Dr John Parkinson

Senior Research Fellow

Pure and Applied Chemistry

Personal statement

John Parkinson is a career-track academic applications specialist in the field of nuclear magnetic resonance (NMR) spectroscopy with a wealth of interdisciplinary research experience. He is head of NMR spectroscopy at Strathclyde having joined the University in November 2001 from positions as NMR spectroscopist with the Metals-in-Medicine group and the EPSRC National Ultra High Field NMR Facility at the University of Edinburgh (1990-2001).

Expertise

Has expertise in:

    John is an expert in the solution-phase aspects of NMR spectroscopy and has wide knowledge of practical experimental NMR methods, NMR instrumentation, NMR data handling and interpretation, NMR laboratory management as well as skills in writing, teaching, molecular modelling, research project supervision, examining at both undergraduate and postgraduate level and disemination of research findings through conference oral and poster presentations. John is also involved in shaping future national UK-wide and local area policy on NMR equipment provision and is a serving member (honourary treasurer) of the Royal Society of Chemistry NMR Discussion Group.

Prizes and awards

Fellow of the Royal Society of Chemistry
Recipient
2010

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Qualifications

John qualified with a PhD from the University of Leeds (1989) and is a Fellow of the Royal Society of Chemistry (FRSC).

Publications

Investigation of molecular and mesoscale clusters in undersaturated glycine aqueous solutions
Zimbitas Georgina, Jawor-Baczynska Anna, Vesga Maria Jazmin, Javid Nadeem, Moore Barry D, Parkinson John, Sefcik Jan
Colloids and Surfaces A: Physicochemical and Engineering Aspects Vol 579 (2019)
https://doi.org/10.1016/j.colsurfa.2019.123633
Metabolomic profiling of the immune stimulatory effect of eicosenoids on PMA-differentiated THP-1 cells
Alqarni Abdulmalik M, Dissanayake Tharushi, Nelson David J, Parkinson John A, Dufton Mark J, Ferro Valerie A, Watson David G
Vaccines Vol 7 (2019)
https://doi.org/10.3390/vaccines7040142
Developing a method to determine the flux of material arriving and leaving a crystal at equilibrium
Nguyen Thai Thu Hien, Vesga Jazmin, Parkinson John, Price Chris John
50th Annual Conference of the British Association of Crystal Growth, pp. 74 (2019)
Sequence-selective minor groove recognition of a DNA duplex containing synthetic genetic components
Padroni Giacomo, Withers Jamie M, Taladriz Sender Andrea, Reichenbach Linus F, Parkinson John A, Burley Glenn A
Journal of the American Chemical Society Vol 141, pp. 9555-9563 (2019)
https://doi.org/10.1021/jacs.8b12444
Structural and kinetic profiling of allosteric modulation of duplex DNA induced by DNA-binding polyamide analogues
Aman Khalid, Padroni Giacomo, Parkinson John A, Welte Thomas, Burley Glenn A
Chemistry - A European Journal Vol 25, pp. 2757-2763 (2019)
https://doi.org/10.1002/chem.201805338
Effect of melittin on metabolomic profile and cytokine production in PMA-differentiated THP-1 cells
Alqarni Abdulmalik M, Ferro Valerie A, Parkinson John A, Dufton Mark J, Watson David G
Vaccines Vol 6 (2018)
https://doi.org/10.3390/vaccines6040072

more publications

Teaching

John teaches NMR spectroscopy to third year undergraduate Chemistry students and Biomolecular, Structure, Dynamics and Mechanism to final year Chemistry with Drug Discovery and postgraduate diploma in Medicinal Chemistry. He also delivers a course in NMR spectroscopy to postgraduate researchers.

Research interests

Research interests include understanding the factors that drive molecular recognition and assembly in biomolecular systems, exploring enzyme reactivity and substrate demand in the context of complex natural product mixtures, defining applications for new experimental developments in the field of NMR spectroscopy, monitoring chemical and biochemical reaction processes and in understanding molecular structure, dynamics and mechanism in the broadest sense.

Professional activities

Chemistry - A European Journal (Journal)
Peer reviewer
28/10/2019
1st International NMReDATA Symposium
Participant
26/9/2019
SMASH - Small Molecules Are Still Hot - NMR Conference
Participant
22/9/2019
Journal of physical chemistry (Journal)
Peer reviewer
6/9/2019
CCPN Meeting
Participant
4/9/2019
Euroismar 2019
Participant
25/8/2019

more professional activities

Projects

Doctoral Training Partnership 2018-19 University of Strathclyde | Mullen, Declan
Moreira, Vania (Principal Investigator) Parkinson, John (Co-investigator) Mullen, Declan (Research Co-investigator)
01-Jan-2018 - 01-Jan-2021
A National Network for Applications of High-Field NMR in the Life and Physical Sciences
Parkinson, John (Principal Investigator)
01-Jan-2018 - 30-Jan-2021
MGB Formulations
Suckling, Colin (Principal Investigator) Graham, Duncan (Co-investigator) Parkinson, John (Co-investigator)
01-Jan-2012 - 30-Jan-2012
Photocatalysis for Organic Synthesis
Mills, Andrew (Principal Investigator) Parkinson, John (Co-investigator)
Inorganic semiconductors such as TiO2 are known to generate free radicals when irradiated with UV-visible light in the presence of suitable substrates. This project will explore the chemistry of such radicals with the particular objective of identifying and optimising free radical addition reactions which will be beneficial in organic synthesis. Organic synthesis driven by heterogeneous photocatalysis is environmentally and economically attractive, and has the potential to achieve higher selectivity to desired products than conventional routes. We propose to explore a wide range of free radical addition reactions initiated by the known photo-Kolbe reaction of carboxylic acids over titania surfaces. Reactions showing the most promise will be examined in more detail, using in particular in-situ EPR spectroscopy (to observe the initially generated free radicals), in-situ NMR spectroscopy (to identify intermediates and products), and time resolved optical spectroscopy (to observe short lived species) to determine the reaction pathways. Initial studies will be made with TiO2, but we will also explore improvements in performance by adding metals to enhance hole:electron separation, or nitrogen dopants to achieve visible light activation. Visible light activation will also be attempted with other semiconductors. A crucial component of the project is the design and construction of reactors for scaling up promising reactions to a scale attractive to the pharmaceutical industry. The project team has wide experience in photocatalysis, free radical chemistry, in-situ spectroscopic methods and photocatalytic reactor design and construction. Advice and assistance in selection of target reactions relevant to the pharmaceutical industry is provided by GlaxoSmithKline. A successful outcome of the project could bring about a paradigm shift in technologies for high value organic synthesis.
01-Jan-2010 - 01-Jan-2011

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Address

Pure and Applied Chemistry
Thomas Graham Building

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