Dr David Nelson

Senior Lecturer

Pure and Applied Chemistry

Personal statement

We conduct research at the intersection of organic and inorganic chemistry, with our primary aim being to discover, develop, and understand metal-catalysed reactions for organic synthesis. We use the tools of physical organic chemistry, organic and organometallic synthesis, and spectroscopy to achieve our aims. Ongoing projects include:

  • Understanding structure/reactivity relationships in nickel catalysed reactions
  • Quantifying reactivity and site-selectivity in metal catalysed C-H functionalisation reactions
  • The design of new ligands and quantification of their properties

We are grateful to have received generous funding from organisations including the EPSRC, the Carnegie Trust, GSK, AstraZeneca, Syngenta, the Leverhulme Trust, and the Royal Society.

Further details can be found on our website at http://personal.strath.ac.uk/david.nelson/.

In addition to research and teaching, I organise colloquia for research students and staff in the Catalysis & Synthesis and Chemical Biology & Medicinal Chemistry sections.

I sit on the Faculty of Science Resources and Planning Committee, and have done so since 2018. I have been a Faculty Education Liason Advisor since March 2020, a role that involves me attending various recruitment events.

I have been a member of the Editorial Board of Communications Chemistry since April 2020. This a relatively new open access journal that is published by Springer Nature.

Expertise

Has expertise in:

    Areas

    • Catalysis
    • Cross-coupling
    • C-H activation
    • N-Heterocyclic carbenes
    • Organometallic chemistry
    • Physical organic chemistry

    Techniques

    • Organometallic and organic synthesis
    • Handling of air- and moisture-sensitive compounds
    • NMR and UV/visible spectroscopies
    • Reaction kinetics
    • Reaction simulation using numerical integration software
    • Density functional theory (DFT)

Prizes and awards

Royal Society of Chemistry Inorganic Reaction Mechanisms Group - Early Career Award 2021
Recipient
1/6/2022
'Digital Innovator' (Strath Union Teaching Excellence Awards 2022)
Recipient
19/5/2022

More prizes and awards

Qualifications

Qualifications and Experience

  • Senior Lecturer, University of Strathclyde, 2018 - Present
  • Chancellor's Fellow and Lecturer, University of Strathclyde, 2014 - 2018
  • Research Fellow (with Prof. S. P. Nolan FRSE), University of St Andrews, 2012 - 2014
  • PhD in Pure and Applied Chemistry (with Prof. J. M. Percy), University of Strathclyde, 2008 - 2012
  • MChem in Chemistry with Industrial Experience, University of Edinburgh, 2003 - 2008

Memberships

  • Fellow of the Royal Society of Chemistry
  • Member of the Americal Chemical Society
  • Member of the Society of Chemical Industry
  • Member of the Society of Chemical Industry Young Chemists' Panel
  • Fellow of the Higher Education Academy

 

Publications

Evaluating a dispersion of sodium in sodium chloride for the synthesis of low-valent nickel complexes
Johnson Humphrey Elliot L B, Kennedy Alan R, Sproules Stephen, Nelson David James
European Journal of Inorganic Chemistry Vol 2022 (2022)
https://doi.org/10.1002/ejic.202101006
Reactions of N-heterocyclic carbene-based chalcogenoureas with halogens : a diverse range of outcomes
Saab Marina, Nelson David James, Leech Matthew C C, Lam Kevin, Nolan Steven P, Nahra Fady, Van Hecke Kristof
Dalton Transactions Vol 51, pp. 3721-3733 (2022)
https://doi.org/10.1039/D2DT00010E
Competitive gold/nickel transmetalation
Demchuk Mitchell J, Zurakowski Joseph A, Austen Brady J H, Nelson David J, Drover Marcus W
Chemical Communications Vol 58, pp. 68-71 (2021)
https://doi.org/10.1039/D1CC06064C
Lewis acid-promoted oxidative addition at a [Ni0(diphosphine)2] complex : the critical role of a secondary coordination sphere
Zurakowski Joseph A, Austen Brady J H, Dufour Maeve C, Spasyuk Denis M, Nelson David J, Drover Marcus W
Chemistry - A European Journal Vol 27, pp. 16021-16027 (2021)
https://doi.org/10.1002/chem.202103121
Inhibition of (dppf)nickel-catalysed Suzuki-Miyaura cross-coupling reactions by α-halo-N-heterocycles
Cooper Alasdair K, Greaves Megan E, Donohoe William, Burton Paul M, Ronson Thomas O, Kennedy Alan R, Nelson David J
Chemical Science Vol 12, pp. 14074-14082 (2021)
https://doi.org/10.1039/D1SC04582B
Are rate and selectivity correlated in iridium-catalysed hydrogen isotope exchange reactions?
Timofeeva Daria S, Lindsay David M, Kerr William J, Nelson David J
Catalysis Science and Technology Vol 11, pp. 5498-5504 (2021)
https://doi.org/10.1039/D1CY00708D

More publications

Teaching

Current Teaching

CH212 Physical Chemistry 1 - Kinetics [2020/21] This lecture course addresses the fundamentals of the kinetics of chemical reactions and covers the core and underpinning topics that allow students to develop a full understanding of what influences the rates of chemical reactions and how (and why) we study this.

