Dr Andrew Paul
Senior Lecturer
Strathclyde Institute of Pharmacy and Biomedical Sciences
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Publications
- IL-1β stimulates a novel, IKKα -dependent, NIK -independent activation of non-canonical NFκB signalling
- McIntosh Kathryn, Khalaf Yousif H, Craig Rachel, West Christopher, McCulloch Ashley, Waghmare Ajay, Lawson Christopher, Chan Edmond YW, MacKay Simon, Paul Andrew, Plevin Robin
- Cellular Signalling Vol 107 (2023)
- https://doi.org/10.1016/j.cellsig.2023.110684
- Determining the prognostic significance of IKKα in prostate cancer
- Montes Melania, MacKenzie Lewis, McAllister Milly J, Roseweir Antonia, McCall Pamela, Hatziieremia Sophia, Underwood Mark A, Boyd Marie, Paul Andrew, Plevin Robin, MacKay Simon P, Edwards Joanne
- The Prostate Vol 80, pp. 1188-1202 (2020)
- https://doi.org/10.1002/pros.24045
- Compromised cardiovascular function in aged rats corresponds with increased expression and activity of calcium/calmodulin dependent protein kinase IIδ in aortic endothelium
- McCluskey Claire, Mooney Laura, Paul Andrew, Currie Susan
- Vascular pharmacology Vol 118-119 (2019)
- https://doi.org/10.1016/j.vph.2019.04.002
- Inhibition of cytokine-mediated JNK signalling by purinergic P2Y11 receptors, a novel protective mechanism in endothelial cells
- Ng Pei Y, McIntosh Kathryn A, Hargrave Gillian, Ho Ka H, Paul Andrew, Plevin Robin
- Cellular Signalling Vol 51, pp. 59-71 (2018)
- https://doi.org/10.1016/j.cellsig.2018.07.016
- CaMKIIδ interacts directly with IKKβ and modulates NF-kB signalling in adult cardiac fibroblasts
- Martin Tamara P, McCluskey Claire, Cunningham Margaret R, Beattie James, Paul Andrew, Currie Susan
- Cellular Signalling (2018)
- https://doi.org/10.1016/j.cellsig.2018.07.008
- Inhibitory Kappa B kinase α (IKKα) inhibitors that recapitulate their selectivity in cells against isoform-related biomarkers
- Anthony Nahoum G, Baiget Jessica, Berretta Giacomo, Boyd Marie, Breen David, Edwards Joanne, Gamble Carly, Gray Alexander I, Harvey Alan L, Hatziieremia Sophia, Ho Ka Ho, Huggan Judith K, Lang Stuart, Llona-Minguez Sabin, Luo Jia Lin, McIntosh Kathryn, Paul Andrew, Plevin Robin J, Robertson Murray N, Scott Rebecca, Suckling Colin J, Sutcliffe Oliver Brook, Young Louise C, MacKay Simon P
- Journal of Medicinal Chemistry Vol 60, pp. 7043-7066 (2017)
- https://doi.org/10.1021/acs.jmedchem.7b00484
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Professional Activities
- EMBO/FEBS Conference , Spain
- Keynote/plenary speaker
- 1/2008
Projects
- Development of a first-in-class IKKalpha inhibitor for the treatment of castrate resistant p
- MacKay, Simon (Principal Investigator) Halbert, Gavin (Co-investigator) Paul, Andrew (Co-investigator) Suckling, Colin (Co-investigator) Watson, David (Co-investigator)
- 01-Jan-2020 - 31-Jan-2024
- Prevention of CXCL12 production in cells of the cardiovascular system by IKK alpha inhibition (BHF PhD Studentship)
- Plevin, Robin (Principal Investigator) Coats, Paul (Co-investigator) MacKay, Simon (Co-investigator) Paul, Andrew (Co-investigator)
- 01-Jan-2018 - 30-Jan-2022
- A proof-of-concept study to establish a systematic approach for the discovery of allosteric sites in proteins
- Anthony, Nahoum Guillaume Hsuan (Principal Investigator) Paul, Andrew (Co-investigator)
- 05-Jan-2015 - 31-Jan-2017
- CXCL12 as a assay system for IKKapha inhibitor drugs
- Plevin, Robin (Principal Investigator) Paul, Andrew (Co-investigator)
- 01-Jan-2015 - 31-Jan-2017
- UNDERSTANDING THE EFFECTS OF CANCER RADIATION THERAPY ON ENDOTHELIAL CELL DYSFUNCTION- THE ROLE OF NUCLEAR FACTOR KAPPPA B
- Plevin, Robin (Principal Investigator) Boyd, Marie (Co-investigator) Paul, Andrew (Co-investigator)
- Understanding the effects of cancer radiation therapy on endothelial cell dysfunction- the role of Nuclear factor kapppa B
- 01-Jan-2013 - 30-Jan-2016
- First-in-class drugs for CRPC
- MacKay, Simon (Principal Investigator) Boyd, Marie (Co-investigator) Paul, Andrew (Co-investigator) Plevin, Robin (Co-investigator) Suckling, Colin (Co-investigator)
- 01-Jan-2013 - 30-Jan-2016
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Contact
Dr
Andrew
Paul
Senior Lecturer
Strathclyde Institute of Pharmacy and Biomedical Sciences
Email: a.paul@strath.ac.uk
Tel: 548 2028