John Parkinson is a career-track academic applications specialist in the field of nuclear magnetic resonance (NMR) spectroscopy with a wealth of interdisciplinary research experience. He is head of NMR spectroscopy at Strathclyde having joined the University in November 2001 from positions as NMR spectroscopist with the Metals-in-Medicine group and the EPSRC National Ultra High Field NMR Facility at the University of Edinburgh (1990-2001).
John teaches NMR spectroscopy to third year undergraduate Chemistry students and Biomolecular, Structure, Dynamics and Mechanism to final year Chemistry with Drug Discovery and postgraduate diploma in Medicinal Chemistry. He also delivers a course in NMR spectroscopy to postgraduate researchers.
Research interests include understanding the factors that drive molecular recognition and assembly in biomolecular systems, exploring enzyme reactivity and substrate demand in the context of complex natural product mixtures, defining applications for new experimental developments in the field of NMR spectroscopy, monitoring chemical and biochemical reaction processes and in understanding molecular structure, dynamics and mechanism in the broadest sense.
- Science and Parliament 2017
- Bruker NMR Users' Meeting
- From Spectral Data to Chemical Knowledge
- Reaction Monitoring Symposium
- The Academy of Medical Sciences (External organisation)
- Chemistry - A European Journal (Journal)
- Peer reviewer
more professional activities
- MGB Formulations
- Suckling, Colin (Principal Investigator) Graham, Duncan (Co-investigator) Parkinson, John (Co-investigator)
- Period 01-Apr-2012 - 30-Jun-2012
- Photocatalysis for Organic Synthesis
- Parkinson, John (Co-investigator)
- Inorganic semiconductors such as TiO2 are known to generate free radicals when irradiated with UV-visible light in the presence of suitable substrates. This project will explore the chemistry of such radicals with the particular objective of identifying and optimising free radical addition reactions which will be beneficial in organic synthesis. Organic synthesis driven by heterogeneous photocatalysis is environmentally and economically attractive, and has the potential to achieve higher selectivity to desired products than conventional routes. We propose to explore a wide range of free radical addition reactions initiated by the known photo-Kolbe reaction of carboxylic acids over titania surfaces. Reactions showing the most promise will be examined in more detail, using in particular in-situ EPR spectroscopy (to observe the initially generated free radicals), in-situ NMR spectroscopy (to identify intermediates and products), and time resolved optical spectroscopy (to observe short lived species) to determine the reaction pathways. Initial studies will be made with TiO2, but we will also explore improvements in performance by adding metals to enhance hole:electron separation, or nitrogen dopants to achieve visible light activation. Visible light activation will also be attempted with other semiconductors. A crucial component of the project is the design and construction of reactors for scaling up promising reactions to a scale attractive to the pharmaceutical industry. The project team has wide experience in photocatalysis, free radical chemistry, in-situ spectroscopic methods and photocatalytic reactor design and construction. Advice and assistance in selection of target reactions relevant to the pharmaceutical industry is provided by GlaxoSmithKline. A successful outcome of the project could bring about a paradigm shift in technologies for high value organic synthesis.
- Period 01-Oct-2010 - 01-Mar-2011
Pure and Applied Chemistry
Thomas Graham Building
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