CH450/8 Distance Learning Course - Reaction Mechanisms. [2014/15 - Present] This distance learning course is completed by MChem students on placement. The aims of the course are to: develop knowledge and understanding of reaction mechanisms, particularly in organic chemistry; develop skills in analysing reaction mechanisms; extend powers of analysis and deduction, and relate these to the choice of appropriate experiments in the study of reaction mechanisms; and show how knowledge of reaction mechanisms is related to synthetic chemistry and the understanding of processes both in the laboratory or production plant and in living systems.

CH508/9 Advanced and Modern Methods in Organic Synthesis. [2017/18 - Present] This course covers a range of state-of-the-art techniques in organic synthesis, including: palladium, copper, iridium, ruthenium, and gold-catalysis, organocatalysis, and asymmetric synthesis. Several lectures are devoted to the study of physical organic chemistry in the understanding of these reactions.

 

Previous Teaching Activities

CH107 Chemistry: Principles and Practice 2 - Organic Chemistry. [2016/17, 2017/18] This first year undergraduate course provides students with the understanding of key reactions, concepts, and principles that are relevant to the study and use of organic chemistry. These include: nucleophiles, electrophiles, and radicals; alkenes and their reactions; epoxides and their reactions; carbonyl compounds and their oxidation, reduction, and reactions.

CH208 Fundamental Organic Chemistry - Aromatic Chemistry. [2016/17] This second year course provides students with the understanding of aromatic molecules and their reactivity, including: identifying aromatic molecules; electrophilic and nucleophilic aromatic substitution; and the generation and reactions of benzyne.

CH538: Molecular Catalysis. [2019/20] This course covers various topics in homogeneous catalysis, including the use of organometallic complexes, enzymes, and main group complexes. Students learn about applications, underlying mechanisms, techniques for interrogating reactions, and techniques for catalyst separation and recycling.

CH721: Well defined complexes of gold: synthesis, properties and homogeneous catalysis. [2014/15, 2016/17, 2018/19] This course for MPhil and PhD students covers a range of organic and organometallic chemistry, with a special focus on catalysis, including: the history of gold catalysis; the properties of gold including favoured oxidation states, ligands and geometries; fundamental reactivity of organogold complexes; the synthesis of modern gold complexes as homogeneous catalysts (Au(I) and Au(III)); synthesis of related gold complexes, such as hydroxides, peroxides, di-, tri- and poly-gold complexes; and C-H activation/functionalisation and cross-coupling with gold.

 

Prizes

Winner of the 'Digital Innovator' category at the Strath Union Teaching Excellence Awards 2022.

Research interests

Many important reactions in industry today are catalysed by transition metal complexes. Our research focusses on the design, discovery, understanding and optimisation of selective and economical processes, with a specific focus on developing reactions to the point that they can be deployed on scale in industry.

Key Phrases: Catalysis; Organometallic Chemistry; Physical Organic Chemistry; Organic Synthesis

Funding: We are grateful to have received funding and support from the following organisations: Johnson-Matthey/Alfa Aesar; Fluorochem; The Carnegie Trust; The Engineering and Physical Sciences Research Council (EPSRC); Syngenta; AstraZeneca; GlaxoSmithKline; The Leverhulme Trust; The Royal Society.

Detailed Summary: A detailed summary can be found on our group website (http://personal.strath.ac.uk/david.nelson/).

Training: Students within the research group gain training and experience in the synthesis, isolation, characterisation, and study of interesting organic and organometallic compounds. We use a variety of tools and techniques to achieve our aims, including: Schlenk techniques; inert atmosphere gloveboxes; NMR, UV/visible, and IR spectroscopy; GC and GC/mass spectrometry; cyclic voltammetry.

Professional activities

Communications Chemistry (Journal)
Editorial board member
1/4/2020
Nickel Catalysis
Consultant
10/3/2020
Unexpected Speciation in the Reactions of Alkyl Halides with Nickel(0) Complexes
Speaker
20/2/2020
Understanding Oxidative Addition to Nickel(0) for Cross-Coupling Catalysis
Speaker
14/2/2020
Understanding Oxidative Addition to Nickel(0) for Cross-Coupling Catalysis
Speaker
11/2/2020
Understanding Oxidative Addition to Nickel(0) for Cross-Coupling Catalysis
Speaker
6/12/2019

More professional activities

Projects

Supply of Compounds to BASF
Nelson, David (Principal Investigator)
01-Jan-2021 - 30-Jan-2021
Understanding the Reliability and Transferability of Machine Learning | Russell, Hayley
Nelson, David (Principal Investigator) Palmer, David (Co-investigator) Russell, Hayley (Research Co-investigator)
01-Jan-2021 - 01-Jan-2025
Understanding the Reliability and Transferability of Machine Learning
Nelson, David (Principal Investigator) Palmer, David (Co-investigator) Reid, Marc (Co-investigator)
01-Jan-2021 - 31-Jan-2024
EasySampler
Nelson, David (Principal Investigator)
Equipment for automated chemical reaction monitoring
01-Jan-2021 - 31-Jan-2030
Industrial Case Account - University of Strathclyde 2020 | Russell, Hayley
Nelson, David (Principal Investigator) Palmer, David (Co-investigator) Russell, Hayley (Research Co-investigator)
01-Jan-2021 - 01-Jan-2025
Syngenta Q1 2020
Nelson, David (Principal Investigator)
01-Jan-2020 - 31-Jan-2020

More projects

Address

Pure and Applied Chemistry
Thomas Graham Building

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