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Dr John Parkinson

Senior Research Fellow

Pure and Applied Chemistry

Personal statement

John Parkinson is a career-track academic applications specialist in the field of nuclear magnetic resonance (NMR) spectroscopy with a wealth of interdisciplinary research experience. He is head of NMR spectroscopy at Strathclyde having joined the University in November 2001 from positions as NMR spectroscopist with the Metals-in-Medicine group and the EPSRC National Ultra High Field NMR Facility at the University of Edinburgh (1990-2001).

Expertise

Has expertise in:

    John is an expert in the solution-phase aspects of NMR spectroscopy and has wide knowledge of practical experimental NMR methods, NMR instrumentation, NMR data handling and interpretation, NMR laboratory management as well as skills in writing, teaching, molecular modelling, research project supervision, examining at both undergraduate and postgraduate level and disemination of research findings through conference oral and poster presentations. John is also involved in shaping future national UK-wide and local area policy on NMR equipment provision and is a serving member (honourary treasurer) of the Royal Society of Chemistry NMR Discussion Group.

Prizes and awards

Fellow of the Royal Society of Chemistry
Recipient
2010

more prizes and awards

Publications

Structural basis of DNA duplex distortion induced by thiazole-containing hairpin polyamides
Padroni Giacomo, Parkinson John A., Fox Keith R., Burley Glenn A.
Nucleic Acids Research, (2017)
http://dx.doi.org/10.1093/nar/gkx1211
Metabolomic profiling of the synergistic effects of melittin in combination with cisplatin on ovarian cancer cells
Alonezi Sanad, Tusiimire Jonans, Wallace Jennifer, Dufton Mark J., Parkinson John A., Young Louise C., Clements Carol J., Park Jin-Kyu, Jeon Jong-Woon, Ferro Valerie A., Watson David G.
Metabolites Vol 7, pp. 1-18, (2017)
http://dx.doi.org/10.3390/metabo7020014
Determination of equilibrium constant of C60 fullerene binding with drug molecules
Mosunov Andrei A, Pashkova Irina, Sidorova Maria, Pronozin Artem, Lantushenko Anastasia, Prylutskyy Yuriy I, Parkinson John A, Evstigneev Maxim P
Physical Chemistry Chemical Physics Vol 19, pp. 6777-6784, (2017)
http://dx.doi.org/10.1039/c6cp07140f
Kinetics of early stages of resorcinol-formaldehyde polymerization investigated by solution phase nuclear magnetic resonance spectroscopy
Gaca Katarzyna Z., Parkinson John A., Sefcik Jan
Polymer Vol 110, pp. 62-73, (2017)
http://dx.doi.org/10.1016/j.polymer.2016.12.069
Metabolomic profiling of the effects of melittin on cisplatin resistant and cisplatin sensitive ovarian cancer cells using mass spectrometry and biolog microarray technology
Alonezi Sanad, Tusiimire Jonans, Wallace Jennifer, Dufton Mark J., Parkinson John A., Young Louise C., Clements Carol J., Park Jin Kyu, Jeon Jong Woon, Ferro Valerie A., Watson David G.
Metabolites Vol 6, (2016)
http://dx.doi.org/10.3390/metabo6040035
Standardless, automated determination of Chlorine-35 by 35Cl nuclear magnetic resonance
Watson Simon A., Edwards Andy J., Parkinson John A.
Analytical Letters Vol 50, pp. 161-172, (2016)
http://dx.doi.org/10.1080/00032719.2016.1172636

more publications

Teaching

John teaches NMR spectroscopy to third year undergraduate Chemistry students and Biomolecular, Structure, Dynamics and Mechanism to final year Chemistry with Drug Discovery and postgraduate diploma in Medicinal Chemistry. He also delivers a course in NMR spectroscopy to postgraduate researchers.

Research interests

Research interests include understanding the factors that drive molecular recognition and assembly in biomolecular systems, exploring enzyme reactivity and substrate demand in the context of complex natural product mixtures, defining applications for new experimental developments in the field of NMR spectroscopy, monitoring chemical and biochemical reaction processes and in understanding molecular structure, dynamics and mechanism in the broadest sense.

Professional activities

Science and Parliament 2017
Participant
15/11/2017
Bruker NMR Users' Meeting
Participant
13/11/2017
From Spectral Data to Chemical Knowledge
Participant
7/11/2017
Reaction Monitoring Symposium
Participant
6/11/2017
The Academy of Medical Sciences (External organisation)
Advisor
23/10/2017
Chemistry - A European Journal (Journal)
Peer reviewer
3/10/2017

more professional activities

Projects

MGB Formulations
Suckling, Colin (Principal Investigator) Graham, Duncan (Co-investigator) Parkinson, John (Co-investigator)
Period 01-Apr-2012 - 30-Jun-2012
Photocatalysis for Organic Synthesis
Parkinson, John (Co-investigator)
Inorganic semiconductors such as TiO2 are known to generate free radicals when irradiated with UV-visible light in the presence of suitable substrates. This project will explore the chemistry of such radicals with the particular objective of identifying and optimising free radical addition reactions which will be beneficial in organic synthesis. Organic synthesis driven by heterogeneous photocatalysis is environmentally and economically attractive, and has the potential to achieve higher selectivity to desired products than conventional routes. We propose to explore a wide range of free radical addition reactions initiated by the known photo-Kolbe reaction of carboxylic acids over titania surfaces. Reactions showing the most promise will be examined in more detail, using in particular in-situ EPR spectroscopy (to observe the initially generated free radicals), in-situ NMR spectroscopy (to identify intermediates and products), and time resolved optical spectroscopy (to observe short lived species) to determine the reaction pathways. Initial studies will be made with TiO2, but we will also explore improvements in performance by adding metals to enhance hole:electron separation, or nitrogen dopants to achieve visible light activation. Visible light activation will also be attempted with other semiconductors. A crucial component of the project is the design and construction of reactors for scaling up promising reactions to a scale attractive to the pharmaceutical industry. The project team has wide experience in photocatalysis, free radical chemistry, in-situ spectroscopic methods and photocatalytic reactor design and construction. Advice and assistance in selection of target reactions relevant to the pharmaceutical industry is provided by GlaxoSmithKline. A successful outcome of the project could bring about a paradigm shift in technologies for high value organic synthesis.
Period 01-Oct-2010 - 01-Mar-2011

more projects

Address

Pure and Applied Chemistry
Thomas Graham Building

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