed summary can be found on our group website (http://personal.strath.ac.uk/david.nelson/).
Training: Students within the research group gain training and experience in the synthesis, isolation, characterisation, and study of interesting organic and organometallic compounds. We use a variety of tools and techniques to achieve our aims, including: Schlenk techniques; inert atmosphere gloveboxes; NMR, UV/visible, and IR spectroscopy; GC and GC/mass spectrometry; cyclic voltammetry.
- Nickel(0) Complexes and Aryl Halides: Reaction Mechanisms and Structure/Reactivity Relationships
- Keynote speaker
- Dialing Molecules with Nickel Catalysis: Understanding Oxidative Addition to Nickel(0) Complexes Relevant to Cross-Coupling
- Understanding Oxidative Addition to Nickel(0)
- 45th Scottish Regional Meeting of the RSC Organic Division
- Meeting of Inorganic Chemists Recently Appointed
- EaStCHEM Conference for Early Career Researchers
- Keynote/plenary speaker
more professional activities
- AstraZeneca ICASE
- Nelson, David (Principal Investigator)
- Period 01-Oct-2017 - 30-Sep-2021
- Defining, Quantifying, and Understanding Selectivity Paradigms in Iridium-Cataly
- Nelson, David (Principal Investigator) Kerr, William (Co-investigator)
- Period 01-Oct-2018 - 30-Sep-2021
- Industrial CASE Account - University of Strathclyde 2017 | Greaves, Megan
- Nelson, David (Principal Investigator) Murphy, John (Co-investigator) Greaves, Megan (Research Co-investigator)
- Period 01-Oct-2017 - 01-Oct-2021
- Industrial Case Account 2016 | Cooper, Alasdair
- Nelson, David (Principal Investigator) Tomkinson, Nicholas (Co-investigator) Cooper, Alasdair (Research Co-investigator)
- Period 01-Oct-2016 - 01-Oct-2020
- Industrial Case Account 2015 | Curle, Jonathan
- Tomkinson, Nicholas (Principal Investigator) Nelson, David (Co-investigator) Curle, Jonathan (Research Co-investigator)
- Period 01-Oct-2016 - 01-Oct-2020
- Industrial Case Account 2015 | Smith, Andrew
- Murphy, John (Principal Investigator) Nelson, David (Co-investigator) Smith, Andrew (Research Co-investigator)
- Period 01-Oct-2015 - 01-Oct-2019
Pure and Applied Chemistry
Thomas Graham Building
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