Dr Iain Oswald

Senior Lecturer

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

EPSRC Early Career Fellow

Iain D.H. Oswald graduated from the University of Edinburgh (2001) and remained there in the group of Professor Simon Parsons to study hydrogen-bonding patterns and co-crystallisation as part of his PhD. Fortunately, this research expanded to investigate the effects of high pressure which allowed him the opportunity to work at the European Synchrotron Radiation Facility in Grenoble. In 2004 he left for Grenoble where he became a postdoctoral researcher on the high pressure beamline (ID27). In 2006, he returned to Edinburgh to join the group of Colin R. Pulham and started a fellowship position funded by the Leverhulme Trust.

In 2009, Iain started his post at SIPBS as a Lecturer in Pharmaceutics and is interested and has been awarded funding in the areas of co-crystallisation of pharmaceutical materials at high pressure (EPSRC Early Career Fellowship) and polymorphism and polymerisation of monomeric materials (Leverhulme Trust 2012-2015). 

Iain has contributed to the MPharm program as the 4th Year Co-ordinator (2012-2016) and has been an integral part of the redevelopment of the MPharm curriculum.  He lectures and is class coordinator for the 2nd year class Pharmaceutics and for the Year 2 class Normal Function of the gastrointestinal tract.  Students in the 4th year of study will be able to work with Iain on research associated with pharmaceutical products in the solid state. His teaching activities extend to postgraduate degrees in the MRes Drug Delivery Systems and MSc Pharmaceutical Analysis course.

He is currently a member of the ESPRC Early Career Forum in Manufacturing that seeks engage with the EPSRC, Industry and academia to highlight challenges in the area of Manufacturing.

Publications

Mannitol crystallization at sub-zero temperatures : time/temperature-resolved synchrotron x-ray diffraction study and the phase diagram
Rodrigues Miguel A, Rego Pedro, Geraldes Vitor, Connor Lauren E, Oswald Iain D H, Sztucki Michael, Shalaev Evgenyi
Journal of Physical Chemistry Letters Vol 12, pp. 1453–1460 (2021)
https://doi.org/10.1021/acs.jpclett.0c03680
Hidden solvates and transient forms of trimesic acid
Ward Martin R, Oswald Iain D H
Crystals Vol 10 (2020)
https://doi.org/10.3390/cryst10121098
Effect of chirality on the compression of 2-(2-Oxo-1-pyrrolidinyl)butyramide : a tale of two crystals
Bebiano Suse S, ter Horst Joop H, Oswald Iain DH
Crystal Growth and Design Vol 20, pp. 6731-6744 (2020)
https://doi.org/10.1021/acs.cgd.0c00871
Crystallography under high pressures
Moggach Stephen A, Oswald Iain D H
21st Century Challenges in Chemical Crystallography I History and Technical Developments (2020) (2020)
https://doi.org/10.1007/430_2020_70
A prolific solvate former, galunisertib, under the pressure of crystal structure prediction, produces ten diverse polymorphs
Bhardwaj Rajni M, McMahon Jennifer A, Nyman Jonas, Price Louise S, Konar Sumit, Oswald Iain D H, Pulham Colin R, Price Sarah L, Reutzel-Edens Susan M
Journal of the American Chemical Society Vol 141, pp. 13887-13897 (2019)
https://doi.org/10.1021/jacs.9b06634
Structural investigation and compression of a co-crystal of indomethacin and saccharin
Connor Lauren E, Vassileiou Antony D, Halbert Gavin W, Johnston Blair F, Oswald Iain DH
CrystEngComm Vol 21, pp. 4465-4472 (2019)
https://doi.org/10.1039/C9CE00838A

More publications

Professional activities

Pressure on molecular systems: insights into new solid forms
Speaker
22/6/2020
Small Molecules at Extreme conditions
Speaker
5/11/2019
Small Molecules at Extreme Conditions
Speaker
3/9/2019
Polymorphism of acrylamide facilitated by pressure-transmitting medium
Speaker
18/6/2018
Under pressure to react - acetylenedicarboxylic acid polymerisation
Speaker
28/8/2017
Analysis of hydrogenated materials at high pressure using Neutron powder diffraction
Speaker
29/7/2017

More professional activities

Projects

Quantifying the Dynamic Response in Metal-Organic Frameworks (MOFs): A Platform for Tuning Chemical Space in Porous Materials
Fletcher, Ashleigh (Principal Investigator) Oswald, Iain (Co-investigator)
01-Jan-2020 - 30-Jan-2023
Investigation of maleic-d2 acid isomerization at high pressure
Ward, Martin (Principal Investigator) Oswald, Iain (Co-investigator)
We will use central facilities time (ISIS neutron and muon facility) to study the conversion of maleic to fumaric acid under high pressure and temperature conditions. Experiments performed in-house show that temperature of pressure alone do not significantly influence the conversion of maleic to fumaric acid; however, the combination of both does result in successful conversion. Neutron experiments will elucidate the conversion in-situ, as it progresses, and allow us to identify ciritcal conditions of temperature and pressure to cause this conversion.
26-Jan-2019
laser-induced nucleation at extreme conditions
Ward, Martin (Principal Investigator) Oswald, Iain (Co-investigator) Alexander, Andrew J (Co-investigator)
In this work we will explore the use of a focussed beam of light to cause crystals to form inside our high-pressure sample holder. The use of laser light (pulse and continuous) has been shown to be able to cause nucleation (the first step of crystallization) to occur at ambient conditions, we will continue with this to (i) see if it is applicable to high pressure conditions, and (ii) develop the methodology to assist with nucleation studies at extreme conditions.
16-Jan-2019
Pressure-dependent In-Situ Monitoring of Granular Materials
Florence, Alastair (Principal Investigator) Halbert, Gavin (Co-investigator) Markl, Daniel (Co-investigator) McArthur, Stephen (Co-investigator) Nordon, Alison (Co-investigator) Oswald, Iain (Co-investigator)
01-Jan-2019 - 31-Jan-2022
assess the potential for API particle shape control in API crystallisation processes (Student Placement Lauren Connor)
Oswald, Iain (Principal Investigator)
13-Jan-2017 - 31-Jan-2018
Evaluation of solid-state form for polymer drug delivery
Oswald, Iain (Principal Investigator)
01-Jan-2017 - 31-Jan-2017

More projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Robertson Wing

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